{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:54:20Z","timestamp":1773017660073,"version":"3.50.1"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T00:00:00Z","timestamp":1364342400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0060476","type":"journal-article","created":{"date-parts":[[2013,3,27]],"date-time":"2013-03-27T21:14:13Z","timestamp":1364418853000},"page":"e60476","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Tyrosine Kinase Btk Regulates the Macrophage Response to Listeria monocytogenes Infection"],"prefix":"10.1371","volume":"8","author":[{"given":"Afitap Derya","family":"K\u00f6pr\u00fcl\u00fc","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate","family":"Kastner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Wienerroither","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Lassnig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Maria","family":"Putz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Majer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Reutterer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Sexl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Kuchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Decker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfried","family":"Ellmeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,3,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1600-065X.2008.00741.x","article-title":"Bruton&apos;s tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain","volume":"228","author":"AJ Mohamed","year":"2009","journal-title":"Immunol Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1615\/CritRevImmunol.v29.i4.30","article-title":"The role of Tec family kinases in mononuclear phagocytes","volume":"29","author":"AD Koprulu","year":"2009","journal-title":"Crit Rev Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ni.2234","article-title":"The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils","volume":"13","author":"F Honda","year":"2012","journal-title":"Nat Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"26258","DOI":"10.1074\/jbc.M301484200","article-title":"Bruton&apos;s tyrosine kinase is a Toll\/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4","volume":"278","author":"CA Jefferies","year":"2003","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.4049\/jimmunol.168.6.2914","article-title":"Macrophage effector functions controlled by Bruton&apos;s tyrosine kinase are more crucial than the cytokine balance of T cell responses for microfilarial clearance","volume":"168","author":"S Mukhopadhyay","year":"2002","journal-title":"J Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.4049\/jimmunol.163.4.1786","article-title":"Bruton&apos;s tyrosine kinase deficiency in macrophages inhibits nitric oxide generation leading to enhancement of IL-12 induction","volume":"163","author":"S Mukhopadhyay","year":"1999","journal-title":"J Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1182\/blood-2004-01-0207","article-title":"Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses","volume":"104","author":"A Mangla","year":"2004","journal-title":"Blood"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"23496","DOI":"10.1074\/jbc.C500053200","article-title":"Bruton&apos;s tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide","volume":"280","author":"SL Doyle","year":"2005","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"817","DOI":"10.4049\/jimmunol.1003631","article-title":"Bruton&apos;s tyrosine kinase is required for TLR-dependent heme oxygenase-1 gene activation via Nrf2 in macrophages","volume":"187","author":"V Vijayan","year":"2011","journal-title":"J Immunol"},{"key":"ref10","first-page":"181","article-title":"Defective Fc-, CR1- and CR3-mediated monocyte phagocytosis and chemotaxis in common variable immunodeficiency and X-linked agammaglobulinemia patients","volume":"13","author":"AL Amoras","year":"2003","journal-title":"J Investig Allergol Clin Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.4049\/jimmunol.176.6.3635","article-title":"Bruton&apos;s tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production","volume":"176","author":"NJ Horwood","year":"2006","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.jaci.2006.01.037","article-title":"Bruton&apos;s tyrosine kinase is not essential for LPS-induced activation of human monocytes","volume":"117","author":"R Perez de Diego","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s10875-012-9706-z","article-title":"Increased Pro-inflammatory Cytokine Production After Lipopolysaccharide Stimulation in Patients with X-linked Agammaglobulinemia","volume":"32","author":"ME Gonzalez-Serrano","year":"2012","journal-title":"J Clin Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jaci.2011.10.009","article-title":"Toll-like receptor 4-, 7-, and 8-activated myeloid cells from patients with X-linked agammaglobulinemia produce enhanced inflammatory cytokines","volume":"129","author":"TU Marron","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"10489","DOI":"10.1074\/jbc.M508892200","article-title":"MyD88 adapter-like (Mal) is phosphorylated by Bruton&apos;s tyrosine kinase during TLR2 and TLR4 signal transduction","volume":"281","author":"P Gray","year":"2006","journal-title":"J Biol Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1600-065X.2010.00993.x","article-title":"Cell biology and immunology of Listeria monocytogenes infections: novel insights","volume":"240","author":"F Stavru","year":"2011","journal-title":"Immunol Rev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.it.2012.04.007","article-title":"Early events regulating immunity and pathogenesis during Listeria monocytogenes infection","volume":"33","author":"MA Williams","year":"2012","journal-title":"Trends Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1371\/journal.ppat.0040006","article-title":"Distinct