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Prevention of acute drug-related mortality in prison populations during the immediate post-release period. http:\/\/www.euro.who.int\/__data\/assets\/pdf_file\/0020\/114914\/E93993.pdf<\/ext-link> Accessed October 5, 2012."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1056\/NEJMsa064115","article-title":"Release from prison--a high risk of death for former inmates","volume":"356","author":"IA Binswanger","year":"2007","journal-title":"N Engl J Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1056\/NEJMp1102385","article-title":"Medicine and the epidemic of incarceration in the United States","volume":"364","author":"JD Rich","year":"2011","journal-title":"N Engl J Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1556-4029.2007.00597.x","article-title":"Oral abuse of fentanyl patches (Duragesic): seven case reports","volume":"53","author":"KL Woodall","year":"2008","journal-title":"J Forensic Sci"},{"key":"ref31","first-page":"CD006605","article-title":"Long-term opioid management for chronic noncancer pain","volume":"20","author":"M Noble","year":"2010","journal-title":"Cochrane Database Syst Rev"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0060600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T00:27:26Z","timestamp":1539995246000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0060600"}},"subtitle":[],"editor":[{"given":"Sam","family":"Eldabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,5]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0060600","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,5]]}}}