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World Health Organization classification of Tumours: Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press. pp. 81\u201397."},{"key":"ref15","unstructured":"Edge SB, Byrd DR, Carducci MA, Compton CC, Fritz AG, <etal>et al<\/etal>.. (2010) TNM classification of carcinomas of the nasopharynx. AJCC cancer staging handbook from the AJCC cancer staging manual. 7th ed ed. 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