{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:20:15Z","timestamp":1760908815537},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T00:00:00Z","timestamp":1363651200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0059009","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T17:24:43Z","timestamp":1363713883000},"page":"e59009","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Increased Expression of IL-22 Is Associated with Disease Activity in Behcet\u2019s Disease"],"prefix":"10.1371","volume":"8","author":[{"given":"Tao","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaokui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aize","family":"Kijlstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peizeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.4049\/jimmunol.164.4.1814","article-title":"Cloning and characterization of IL-10-related T cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9","volume":"164","author":"L Dumoutier","year":"2000","journal-title":"J Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2004.07.007","article-title":"IL-22 increases the innate immunity of tissues","volume":"21","author":"K Wolk","year":"2004","journal-title":"Immunity"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1084\/jem.20061308","article-title":"Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides","volume":"203","author":"SC Liang","year":"2006","journal-title":"J Exp Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/sj.cr.7310106","article-title":"Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes","volume":"16","author":"Y Chung","year":"2006","journal-title":"Cell Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.4049\/jimmunol.168.11.5397","article-title":"Cutting edge: immune cells as sources and targets of the IL-10 family members","volume":"168","author":"K Wolk","year":"2002","journal-title":"J Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/art.20965","article-title":"Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine","volume":"52","author":"H Ikeuchi","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/art.33446","article-title":"Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts","volume":"64","author":"KW Kim","year":"2012","journal-title":"Arthritis Rheum"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/jid.2009.399","article-title":"Circulating Th17, Th22, and Th1 cells are increased in psoriasis","volume":"130","author":"S Kagami","year":"2010","journal-title":"J Invest Dermatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/art.25043","article-title":"1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis","volume":"62","author":"EM Colin","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"G827","DOI":"10.1152\/ajpgi.00513.2005","article-title":"IL-22 is increased in active Crohn\u2019s disease and promotes proinflammatory gene expression and intestinal epithelial cell migration","volume":"290","author":"S Brand","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/ard.2011.154013","article-title":"Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjogren\u2019s syndrome","volume":"71","author":"F Ciccia","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10238-011-0134-9","article-title":"Expressions of IL-22 in circulating CD4+\/CD8+ T cells and their correlation with disease activity in SLE patients","volume":"11","author":"WZ Qin","year":"2011","journal-title":"Clin Exp Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5147","DOI":"10.4049\/jimmunol.181.7.5147","article-title":"Gene expression profiling in autoimmune noninfectious uveitis disease","volume":"181","author":"Z Li","year":"2008","journal-title":"J Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm1720","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume":"14","author":"Y Zheng","year":"2008","journal-title":"Nat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nm1710","article-title":"IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia","volume":"14","author":"SJ Aujla","year":"2008","journal-title":"Nat Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2007.07.023","article-title":"Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation","volume":"27","author":"LA Zenewicz","year":"2007","journal-title":"Immunity"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.4049\/jimmunol.178.9.5973","article-title":"IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn\u2019s disease","volume":"178","author":"K Wolk","year":"2007","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1167\/iovs.07-1390","article-title":"Upregulated IL-23 and IL-17 in Behcet patients with active uveitis","volume":"49","author":"W Chi","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref19","first-page":"1078","article-title":"Criteria for diagnosis of Behcet\u2019s disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Yang P, Fang W, Meng Q, Ren Y, Xing L, et al. (2008) Clinical features of chinese patients with Behcet\u2019s disease. Ophthalmology 115: 312\u2013318 e314.","DOI":"10.1016\/j.ophtha.2007.04.056"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1136\/ard.2011.152074","article-title":"Interleukin 22 serum levels are associated with radiographic progression in rheumatoid arthritis","volume":"70","author":"J Leipe","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/ibd.20315","article-title":"Linking genetic susceptibility to Crohn\u2019s disease with Th17 cell function: IL-22 serum levels are increased in Crohn\u2019s disease and correlate with disease activity and IL23R genotype status","volume":"14","author":"S Schmechel","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"ref23","first-page":"3573","article-title":"Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling","volume":"119","author":"S Eyerich","year":"2009","journal-title":"J Clin Invest"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cca.2008.11.009","article-title":"Decreased serum IL-22 levels in patients with systemic lupus erythematosus","volume":"401","author":"HF Pan","year":"2009","journal-title":"Clin Chim Acta"},{"key":"ref25","first-page":"12","article-title":"Histopathologic features of erythema nodosum\u2013like lesions in Beh\u00e7et disease: a comparison with erythema nodosum focusing on the role of vasculitis","volume":"22","author":"B Kim","year":"2000","journal-title":"Am J Dermatopathol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm1651","article-title":"Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation","volume":"13","author":"H Kebir","year":"2007","journal-title":"Nat Med"},{"key":"ref27","first-page":"6","article-title":"The effects of Th17 cytokines on the inflammatory mediator production and barrier function of ARPE-19 cells","volume":"6","author":"Y Chen","year":"2011","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.4049\/jimmunol.1100482","article-title":"IL-22-induced regulatory CD11b+ APCs suppress experimental autoimmune uveitis","volume":"187","author":"Y Ke","year":"2011","journal-title":"J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0059009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T00:08:08Z","timestamp":1539994088000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0059009"}},"subtitle":[],"editor":[{"given":"Gernot","family":"Zissel","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,19]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0059009","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,19]]}}}