{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:53:27Z","timestamp":1790380407033,"version":"4.1.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T00:00:00Z","timestamp":1363132800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0058565","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T22:48:36Z","timestamp":1363214916000},"page":"e58565","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Human Female Genital Tract Infection by the Obligate Intracellular Bacterium Chlamydia trachomatis Elicits Robust Type 2 Immunity"],"prefix":"10.1371","volume":"8","author":[{"given":"Rodolfo D.","family":"Vicetti Miguel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A. K.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"LaFramboise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth D.","family":"Reighard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean B.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Cherpes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,3,13]]},"reference":[{"key":"ref1","first-page":"673","article-title":"Epidemiology and control of trachoma: systematic review","volume":"15","author":"VH Hu","year":"2011","journal-title":"Trop Med Int Health"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1086\/652402","article-title":"Duration of untreated, uncomplicated Chlamydia trachomatis genital infection and factors associated with Chlamydia resolution: a review of human studies","volume":"201","author":"WM Geisler","year":"2010","journal-title":"J Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1056\/NEJMcp030542","article-title":"Clinical practice. Genital chlamydial infections","volume":"349","author":"JF Peipert","year":"2003","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1086\/428287","article-title":"The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: a 5-year follow-up study","volume":"191","author":"M Molano","year":"2005","journal-title":"J Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nri1551","article-title":"Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine","volume":"5","author":"RC Brunham","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.mehy.2012.07.032","article-title":"Hypothesis: Chlamydia trachomatis infection of the female genital tract is controlled by Type 2 immunity","volume":"79","author":"RD Vicetti Miguel","year":"2012","journal-title":"Med Hypotheses"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1086\/652397","article-title":"Pathogenesis of genital tract disease due to Chlamydia trachomatis","volume":"201","author":"T Darville","year":"2010","journal-title":"J Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri2992","article-title":"Diversity and dialogue in immunity to helminths","volume":"11","author":"JE Allen","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nm1451","article-title":"Memory T<sub>H<\/sub>2 cells induce alternatively activated macrophages to mediate protection against nematode parasites","volume":"12","author":"RM Anthony","year":"2006","journal-title":"Nature Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/aji.12008","article-title":"Transient detection of chlamydial-specific Th1 memory cells in the peripheral circulation of women with history of Chlamydia trachomatis genital tract infection","volume":"68","author":"RD Vicetti Miguel","year":"2012","journal-title":"Amer J Repro Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev.ecolsys.36.102003.152622","article-title":"Evolutionary causes and consequences of immunopathology","volume":"36","author":"AL Graham","year":"2005","journal-title":"Annu Rev Ecol Evol Syst"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/art.1780370626","article-title":"Human T lymphocytes express a member of the matrix metalloproteinase gene family","volume":"37","author":"W Conca","year":"1994","journal-title":"Arthritis Rheum"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.4049\/jimmunol.173.6.3605","article-title":"Stromelysin-2 (matrix metalloproteinase 10) is inducible in lymphoma cells and accelerates the growth of lymphoid tumors in vivo","volume":"173","author":"C Van Themsche","year":"2004","journal-title":"J Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nm1332","article-title":"IL-13 signaling through the IL-13\u03b1<sub>2<\/sub> receptor is involved in induction of TGF-\u03b2<sub>1<\/sub> production and fibrosis","volume":"12","author":"S Fichtner-Feigl","year":"2006","journal-title":"Nat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1053\/j.gastro.2008.08.055","article-title":"IL-13 signaling via IL-13R\u03b1<sub>2<\/sub> induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis","volume":"135","author":"S Fichtner-Feigl","year":"2008","journal-title":"Gastroenterology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/j.1365-2567.2005.02094.x","article-title":"Interleukin-24 and its receptors","volume":"114","author":"M Wang","year":"2005","journal-title":"Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.4049\/jimmunol.166.10.5859","article-title":"Cutting edge: FISP (IL-4 induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells","volume":"166","author":"G