{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:03:34Z","timestamp":1793361814508,"version":"4.5.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0060442","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T23:25:03Z","timestamp":1365031503000},"page":"e60442","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":338,"title":["Common and Distinct Clinical Features in Adult Patients with Anti-Aminoacyl-tRNA Synthetase Antibodies: Heterogeneity within the Syndrome"],"prefix":"10.1371","volume":"8","author":[{"given":"Yasuhito","family":"Hamaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenzo","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Komura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanari","family":"Kodera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Muroi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keita","family":"Fujikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Seishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Takehara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Kuwana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Targoff IN (2002) Laboratory testing in the diagnosis and management of idiopathic inflammatory myopathies. Rheum Dis Clin North Am. 28: 859\u2013890, viii.","DOI":"10.1016\/S0889-857X(02)00032-7"},{"key":"ref2","first-page":"134","article-title":"Dermatomyositis and polymyositis: Clinical presentation, autoantibodies, and pathogenesis. Ann N Y Acad Sci","volume":"1184","author":"AL Mammen","year":"2010"},{"key":"ref3","first-page":"391","article-title":"Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study. Arch Dermatol","volume":"147","author":"Y Hamaguchi","year":"2011"},{"key":"ref4","first-page":"360","article-title":"A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups. Medicine (Baltimore)","volume":"70","author":"LA Love","year":"1991"},{"key":"ref5","first-page":"868","article-title":"Strong association of dermatomyositis-specific Mi-2 autoantibodies with a tryptophan at position 9 of the HLA-DR beta chain. Arthritis Rheum","volume":"39","author":"R Mierau","year":"1996"},{"key":"ref6","first-page":"215","article-title":"Prevalence and clinical characteristics of anti-Mi-2 antibodies in Japanese patients with dermatomyositis. J Dermatol Sci","volume":"40","author":"K Komura","year":"2005"},{"key":"ref7","first-page":"25","article-title":"Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancy. Rheumatology (Oxford)","volume":"46","author":"K Kaji","year":"2007"},{"key":"ref8","first-page":"3682","article-title":"A novel autoantibody to a 155-kd protein is associated with dermatomyositis. Arthritis Rheum","volume":"54","author":"IN Targoff","year":"2006"},{"key":"ref9","first-page":"324","article-title":"Clinical associations of autoantibodies to a p155\/140 kDa doublet protein in juvenile dermatomyositis. Rheumatology (Oxford)","volume":"47","author":"H Gunawardena","year":"2008"},{"key":"ref10","first-page":"513","article-title":"Myositis-specific anti-155\/140 autoantibodies target transcription intermediary factor 1 family proteins. Arthritis Rheum","volume":"64","author":"M Fujimoto","year":"2012"},{"key":"ref11","first-page":"1571","article-title":"Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis. Arthritis Rheum","volume":"52","author":"S Sato","year":"2005"},{"key":"ref12","first-page":"2193","article-title":"RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease. Arthritis Rheum","volume":"60","author":"S Sato","year":"2009"},{"key":"ref13","first-page":"449","article-title":"Autoantibodies to small nuclear and cytoplasmic ribonucleoproteins in Japanese patients with inflammatory muscle disease. Arthritis Rheum","volume":"35","author":"M Hirakata","year":"1992"},{"key":"ref14","first-page":"604","article-title":"The precipitating antibody to an acidic nuclear protein antigen, the Jo-1, in connective tissue diseases. A marker for a subset of polymyositis with interstitial pulmonary fibrosis. Arthritis Rheum","volume":"26","author":"S Yoshida","year":"1983"},{"key":"ref15","first-page":"420","article-title":"Anti-threonyl-tRNA