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Vancouver."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/archpediatrics.2011.43","article-title":"Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial","volume":"165","author":"SE Jacobs","year":"2011","journal-title":"Arch Pediatr Adolesc Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/pr.2011.43","article-title":"Resuscitation with 100% oxygen increases injury and counteracts the neuroprotective effect of therapeutic hypothermia in the neonatal rat","volume":"71","author":"ML Dalen","year":"2012","journal-title":"Pediatr Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1203\/00006450-200109000-00017","article-title":"Twenty-four hours of mild hypothermia in unsedated newborn pigs starting after a severe global hypoxic-ischemic insult is not neuroprotective","volume":"50","author":"M Thoresen","year":"2001","journal-title":"Pediatr Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1053\/j.semperi.2010.09.007","article-title":"Neonatal hypothermia in low-resource settings","volume":"34","author":"LC Mullany","year":"2010","journal-title":"Semin Perinatol"},{"key":"ref29","unstructured":"NNPD (2003): http:\/\/<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.newbornwhocc.org\/pdf\/nnpd_report_2002-03.PDF\" xlink:type=\"simple\">www.newbornwhocc.org\/pdf\/nnpd_report_2002-03.PDF<\/ext-link> (Accessed 2013 Feb 11)."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"F75","DOI":"10.1136\/adc.2010.184689","article-title":"Ethical and practical issues relating to the global use of therapeutic hypothermia for perinatal asphyxial encephalopathy","volume":"96","author":"DJ Wilkinson","year":"2011","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref31","unstructured":"Tann C, Hagmann C, Nakakeeto M, Costello A, Jacobs I, et al. A Randomised Pilot Feasibility Study Of Therapeutic Hypothermia Using Water Bottles For Neonatal Encephalopathy In Uganda: Optimality Score, cUS and 18\u201322 month Neurodevelopmental Outcomes. Pediatric Academic Society Annual Meeting Vancouver 2010."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jpeds.2011.08.004","article-title":"Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop","volume":"159","author":"RD Higgins","year":"2011","journal-title":"J Pediatr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1515\/jpm-2011-0292","article-title":"Therapeutic hypothermia and hypoxic ischemic encephalopathy: opinion and practice of pediatricians in South Africa","volume":"40","author":"Y Joolay","year":"2012","journal-title":"J Perinat Med"},{"key":"ref34","first-page":"S123","article-title":"Reducing intrapartum-related deaths and disability: can the health system deliver?","volume":"107","author":"JE Lawn","year":"2009","journal-title":"Int J Gynaecol Obstet 2009 Oct;107 Suppl 1:S123\u201340, S140\u20132"},{"key":"ref35","unstructured":"Thayyil S, Shankaran S (2013) Hypothermia for Encephalopathy in Low Income countries (HELIX) Trial (NCT01760629). <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/wwwclinicaltrialsgov\/ct2\/show\/NCT01760629?term=helix&rank=1\" xlink:type=\"simple\">http:\/\/wwwclinicaltrialsgov\/ct2\/show\/NCT01760629?term=helix&amp;rank=1<\/ext-link> (Accessed 2013 Jan 25)."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/tropej\/fmp089","article-title":"Evaluating a Simple Method of Neuroprotective Hypothermia for Newborn Infants","volume":"56","author":"A Horn","year":"2009","journal-title":"J Trop Pediatr"},{"key":"ref37","unstructured":"Rajhans AP, Chouthai N, Joshi RV (2012) Whole Body Hypothermia (WBH) for Newborns with Moderate to Severe Hypoxic Ischemic Encephalopathy (HIE) in India. Pediatric Academic Society. Boston."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/tropej\/fmr069","article-title":"A servo-assisted gel-pack cooling method for newborn infants with hypoxic-ischemic encephalopathy","volume":"58","author":"AR Horn","year":"2012","journal-title":"J Trop Pediatr"},{"key":"ref39","first-page":"265","article-title":"Short term outcome of therapeutic hypothermia in term infants with moderate to severe hypoxic ischaemic encephalopathy; the Sungai Buloh experience","volume":"67","author":"KC See","year":"2012","journal-title":"Med J Malaysia"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3810\/hp.2009.12.269","article-title":"Systemic hypothermia induced within 10 hours after birth improved neurological outcome in newborns with hypoxic-ischemic encephalopathy","volume":"37","author":"T Li","year":"2009","journal-title":"Hosp Pract (Minneap)"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0058834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T19:20:47Z","timestamp":1540322447000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0058834"}},"subtitle":[],"editor":[{"given":"Olivier","family":"Baud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,19]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0058834","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717995577.793474860","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,19]]}}}