{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T06:00:10Z","timestamp":1771567210382,"version":"3.50.1"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:00:00Z","timestamp":1365120000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0058599","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T21:17:38Z","timestamp":1365196658000},"page":"e58599","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["RNAi-Mediated Silencing of Atp6i and Atp6i Haploinsufficiency Prevents Both Bone Loss and Inflammation in a Mouse Model of Periodontal Disease"],"prefix":"10.1371","volume":"8","author":[{"given":"Hongbing","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guochun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byron","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengmei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Ci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Stashenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,4,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Kawai T, Matsuyama T, Hosokawa Y, Makihira S, Seki M, et al.. (2006) B and T lymphocytes are the primary sources of RANKL in the bone resorptive lesion of periodontal disease. Am J Pathol 169: 987\u2013998. S0002-9440(10)62774-5 [pii];10.2353\/ajpath.2006.060180<\/ext-link> [doi]<\/comment>.","DOI":"10.2353\/ajpath.2006.060180"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1128\/IAI.00944-10","article-title":"Antibody to receptor activator of NF-kappaB ligand ameliorates T cell-mediated periodontal bone resorption","volume":"79","author":"X Lin","year":"2011","journal-title":"Infect Immun"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/70563","article-title":"Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification","volume":"23","author":"YP Li","year":"1999","journal-title":"Nat Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/BJ20081073","article-title":"Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts","volume":"417","author":"S Feng","year":"2009","journal-title":"Biochem J"},{"key":"ref5","first-page":"401","article-title":"T-cell immune response cDNA 7 in allograft rejection and inflammation","volume":"8","author":"N Utku","year":"2007","journal-title":"Curr Opin Investig Drugs"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1006\/geno.1999.5751","article-title":"Genomic organization of the gene coding for TIRC7, a novel membrane protein essential for T cell activation","volume":"57","author":"T Heinemann","year":"1999","journal-title":"Genomics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.4049\/jimmunol.173.4.2342","article-title":"TIRC7 deficiency causes in vitro and in vivo augmentation of T and B cell activation and cytokine response","volume":"173","author":"N Utku","year":"2004","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1074-7613(00)80634-2","article-title":"Prevention of acute allograft rejection by antibody targeting of TIRC7, a novel T cell membrane protein","volume":"9","author":"N Utku","year":"1998","journal-title":"Immunity"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.trim.2006.09.027","article-title":"TIRC7 is induced in rejected human kidneys and anti-TIRC7 mAb with FK506 prolongs survival of kidney allografts in rats","volume":"16","author":"Y Kumamoto","year":"2006","journal-title":"Transpl Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1089\/hum.2005.16.541","article-title":"Adeno-associated virus vectors in clinical trials","volume":"16","author":"BJ Carter","year":"2005","journal-title":"Hum Gene Ther"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1016\/S0140-6736(07)60982-9","article-title":"Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial","volume":"369","author":"MG Kaplitt","year":"2007","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/sj.mt.6300010","article-title":"Striatal delivery of neurturin by CERE-120, an AAV2 vector for the treatment of dopaminergic neuron degeneration in Parkinson's disease","volume":"15","author":"M Gasmi","year":"2007","journal-title":"Mol Ther"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"10456","DOI":"10.1073\/pnas.0603045103","article-title":"RNAi-mediated silencing of estrogen receptor {alpha} in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors","volume":"103","author":"S