Schaefer","year":"2001","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-4644(19990701)74:1<1::AID-JCB1>3.0.CO;2-M","article-title":"Cutaneous rat wounds express c49a, a novel gene with homology to the human melanoma differentiation associated gene, mda-7","volume":"74","author":"C Soo","year":"1999","journal-title":"J Cell Biochem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1471-2407-5-124","article-title":"Differential expression of MUC genes in endometrial and cervical tissues and tumors","volume":"27","author":"V Hebbar","year":"2005","journal-title":"BMC Cancer"},{"key":"ref20","first-page":"877","article-title":"Regulation of mucin expression in respiratory diseases Biochem Soc Trans","volume":"37","author":"J Turner","year":"2009"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1165\/rcmb.2011-0160OC","article-title":"Distinct microRNA expression in human airway cells of asthmatic donors identifies a novel asthma-associated gene","volume":"47","author":"MJ Jardim","year":"2012","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1476-4598-7-49","article-title":"Meta-analysis of human cancer microarray reveals GATA3 is integral to the estrogen receptor alpha pathway","volume":"7","author":"BJ Wilson","year":"2008","journal-title":"Mol Cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.2337\/db08-1475","article-title":"Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice","volume":"58","author":"S Fujisaka","year":"2009","journal-title":"Diabetes"},{"key":"ref24","first-page":"375","article-title":"Evolution of Th2 immunity: a rapid repair response to the tissue destructive pathogens","volume":"11","author":"JE Allen","year":"2011","journal-title":"PLoS Pathogens"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1126\/science.1221064","article-title":"New paradigms in type 2 immunity","volume":"337","author":"B Pulendran","year":"2012","journal-title":"Science"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"FO Martinez","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1126\/science.290.5497.1768","article-title":"Downregulation of the macrophage lineage through interaction with OX2 (CD200)","volume":"290","author":"RM Hoek","year":"2000","journal-title":"Science"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1471-4906(02)02223-8","article-title":"CD200 and membrane protein interactions in the control of myeloid cells","volume":"23","author":"AN Barclay","year":"2002","journal-title":"Trends Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/ni.1637","article-title":"A critical function for CD200 in lung immune homeostasis and the severity of influenza infection","volume":"9","author":"RJ Snelgrove","year":"2008","journal-title":"Nat Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.176.1.287","article-title":"Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation","volume":"176","author":"M Stein","year":"1992","journal-title":"J Exp Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.4049\/jimmunol.1103054","article-title":"Dendritic cell activation and memory cell development are impaired among mice administered medroxyprogesterone acetate prior to mucosal herpes simplex virus type 1 Infection","volume":"189","author":"RD Vicetti Miguel","year":"2012","journal-title":"J Immunol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.immunol.22.012703.104807","article-title":"Transcriptional control of early B cell development","volume":"22","author":"M Busslinger","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ni1454","article-title":"Pax5: the guardian of B cell identify and function","volume":"5","author":"C Cobaleda","year":"2007","journal-title":"Nat Immunol"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Taylor BD, Darville T, Ferrell RE, Ness RB, Haggerty CL (2013) Racial variation in Toll-like Receptor variants among women with pelvic inflammatory disease. J Infect Dis (in press).","DOI":"10.1093\/infdis\/jis922"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1086\/432070","article-title":"Immunoepidemiologic profile of Chlamydia trachomatis infection: importance of heat-shock protein 60 and interferon-\u03b3","volume":"192","author":"CR Cohen","year":"2005","journal-title":"J Infect Dis"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jim.2012.07.018","article-title":"Brefeldin A, but not monensin, enables flow cytometric detection of interleukin-4 within peripheral T cells responding to ex vivo stimulation with Chlamydia trachomatis","volume":"384","author":"RD Vicetti Miguel","year":"2012","journal-title":"J Immunol Methods"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/intimm\/dxh260","article-title":"Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells","volume":"17","author":"G Tanaka","year":"2005","journal-title":"Int Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0058565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T13:52:07Z","timestamp":1589032327000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0058565"}},"subtitle":[],"editor":[{"given":"J\u00f6rn","family":"Coers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,13]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0058565","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,13]]}}}