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Intensive Care Med 29: 530\u2013538. 10.1007\/s00134-003-1662-x [doi].","DOI":"10.1007\/s00134-003-1662-x"},{"key":"ref5","unstructured":"Grimont PA, Weill F.X. (2007) Antigenic formulae of the Salmonella serovars. 9th edition: 1\u2013166."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/JB.98.2.447-452.1969","article-title":"Erythromycin-inducible resistance in Staphylococcus aureus: survey of antibiotic classes involved","volume":"98","author":"B Weisblum","year":"1969","journal-title":"J Bacteriol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/clinids\/10.4.867","article-title":"Extended broad-spectrum beta-lactamases conferring transferable resistance to newer beta-lactam agents in Enterobacteriaceae: hospital prevalence and susceptibility patterns","volume":"10","author":"V Jarlier","year":"1988","journal-title":"Rev Infect Dis"},{"key":"ref8","unstructured":"CLSI (1\u20131-2012) CLSI M100-S22. Performance Standards for Antimicrobial Susceptibility Testing; Twenty-second Informational Supplement. CLSI document M100-S22. Clinical and Laboratory Standards Institute. ISBN: 1562387162. 28[1]. 1-1-2012. Wayne, PA: Clinical and Laboratory Standards Institute."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1128\/AAC.00590-11","article-title":"Antimicrobial susceptibility to azithromycin among Salmonella enterica isolates from the United States","volume":"55","author":"M Sjolund-Karlsson","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Cornaglia G, Hryniewicz W, Jarlier V, Kahlmeter G, Mittermayer H, <etal>et al<\/etal>. (2004) European recommendations for antimicrobial resistance surveillance. Clin Microbiol Infect 10: 349\u2013383. 10.1111\/j.1198-743X.2004.00887.x [doi];CLM887 [pii].","DOI":"10.1111\/j.1198-743X.2004.00887.x"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Vlieghe ER, Phe T, De Smet B, Veng CH, Kham C, <etal>et al<\/etal>. (2012) Azithromycin and ciprofloxacin resistance in salmonella bloodstream infections in cambodian adults. PLoS Negl Trop Dis 6: e1933. 10.1371\/journal.pntd.0001933 [doi];PNTD-D-12-01000 [pii].","DOI":"10.1371\/journal.pntd.0001933"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Vlieghe E, Kruy L, De Smet B, Kham C, Veng CH, <etal>et al<\/etal>. (2011) Melioidosis, phnom penh, Cambodia. Emerg Infect Dis 17: 1289\u20131292. 10.3201\/eid1707.101069 [doi].","DOI":"10.3201\/eid1707.101069"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"White NJ (2003) Melioidosis. Lancet 361: 1715\u20131722. S0140673603133740 [pii].","DOI":"10.1016\/S0140-6736(03)13374-0"},{"key":"ref14","unstructured":"WHO (2012) Community-Based Surveillance of Antimicrobial Use and Resistance in Resource-Constrained Settings. Report on Five Pilot Projects - EDM Research Series No. 037. WHO\/EMP\/MAR\/2009.2. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/appswhoint\/medicinedocs\/documents\/s16168e\/s16168epdf\" xlink:type=\"simple\">http:\/\/appswhoint\/medicinedocs\/documents\/s16168e\/s16168epdf<\/ext-link>; accessed September 12th 2012."},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Kasper MR, Blair PJ, Touch S, Sokhal B, Yasuda CY, <etal>et al<\/etal>. (2012) Infectious etiologies of acute febrile illness among patients seeking health care in south-central Cambodia. Am J Trop Med Hyg 86: 246\u2013253. 86\/2\/246 [pii];10.4269\/ajtmh.2012.11-0409 [doi].","DOI":"10.4269\/ajtmh.2012.11-0409"},{"key":"ref16","first-page":"347","article-title":"Bacteremia and antimicrobial susceptibilities in HIV-infected patients at Siriraj Hospital","volume":"36","author":"S Srifuengfung","year":"2005","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref17","first-page":"464","article-title":"Etiologies of acute undifferentiated febrile illness in Thailand","volume":"87","author":"A Leelarasamee","year":"2004","journal-title":"J Med Assoc Thai"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Wertheim HF, Nghia HD, Taylor W, Schultsz C (2009) Streptococcus suis: an emerging human pathogen. Clin Infect Dis 48: 617\u2013625. 