{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:02:41Z","timestamp":1771002161940,"version":"3.50.1"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,14]],"date-time":"2013-03-14T00:00:00Z","timestamp":1363219200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0058644","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:06:58Z","timestamp":1363306018000},"page":"e58644","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Increased Zinc and Manganese in Parallel with Neurodegeneration, Synaptic Protein Changes and Activation of Akt\/GSK3 Signaling in Ovine CLN6 Neuronal Ceroid Lipofuscinosis"],"prefix":"10.1371","volume":"8","author":[{"given":"Katja M.","family":"Kanninen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Grubman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodi","family":"Meyerowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang-Li","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah J.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Crouch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett M.","family":"Paterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Hickey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Volitakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imke","family":"Tammen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony R.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Mole S, Williams R, Goebel H. (2011) The neuronal ceroid lipofuscinoses (batten disease). Second edition. Oxford University Press. 480 p.","DOI":"10.1093\/med\/9780199590018.001.0001"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/ajmg.1320310606","article-title":"Batten disease: Past, present, and future","author":"JA Rider","year":"1988","journal-title":"American J Med Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/humu.21624","article-title":"Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses","volume":"33","author":"M Kousi","year":"2012","journal-title":"Hum Mutat"},{"key":"ref4","first-page":"241","article-title":"Mutations in DNAJC5, encoding cysteine-string protein alpha, cause autosomal-dominant adult-onset neuronal ceroid lipofuscinosis","volume":"89","author":"L Noskova","year":"2011","journal-title":"Am J Med Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e29729","DOI":"10.1371\/journal.pone.0029729","article-title":"Mutations in the gene DNAJC5 cause autosomal dominant kufs disease in a proportion of cases: Study of the parry family and 8 other families","volume":"7","author":"M Velinov","year":"2012","journal-title":"PloS One"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.bbadis.2006.06.010","article-title":"The neuronal ceroid-lipofuscinoses: From past to present","volume":"1762","author":"M Haltia","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"21883","DOI":"10.1074\/jbc.M402074200","article-title":"Lysine 43 is trimethylated in subunit C from bovine mitochondrial ATP synthase and in storage bodies associated with batten disease","volume":"279","author":"R Chen","year":"2004","journal-title":"J Biol Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/ajmg.1320420428","article-title":"Mitochondrial ATP synthase subunit c storage in the ceroid-lipofuscinoses (batten disease)","volume":"42","author":"DN Palmer","year":"1992","journal-title":"Am J Med Genet"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Mole SE, Williams RE, Goebel HH, editors. (2011) The neuronal ceroid liopfuscinoses (batten disease). United States: Oxford University Press. 444 p.","DOI":"10.1093\/med\/9780199590018.001.0001"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.yexcr.2004.04.042","article-title":"CLN6, which is associated with a lysosomal storage disease, is an endoplasmic reticulum protein","volume":"298","author":"SE Mole","year":"2004","journal-title":"Exp Cell Res"},{"key":"ref11","first-page":"22347","article-title":"Defective endoplasmic reticulum-resident membrane protein CLN6 affects lysosomal degradation of endocytosed arylsulfatase A. J Biol Chem","volume":"279","author":"C Heine","year":"2004"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2990.1989.tb01236.x","article-title":"Ceroid-lipofuscinosis (batten's disease): Pathogenesis and sequential neuropathological changes in the ovine model","volume":"15","author":"RD Jolly","year":"1989","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.bbadis.2006.09.004","article-title":"A missense mutation (c.184C>T) in ovine CLN6 causes neuronal ceroid lipofuscinosis in merino sheep whereas affected south hampshire sheep have reduced levels of CLN6 mRNA","volume":"1762","author":"I Tammen","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.nbd.2010.11.008","article-title":"The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction","volume":"41","author":"GW Kay","year":"2011","journal-title":"Neurobiol Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.nbd.2005.01.025","article-title":"Glial activation spreads from specific cerebral foci and precedes neurodegeneration in presymptomatic ovine neuronal ceroid lipofuscinosis (CLN6)","volume":"20","author":"MJ Oswald","year":"2005","journal-title":"Neurobiol Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1750-3639.2006.00002.x","article-title":"Activation of non-neuronal cells within the prenatal developing brain of sheep with neuronal ceroid lipofuscinosis","volume":"16","author":"GW Kay","year":"2006","journal-title":"Brain Pathol (Zurich, Switzerland)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.nbd.2008.06.004","article-title":"Location and connectivity determine GABAergic interneuron survival in the brains of south hampshire sheep with CLN6 neuronal ceroid lipofuscinosis","volume":"32","author":"MJ Oswald","year":"2008","journal-title":"Neurobiol Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.nbd.2010.11.008","article-title":"The specific loss of GnRH-positive neurons from the hypothalamus of sheep with CLN6 neuronal ceroid lipofuscinosis occurs without glial activation and has only