Musatov","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.4049\/jimmunol.180.9.6193","article-title":"T cell response mediated by myeloid cell-derived IL-12 is responsible for Porphyromonas gingivalis-induced periodontitis in IL-10-deficient mice","volume":"180","author":"H Sasaki","year":"2008","journal-title":"J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Wilensky A, Polak D, Awawdi S, Halabi A, Shapira L, et al.. (2009) Strain-dependent activation of the mouse immune response is correlated with Porphyromonas gingivalis-induced experimental periodontitis. J Clin Periodontol 36: 915-921. CPE1464 [pii];10.1111\/j.1600-051X.2009.01464.x<\/ext-link> [doi]<\/comment>.","DOI":"10.1111\/j.1600-051X.2009.01464.x"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1359\/jbmr.061007","article-title":"RGS12 Is Essential for RANKL-Evoked Signaling for Terminal Differentiation of Osteoclasts In Vitro","volume":"22","author":"S Yang","year":"2007","journal-title":"J Bone Miner Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1242\/jcs.008300","article-title":"Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation","volume":"120","author":"S Yang","year":"2007","journal-title":"J Cell Sci"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1210\/endo.139.4.5915","article-title":"Murine bone marrow stromally derived BMS2 adipocytes support differentiation and function of osteoclast-like cells in vitro","volume":"139","author":"KA Kelly","year":"1998","journal-title":"Endocrinology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1084\/jem.146.5.1420","article-title":"Regulation of B-lymphocyte clonal proliferation by stimulatory and inhibitory macrophage-derived factors","volume":"146","author":"JI Kurland","year":"1977","journal-title":"J Exp Med"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Alexander B, Warner-Schmidt J, Eriksson T, Tamminga C, Arango-Lievano M, et al.. (2010) Reversal of depressed behaviors in mice by p11 gene therapy in the nucleus accumbens. Sci Transl Med 2: 54ra76. 2\/54\/54ra76 [pii];10.1126\/scitranslmed.3001079<\/ext-link> [doi]<\/comment>.","DOI":"10.1126\/scitranslmed.3001079"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1038\/nm964","article-title":"Local gene knockdown in the brain using viral-mediated RNA interference","volume":"9","author":"JD Hommel","year":"2003","journal-title":"Nat Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"5712","DOI":"10.1038\/sj.onc.1206733","article-title":"Use of adeno-associated viral vector for delivery of small interfering RNA","volume":"22","author":"RS Tomar","year":"2003","journal-title":"Oncogene"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/jcp.21576","article-title":"Targeted overexpression of BSP in osteoclasts promotes bone metastasis of breast cancer cells","volume":"218","author":"Q Tu","year":"2009","journal-title":"J Cell Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1600-0765.2004.00760.x","article-title":"The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss","volume":"39","author":"H Sasaki","year":"2004","journal-title":"J Periodontal Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0099-2399(77)80096-4","article-title":"Quantitative study of sodium hypochlorite as an in vitro endodontic irrigant","volume":"3","author":"CM Trepagnier","year":"1977","journal-title":"J Endod"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1359\/jbmr.2003.18.4.705","article-title":"In vitro and in vivo synergistic interactions between the Runx2\/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation","volume":"18","author":"S Yang","year":"2003","journal-title":"J Bone Miner Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1034\/j.1600-0757.2000.2240104.x","article-title":"Role of physical forces in regulating the form and function of the periodontal ligament","volume":"24","author":"CA McCulloch","year":"2000","journal-title":"Periodontol 2000"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Jules J, Shi Z, Liu J, Xu D, Wang S, et al.. (2010) Receptor activator of NF-{kappa}B (RANK) cytoplasmic IVVY535\u2013538 motif plays an essential role in tumor necrosis factor-{alpha} (TNF)-mediated osteoclastogenesis. J Biol Chem 285: 37427\u201337435. M110.149484 [pii];10.1074\/jbc.M110.149484<\/ext-link> [doi]<\/comment>.","DOI":"10.1074\/jbc.M110.149484"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Muzylak M, Arnett TR, Price JS, Horton MA (2007) The in vitro effect of pH on osteoclasts and bone resorption in the cat: implications for the pathogenesis of FORL. J Cell Physiol 213: 144\u2013150. 