{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:36:40Z","timestamp":1790001400619,"version":"4.0.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T00:00:00Z","timestamp":1364256000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0059746","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T20:50:39Z","timestamp":1364331039000},"page":"e59746","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Surveillance on the Status of Immune Cells after Echinnococcus granulosus Protoscoleces Infection in Balb\/c Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Wei","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Jun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Juan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Yan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Ying","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidiebere E.","family":"Ugwu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Ping","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1863-2378.2007.01100.x","article-title":"<italic>Echinococcus granulosus<\/italic> infection in Spain","volume":"55","author":"D Carmena","year":"2008","journal-title":"Zoonoses Public Health"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11259-009-9247-y","article-title":"Echinococcosis: costs, losses and social consequences of a neglected zoonosis","volume":"33","author":"G Battelli","year":"2009","journal-title":"Vet Res Commun"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e1475","DOI":"10.1371\/journal.pntd.0001475","article-title":"Neglected tropical diseases of the Middle East and North Africa: review of their prevalence distribution, and opportunities for control","volume":"6","author":"PJ Hotez","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12016-004-0004-2","article-title":"Echinococcosis and allergy","volume":"26","author":"DA Vuitton","year":"2004","journal-title":"Clin Rev Allergy Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1684\/ecn.2009.0154","article-title":"Involvement of IL-10 and IL-4 in evasion strategies of <italic>Echinococcus granulosus<\/italic> to host immune response.","volume":"20","author":"M Amri","year":"2009","journal-title":"Eur.Cytokine Netw"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1046\/j.1365-3024.1998.00180.x","article-title":"T\u2013cell activity associated with secondary infections and implanted cysts of <italic>Echinococcus granulosus<\/italic> in BALB\/c mice","volume":"20","author":"MT Rogan","year":"1998","journal-title":"Parasite Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1128\/IAI.01156-06","article-title":"<italic>Echinococcus granulosus<\/italic> antigen B impairs human dendritic cell differentiation and polarizes immature dendritic cell maturation towards a Th2 cell response","volume":"75","author":"R Rigan\u00f2","year":"2007","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e1516","DOI":"10.1371\/journal.pntd.0001516","article-title":"Excretory\/secretory-products of <italic>Echinnoccus multilocularis<\/italic> larvae induce apoptosis and tolerogenic properties in dendritic cells in vitro","volume":"6","author":"KN Justin","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref9","first-page":"350","article-title":"Idiotypic modulation of the antibody response to <italic>Echinococcus granulosus<\/italic> antigens","volume":"84","author":"A Baz","year":"1995","journal-title":"Immunology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1006\/expr.2001.4662","article-title":"<italic>Echinococcus granulosus<\/italic>: regulation of leukocyte growth by living protoscoleces from horses, sheep, and cattle","volume":"99","author":"AR Macintyre","year":"2001","journal-title":"Exp Parasitol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/00034983.1985.11811897","article-title":"<italic>Echinococcus granulosus<\/italic>: failure of eosin-exclusion test to demonstrate death of protoscoleces","volume":"79","author":"RD Robinson","year":"1985","journal-title":"Ann Trop Med Parasitol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00380555","article-title":"The host response in secondary hydatidosis of mice. I. Circulating antibodies","volume":"52","author":"GF Araj","year":"1977","journal-title":"Z Parasitenkd"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e1612","DOI":"10.1371\/journal.pone.0001612","article-title":"FOXP3 promoter demethlation reveals the committed Treg population in humans","volume":"3","author":"PC Janson","year":"2008","journal-title":"PLoS ONE"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/intimm\/5.9.1139","article-title":"CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection","volume":"5","author":"I Yamashita","year":"1993","journal-title":"Int Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/84701","article-title":"11-color, 13-parameter flow cytometry: identification of human na\u00efve T cells by phenotype, function, and T-cell receptor diversity","volume":"7","author":"SC De Rosa","year":"2001","journal-title":"Nat Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/PL00000776","article-title":"The CD40\/CD154 receptor\/ligand dyad","volume":"58","author":"U Schonbeck","year":"2001","journal-title":"Cell Mol Life Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nri2657","article-title":"Na\u00efve T cell homeostasis: from awareness of space to a sense of place","volume":"9","author":"K Takada","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4049\/jimmunol.182.1.111","article-title":"CD69<sup>+<\/sup> CD4<sup>+<\/sup> CD25<sup>\u2212<\/sup> T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta-1","volume":"182","author":"Y Han","year":"2009","journal-title":"J Immunol"},{"key":"ref19","volume":"16","unstructured":"Tuxun T, Wang JH, Lin RY, Shan JY, Tai QW, <etal>et al<\/etal>.. (2012) Th17\/Treg imbalance in patients with liver cystic echinococcosis. Parasite Immunol Jul <volume>16<\/volume> .doi: 10.1111\/j.1365-3024.2012.01383.x."