{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T04:11:49Z","timestamp":1746072709655,"version":"3.40.4"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0059964","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T21:03:29Z","timestamp":1366059809000},"page":"e59964","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Amphetamine-Induced Sensitization Has Little Effect on Multiple Learning Paradigms and Fails to Rescue Mice with a Striatal Learning Defect"],"prefix":"10.1371","volume":"8","author":[{"given":"Kiara C.","family":"Eldred","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Palmiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuropharm.2004.07.006","article-title":"Psychomotor stimulants and neuronal plasticity","volume":"47","author":"ME Wolf","year":"2004","journal-title":"Neuropharmacology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrn2515","article-title":"The glutamate homeostasis hypothesis of addiction","volume":"10","author":"PW Kalivas","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nature10709","article-title":"Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour","volume":"481","author":"V Pascoli","year":"2012","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.coph.2006.08.012","article-title":"ERK2: a logical AND gate critical for drug-induced plasticity?","volume":"7","author":"JA Girault","year":"2007","journal-title":"Curr Opin Pharmacol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nature06994","article-title":"A phosphatase cascade by which rewarding stimuli control nucleosomal response","volume":"453","author":"A Stipanovich","year":"2008","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nrn3111","article-title":"Transcriptional and epigenetic mechanisms of addiction","volume":"12","author":"AJ Robison","year":"2011","journal-title":"Nat Rev Neurosci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1111\/j.1460-9568.2004.03612.x","article-title":"The induction of behavioral sensitization is associated with cocaine-induced structural plasticity in the core (but not the shell) of the nucleus accumbens","volume":"20","author":"Y Li","year":"2004","journal-title":"Eur J Neurosci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1111\/j.1460-9568.2007.05316.x","article-title":"Methamphetamine-induced structural plasticity in the dorsal striatum","volume":"25","author":"JP Jedynak","year":"2007","journal-title":"Eur J Neurosci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tins.2010.02.002","article-title":"The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens","volume":"33","author":"SJ Russo","year":"2010","journal-title":"Trends Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/35079077","article-title":"Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons","volume":"411","author":"MA Ungless","year":"2001","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/nn1682","article-title":"Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression","volume":"9","author":"C Bellone","year":"2006","journal-title":"Nat Neurosci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nn.2763","article-title":"Cocaine inverts rules for synaptic plasticity of glutamate transmission in the VTA","volume":"14","author":"M Mameli","year":"2011","journal-title":"Nat Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"10621","DOI":"10.1523\/JNEUROSCI.2163-07.2007","article-title":"Cell surface AMPA receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with activation of mitogen-activated protein kinases","volume":"27","author":"AC Boudreau","year":"2007","journal-title":"J Neurosci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"7921","DOI":"10.1523\/JNEUROSCI.1859-07.2007","article-title":"Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens","volume":"27","author":"S Kourrich","year":"2007","journal-title":"J Neurosci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nn1713","article-title":"Cocaine self-administration selectively abolishes LTD in the core of the nucleus accumbens","volume":"9","author":"M Martin","year":"2006","journal-title":"Nat Neurosci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.neubiorev.2010.01.013","article-title":"AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine","volume":"35","author":"ME Wolf","year":"2010","journal-title":"Neurosci Biobehav Rev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature06995","article-title":"Formation of accumbens GluR2-lacking AMPA receptors mediate incubation of cocaine craving","volume":"454","author":"KL Conrad","year":"2008","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.neuron.2011.01.017","article-title":"Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling","volume":"69","author":"C L\u00fcscher","year":"2011","journal-title":"Neuron"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5274","DOI":"10.1073\/pnas.85.14.5274","article-title":"Drugs abused by humans preferentially increase synaptic dopamine concentrations in mesolimbic system of freely moving rats","volume":"85","author":"G Di Chiara","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.neuro.29.051605.113009","article-title":"Neural mechanisms of addiction: the role of reward-related learning and memory","volume":"29","author":"SE Hyman","year":"2006","journal-title":"Annu Rev Neurosci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1523\/JNEUROSCI.13-01-00266.1993","article-title":"Time course of extracellular dopamine and behavioral sensitization to cocaine. I. Dopamine axon terminals","volume":"13","author":"PW Kalivas","year":"1993","journal-title":"J Neurosci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.psych.54.101601.145237","article-title":"Addiction","volume":"54","author":"TE Robinson","year":"2003","journal-title":"Annu Rev Psychol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuroscience.2011.06.089","article-title":"Dopamine signaling as a neural correlate of consciousness","volume":"198","year":"2011","journal-title":"Neuroscience"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1523\/JNEUROSCI.4576-09.2010","article-title":"Restricting dopaminergic signaling to either dorsolateral or medial striatum facilitates cognition","volume":"30","author":"M Darvas","year":"2010","journal-title":"J