{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:20:22Z","timestamp":1768285222184,"version":"3.49.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0058823","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T22:40:13Z","timestamp":1363992013000},"page":"e58823","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Quantitative Molecular Analysis of Sentinel Lymph Node May Be Predictive of Axillary Node Status in Breast Cancer Classified by Molecular Subtypes"],"prefix":"10.1371","volume":"8","author":[{"given":"Simonetta","family":"Buglioni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Di Filippo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Terrenato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Casini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enzo","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinando","family":"Marandino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo L.","family":"Maini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Pasqualoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Botti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Di Filippo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Pescarmona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcella","family":"Mottolese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S1470-2045(06)70947-0","article-title":"Sentinel-lymph-node biopsy as a staging procedure in breast cancer: update of a randomised controlled study","volume":"7","author":"U Veronesi","year":"2006","journal-title":"Lancet Oncol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1200\/JCO.2005.08.001","article-title":"American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer","volume":"23","year":"2005","journal-title":"J Clin Oncol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10549-005-9025-7","article-title":"Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer","volume":"95","author":"A Fleissig","year":"2006","journal-title":"Breast Cancer Res Treat"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/cncr.20760","article-title":"Improving the reproducibility of diagnosing micrometastases and isolated tumor cells","volume":"103","author":"G Cserni","year":"2005","journal-title":"Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/bjs.7229","article-title":"Intraoperative assessment of sentinel lymph nodes in breast cancer","volume":"98","author":"DM Layfield","year":"2011","journal-title":"Br J Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00129039-200303000-00008","article-title":"Rapid immunohistochemistry for cytokeratin in the intraoperative evaluation of sentinel lymph nodes for metastatic breast carcinoma","volume":"11","author":"RA Beach","year":"2003","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/cncr.21133","article-title":"Rapid immunohistochemistry enhances the intraoperative diagnosis of sentinel lymph node metastases in invasive lobular breast carcinoma","volume":"104","author":"JP Leikola","year":"2005","journal-title":"Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"4807","DOI":"10.1158\/1078-0432.CCR-06-2512","article-title":"One-step nucleic acid amplification for intraoperative detection of lymph node metastasis in breast cancer patients","volume":"13","author":"M Tsujimoto","year":"2007","journal-title":"Clin Cancer Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1093\/annonc\/mdr304","article-title":"Strategies for subtypes\u2013dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011","volume":"22","author":"A Goldhirsch","year":"2011","journal-title":"Ann Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/415530a","article-title":"Gene expression profiling predicts clinical outcome of breast cancer","volume":"415","author":"LJ van \u2018t Veer","year":"2002","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1158\/1078-0432.CCR-07-4756","article-title":"Biological processes associated with breast cancer clinical outcome depend on the molecular subtypes","volume":"14","author":"C Desmedt","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.molonc.2010.11.003","article-title":"Deconstructing the molecular portraits of breast cancer","volume":"5","author":"A Prat","year":"2011","journal-title":"Mol Oncol"},{"key":"ref13","unstructured":"Tavassoli FA DP (2003) Pathology and Genetics Tumours of the breast and female genital organs. Lyon (France): IARC Press. 9\u2013112 p."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5858\/2007-131-18-ASOCCO","article-title":"American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer","volume":"131","author":"AC Wolff","year":"2007","journal-title":"Arch Pathol Lab Med"},{"key":"ref15","unstructured":"Greenacre M (1984) Theory and applications of correspondence analysis.Academic Press, London."},{"key":"ref16","unstructured":"Lebart L Morineau A, Warwick KM (1984) Multivariate descriptive statistical analysis. Wiley, New York."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1002\/ijc.23451","article-title":"Intra-operative rapid diagnostic method based on CK19 mRNA expression for the detection of lymph node metastases in breast cancer","volume":"122","author":"M Visser","year":"2008","journal-title":"Int J Cancer"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00428-008-0703-9","article-title":"One-step nucleic acid amplification-a molecular method for the detection of lymph node metastases in breast cancer patients; results of the German study group","volume":"454","author":"C Schem","year":"2009","journal-title":"Virchows Arch"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1158\/1078-0432.CCR-08-1881","article-title":"Molecular detection of lymph node metastases in breast cancer patients: results of a multicenter trial using the one-step nucleic acid amplification