},{"key":"ref20","first-page":"57","article-title":"Cytokine profile in human hydatidosis: possible role in the immunosurveillance of patients infected with <italic>Echinococcus granulosus<\/italic>","volume":"16","author":"D Mezioug","year":"2009","journal-title":"Parasite"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system [J]","volume":"93","author":"DI Gabrilovich","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e40677","DOI":"10.1371\/journal.pone.0040677","article-title":"Myeloid suppressor cell depletion augments antitumor activity in lung cancer","volume":"7","author":"MK Srivastava","year":"2012","journal-title":"PLoS ONE"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.4049\/jimmunol.181.5.3291","article-title":"Tumor-induced CD11b<sup>+<\/sup> Gr-1<sup>+<\/sup> myeloid cells suppress T cells sensitization in tumor-draining lymph nodes","volume":"181","author":"S Watanabe","year":"2008","journal-title":"J Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00262-005-0048-z","article-title":"Role of immature myeloid cells in mechanisms of immune evasion in cancer","volume":"55","author":"S Kusmartsev","year":"2006","journal-title":"Cancer Immunol Immunother"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4049\/jimmunol.172.2.989","article-title":"Antigen-specific inhibition of CD8<sup>+<\/sup> T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species","volume":"172","author":"S Kusmartsev","year":"2004","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1600-065X.2008.00608.x","article-title":"Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives","volume":"222","author":"PC Rodr\u00edguez","year":"2008","journal-title":"Immunol Rev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.4049\/jimmunol.181.8.5791","article-title":"Subsets of myeloidderived suppressor cells in tumor-bearing mice","volume":"181","author":"JI Youn","year":"2008","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1158\/0008-5472.CAN-07-6621","article-title":"Myeloid-derived suppressor cells promote cross-tolerance in B-cell lymphoma by expanding regulatory T cells","volume":"68","author":"P Serafini","year":"2008","journal-title":"Cancer Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1084\/jem.20062602","article-title":"MyD88-dependent expansion of an immature GR-1<sup>+<\/sup> CD11b<sup>+<\/sup> population induces T cell suppression and Th2 polarization in sepsis","volume":"204","author":"MJ Delano","year":"2007","journal-title":"J Exp Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.4049\/jimmunol.182.2.1107","article-title":"IL-10 dampens TNF\/inducible nitric oxide synthase-producing dendritic cell-mediated pathogenicity during parasitic infection","volume":"182","author":"M Guilliams","year":"2009","journal-title":"J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1242\/jcs.104.2.477","article-title":"Cell membrane-associated proteoglycans mediate extramedullar myeloid proliferation in granulomatous inflammatory reactions to schistosome egg","volume":"104","author":"M Alvarez-Silva","year":"1993","journal-title":"J Cell SCi"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s004360050467","article-title":"Murine schistosomiasis mansoni: experimental analysis of bone marrow and peripheral myelopoiesis","volume":"84","author":"HS Dutra","year":"1998","journal-title":"Parasitol Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1182\/blood.V95.5.1642.005k10_1642_1651","article-title":"<italic>Leishmania donovani<\/italic> infection of bone marrow stromal macrophages selectively enhances myelopoiesis, by a mechanism involving GM-CSF and TNF-alpha","volume":"95","author":"SE Cotterell","year":"2000","journal-title":"Blood"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1128\/IAI.68.4.1840-1848.2000","article-title":"Enhanced hematopoietic activity accompanies parasite expansion in the spleen and bone marrow of mice infected with <italic>Leishmania donovani<\/italic>","volume":"68","author":"SE Cotterell","year":"2000","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"5487","DOI":"10.1128\/IAI.72.9.5487-5492.2004","article-title":"Both expansion of regulatory GR-1<sup>+<\/sup> CD11b<sup>+<\/sup> myeloid cells and anergy of T lymphocytes participate in hyporesponsiveness of the lung-associated immune system during acute toxoplasmosis","volume":"72","author":"MB Voisin","year":"2004","journal-title":"Infect Immun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.immuni.2008.05.019","article-title":"GR-1<sup>+<\/sup> inflammatory monocytes are required for mucosal resistence to the pathogen <italic>Toxoplasma gondii<\/italic>","volume":"29","author":"IR Dunay","year":"2008","journal-title":"Immunity"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1017\/S0031182002002330","article-title":"Anti-parasitic effect of cyclosporine A on <italic>Echinococcus granulosus<\/italic> and characterization of the associated cyclophilin protein","volume":"125","author":"AL Colebrook","year":"2002","journal-title":"Parasitology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1365-3024.2003.00617.x","article-title":"Molecular and immunological characterization of the C-terminal region of a new <italic>Echinococcus granulosus<\/italic> heat shock protein 70","volume":"25","author":"E Ortona","year":"2003","journal-title":"Parasite Immunol"},{"key":"ref39","first-page":"1122","article-title":"Liver and parasitic diseases","volume":"28","author":"DA Vuitton","year":"2004","journal-title":"Gastroenterol Clin Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cyto.2008.03.002","article-title":"Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and \u2018emergency\u2019 hematopoiesis","volume":"42","author":"AD Panopoulos","year":"2008","journal-title":"Cytokine"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0059746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T12:33:22Z","timestamp":1644669202000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0059746"}},"subtitle":[],"editor":[{"given":"Jianqing","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,26]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0059746","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,26]]}}}