{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T14:16:36Z","timestamp":1776003396496,"version":"3.50.1"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T00:00:00Z","timestamp":1364256000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0060235","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T20:51:13Z","timestamp":1364331073000},"page":"e60235","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Non-Selective Calcium Channel Blocker Bepridil Decreases Secondary Pathology in Mice after Photothrombotic Cortical Lesion"],"prefix":"10.1371","volume":"8","author":[{"given":"Anu","family":"Lipsanen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Flunkert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Kuptsova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Hiltunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Windisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Hutter-Paier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Jolkkonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jns.2004.09.004","article-title":"Vascular pathologies and cognition in a population-based cohort of elderly people","volume":"226","author":"MS Fernando","year":"2004","journal-title":"Journal of the Neurological Sciences"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1212\/01.wnl.0000271090.28148.24","article-title":"Mixed brain pathologies account for most dementia cases in community-dwelling older persons","volume":"69","author":"JA Schneider","year":"2007","journal-title":"Neurology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/bse0430153","article-title":"Hypoxia and Alzheimer's disease","volume":"43","author":"C Peers","year":"2007","journal-title":"Essays in Biochemistry"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0304-3940(91)90020-T","article-title":"Selective induction of kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex","volume":"125","author":"K Abe","year":"1991","journal-title":"Neuroscience Letters"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1111\/j.0953-816X.2004.03323.x","article-title":"Accelerated accumulation of N- and C-terminal beta APP fragments and delayed recovery of microtubule-associated protein 1B expression following stroke in aged rats","volume":"19","author":"I Badan","year":"2004","journal-title":"The European Journal of Neuroscience"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1097\/00001756-199611040-00064","article-title":"Expression of beta-amyloid precursor protein mRNAs following transient focal ischaemia","volume":"7","author":"J Koistinaho","year":"1996","journal-title":"Neuroreport"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(99)02113-7","article-title":"Hypoperfusion induces overexpression of beta-amyloid precursor protein mRNA in a focal ischemic rodent model","volume":"853","author":"J Shi","year":"2000","journal-title":"Brain Research"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.brainresrev.2004.12.014","article-title":"Interactions between Alzheimer's disease and cerebral ischemia-focus on inflammation","volume":"48","author":"M Koistinaho","year":"2005","journal-title":"Brain Research Reviews"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.pbb.2011.04.019","article-title":"Chronic ibuprofen treatment does not affect the secondary pathology in the thalamus or improve behavioral outcome in middle cerebral artery occlusion rats","volume":"99","author":"A Lipsanen","year":"2011","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"7655","DOI":"10.1523\/JNEUROSCI.17-20-07655.1997","article-title":"Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein","volume":"17","author":"F Zhang","year":"1997","journal-title":"The Journal of Neuroscience"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1073\/pnas.032670899","article-title":"\u0392-amyloid precursor protein transgenic mice that harbor diffuse A\u03b2 deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation","volume":"99","author":"M Koistinaho","year":"2002","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/01.STR.0000149627.30763.f9","article-title":"Interaction between a rat model of cerebral ischemia and beta-amyloid toxicity: Inflammatory responses","volume":"36","author":"SN Whitehead","year":"2005","journal-title":"Stroke"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.brainres.2010.10.008","article-title":"Triflusal reduces cerebral ischemia induced inflammation in a combined mouse model of alzheimer's disease and stroke","volume":"1366","author":"SN Whitehead","year":"2010","journal-title":"Brain Research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1161\/STROKEAHA.107.492660","article-title":"Progressive increase in infarct size, neuroinflammation, and cognitive deficits in the presence of high levels of amyloid","volume":"38","author":"SN Whitehead","year":"2007","journal-title":"Stroke"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1161\/01.STR.0000169933.88903.cf","article-title":"Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats","volume":"36","author":"T van Groen","year":"2005","journal-title":"Stroke"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.nbd.2009.04.009","article-title":"Focal cerebral ischemia in rats alters APP processing and expression of abeta peptide degrading enzymes in the thalamus","volume":"35","author":"M Hiltunen","year":"2009","journal-title":"Neurobiology of Disease"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/sj.jcbfm.9600529","article-title":"Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats","volume":"28","author":"S M\u00e4kinen","year":"2008","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"ref18","unstructured":"Hiltunen M, Jolkkonen J (2011) Complex pathology in the thalamus following cerebral ischemia. In: Song JL, editor. Thalamus: Anatomy, Functions and Disorders. Nova Science Publishers, Inc. pp. 83\u201398."