Neurosci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"15254","DOI":"10.1073\/pnas.0601758103","article-title":"Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. Proc Nat","volume":"103","author":"MT Dang","year":"2006","journal-title":"Acad Sci USA"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e28168","DOI":"10.1371\/journal.pone.0028168","article-title":"Severely impaired learning and altered neuronal morphology in mice lacking NMDA receptors in medium spiny neurons","volume":"6","author":"LR Beutler","year":"2011","journal-title":"PLoS ONE"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.neuron.2008.05.028","article-title":"Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors","volume":"59","author":"LS Zweifel","year":"2008","journal-title":"Neuron"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.neuron.2008.07.010","article-title":"Glutamate receptors on dopamine neurons control persistence of cocaine seeking","volume":"59","author":"D Engblom","year":"2008","journal-title":"Neuron"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.neuron.2011.10.019","article-title":"NMDA receptors in dopaminergic neurons are crucial for habit learning","volume":"72","author":"LP Wang","year":"2011","journal-title":"Neuron"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"12961","DOI":"10.1073\/pnas.0806180105","article-title":"Functional disturbances in the striatum by region-specific ablation of NMDA receptors","volume":"105","author":"N Ohtsuka","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.neuron.2008.05.024","article-title":"Cocaine but not natural reward self-administration nor passive cocaine infusion produces LTP in the VTA","volume":"59","author":"BT Chen","year":"2008","journal-title":"Neuron"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1126\/science.1160873","article-title":"Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons","volume":"321","author":"GD Stuber","year":"2008","journal-title":"Science"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1073\/pnas.1101424108","article-title":"Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization","volume":"108","author":"LR Beutler","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1038\/nn.3239","article-title":"Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors","volume":"15","author":"A Quintana","year":"2012","journal-title":"Nat Neurosci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"14664","DOI":"10.1073\/pnas.0907299106","article-title":"Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors","volume":"106","author":"M Darvas","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1523\/JNEUROSCI.2136-12.2013","article-title":"Amphetamine paradoxically augments exocytotic dopamine release and phasic dopamine signals","volume":"33","author":"D Daberkow","year":"2013","journal-title":"J Neurosci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbr.2007.12.032","article-title":"A sensitizing regimen of amphetamine that disrupts attentional set-shifting does not disrupt working or long-term memory","volume":"189","author":"RE Featherstone","year":"2008","journal-title":"Behav Brain Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0306-4522(98)00464-3","article-title":"Enhanced dopamine efflux in the amygdale by a predictive, but not a no-predictive, stimulus: facilitation by prior repeated D-amphetamine","volume":"90","author":"C Harmer","year":"1999","journal-title":"Neuroscience"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1523\/JNEUROSCI.4080-06.2007","article-title":"Previous cocaine exposure makes rate hypersensitive to both delay and reward magnitude","volume":"27","author":"MR Roesch","year":"2007","journal-title":"J Neurosci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0006-8993(88)90549-5","article-title":"Persistent sensitization of dopamine transmission in ventral striatum (nucleus accumbens) produced by prior experience with (+)-amphetamine: a microdialysis study in freely moving rats","volume":"462","author":"TE Robinson","year":"1988","journal-title":"Brain Res"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1523\/JNEUROSCI.4697-11.2012","article-title":"GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons","volume":"32","author":"E Vashchinkina","year":"2012","journal-title":"J Neurosci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuron.2008.01.033","article-title":"Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration","volume":"58","author":"NS Bamford","year":"2008","journal-title":"Neuron"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nrn1406","article-title":"Dopamine, learning and motivation","volume":"5","author":"RA Wise","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1124\/pr.109.001933","article-title":"Drug wanting: behavioral sensitization and relapse to drug-seeking behavior","volume":"63","author":"JD Steketee","year":"2011","journal-title":"Pharmacol Rev"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1369-1600.2007.00070.x","article-title":"Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade","volume":"12","author":"TM Tzschentke","year":"2007","journal-title":"Addict Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1126\/science.2781295","article-title":"Factors that predict individual vulnerability for amphetamine self-administration","volume":"245","author":"PV Piazza","year":"1989","journal-title":"Science"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0166-4328(99)00109-6","article-title":"Previous exposure to amphetamine increases incentive to obtain the drug: long-lasting effects revealed by the progressive ratio schedule","volume":"107","author":"DS Lorrain","year":"2000","journal-title":"Behav Brain Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"9196","DOI":"10.1523\/JNEUROSCI.1124-06.2006","article-title":"Delta FosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation","volume":"26","author":"P Olausson","year":"2006","journal-title":"J Neurosci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.euroneuro.2006.08.005","article-title":"Amphetamine pretreatment accelerates the subsequent escalation of cocaine self-administration behavior","volume":"17","author":"CR Ferrario","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1126\/science.1187801","article-title":"Transition