{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:32:08Z","timestamp":1790659928586,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T00:00:00Z","timestamp":1365552000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0060965","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T20:44:23Z","timestamp":1365626663000},"page":"e60965","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["Fluid-Flow Induced Wall Shear Stress and Epithelial Ovarian Cancer Peritoneal Spreading"],"prefix":"10.1371","volume":"8","author":[{"given":"Liron","family":"Avraham-Chakim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Elad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Zaretsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoel","family":"Kloog","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Jaffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Grisaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1023\/A:1023791229361","article-title":"Intraperitoneal cancer dissemination: mechanisms of the patterns of spread","volume":"22","author":"CP Carmignani","year":"2003","journal-title":"Cancer Metastasis Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0014-4827(85)90197-1","article-title":"Interactions of human ovarian tumor cells with human mesothelial cells grown on extracellular matrix. An in vitro model system for studying tumor cell adhesion and invasion","volume":"160","author":"MJ Niedbala","year":"1985","journal-title":"Exp Cell Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1152\/physrev.1995.75.3.519","article-title":"Flow-mediated endothelial mechanotransduction","volume":"75","author":"PF Davies","year":"1995","journal-title":"Physiol Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2741\/1535","article-title":"Micromechanics of tumor cell adhesion and migration under dynamic flow conditions","volume":"10","author":"C Dong","year":"2005","journal-title":"Front Biosci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1023\/A:1006658414040","article-title":"Beta1-integrin-mediated dynamic adhesion of colon carcinoma cells to extracellular matrix under laminar flow","volume":"17","author":"J Haier","year":"1999","journal-title":"Clin Exp Metastasis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.gastro.2003.10.078","article-title":"Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling","volume":"126","author":"V Thamilselvan","year":"2004","journal-title":"Gastroenterology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jcb.20072","article-title":"Colon cancer cell adhesion in response to Src kinase activation and actin-cytoskeleton by non-laminar shear stress","volume":"92","author":"V Thamilselvan","year":"2004","journal-title":"J Cell Biochem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.4161\/cbt.5.9.3002","article-title":"Extracellular pressure stimulates tumor cell adhesion in vitro by paxillin activation","volume":"5","author":"J van Zyp","year":"2006","journal-title":"Cancer Biol Ther"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"C831","DOI":"10.1152\/ajpcell.00439.2004","article-title":"Distinct role of hydrodynamic shear in leukocyte-facilitated tumor cell extravasation","volume":"288","author":"MJ Slattery","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"C1320","DOI":"10.1152\/ajpcell.00159.2004","article-title":"Shear stress modulates the interaction of platelet-secreted matrix proteins with tumor cells through the integrin alphavbeta3","volume":"287","author":"K Lawler","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/j.1349-7006.2009.01160.x","article-title":"Shear stress induces internalization of E-cadherin and invasiveness in metastatic oesophageal cancer cells by a Src-dependent pathway","volume":"100","author":"K Lawler","year":"2009","journal-title":"Cancer Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"C668","DOI":"10.1152\/ajpcell.00626.2005","article-title":"Mobility and invasiveness of metastatic esophageal cancer are potentiated by shear stress in a ROCK- and Ras-dependent manner","volume":"291","author":"K Lawler","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jbiomech.2006.01.001","article-title":"Morphological analysis of tumor cell\/endothelial cell interactions under shear flow","volume":"40","author":"R Chotard-Ghodsnia","year":"2007","journal-title":"J Biomech"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1034\/j.1600-0463.2001.d01-118.x","article-title":"Tumor cell adhesion under hydrodynamic conditions of fluid flow","volume":"109","author":"J Haier","year":"2001","journal-title":"APMIS"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s12195-010-0118-y","article-title":"Air-liquid interface culture of nasal epithelial cells on denuded amniotic membranes","volume":"3","author":"N Even-Tzur","year":"2010","journal-title":"Cell Molec Bioeng"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"G907","DOI":"10.1152\/ajpgi.00062.2003","article-title":"Flow fields generated by peristaltic reflex in isolated guinea pig ileum: impact of contraction depth and shoulders","volume":"285","author":"B Jeffrey","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1529\/biophysj.107.127142","article-title":"Mucus secretion and cytoskeletal modifications in cultured nasal epithelial cells exposed to wall shear stresses","volume":"95","author":"N Even-Tzur","year":"2008","journal-title":"Biophys J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1148\/rg.241035078","article-title":"PET-CT in recurrent ovarian cancer: initial observations","volume":"24","author":"HK Pannu","year":"2004","journal-title":"Radiographics"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Chobanian N, Dietrich CS, 3rd (2008) Ovarian cancer. Surg Clin North Am 88: 285\u2013299, vi.","DOI":"10.1016\/j.suc.2007.12.002"},{"key":"ref20","first-page":"5379","article-title":"Characterization of a human ovarian carcinoma cell line (NIH:OVCAR-3) with androgen and estrogen