synthetase, a second myositis-related autoantibody. J Exp Med","volume":"160","author":"MB Mathews","year":"1984"},{"key":"ref16","first-page":"1281","article-title":"Autoantibodies against alanyl-tRNA synthetase and tRNAAla coexist and are associated with myositis. J Exp Med","volume":"163","author":"CC Bunn","year":"1986"},{"key":"ref17","first-page":"1737","article-title":"Autoantibodies to aminoacyl-transfer RNA synthetases for isoleucine and glycine. Two additional synthetases are antigenic in myositis. J Immunol","volume":"144","author":"IN Targoff","year":"1990"},{"key":"ref18","first-page":"2315","article-title":"Anti-KS: identification of autoantibodies to asparaginyl-transfer RNA synthetase associated with interstitial lung disease. J Immunol","volume":"162","author":"M Hirakata","year":"1999"},{"key":"ref19","first-page":"1005","article-title":"Anti-synthetase syndrome: a new autoantibody to phenylalanyl transfer RNA synthetase (anti-Zo) associated with polymyositis and interstitial pneumonia. Rheumatology (Oxford)","volume":"46","author":"Z Betteridge","year":"2007"},{"key":"ref20","first-page":"S312","article-title":"Identification of autoantibodies to tyrosyl-tRNA synthetase in dermatomyositis with features consistent with antisynthetase syndrome","volume":"52","author":"L Hashish","year":"2005","journal-title":"Arthritis Rheum"},{"key":"ref21","first-page":"455","article-title":"Autoantibodies in polymyositis. Rheum Dis Clin North Am","volume":"18","author":"IN Targoff","year":"1992"},{"key":"ref22","first-page":"210","article-title":"Hierarchical cluster and survival analyses of antisynthetase syndrome: Phenotype and outcome are correlated with anti-tRNA synthetase antibody specificity. Autoimmun Rev","volume":"12","author":"B Hervier","year":"2012"},{"key":"ref23","first-page":"1550","article-title":"Clinical profile of anti-PL-12 autoantibody. Cohort study and review of the literature. Chest","volume":"135","author":"M Kalluri","year":"2009"},{"key":"ref24","first-page":"609","article-title":"Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies. Clin Exp Rheumatol","volume":"23","author":"S Sato","year":"2005"},{"key":"ref25","first-page":"403","article-title":"Polymyositis and dermatomyositis (second of two parts). N Engl J Med","volume":"292","author":"A Bohan","year":"1975"},{"key":"ref26","first-page":"626","article-title":"Would a new name hasten the acceptance of amyopathic dermatomyositis (dermatomyositis sine myositis) as a distinctive subset within the idiopathic inflammatory dermatomyopathies spectrum of clinical illness? J Am Acad Dermatol","volume":"46","author":"RD Sontheimer","year":"2002"},{"key":"ref27","first-page":"1271","article-title":"The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum","volume":"25","author":"EM Tan","year":"1982"},{"key":"ref28","first-page":"581","article-title":"Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheum","volume":"23","year":"1980"},{"key":"ref29","first-page":"1174","article-title":"The role of MRI in the assessment of polymyositis and dermatomyositis. Rheumatology (Oxford)","volume":"46","author":"J Tomasova, Studynkova","year":"2007"},{"key":"ref30","first-page":"554","article-title":"Classification criteria for Sjogren&apos;s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis","volume":"61","author":"C Vitali","year":"2002"},{"key":"ref31","first-page":"487","article-title":"The clinical relevance of serum antinuclear antibodies in Japanese patients with systemic sclerosis. Br J Dermatol","volume":"158","author":"Y Hamaguchi","year":"2008"},{"key":"ref32","first-page":"1295","article-title":"Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase. Arthritis Rheum","volume":"56","author":"M Hirakata","year":"2007"},{"key":"ref33","first-page":"1399","article-title":"Antoantibody reactive with three classes of RNA polymerases in sera from patients with systemic sclerosis. J Clin Invest","volume":"91","author":"M Kuwana","year":"1993"},{"key":"ref34","first-page":"1627","article-title":"Autoantibody to centromere (kinetochore) in scleroderma sera. Proc Natl Acad Sci U S A","volume":"77","author":"Y Moroi","year":"1980"},{"key":"ref35","first-page":"125","article-title":"Myositis-specific and myositis-associated antibodies in overlap myositis in comparison to primary dermatopolymyositis: Relevance for clinical classification: retrospective study of 169 patients. Joint Bone Spine","volume":"77","author":"A Vancsa","year":"2010"},{"key":"ref36","first-page":"257","article-title":"Sequential changes of KL-6 in sera of patients with interstitial pneumonia associated with polymyositis\/dermatomyositis. Ann Rheum Dis","volume":"59","author":"S Bandoh","year":"2000"},{"key":"ref37","first-page":"1860","article-title":"Pulmonary surfactant protein D in sera and bronchoalveolar lavage fluids. Am J Respir Crit Care Med","volume":"152","author":"Y Honda","year":"1995"},{"key":"ref38","first-page":"1012","article-title":"Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis. J Rheumatol","volume":"34","author":"T Matsushita","year":"2007"},{"key":"ref39","first-page":"343","article-title":"Autoimmune myopathies: autoantibodies, phenotypes and pathogenesis. Nat Rev Neurol","volume":"7","author":"AL Mammen","year":"2011"},{"key":"ref40","first-page":"1464","article-title":"Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years? Chest","volume":"138","author":"GR Connors","year":"2010"},{"key":"ref41","first-page":"607","article-title":"Myositis-specific autoantibodies: their clinical and pathogenic significance in disease expression. Rheumatology (Oxford)","volume":"48","author":"H Gunawardena","year":"2009"},{"key":"ref42","first-page":"297","article-title":"Pathogenesis, classification and treatment of inflammatory myopathies. Nat Rev Rheumatol","volume":"7","author":"M Zong","year":"2011"},{"key":"ref43","first-page":"501","article-title":"Interstitial lung disease in polymyositis and dermatomyositis. Curr Opin Rheumatol","volume":"12","author":"M Hirakata","year":"2000"},{"key":"ref44","first-page":"233","article-title":"Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease complicated with idiopathic inflammatory myopathies. Autoimmunity","volume":"39","author":"H Yoshifuji","year":"2006"},{"key":"ref45","first-page":"175","article-title":"Antisynthetase syndrome. Curr Rheumatol Rep","volume":"13","author":"E Katzap","year":"2011"},{"key":"ref46","first-page":"523","article-title":"Autoantibodies in idiopathic inflammatory myopathy: an update on clinical and pathophysiological significance. Curr Opin Rheumatol","volume":"19","author":"T Mimori","year":"2007"},{"key":"ref47","first-page":"821","article-title":"Antibodies to glycyl-transfer RNA synthetase in patients with myositis and interstitial lung disease. Arthritis Rheum","volume":"35","author":"IN Targoff","year":"1992"},{"key":"ref48","first-page":"1238","article-title":"Detection of antisynthetase syndrome in patients with idiopathic interstitial pneumonias. Respir Med","volume":"105","author":"K Watanabe","year":"2011"},{"key":"ref49","first-page":"2004","article-title":"Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis\/dermatomyositis. Arthritis Rheum","volume":"54","author":"Y Yamasaki","year":"2006"},{"key":"ref50","first-page":"241","article-title":"Clinical manifestations in patients with antibody to PL-12 antigen (alanyl-tRNA synthetase). Am J Med","volume":"88","author":"IN Targoff","year":"1990"},{"key":"ref51","first-page":"842","article-title":"Clinical characteristics of Japanese patients with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibodies. Rheumatology (Oxford)","volume":"46","author":"S Sato","year":"2007"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0060442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T12:26:25Z","timestamp":1540211185000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0060442"}},"subtitle":[],"editor":[{"given":"Frederick","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,3]]},"references-count":51,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0060442","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,3]]}}}