TLR- and NLR-mediated transcriptional responses to an intracellular pathogen","volume":"4","author":"JH Leber","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/B978-0-12-394590-7.00002-6","article-title":"Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity","volume":"113","author":"CE Witte","year":"2012","journal-title":"Adv Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"T Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1462-5822.2009.01294.x","article-title":"Listeria monocytogenes infection in the face of innate immunity","volume":"11","author":"SC Corr","year":"2009","journal-title":"Cell Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/ni.1876","article-title":"The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway","volume":"11","author":"P Yang","year":"2010","journal-title":"Nat Immunol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/1074-7613(95)90114-0","article-title":"Defective B cell development and function in Btk-deficient mice","volume":"3","author":"WN Khan","year":"1995","journal-title":"Immunity"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.4049\/jimmunol.134.4.2658","article-title":"In vitro natural cell-mediated cytotoxicity against Candida albicans: macrophage precursors as effector cells","volume":"134","author":"M Baccarini","year":"1985","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"16004","DOI":"10.1016\/S0021-9258(17)36358-5","article-title":"Purification of two forms of colony-stimulating factor from mouse L-cell-conditioned medium","volume":"260","author":"AW Burgess","year":"1985","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0092-8674(92)90188-I","article-title":"L. monocytogenes-induced actin assembly requires the actA gene product, a surface protein","volume":"68","author":"C Kocks","year":"1992","journal-title":"Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1111\/j.1462-5822.2007.01114.x","article-title":"Type I IFN are host modulators of strain-specific Listeria monocytogenes virulence","volume":"10","author":"B Reutterer","year":"2008","journal-title":"Cell Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7069","DOI":"10.4049\/jimmunol.0802410","article-title":"Identification of an IFN-gamma-producing neutrophil early in the response to Listeria monocytogenes","volume":"182","author":"J Yin","year":"2009","journal-title":"J Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.2741\/2364","article-title":"The role of the activated macrophage in clearing Listeria monocytogenes infection","volume":"12","author":"LM Shaughnessy","year":"2007","journal-title":"Front Biosci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.4049\/jimmunol.180.12.8048","article-title":"Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival","volume":"180","author":"M Melcher","year":"2008","journal-title":"J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1074-7613(00)80417-3","article-title":"Regulation of Btk function by a major autophosphorylation site within the SH3 domain","volume":"4","author":"H Park","year":"1996","journal-title":"Immunity"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1172\/JCI119782","article-title":"Inducible nitric oxide synthase: what difference does it make?","volume":"100","author":"C Nathan","year":"1997","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"288","DOI":"10.4049\/jimmunol.181.1.288","article-title":"Dual functions of Bruton&apos;s tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis","volume":"181","author":"J Jongstra-Bilen","year":"2008","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1128\/IAI.72.4.2131-2139.2004","article-title":"Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection","volume":"72","author":"D Torres","year":"2004","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"13766","DOI":"10.1073\/pnas.250476497","article-title":"The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors","volume":"97","author":"A Ozinsky","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1128\/IAI.59.9.2892-2900.1991","article-title":"Early gamma interferon production by natural killer cells is important in defense against murine listeriosis","volume":"59","author":"PL Dunn","year":"1991","journal-title":"Infect Immun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1073\/pnas.90.8.3725","article-title":"Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist","volume":"90","author":"CS Tripp","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1084\/jem.189.12.1981","article-title":"Interleukin 12-dependent interferon gamma production by CD8alpha+ lymphoid dendritic cells","volume":"189","author":"T Ohteki","year":"1999","journal-title":"J Exp Med"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Bao Y, Zheng J, Han C, Jin J, Han H, <etal>et al<\/etal>.. (2012) Tyrosine kinase Btk is required for NK cell activation. J Biol Chem.","DOI":"10.1074\/jbc.M112.372425"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5447","DOI":"10.4049\/jimmunol.171.10.5447","article-title":"Localized reactive oxygen and nitrogen intermediates inhibit escape of Listeria monocytogenes from vacuoles in activated macrophages","volume":"171","author":"JT Myers","year":"2003","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/eji.201040840","article-title":"IFN-alpha-producing PDCA-1+ Siglec-H- B cells mediate innate immune defense by activating NK cells","volume":"41","author":"Y Bao","year":"2011","journal-title":"Eur J Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0060476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T17:47:00Z","timestamp":1688147220000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0060476"}},"subtitle":[],"editor":[{"given":"Laurel L.","family":"Lenz","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,3,27]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0060476","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,27]]}}}