{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:06:54Z","timestamp":1767006414652},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T00:00:00Z","timestamp":1363910400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0059168","type":"journal-article","created":{"date-parts":[[2013,3,22]],"date-time":"2013-03-22T22:41:33Z","timestamp":1363992093000},"page":"e59168","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Meconium Fatty Acid Ethyl Esters as Biomarkers of Late Gestational Ethanol Exposure and Indicator of Ethanol-Induced Multi-Organ Injury in Fetal Sheep"],"prefix":"10.1371","volume":"8","author":[{"given":"Irene","family":"Zelner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Kenna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Bocking","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Harding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"Koren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,3,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11065-011-9166-x","article-title":"Fetal alcohol spectrum disorders: an overview","volume":"21","author":"EP Riley","year":"2011","journal-title":"Neuropsychol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(73)91092-1","article-title":"Recognition of the fetal alcohol syndrome in early infancy","volume":"302","author":"KL Jones","year":"1973","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/tera.1420120102","article-title":"The fetal alcohol syndrome","volume":"12","author":"KL Jones","year":"1975","journal-title":"Teratology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/13556210410001716962","article-title":"Fetal alcohol syndrome. Introduction","volume":"9","author":"L Burd","year":"2004","journal-title":"Addict Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0376-8716(87)90087-1","article-title":"Incidence of fetal alcohol syndrome and economic impact of FAS-related anomalies","volume":"19","author":"EL Abel","year":"1987","journal-title":"Drug Alcohol Depend"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/ddrr.68","article-title":"Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies","volume":"15","author":"PA May","year":"2009","journal-title":"Dev Disabil Res Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1503\/cmaj.1040302","article-title":"Fetal alcohol spectrum disorder: Canadian guidelines for diagnosis","volume":"172","author":"AE Chudley","year":"2005","journal-title":"CMAJ"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2105\/AJPH.86.10.1435","article-title":"Detecting risk drinking during pregnancy: a comparison of four screening questionnaires","volume":"86","author":"M Russell","year":"1996","journal-title":"Am J Public Health"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00004703-200408000-00002","article-title":"Risk factors for adverse life outcomes in fetal alcohol syndrome and fetal alcohol effects","volume":"25","author":"AP Streissguth","year":"2004","journal-title":"J Dev Behav Pediatr"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.2741\/931","article-title":"Fatty acid ethyl esters: toxic non-oxidative metabolites of ethanol and markers of ethanol intake","volume":"8","author":"CA Best","year":"2003","journal-title":"Front Biosci"},{"key":"ref11","unstructured":"Arvedson JC (2006) Swallowing and feeding in infants and young children. In: Goyal RK, Shaker R, editors. Goyal and Shaker\u2019s GI Motility Online. New York: Nature Publishing."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1067\/S0022-3476(03)00442-6","article-title":"Validation of a new biomarker of fetal exposure to alcohol","volume":"143","author":"CF Bearer","year":"2003","journal-title":"J Pediatr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jpeds.2005.01.048","article-title":"Fatty Acid ethyl esters: quantitative biomarkers for maternal alcohol consumption","volume":"146","author":"CF Bearer","year":"2005","journal-title":"J Pediatr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/sj.clpt.6100506","article-title":"Novel methods for the detection of drug and alcohol exposure during pregnancy: implications for maternal and child health","volume":"83","author":"G Koren","year":"2008","journal-title":"Clin Pharmacol Ther"},{"key":"ref15","first-page":"e344","article-title":"Development of Canadian screening tools for fetal alcohol spectrum disorder","volume":"15","author":"YI Goh","year":"2008","journal-title":"Can J Clin Pharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/alcalc\/agm054","article-title":"The prevalence of alcohol intoxication in the night-time economy","volume":"42","author":"S Moore","year":"2007","journal-title":"Alcohol and Alcoholism"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"H645","DOI":"10.1152\/ajpheart.00689.2010","article-title":"Alcohol exposure during late gestation adversely affects myocardial development with implications for postnatal cardiac function","volume":"300","author":"JM Goh","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"R568","DOI":"10.1152\/ajpregu.90316.2008","article-title":"Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep","volume":"295","author":"SP Gray","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"L510","DOI":"10.1152\/ajplung.90532.2008","article-title":"Repeated ethanol exposure during late gestation alters the maturation and innate immune status of the ovine fetal lung","volume":"296","author":"F Sozo","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"R926","DOI":"10.1152\/ajpregu.00711.2010","article-title":"Daily ethanol exposure during late ovine pregnancy: physiological effects in the mother and fetus in the apparent absence of overt fetal cerebral dysmorphology","volume":"301","author":"K Kenna","year":"2011","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.alcohol.2010.07.005","article-title":"An improved method for rapidly quantifying fatty acid ethyl esters in meconium