10.1086\/596763 [doi];10.1086\/596763 [pii].","DOI":"10.1086\/596763"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1128\/CMR.17.2.311-322.2004","article-title":"Salmonella enterica serotype Choleraesuis: epidemiology, pathogenesis, clinical disease, and treatment","volume":"17","author":"CH Chiu","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Ong CW, Lye DC, Khoo KL, Chua GS, Yeoh SF, <etal>et al<\/etal>. (2009) Severe community-acquired Acinetobacter baumannii pneumonia: an emerging highly lethal infectious disease in the Asia-Pacific. Respirology 14: 1200\u20131205. RES1630 [pii];10.1111\/j.1440-1843.2009.01630.x [doi].","DOI":"10.1111\/j.1440-1843.2009.01630.x"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Chen YH, Hsueh PR, Badal RE, Hawser SP, Hoban DJ, <etal>et al<\/etal>. (2011) Antimicrobial susceptibility profiles of aerobic and facultative Gram-negative bacilli isolated from patients with intra-abdominal infections in the Asia-Pacific region according to currently established susceptibility interpretive criteria. J Infect 62: 280\u2013291. S0163-4453(11)00060-0 [pii];10.1016\/j.jinf.2011.02.009 [doi].","DOI":"10.1016\/j.jinf.2011.02.009"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Nga TV, Parry CM, Le T, Lan NP, Diep TS, <etal>et al<\/etal>. (2012) The decline of typhoid and the rise of non-typhoid salmonellae and fungal infections in a changing HIV landscape: bloodstream infection trends over 15 years in southern Vietnam. Trans R Soc Trop Med Hyg 106: 26\u201334. S0035-9203(11)00208-2 [pii];10.1016\/j.trstmh.2011.10.004 [doi].","DOI":"10.1016\/j.trstmh.2011.10.004"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Phetsouvanh R, Phongmany S, Soukaloun D, Rasachak B, Soukhaseum V, <etal>et al<\/etal>. (2006) Causes of community-acquired bacteremia and patterns of antimicrobial resistance in Vientiane, Laos. Am J Trop Med Hyg 75: 978\u2013985. 75\/5\/978 [pii].","DOI":"10.4269\/ajtmh.2006.75.978"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3201\/eid1505.071299","article-title":"CTX-M beta-lactamases in Escherichia coli from community-acquired urinary tract infections, Cambodia","volume":"15","author":"E Ruppe","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Isozumi R, Yoshimatsu K, Yamashiro T, Hasebe F, Nguyen BM, <etal>et al<\/etal>. (2012) bla(NDM-1)-positive Klebsiella pneumoniae from Environment, Vietnam. Emerg Infect Dis 18: 1383\u20131385. 10.3201\/eid1808.111816 [doi].","DOI":"10.3201\/eid1808.111816"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Rimrang B, Chanawong A, Lulitanond A, Wilailuckana C, Charoensri N, <etal>et al<\/etal>. (2012) Emergence of NDM-1- and IMP-14a-producing Enterobacteriaceae in Thailand. J Antimicrob Chemother. dks267 [pii];10.1093\/jac\/dks267 [doi].","DOI":"10.1093\/jac\/dks267"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Nickerson EK, Hongsuwan M, Limmathurotsakul D, Wuthiekanun V, Shah KR, <etal>et al<\/etal>. (2009) Staphylococcus aureus bacteraemia in a tropical setting: patient outcome and impact of antibiotic resistance. PLoS One 4: e4308. 10.1371\/journal.pone.0004308 [doi].","DOI":"10.1371\/journal.pone.0004308"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Chheng K, Tarquinio S, Wuthiekanun V, Sin L, Thaipadungpanit J, <etal>et al<\/etal>. (2009) Emergence of community-associated methicillin-resistant Staphylococcus aureus associated with pediatric infection in Cambodia. PLoS One 4: e6630. 