{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:32:02Z","timestamp":1791351122439,"version":"4.3.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0058570","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T22:29:55Z","timestamp":1362522595000},"page":"e58570","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["TNNI3K, a Cardiac-Specific Kinase, Promotes Physiological Cardiac Hypertrophy in Transgenic Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Xiaojian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jizheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhou","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutai","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,3,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly","volume":"65","author":"N Frey","year":"2003","journal-title":"Annu Rev Physiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1161\/HYPERTENSIONAHA.106.079426","article-title":"The fuzzy logic of physiological cardiac hypertrophy","volume":"49","year":"2007","journal-title":"Hypertension"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0092-8674(00)80043-4","article-title":"Stress pathways and heart failure","volume":"98","author":"KR Chien","year":"1999","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1161\/01.CIR.0000120390.68287.BB","article-title":"Hypertrophy of the heart: a new therapeutic target?","volume":"109","author":"N Frey","year":"2004","journal-title":"Circulation"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"JA Hill","year":"2008","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1172\/JCI24178","article-title":"Protein kinase cascades in the regulation of cardiac hypertrophy","volume":"115","year":"2005","journal-title":"J Clin Invest"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.yjmcc.2010.09.007","article-title":"Analysis of cardiac myosin binding protein-C phosphorylation in human heart muscle","volume":"49","author":"O Copeland","year":"2010","journal-title":"J Mol Cell Cardiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.yjmcc.2008.05.020","article-title":"Myosin binding protein C phosphorylation in normal, hypertrophic and failing human heart muscle","volume":"45","author":"AM Jacques","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"ref9","first-page":"31","article-title":"[Phosphorylation of troponin in the heart and skeletal muscle by Ca2+\u2212phospholipid-dependent protein kinase]","volume":"53","author":"AV Vorotnikov","year":"1988","journal-title":"Biokhimiia"},{"key":"ref10","first-page":"297","article-title":"Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I. J Mol Med (Berl)","volume":"81","author":"Y Zhao","year":"2003"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.4049\/jimmunol.1100159","article-title":"Quantitative trait locus analysis, pathway analysis, and consomic mapping show genetic variants of Tnni3k, Fpgt, or H28 control susceptibility to viral myocarditis","volume":"186","author":"SA Wiltshire","year":"2011","journal-title":"J Immunol"},{"key":"ref12","first-page":"A16031","article-title":"Tnni3k is a Novel Modulator of Cardiac Conduction","volume":"124","author":"A Milano","year":"2011","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1582-4934.2007.00155.x","article-title":"Mef2c is an essential regulatory element required for unique expression of the cardiac-specific CARK gene","volume":"12","author":"H Wang","year":"2008","journal-title":"J Cell Mol Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1440-1681.2011.05499.x","article-title":"Adenovirus-mediated overexpression of cardiac troponin I-interacting kinase promotes cardiomyocyte hypertrophy","volume":"38","author":"L Wang","year":"2011","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"H708","DOI":"10.1152\/ajpheart.00252.2008","article-title":"Overexpression of TNNI3K, a cardiac-specific MAP kinase, promotes P19CL6-derived cardiac myogenesis and prevents myocardial infarction-induced injury","volume":"295","author":"ZF Lai","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1000647","DOI":"10.1371\/journal.pgen.1000647","article-title":"Tnni3k modifies disease progression in murine models of cardiomyopathy","volume":"5","author":"FC Wheeler","year":"2009","journal-title":"PLoS Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijcard.2008.03.006","article-title":"The changes of the cardiac structure and function in cTnTR141W transgenic mice","volume":"128","author":"F Juan","year":"2008","journal-title":"Int J Cardiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1161\/01.RES.0000185833.42544.06","article-title":"Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure","volume":"97","author":"J Wang","year":"2005","journal-title":"Circ Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/CS20080637","article-title":"The haplotype of the growth-differentiation factor 15 gene is associated with left ventricular hypertrophy in human essential hypertension","volume":"118","author":"X Wang","year":"2010","journal-title":"Clin Sci (Lond)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"MM Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1172\/JCI112908","article-title":"Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals","volume":"79","author":"S Izumo","year":"1987","journal-title":"J Clin Invest"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1073\/pnas.85.2.339","article-title":"Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload","volume":"85","author":"S Izumo","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.yjmcc.2007.07.045","article-title":"Factors controlling cardiac myosin-isoform shift during hypertrophy and heart failure","volume":"43","author":"MP Gupta","year":"2007","journal-title":"J Mol Cell Cardiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"28180","DOI":"10.1074\/jbc.M109.036566","article-title":"Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17","volume":"284","author":"D Catalucci","year":"2009","journal-title":"J Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1152\/physiol.00043.2010","article-title":"The athlete&apos;s heart vs. the failing heart: can signaling explain the two distinct outcomes?","volume":"26","author":"KL Weeks","year":"2011","journal-title":"Physiology (Bethesda)"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1093\/emboj\/19.11.2537","article-title":"The conserved phosphoinositide 3-kinase pathway determines heart size in mice","volume":"19","author":"T Shioi","year":"2000","journal-title":"EMBO J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"6341","DOI":"10.1093\/emboj\/19.23.6341","article-title":"The MEK1-ERK1\/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice","volume":"19","author":"OF Bueno","year":"2000","journal-title":"EMBO J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1196\/annals.1302.004","article-title":"Molecular and integrated biology of thin filament protein phosphorylation in heart muscle","volume":"1015","author":"MP Sumandea","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cardiores.2004.12.022","article-title":"Regulation of cardiac contractile function by troponin I phosphorylation","volume":"66","author":"J Layland","year":"2005","journal-title":"Cardiovasc Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.abb.2011.02.013","article-title":"The significance of regulatory light chain phosphorylation in cardiac physiology","volume":"510","author":"SB Scruggs","year":"2011","journal-title":"Arch Biochem Biophys"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0008-6363(00)00050-X","article-title":"Effect of protein kinase A on calcium sensitivity of force and its sarcomere length dependence in human cardiomyocytes","volume":"46","author":"J van der Velden","year":"2000","journal-title":"Cardiovasc Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1161\/01.CIR.96.5.1495","article-title":"Troponin I phosphorylation in the normal and failing adult human heart","volume":"96","author":"GS Bodor","year":"1997","journal-title":"Circulation"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.yjmcc.2010.01.002","article-title":"Effect of troponin I Ser23\/24 phosphorylation on Ca2+\u2212sensitivity in human myocardium depends on the phosphorylation background","volume":"48","author":"V Kooij","year":"2010","journal-title":"J Mol Cell Cardiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0058570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T23:20:32Z","timestamp":1540336832000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0058570"}},"subtitle":[],"editor":[{"given":"Tohru","family":"Fukai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,5]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0058570","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,5]]}}}