suitable for prenatal alcohol screening","volume":"45","author":"JR Hutson","year":"2011","journal-title":"Alcohol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/jmf.13.2.85.93","article-title":"Prevalence of prenatal drinking assessed at an urban public hospital and a suburban private hospital","volume":"13","author":"CD Drews","year":"2003","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.15288\/jsa.2006.67.245","article-title":"Alcohol use by pregnant women: partners, knowledge, and other predictors","volume":"67","author":"G Chang","year":"2006","journal-title":"J Stud Alcohol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1177\/15353702-0323006-06","article-title":"Animal model systems for the study of alcohol teratology","volume":"230","author":"TA Cudd","year":"2005","journal-title":"Exp Biol Med (Maywood )"},{"key":"ref25","first-page":"21","article-title":"Effects of alcohol (ethanol) on the fetus","volume":"15","author":"JF Brien","year":"1991","journal-title":"J Dev Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1139\/y91-082","article-title":"Effects of ethanol exposure on the embryo-fetus: experimental considerations, mechanisms, and the role of prostaglandins","volume":"69","author":"GN Smith","year":"1991","journal-title":"Can J Physiol Pharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000480980","article-title":"Activity of alcohol dehydrogenase and aldehyde dehydrogenase in maternal liver, fetal liver and placenta of the near-term pregnant ewe","volume":"12","author":"DW Clarke","year":"1989","journal-title":"Dev Pharmacol Ther"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1203\/PDR.0b013e31815f651e","article-title":"Elevated fatty acid ethyl esters in meconium of sheep fetuses exposed in utero to ethanol\u2013a new animal model","volume":"63","author":"Y Littner","year":"2008","journal-title":"Pediatr Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00007691-200306000-00004","article-title":"Population baseline of meconium fatty acid ethyl esters among infants of nondrinking women in Jerusalem and Toronto","volume":"25","author":"D Chan","year":"2003","journal-title":"Ther Drug Monit"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/01.ftd.0000211819.35182.82","article-title":"Chronic prenatal ethanol exposure and increased concentration of fatty acid ethyl esters in meconium of term fetal Guinea pig","volume":"28","author":"JF Brien","year":"2006","journal-title":"Ther Drug Monit"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1203\/01.pdr.0000185201.83801.ed","article-title":"A Guinea pig model for the identification of in utero alcohol exposure using fatty acid ethyl esters in neonatal hair","volume":"58","author":"DL Caprara","year":"2005","journal-title":"Pediatr Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1530-0277.2006.00131.x","article-title":"Fatty acid ethyl esters in meconium: are they biomarkers of fetal alcohol exposure and effect","volume":"30","author":"EM Ostrea Jr","year":"2006","journal-title":"Alcohol Clin Exp Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1373\/49.1.133","article-title":"Prevalence of fatty acid ethyl esters in meconium specimens","volume":"49","author":"C Moore","year":"2003","journal-title":"Clin Chem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/bdra.20464","article-title":"Biomarkers for detection of prenatal alcohol exposure: a critical review of fatty acid ethyl esters in meconium","volume":"82","author":"L Burd","year":"2008","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"ref35","unstructured":"Gareri J, Lynn H, Koren G (2006) Evaluating the use of gas chromatography with flame ionization detection in mass screening for meconium fatty acid ethylesters. Alcohol Clin Exp Res 30 (6 Suppl S): 110A."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1002\/jssc.201000118","article-title":"Determination of eight fatty acid ethyl esters in meconium samples by headspace solid-phase microextraction and gas chromatography-mass spectrometry","volume":"33","author":"M Roehsig","year":"2010","journal-title":"J Sep Sci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1177\/002204260303300411","article-title":"The prevalence of methamphetamine and other drug use during pregnancy in Hawaii","volume":"33","author":"C Derauf","year":"2003","journal-title":"J Drug Issues"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1530-0277.2003.tb04401.x","article-title":"Executive functioning in preschool-age children prenatally exposed to alcohol, cocaine, and marijuana","volume":"27","author":"JS Noland","year":"2003","journal-title":"Alcohol Clin Exp Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.jpeds.2007.11.009","article-title":"Fatty acid ethyl esters in meconium are associated with poorer neurodevelopmental outcomes to two years of age","volume":"152","author":"J Peterson","year":"2008","journal-title":"J Pediatr"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1124\/jpet.104.066597","article-title":"Placental handling of fatty acid ethyl esters: perfusion and subcellular studies","volume":"310","author":"D Chan","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1046\/j.1365-2672.1997.00217.x","article-title":"Formate and ethanol are the major products of glycerol fermentation produced by a <italic>Klebsiella planticola<\/italic> strain isolated from red deer","volume":"83","author":"GN Jarvis","year":"1997","journal-title":"J Appl Microbiol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0059168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T08:08:03Z","timestamp":1562832483000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0059168"}},"subtitle":[],"editor":[{"given":"Michael","family":"Koval","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,22]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0059168","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,22]]}}}