minor effects on reproduction","volume":"41","author":"GW Kay","year":"2011","journal-title":"Neurobiol Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s12017-009-8102-1","article-title":"Metal ion physiopathology in neurodegenerative disorders","volume":"11","author":"S Bolognin","year":"2009","journal-title":"Neuromolecular Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2010.04.003","article-title":"Biological metals and alzheimer's disease: Implications for therapeutics and diagnostics","volume":"92","author":"JA Duce","year":"2010","journal-title":"Prog Neurobiol"},{"issue":"1\u20133","key":"ref21","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s12011-011-9146-2","article-title":"Altered heavy metals and transketolase found in autistic spectrum disorder","volume":"2144","author":"ME Obrenovich","year":"2011","journal-title":"Biol Trace Elem Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1469-8749.2011.03955.x","article-title":"Childhood disorders of neurodegeneration with brain iron accumulation (NBIA)","volume":"53","author":"MA Kurian","year":"2011","journal-title":"Dev Med Child Neurol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"16076","DOI":"10.1523\/JNEUROSCI.3454-11.2011","article-title":"The neurophysiology and pathology of brain zinc","volume":"31","author":"SL Sensi","year":"2011","journal-title":"J Neurosci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1756-6606-3-30","article-title":"Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes","volume":"3","author":"SJ Lee","year":"2010","journal-title":"Mol Brain"},{"key":"ref25","first-page":"139","article-title":"Altered elemental profiles in neuronal ceroid lipofuscinosis","volume":"4","author":"E Johansson","year":"1990","journal-title":"J Trace Elem Electrolytes Health Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ajmg.1320310622","article-title":"Bleomycin-detectable iron and phenanthroline-detectable copper in the cerebrospinal fluid of patients with neuronal ceroid-lipofuscinoses","author":"H Heiskala","year":"1988","journal-title":"Am J Med Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ajmg.1320310618","article-title":"Ovine ceroid-lipofuscinosis. I: Lipopigment composition is indicative of a lysosomal proteinosis","author":"DN Palmer","year":"1988","journal-title":"Am J Med Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0197-4580(90)90034-W","article-title":"X-ray microprobe analysis of the retina and RPE in sheep with ovine ceroid-lipofuscinosis","volume":"11","author":"DA Samuelson","year":"1990","journal-title":"Neurobiol Aging"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.nbd.2007.09.006","article-title":"A new large animal model of CLN5 neuronal ceroid lipofuscinosis in borderdale sheep is caused by a nucleotide substitution at a consensus splice site (c.571+1G>A) leading to excision of exon 3","volume":"29","author":"T Frugier","year":"2008","journal-title":"Neurobiol Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"44670","DOI":"10.1074\/jbc.M204379200","article-title":"Overexpression of alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron","volume":"277","author":"CJ Maynard","year":"2002","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1042\/bj2210569","article-title":"Chemical modifications of metallothionein. preparation and characterization of polymers","volume":"221","author":"DM Templeton","year":"1984","journal-title":"Biochem J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1042\/bj3590353","article-title":"Oxidative dimerization in metallothionein is a result of intermolecular disulphide bonds between cysteines in the alpha-domain","volume":"359","author":"K Zangger","year":"2001","journal-title":"Biochem J"},{"key":"ref33","first-page":"188","article-title":"Identification and spatial analysis of metallothioneins expressed by the adult human lens","volume":"42","author":"B Oppermann","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1093\/hmg\/ddp355","article-title":"Molecular correlates of axonal and synaptic pathology in mouse models of batten disease","volume":"18","author":"C Kielar","year":"2009","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s12640-011-9291-6","article-title":"Zinc and the ERK kinases in the developing brain","volume":"21","author":"JR Nuttall","year":"2012","journal-title":"Neurotox Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1038\/cdd.2011.80","article-title":"Intracellular zinc release-activated ERK-dependent GSK-3beta-p53 and noxa-mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury","volume":"18","author":"CL Lin","year":"2011","journal-title":"Cell Death Differ"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2990.1985.tb00025.x","article-title":"Ceroid-lipofuscinosis (batten's disease): Pathogenesis of blindness in the ovine model","volume":"11","author":"IG Mayhew","year":"1985","journal-title":"Neuropathol Appl Neurobiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.2527\/jas.2006-714","article-title":"Elevated manganese levels in blood and central nervous system occur before onset of clinical signs in scrapie and bovine spongiform encephalopathy","volume":"85","author":"S Hesketh","year":"2007","journal-title":"J Anim Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s12011-010-8804-0","article-title":"Determination of zinc, copper, iron, and manganese in different regions of lamb brain","volume":"142","author":"S Bakirdere","year":"2011","journal-title":"Biol Trace Elem Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.vetpar.2009.11.013","article-title":"Psoroptic mange infestation increases oxidative stress and decreases antioxidant status in sheep","volume":"168","author":"U Dimri","year":"2010","journal-title":"Vet Parasitol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/308734a0","article-title":"Release of endogenous Zn2+ from brain tissue during activity","volume":"308","author":"SY Assaf","year":"1984","journal-title":"Nature"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/j.1939-4640.2002.tb02339.x","article-title":"High-level