{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T17:19:57Z","timestamp":1771262397792,"version":"3.50.1"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0058737","type":"journal-article","created":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T06:03:15Z","timestamp":1363413795000},"page":"e58737","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":60,"title":["miR-141 Contributes to Fetal Growth Restriction by Regulating PLAG1 Expression"],"prefix":"10.1371","volume":"8","author":[{"given":"Qiuqin","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yankai","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Sha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinru","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daozhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00404-012-2330-6","article-title":"Fetal growth restriction: current knowledge to the general Obs\/Gyn","volume":"286","author":"LM Nardozza","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.0001-6349.2004.00602.x","article-title":"Restricted fetal growth in sudden intrauterine unexplained death","volume":"83","author":"JF Froen","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/0140-6736(93)91224-A","article-title":"Fetal nutrition and cardiovascular disease in adult life","volume":"341","author":"DJ Barker","year":"1993","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0095-5108(18)30289-6","article-title":"Causes of intrauterine growth restriction","volume":"22","author":"MG Neerhof","year":"1995","journal-title":"Clin Perinatol"},{"key":"ref5","first-page":"1044","article-title":"Current concepts of fetal growth restriction: part I. Causes, classification, and pathophysiology","volume":"92","author":"CC Lin","year":"1998","journal-title":"Obstet Gynecol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1056\/NEJMoa010107","article-title":"IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation","volume":"349","author":"MJ Abuzzahab","year":"2003","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e12630","DOI":"10.1371\/journal.pone.0012630","article-title":"Complete biallelic insulation at the H19\/Igf2 imprinting control region position results in fetal growth retardation and perinatal lethality","volume":"5","author":"DH Lee","year":"2010","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.2105\/AJPH.84.7.1127","article-title":"Low birthweight at term and the timing of fetal exposure to maternal smoking","volume":"84","author":"E Lieberman","year":"1994","journal-title":"Am J Public Health"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejogrb.2010.11.017","article-title":"Placental pathology in fetal growth restriction","volume":"155","author":"N Vedmedovska","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0897.2012.01132.x","article-title":"Changes in the maternal cytokine profile in pregnancies complicated by fetal growth restriction","volume":"68","author":"E Mullins","year":"2012","journal-title":"Am J Reprod Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0897.2009.00716.x","article-title":"Epigenetics in the placenta","volume":"62","author":"MA Maccani","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.cellbio.23.090506.123406","article-title":"microRNA functions","volume":"23","author":"N Bushati","year":"2007","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1478-811X-7-18","article-title":"Regulation of MicroRNA Biogenesis: A miRiad of mechanisms","volume":"7","author":"BN Davis","year":"2009","journal-title":"Cell Commun Signal"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.devcel.2006.09.009","article-title":"The diverse functions of microRNAs in animal development and disease","volume":"11","author":"WP Kloosterman","year":"2006","journal-title":"Dev Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/nrm2621","article-title":"MicroRNAs: key regulators of stem cells","volume":"10","author":"VK Gangaraju","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e3148","DOI":"10.1371\/journal.pone.0003148","article-title":"Serum microRNAs are promising novel biomarkers","volume":"3","author":"S Gilad","year":"2008","journal-title":"PLoS One"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1055\/s-0028-1096128","article-title":"MicroRNA signature and regulatory functions in the endometrium during normal and disease states","volume":"26","author":"Q Pan","year":"2008","journal-title":"Semin Reprod Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"622","DOI":"10.3349\/ymj.2010.51.5.622","article-title":"MicroRNAs in human embryonic and cancer stem cells","volume":"51","author":"A Navarro","year":"2010","journal-title":"Yonsei Med J"},{"key":"ref19","first-page":"923","article-title":"Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia","volume":"47","author":"Y Hu","year":"2009","journal-title":"Clin Chem Lab Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1007\/s10620-009-1008-9","article-title":"MicroRNA-141 regulates Smad interacting protein 1 (SIP1) and inhibits migration and invasion of colorectal cancer cells","volume":"55","author":"M Hu","year":"2010","journal-title":"Dig Dis Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"PS Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.placenta.2010.07.001","article-title":"The levels of hypoxia-regulated microRNAs in plasma of pregnant women with fetal growth restriction","volume":"31","author":"JF Mouillet","year":"2010","journal-title":"Placenta"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e29562","DOI":"10.1371\/journal.pone.0029562","article-title":"Effects