10.1002\/jcp.21103<\/ext-link> [doi]<\/comment>.","DOI":"10.1002\/jcp.21103"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Allaire JM, Darsigny M, Marcoux SS, Roy SA, Schmouth JF, et al.. (2011) Loss of Smad5 leads to the disassembly of the apical junctional complex and increased susceptibility to experimental colitis. Am J Physiol Gastrointest Liver Physiol 300: G586\u2013G597. ajpgi.00041.2010 [pii];10.1152\/ajpgi.00041.2010<\/ext-link> [doi]<\/comment>.","DOI":"10.1152\/ajpgi.00041.2010"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Nijenhuis T, van der Eerden BC, Hoenderop JG, Weinans H, van Leeuwen JP, et al.. (2008) Bone resorption inhibitor alendronate normalizes the reduced bone thickness of TRPV5(\u2212\/\u2212) mice. J Bone Miner Res 23: 1815\u20131824. 10.1359\/jbmr.080613<\/ext-link> [doi]<\/comment>.","DOI":"10.1359\/jbmr.080613"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.4049\/jimmunol.165.7.3626","article-title":"IL-10, but not IL-4, suppresses infection-stimulated bone resorption in vivo","volume":"165","author":"H Sasaki","year":"2000","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/hmg\/ddl474","article-title":"Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence","volume":"16","author":"W Chen","year":"2007","journal-title":"Hum Mol Genet"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Yang S, Li YP (2007) RGS10-null mutation impairs osteoclast differentiation resulting from the loss of [Ca2+]i oscillation regulation. Genes Dev 21: 1803\u20131816. gad.1544107 [pii];10.1101\/gad.1544107<\/ext-link> [doi]<\/comment>.","DOI":"10.1101\/gad.1544107"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0757.1994.tb00020.x","article-title":"Microbial etiological agents of destructive periodontal diseases","volume":"5","author":"AD Haffajee","year":"1994","journal-title":"Periodontol 2000"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Evans C (2010) Arthritis gene therapy trials reach phase II. J Rheumatol 37: 683\u2013685. 37\/4\/683 [pii];10.3899\/jrheum.100055<\/ext-link> [doi]<\/comment>.","DOI":"10.3899\/jrheum.100055"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Goodson JM, Haffajee AD, Socransky SS, Kent R, Teles R, et al.. (2012) Control of periodontal infections: a randomized controlled trial I. The primary outcome attachment gain and pocket depth reduction at treated sites. J Clin Periodontol 39: 526\u2013536. 10.1111\/j.1600-051X.2012.01870.x<\/ext-link> [doi]<\/comment>.","DOI":"10.1111\/j.1600-051X.2012.01870.x"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1006\/bbrc.1996.0145","article-title":"Molecular cloning and characterization of a putative novel human osteoclast-specific 116-kDa vacuolar proton pump subunit","volume":"218","author":"YP Li","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Zhou Q, Guo R, Wood R, Boyce BF, Liang Q, et al.. (2011) Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice. Arthritis Rheum 63: 2318\u20132328. 10.1002\/art.30421<\/ext-link> [doi]<\/comment>.","DOI":"10.1002\/art.30421"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Ulrich-Vinther M (2007) Gene therapy methods in bone and joint disorders. Evaluation of the adeno-associated virus vector in experimental models of articular cartilage disorders, periprosthetic osteolysis and bone healing. Acta Orthop Suppl 78: 1\u201364.","DOI":"10.1080\/17453690610046512"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Zhang L, Jia TH, Chong AC, Bai L, Yu H, et al.. (2010) Cell-based osteoprotegerin therapy for debris-induced aseptic prosthetic loosening on a murine model. Gene Ther 17: 1262\u20131269. gt201064 [pii];10.1038\/gt.2010.64<\/ext-link> [doi]<\/comment>.","DOI":"10.1038\/gt.2010.64"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Buff SM, Yu H, McCall JN, Caldwell SM, Ferkol TW, et al.. (2010) IL-10 delivery by AAV5 vector attenuates inflammation in mice with Pseudomonas pneumonia. Gene Ther 17: 567\u2013576. gt201028 [pii];10.1038\/gt.2010.28<\/ext-link> [doi]<\/comment>.","DOI":"10.1038\/gt.2010.28"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"Cottard V, Mulleman D, Bouille P, Mezzina M, Boissier MC, et al.. (2000) Adeno-associated virus-mediated delivery of IL-4 prevents collagen-induced arthritis. Gene Ther 7: 1930\u20131939. 