to addiction is associated with a persistent impairment in synaptic plasticity","volume":"328","author":"F Kasanetz","year":"2010","journal-title":"Science"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0166-4328(01)00321-7","article-title":"Chronic intermittent amphetamine pretreatment enhances future appetitive behavior for drug- and natural-reward: interaction with environmental variables","volume":"128","author":"C Nocjar","year":"2002","journal-title":"Behav Brain Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"7831","DOI":"10.1523\/JNEUROSCI.21-19-07831.2001","article-title":"Incentive sensitization by previous amphetamine exposure: increased cue-triggered \u201cwanting\u201d for sucrose reward","volume":"21","author":"C Wyvell","year":"2001","journal-title":"J Neurosci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1111\/j.1460-9568.2011.07683.x","article-title":"Neural correlates of Pavlovian-to-instrumental transfer in the nucleus accumbens shell are selectively potentiated following cocaine self-administration","volume":"33","author":"MP Saddoris","year":"2011","journal-title":"Eur J Neurosci"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"6235","DOI":"10.1523\/JNEUROSCI.1478-05.2005","article-title":"Dopamine cells respond to predicted events during classical conditioning: evidence for eligibility traces in the reward learning network","volume":"25","author":"WX Pan","year":"2005","journal-title":"J Neurosci"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.tins.2007.03.007","article-title":"Behavioral dopamine signals","volume":"30","author":"W Schultz","year":"1997","journal-title":"Trends Neurosci"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/nn1923","article-title":"Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens","volume":"10","author":"JJ Day","year":"2007","journal-title":"Nat Neurosci"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"13491","DOI":"10.1073\/pnas.1007827107","article-title":"Absence of NMDA receptors in dopamine neurons attenuate dopamine release but not conditioned approach during Pavlovian conditioning","volume":"107","author":"JG Parker","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0166-4328(02)00291-7","article-title":"Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetive Pavlovian approach behavior","volume":"137","author":"JA Parkinson","year":"2002","journal-title":"Behav Brain Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuropharm.2008.06.028","article-title":"Dissecting motivational circuitry to understand substance abuse","volume":"56","author":"RA Wheeler","year":"2009","journal-title":"Neuropharmacology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1093\/cercor\/bhh216","article-title":"Cocaine makes actions insensitive to outcomes but not extinction: implications for altered orbitofrontal-amygdalar function","volume":"15","author":"G Schoenbaum","year":"2005","journal-title":"Cerebral Cortex"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"11362","DOI":"10.1523\/JNEUROSCI.2411-11.2011","article-title":"The contribution of NMDA receptor signaling in the corticobasal ganglia reward network to appetitive Pavlovian learning","volume":"31","author":"JG Parker","year":"2011","journal-title":"J Neurosci"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neuron.2004.09.012","article-title":"LTP and LTD: an embarrassment of riches","volume":"44","author":"RC Malenka","year":"2004","journal-title":"Neuron"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbr.2008.10.030","article-title":"Synaptic plasticity in the basal ganglia","volume":"199","author":"JR Wickens","year":"2009","journal-title":"Behav Brain Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1073\/pnas.0813415106","article-title":"Disruption of NMDAR-dependent burst firing by dopamine neurons provides selective assessment of phasic dopamine-dependent behavior","volume":"106","author":"LS Zweifel","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0022-3565(25)39530-3","article-title":"Involvement of N-methyl-D-aspartate receptor stimulation in the ventral tegmental area and amygdala in behavioral sensitization to cocaine","volume":"267","author":"PW Kalivas","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/sj.npp.1300011","article-title":"Critical role for ventral tegmental glutamate in preference for a cocaine-conditioned environment","volume":"28","author":"GC Harris","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1007\/s002130000463","article-title":"Induction of locomotor sensitization by amphetamine requires activation of NMDA receptors in rat ventral tegmental area","volume":"151","author":"P Vesina","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"e12141","DOI":"10.1371\/journal.pone.0012141","article-title":"NMDA receptors on non-dopaminergic neurons in the VTA support cocaine sensitization","volume":"5","author":"Y Luo","year":"2010","journal-title":"PLoS ONE"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"6578","DOI":"10.1523\/JNEUROSCI.6391-11.2012","article-title":"AMPAR-independent effect of striatal (alpha)CaMKII promotes the sensitization of cocaine reward","volume":"32","author":"A Kourrich","year":"2012","journal-title":"J Neurosci"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"11214","DOI":"10.1523\/JNEUROSCI.23-35-11214.2003","article-title":"Selective encoding of cocaine versus natural rewards by nucleus accumbens neurons is not related to chronic drug exposure","volume":"23","author":"RM Carelli","year":"2003","journal-title":"J Neurosci"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/nn.2364","article-title":"Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization","volume":"12","author":"E Koya","year":"2009","journal-title":"Nat Neurosci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0059964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:49:59Z","timestamp":1745988599000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0059964"}},"subtitle":[],"editor":[{"given":"Ya-Ping","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,15]]},"references-count":71,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0059964","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2013,4,15]]}}}