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1111\/j.1582-4934.2012.01599.x","article-title":"Bepridil decreases abeta and calcium levels in the thalamus after middle cerebral artery occlusion in rats","volume":"16","author":"T Saraj\u00e4rvi","year":"2012","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"12463","DOI":"10.1074\/jbc.R109.080895","article-title":"Calcium signaling and amyloid toxicity in alzheimer disease","volume":"285","author":"A Demuro","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00401-011-0865-4","article-title":"Age-related loss of calcium buffering and selective neuronal vulnerability in Alzheimer's disease","volume":"122","author":"D Riascos","year":"2011","journal-title":"Acta Neuropathologica"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ceca.2009.12.014","article-title":"The dysregulation of intracellular calcium in Alzheimer disease","volume":"47","author":"C Supnet","year":"2010","journal-title":"Cell Calcium"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3233\/JAD-2011-101866","article-title":"A longitudinal study of behavioral deficits in an AbetaPP transgenic mouse model of Alzheimer's disease","volume":"25","author":"D Havas","year":"2011","journal-title":"Journal of Alzheimer's Disease"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/NEN.0b013e3181e77ed9","article-title":"The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice","volume":"69","author":"HJ Huttunen","year":"2010","journal-title":"Journal of Neuropathology & Experimental Neurology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1101\/lm.5.4.302","article-title":"\u03917 nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: A behavioral characterization of acra7-deficient mice","volume":"5","author":"R Paylor","year":"1998","journal-title":"Learning & Memory"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0165-0173(98)00017-4","article-title":"The organization of corticothalamic projections: Reciprocity versus parity","volume":"28","author":"M Desch\u00eanes","year":"1998","journal-title":"Brain Research Reviews"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1074\/jbc.R800018200","article-title":"Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease","volume":"284","author":"BA Yankner","year":"2009","journal-title":"Journal of Biological Chememistry"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1111\/j.1460-9568.2007.05807.x","article-title":"Overexpression of APP provides neuroprotection in the absence of functional benefit following middle cerebral artery occlusion in rats","volume":"26","author":"J Clarke","year":"2007","journal-title":"The European Journal of Neuroscience"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"7707","DOI":"10.1523\/JNEUROSCI.2211-04.2004","article-title":"Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis","volume":"24","author":"TD Stein","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"11542","DOI":"10.1523\/JNEUROSCI.3831-05.2005","article-title":"Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation","volume":"25","author":"P Han","year":"2005","journal-title":"Journal of Neuroscience"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"15016","DOI":"10.1074\/jbc.M808755200","article-title":"Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers","volume":"284","author":"M Gralle","year":"2009","journal-title":"Journal of Biological Chemistry"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1046\/j.1471-4159.1994.63020781.x","article-title":"Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury","volume":"63","author":"VL Smith-Swintosky","year":"1994","journal-title":"Journal of Neurochemistry"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.brainres.2006.03.107","article-title":"Soluble amyloid precursor protein alpha reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats","volume":"1094","author":"E Thornton","year":"2006","journal-title":"Brain Research"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.brainres.2010.12.077","article-title":"The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains","volume":"1378","author":"F Corrigan","year":"2011","journal-title":"Brain Research"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0896-6273(93)90315-I","article-title":"Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein","volume":"10","author":"MP Mattson","year":"1993","journal-title":"Neuron"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00221-011-2932-4","article-title":"Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging","volume":"217(3\u20134)","author":"D K\u00f6gel","year":"2012","journal-title":"Experimental Brain Research"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0306-4522(90)90327-Z","article-title":"Thalamic retrograde degeneration following cortical injury: an excitotoxic process?","volume":"35","author":"DT Ross","year":"1990","journal-title":"Neuroscience"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1471-4159.2011.07496.x","article-title":"Autophagosomes accumulation is associated with \u03b2-amyloid deposits and secondary damage in the thalamus after focal cortical infarction in hypertensive rats","volume":"120","author":"J Zhang","year":"2012","journal-title":"Journal of Neurochemistry"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1016\/j.biocel.2004.05.010","article-title":"Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease","volume":"36","author":"WH Yu","year":"2004","journal-title":"International Journal of Biochemistry and Cell Biology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"11172","DOI":"10.1073\/pnas.0603838103","article-title":"Alzheimer's disease beta-amyloid peptides are released in association with exosomes","volume":"103","author":"L Rajendran","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1161\/01.STR.0000248777.44128.93","article-title":"Beta-amyloid aggregation in human brains with cerebrovascular lesions","volume":"37","author":"L Aho","year":"2006","journal-title":"Stroke"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/00004647-199806000-00011","article-title":"Changes in protein synthesis and calcium homeostasis in the thalamus of spontaneously hypertensive rats with focal cerebral ischemia","volume":"18","author":"H Watanabe","year":"1998","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e52347","DOI":"10.1371\/journal.pone.0052347","article-title":"Autophagy induced by calcium phosphate precipitates involves endoplasmic reticulum membranes in autophagosome biogenesis","volume":"7","author":"X Chen","year":"2012","journal-title":"PLoS One"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0306-4522(97)00230-3","article-title":"Mechanisms of calcium and sodium fluxes in anoxic myelinated central nervous system axons","volume":"82","author":"PK Stys","year":"1997","journal-title":"Neuroscience"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0060235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T12:33:24Z","timestamp":1644669204000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0060235"}},"subtitle":[],"editor":[{"given":"Hemachandra","family":"Reddy","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,26]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0060235","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,26]]}}}