10.1038\/sj.gt.3301324<\/ext-link> [doi]<\/comment>.","DOI":"10.1038\/sj.gt.3301324"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Kunze M, Huber A, Krajewski A, Lowden E, Schuhmann N, et al.. (2009) Efficient gene transfer to periodontal ligament cells and human gingival fibroblasts by adeno-associated virus vectors. J Dent 37: 502\u2013508. S0300-5712(09)00047-5 [pii];10.1016\/j.jdent.2009.03.001<\/ext-link> [doi]<\/comment>.","DOI":"10.1016\/j.jdent.2009.03.001"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"Ramamurthy NS, Greenwald RA, Celiker MY, Shi EY (2005) Experimental arthritis in rats induces biomarkers of periodontitis which are ameliorated by gene therapy with tissue inhibitor of matrix metalloproteinases. J Periodontol 76: 229\u2013233. 10.1902\/jop.2005.76.2.229<\/ext-link> [doi]<\/comment>.","DOI":"10.1902\/jop.2005.76.2.229"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Yu H, Li Q, Herbert B, Zinna R, Martin K, et al.. (2011) Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss. Gene Ther 18: 344\u2013353. gt2010139 [pii];10.1038\/gt.2010.139<\/ext-link> [doi]<\/comment>.","DOI":"10.1038\/gt.2010.139"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Cirelli JA, Park CH, MacKool K, Taba M Jr, Lustig KH, et al.. (2009) AAV2\/1-TNFR:Fc gene delivery prevents periodontal disease progression. Gene Ther 16: 426\u2013436. gt2008174 [pii];10.1038\/gt.2008.174<\/ext-link> [doi]<\/comment>.","DOI":"10.1038\/gt.2008.174"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Ma J, Chen W, Zhang L, Tucker B, Zhu G, et al.. (2012) RNAi mediated silencing of Atp6i prevents both periapical bone erosion and inflammation in the mouse model of endodontic disease. Infect Immun. In press. IAI.00756-12 [pii];10.1128\/IAI.00756-12<\/ext-link> [doi]<\/comment>.","DOI":"10.1128\/IAI.00756-12"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1601-0825.1998.tb00255.x","article-title":"The role of IL-6 in the pathogenesis of periodontal disease","volume":"4","author":"CR Irwin","year":"1998","journal-title":"Oral Dis"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Lourbakos A, Potempa J, Travis J, D'Andrea MR, Andrade-Gordon P, et al.. (2001) Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion. Infect Immun 69: 5121\u20135130. 10.1128\/IAI.69.8.5121-5130.2001<\/ext-link> [doi]<\/comment>.","DOI":"10.1128\/IAI.69.8.5121-5130.2001"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1084\/jem.171.2.465","article-title":"Endotoxin-responsive sequences control cachectin\/tumor necrosis factor biosynthesis at the translational level","volume":"171","author":"J Han","year":"1990","journal-title":"J Exp Med"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Li Q, Valerio MS, Kirkwood KL (2012) MAPK usage in periodontal disease progression. J Signal Transduct 2012: 308943. 10.1155\/2012\/308943<\/ext-link> [doi]<\/comment>.","DOI":"10.1155\/2012\/308943"},{"key":"ref53","unstructured":"Pera M (2012) Oral Health-Total Health: Know the Connection. ADHA Fact Sheet. American Dental Hygienists' Association. Available:http:\/\/www.adha.org\/media\/facts\/total_health.htm<\/ext-link> Accessed 11-20-2012."},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Shay K (2002) Infectious complications of dental and periodontal diseases in the elderly population. Clin Infect Dis 34: 1215\u20131223. CID011329 [pii];10.1086\/339865<\/ext-link> [doi]<\/comment>.","DOI":"10.1086\/339865"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0301147","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0058599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:25:26Z","timestamp":1595636726000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0058599"}},"subtitle":[],"editor":[{"given":"Michael","family":"Glogauer","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,5]]},"references-count":54,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0058599","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0301147","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,5]]}}}