of cord serum insulin, IGF-II, IGFBP-2, IL-6 and cortisol concentrations on human birth weight and length: pilot study","volume":"6","author":"A Smerieri","year":"2011","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.placenta.2011.07.086","article-title":"System A activity and vascular function in the placental-specific Igf2 knockout mouse","volume":"32","author":"LC Kusinski","year":"2011","journal-title":"Placenta"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ymgme.2005.07.028","article-title":"The role of the insulin-like growth factor system in prenatal growth","volume":"86","author":"R Randhawa","year":"2005","journal-title":"Mol Genet Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1373\/clinchem.2010.147660","article-title":"Identification of pregnancy-associated microRNAs in maternal plasma","volume":"56","author":"K Miura","year":"2010","journal-title":"Clin Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1177\/1933719110374115","article-title":"Expression profile of microRNAs and mRNAs in human placentas from pregnancies complicated by preeclampsia and preterm labor","volume":"18","author":"K Mayor-Lynn","year":"2011","journal-title":"Reprod Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1373\/clinchem.2007.097972","article-title":"Detection and characterization of placental microRNAs in maternal plasma","volume":"54","author":"SS Chim","year":"2008","journal-title":"Clin Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.devcel.2012.01.013","article-title":"Atypical E2F repressors and activators coordinate placental development","volume":"22","author":"MM Ouseph","year":"2012","journal-title":"Dev Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1128\/MCB.01161-08","article-title":"E2f3a and E2f3b contribute to the control of cell proliferation and mouse development","volume":"29","author":"JL Chong","year":"2009","journal-title":"Mol Cell Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1128\/MCB.01854-06","article-title":"Selective requirements for E2f3 in the development and tumorigenicity of Rb-deficient chimeric tissues","volume":"27","author":"T Parisi","year":"2007","journal-title":"Mol Cell Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/j.1440-169x.2004.00762.x","article-title":"Targeted disruption of the murine Plag1 proto-oncogene causes growth retardation and reduced fertility","volume":"46","author":"K Hensen","year":"2004","journal-title":"Dev Growth Differ"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00428-011-1063-4","article-title":"Aberrant PLAG1 expression in pleomorphic adenomas of the salivary gland: a molecular genetic and immunohistochemical study","volume":"458","author":"A Matsuyama","year":"2011","journal-title":"Virchows Arch"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0002-9440(10)61771-3","article-title":"PLAG1 alterations in lipoblastoma: involvement in varied mesenchymal cell types and evidence for alternative oncogenic mechanisms","volume":"159","author":"D Gisselsson","year":"2001","journal-title":"Am J Pathol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/gcc.10307","article-title":"Amplification and overexpression of the IGF2 regulator PLAG1 in hepatoblastoma","volume":"39","author":"A Zatkova","year":"2004","journal-title":"Genes Chromosomes Cancer"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"19673","DOI":"10.1074\/jbc.M112112200","article-title":"Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal","volume":"277","author":"CV Braem","year":"2002","journal-title":"J Biol Chem"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"36121","DOI":"10.1074\/jbc.M401753200","article-title":"Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation","volume":"279","author":"F Van Dyck","year":"2004","journal-title":"J Biol Chem"},{"key":"ref38","first-page":"481","article-title":"Loss of imprinting and aberrant methylation of IGF2 in placentas from pregnancies complicated with fetal growth restriction","volume":"28","author":"O Koukoura","year":"2011","journal-title":"Int J Mol Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0955-0674(94)90141-4","article-title":"Sequential protein kinase reactions controlling cell growth and differentiation","volume":"6","author":"GL Johnson","year":"1994","journal-title":"Curr Opin Cell Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/jmcb\/mjq029","article-title":"Genome-wide gene expression profiling reveals aberrant MAPK and Wnt signaling pathways associated with early parthenogenesis","volume":"2","author":"N Liu","year":"2010","journal-title":"J Mol Cell Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/35080570","article-title":"Placental development: lessons from mouse mutants","volume":"2","author":"J Rossant","year":"2001","journal-title":"Nat Rev Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1146\/annurev.cellbio.14.1.59","article-title":"Mechanisms of Wnt signaling in development","volume":"14","author":"A Wodarz","year":"1998","journal-title":"Annu Rev Cell Dev Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0058737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T17:54:26Z","timestamp":1589046866000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0058737"}},"subtitle":[],"editor":[{"given":"Ana Claudia","family":"Zenclussen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,15]]},"references-count":42,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0058737","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,15]]}}}