assay","volume":"15","author":"Y Tamaki","year":"2009","journal-title":"Clin Cancer Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/bjs.7347","article-title":"Multicentre evaluation of intraoperative molecular analysis of sentinel lymph nodes in breast carcinoma","volume":"98","author":"KL Snook","year":"2010","journal-title":"Br J Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1002\/cncr.25822","article-title":"A novel automated assay for the rapid identification of metastatic breast carcinoma in sentinel lymph nodes","volume":"117","author":"S Feldman","year":"2011","journal-title":"Cancer"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1002\/ijc.26291","article-title":"Diagnostic performance of one-step nucleic acid amplification for intraoperative sentinel node metastasis detection in breast cancer patients","volume":"130","author":"MA Le Frere-Belda","year":"2012","journal-title":"Int J Cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/PDM.0b013e3181eb9b30","article-title":"Molecular diagnosis of sentinel lymph nodes for breast cancer: one step ahead for standardization","volume":"20","author":"BV Laia","year":"2011","journal-title":"Diagn Mol Pathol"},{"key":"ref24","first-page":"585","article-title":"Implementation of molecular intra-operative assessment of sentinel lymph node in breast cancer","volume":"31","author":"A Khaddage","year":"2011","journal-title":"Anticancer Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/SLA.0b013e31823000ed","article-title":"Reliability of whole sentinel lymph node analysis by one-step nucleic acid amplification for intraoperative diagnosis of breast cancer metastases","volume":"255","author":"I Castellano","year":"2011","journal-title":"Ann Surg"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Sagara Y, Ohi Y, Matsukata A, Yotsumoto D, Baba S, <etal>et al<\/etal>.. (2011) Clinical application of the one-step nucleic acid amplification method to detect sentinel lymph node metastasis in breast cancer. Breast Cancer.","DOI":"10.1007\/s12282-011-0324-z"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Tamaki Y, Sato N, Homma K, Takabatake D, Nishimura R, <etal>et al<\/etal>.. (2011) Routine clinical use of the one-step nucleic acid amplification assay for detection of sentinel lymph node metastases in breast cancer patients: Results of a multicenter study in Japan. Cancer.","DOI":"10.1002\/cncr.26683"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/bjc.2011.350","article-title":"Accurate staging of axillary lymph nodes from breast cancer patients using a novel molecular method","volume":"105","author":"T Osako","year":"2011","journal-title":"Br J Cancer"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10549-011-1808-4","article-title":"Sentinel lymph node analysis in breast cancer: contribution of one-step nucleic acid amplification (OSNA)","volume":"131","author":"F Godey","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Ohi Y, Umekita Y, Sagara Y, Rai Y, Yotsumoto D, <etal>et al<\/etal>.. (2012) Whole sentinel lymph node analysis by a molecular assay predicts axillary node status in breast cancer. Br J Cancer.","DOI":"10.1038\/bjc.2012.387"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/j.1365-2559.2011.03836.x","article-title":"Diagnosis of the sentinel lymph node in breast cancer: a reproducible molecular method: a multicentric Spanish study","volume":"58","author":"L Bernet","year":"2011","journal-title":"Histopathology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1002\/cncr.26060","article-title":"Intraoperative molecular assay for sentinel lymph node metastases in early stage breast cancer: a comparative analysis between one-step nucleic acid amplification whole node assay and routine frozen section histology","volume":"117","author":"T Osako","year":"2011","journal-title":"Cancer"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1001\/archsurg.2009.269","article-title":"Underuse of axillary dissection for the management of sentinel node micrometastases in breast cancer","volume":"145","author":"N Wasif","year":"2010","journal-title":"Arch Surg"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10549-011-1486-2","article-title":"Can we avoid axillary dissection in the micrometastatic sentinel node in breast cancer?","volume":"131","author":"V Galimberti","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1245\/ASO.2003.03.015","article-title":"A nomogram for predicting the likelihood of additional nodal metastases in breast cancer patients with a positive sentinel node biopsy","volume":"10","author":"KJ Van Zee","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.amjsurg.2005.06.008","article-title":"Nonsentinel node metastasis in breast cancer patients: assessment of an existing and a new predictive nomogram","volume":"190","author":"AC Degnim","year":"2005","journal-title":"Am J Surg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1471-2407-8-66","article-title":"New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients","volume":"8","author":"HE Kohrt","year":"2008","journal-title":"BMC Cancer"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/bjs.5943","article-title":"A model for predicting non-sentinel lymph node metastatic disease when the sentinel lymph node is positive","volume":"95","author":"A Pal","year":"2008","journal-title":"Br J Surg"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0058823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T05:40:28Z","timestamp":1644644428000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0058823"}},"subtitle":[],"editor":[{"given":"Syed A.","family":"Aziz","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,22]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0058823","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,22]]}}}