receptors","volume":"43","author":"TC Hamilton","year":"1983","journal-title":"Cancer Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1114\/1.226","article-title":"Measurement of orientation and distribution of cellular alignment and cytoskeletal organization","volume":"27","author":"WJ Karlon","year":"1999","journal-title":"Ann Biomed Eng"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1242\/jcs.109.4.713","article-title":"Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress","volume":"4)","author":"AM Malek","year":"1996","journal-title":"J Cell Sci 109 (Pt"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1006\/excr.1995.1249","article-title":"Elongation of confluent endothelial cells in culture: the importance of fields of force in the associated alterations of their cytoskeletal structure","volume":"219","author":"O Thoumine","year":"1995","journal-title":"Exp Cell Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1115\/1.3138567","article-title":"The elongation and orientation of cultured endothelial cells in response to shear stress","volume":"107","author":"MJ Levesque","year":"1985","journal-title":"J Biomech Eng"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1016\/j.bpj.2011.04.040","article-title":"Mechanophysical stimulations of mucin secretion in cultures of nasal epithelial cells","volume":"100","author":"NE Davidovich","year":"2011","journal-title":"Biophys J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1055\/s-2007-1002771","article-title":"Hemodynamic effects on atherosclerosis and thrombosis","volume":"14","author":"SG Eskin","year":"1988","journal-title":"Semin Thromb Hemost"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1161\/01.RES.74.5.852","article-title":"Endothelial expression of thrombomodulin is reversibly regulated by fluid shear stress","volume":"74","author":"AM Malek","year":"1994","journal-title":"Circ Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.1116995","article-title":"Tissue cells feel and respond to the stiffness of their substrate","volume":"310","author":"DE Discher","year":"2005","journal-title":"Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1115\/1.3138276","article-title":"The dynamic response of vascular endothelial cells to fluid shear stress","volume":"103","author":"CF Dewey Jr","year":"1981","journal-title":"J Biomech Eng"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0026-2862(84)90031-1","article-title":"Response of cultured endothelial cells to steady flow","volume":"28","author":"SG Eskin","year":"1984","journal-title":"Microvasc Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/307648a0","article-title":"Induction of human vascular endothelial stress fibres by fluid shear stress","volume":"307","author":"RP Franke","year":"1984","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/BF02621134","article-title":"Mechanical effects on endothelial cell morphology: in vitro assessment","volume":"22","author":"CL Ives","year":"1986","journal-title":"In Vitro Cell Dev Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/01.ATV.7.3.276","article-title":"Micropipette aspiration of cultured bovine aortic endothelial cells exposed to shear stress","volume":"7","author":"M Sato","year":"1987","journal-title":"Arteriosclerosis"},{"key":"ref34","first-page":"639","article-title":"Fibronectin and F-actin redistribution in cultured endothelial cells exposed to shear stress","volume":"53","author":"AR Wechezak","year":"1985","journal-title":"Lab Invest"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.yexcr.2004.06.001","article-title":"Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion","volume":"299","author":"T Korb","year":"2004","journal-title":"Exp Cell Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/(SICI)1097-0169(1998)40:4<317::AID-CM1>3.0.CO;2-8","article-title":"Shear stress induces spatial reorganization of the endothelial cell cytoskeleton","volume":"40","author":"CG Galbraith","year":"1998","journal-title":"Cell Motil Cytoskeleton"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.0000216595.15868.55","article-title":"Shear stress regulates forward and reverse planar cell polarity of vascular endothelium in vivo and in vitro","volume":"98","author":"S McCue","year":"2006","journal-title":"Circ Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.7150\/ijbs.3.303","article-title":"The forces behind cell movement","volume":"3","author":"R Ananthakrishnan","year":"2007","journal-title":"Int J Biol Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/ncb0703-599","article-title":"Conserved microtubule-actin interactions in cell movement and morphogenesis","volume":"5","author":"OC Rodriguez","year":"2003","journal-title":"Nat Cell Biol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1349-7006.2005.00062.x","article-title":"Regulation of cancer cell motility through actin reorganization","volume":"96","author":"D Yamazaki","year":"2005","journal-title":"Cancer Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ki.1993.25","article-title":"Cytoskeletal agents inhibit motility and adherence of human tumor cells","volume":"43","author":"ML Stracke","year":"1993","journal-title":"Kidney Int"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bcp.2008.06.014","article-title":"Interference with actin dynamics is superior to disturbance of microtubule function in the inhibition of human ovarian cancer cell motility","volume":"76","author":"MN Bijman","year":"2008","journal-title":"Biochem Pharmacol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0060965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T14:33:45Z","timestamp":1644762825000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0060965"}},"subtitle":[],"editor":[{"given":"Gil","family":"Ast","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,10]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0060965","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,10]]}}}