10.1371\/journal.pone.0006630 [doi].","DOI":"10.1371\/journal.pone.0006630"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Nayyar GM, Breman JG, Newton PN, Herrington J (2012) Poor-quality antimalarial drugs in southeast Asia and sub-Saharan Africa. Lancet Infect Dis 12: 488\u2013496. S1473-3099(12)70064-6 [pii];10.1016\/S1473-3099(12)70064-6 [doi].","DOI":"10.1016\/S1473-3099(12)70064-6"},{"key":"ref30","first-page":"418","article-title":"Rational drug use in Cambodia: study of three pilot health centers in Kampong Thom Province","volume":"33","author":"C Chareonkul","year":"2002","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref31","unstructured":"GARP Vietnam report: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.cddep.org\/publications\/situation_analysis_antibiotic_use_and_resistance_vietnam\" xlink:type=\"simple\">http:\/\/www.cddep.org\/publications\/situation_analysis_antibiotic_use_and_resistance_vietnam<\/ext-link>; accessed November 2nd, 2011."},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Lay KS, Vuthy Y, Song P, Phol K, Sarthou JL (2011) Prevalence, numbers and antimicrobial susceptibilities of Salmonella serovars and Campylobacter spp. in retail poultry in Phnom Penh, Cambodia. J Vet Med Sci 73: 325\u2013329. JST.JSTAGE\/jvms\/10-0373 [pii].","DOI":"10.1292\/jvms.10-0373"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Hancart-Petitet P, Dumas C, Faurand-Tournaire AL, Desclaux A, Vong S (2011) Social and cultural dimensions of hygiene in Cambodian health care facilities. BMC Public Health 11: 83. 1471-2458-11-83 [pii];10.1186\/1471-2458-11-83 [doi].","DOI":"10.1186\/1471-2458-11-83"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Aiken AM, Mturi N, Njuguna P, Mohammed S, Berkley JA, <etal>et al<\/etal>. (2011) Risk and causes of paediatric hospital-acquired bacteraemia in Kilifi District Hospital, Kenya: a prospective cohort study. Lancet 378: 2021\u20132027. S0140-6736(11)61622-X [pii];10.1016\/S0140-6736(11)61622-X [doi].","DOI":"10.1016\/S0140-6736(11)61622-X"},{"key":"ref35","unstructured":"Ministry of Health Cambodia, Department of drugs food and cosmetics (2010) Medicines policy of the Kingdom of Cambodia (2010). <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ddf.cambodia.com\/images\/stories\/EDB\/nmp_englishpdf\" xlink:type=\"simple\">http:\/\/ddf.cambodia.com\/images\/stories\/EDB\/nmp_englishpdf<\/ext-link>, accessed September 12th 2012."},{"key":"ref36","unstructured":"Ministry of Health Cambodia, Department of Hospital Services (2012) Infection Prevention And Control Guidelines For Health Care Facilities July 26, 2010."},{"key":"ref37","unstructured":"Ministry of Health Cambodia, Department of drugs food and cosmetics (2010) Essential medicines list.Revision 2010. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ddfcambodia.com\/\" xlink:type=\"simple\">http:\/\/www.ddfcambodia.com\/<\/ext-link>, accessed September 12th 2012."},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Klugman KP, Madhi SA, Huebner RE, Kohberger R, Mbelle N, <etal>et al<\/etal>. (2003) A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection. N Engl J Med 349: 1341\u20131348. 10.1056\/NEJMoa035060 [doi];349\/14\/1341 [pii].","DOI":"10.1056\/NEJMoa035060"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0059775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T11:38:23Z","timestamp":1595590703000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0059775"}},"subtitle":[],"editor":[{"given":"Heiman Frank Louis","family":"Wertheim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,29]]},"references-count":38,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0059775","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,29]]}}}