expression of zinc transporter-2 in the rat lateral and dorsal prostate","volume":"23","author":"K Iguchi","year":"2002","journal-title":"J J Androl"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/j.1460-2075.1996.tb00527.x","article-title":"ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration","volume":"15","author":"RD Palmiter","year":"1996","journal-title":"EMBO J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-nutr-072610-145218","article-title":"Zinc in neurotransmission","volume":"31","author":"K Toth","year":"2011","journal-title":"Annu Rev Nutr"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1021\/pr0603699","article-title":"Zinc through the three domains of life","volume":"5","author":"C Andreini","year":"2006","journal-title":"J Proteome Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1020702213099","article-title":"DMT1: A mammalian transporter for multiple metals","volume":"16","author":"MD Garrick","year":"2003","journal-title":"Biometals"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.biochi.2009.04.002","article-title":"The role of zinc transporters in cadmium and manganese transport in mammalian cells","volume":"91","author":"S Himeno","year":"2009","journal-title":"Biochimie"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jtemb.2011.08.144","article-title":"Role of manganese in neurodegenerative diseases","volume":"25","author":"AB Bowman","year":"2011","journal-title":"J Trace Elem Med Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.nbd.2011.02.009","article-title":"A truncating mutation in ATP13A2 is responsible for adult-onset neuronal ceroid lipofuscinosis in tibetan terriers","volume":"42","author":"FH Farias","year":"2011","journal-title":"Neurobiol Dis"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/hmg\/ddr606","article-title":"PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity","volume":"21","author":"D Ramonet","year":"2012","journal-title":"Hum Mol Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e39942","DOI":"10.1371\/journal.pone.0039942","article-title":"Common pathogenic effects of missense mutations in the P-type ATPase ATP13A2 (PARK9) associated with early-onset parkinsonism","volume":"7","author":"A Podhajska","year":"2012","journal-title":"PloS One"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1093\/hmg\/ddr274","article-title":"Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death","volume":"20","author":"J Ugolino","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/ng1884","article-title":"Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase","volume":"38","author":"A Ramirez","year":"2006","journal-title":"Nat Genet"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e1002304","DOI":"10.1371\/journal.pgen.1002304","article-title":"A one base pair deletion in the canine ATP13A2 gene causes exon skipping and late-onset neuronal ceroid lipofuscinosis in the tibetan terrier","volume":"7","author":"A Wohlke","year":"2011","journal-title":"PLoS Genet"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1093\/hmg\/dds089","article-title":"Mutation of the parkinsonism gene ATP13A2 causes neuronal ceroid-lipofuscinosis","volume":"21","author":"J Bras","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"4","key":"ref56","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s13105-012-0174-y","article-title":"Effect of zinc supplementation on type 2 diabetes parameters and liver metallothionein expressions in wistar rats","volume":"68","author":"X Wang","year":"2012","journal-title":"J Physiol Biochem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/ajmg.1320310629","article-title":"Experience over 17 years with antioxidant treatment in spielmeyer-sjogren disease","author":"P Santavuori","year":"1988","journal-title":"Am J Med Genet"},{"key":"ref58","first-page":"PE45","article-title":"Emerging role for ERK as a key regulator of neuronal apoptosis","volume":"251","author":"EC Cheung","year":"2004","journal-title":"Science's STKE : Sci STKE"},{"key":"ref59","first-page":"189246","article-title":"GSK-3 in neurodegenerative diseases","volume":"2011","author":"P Lei","year":"2011","journal-title":"Int J Alzheimers Dis"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1196\/annals.1306.018","article-title":"Manganese-induced parkinsonism and parkinson's disease","volume":"1012","author":"CW Olanow","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1042\/bj20030598","article-title":"Enhanced expression of manganese-dependent superoxide dismutase in human and sheep CLN6 tissues","volume":"376","author":"C Heine","year":"2003","journal-title":"Biochem J"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1016\/j.yexcr.2008.06.016","article-title":"Novel interactions of CLN3 protein link batten disease to dysregulation of fodrin-na+, K+ ATPase complex","volume":"314","author":"K Uusi-Rauva","year":"2008","journal-title":"Exp Cell Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e17669","DOI":"10.1371\/journal.pone.0017669","article-title":"Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of alzheimer's disease","volume":"6","author":"PA Adlard","year":"2011","journal-title":"PloS One"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/jnr.22032","article-title":"Protein product of CLN6 gene responsible for variant late-onset infantile neuronal ceroid lipofuscinosis interacts with CRMP-2","volume":"87","author":"JW Benedict","year":"2009","journal-title":"J Neurosci Res"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0058644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T12:59:49Z","timestamp":1715086789000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0058644"}},"subtitle":[],"editor":[{"given":"Philipp J.","family":"Kahle","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,14]]},"references-count":64,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0058644","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,14]]}}}