{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:17:07Z","timestamp":1793197027488,"version":"4.5.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:00:00Z","timestamp":1365120000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0060984","type":"journal-article","created":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T17:15:56Z","timestamp":1365182156000},"page":"e60984","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":57,"title":["Mifepristone Reduces Insulin Resistance in Patient Volunteers with Adrenal Incidentalomas That Secrete Low Levels of Cortisol: A Pilot Study"],"prefix":"10.1371","volume":"8","clinical-trial-number":[{"clinical-trial-number":"nct00721201","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Miguel","family":"Debono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Chadarevian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Eastell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Newell-Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,4,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1210\/er.2002-0031","article-title":"The clinically inapparent adrenal mass: update in diagnosis and management","volume":"25","author":"G Mansmann","year":"2004","journal-title":"Endocr Rev"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1056\/NEJMcp065470","article-title":"Clinical practice. The incidentally discovered adrenal mass","volume":"356","author":"WF Young Jr","year":"2007","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1530\/EJE-10-1147","article-title":"AME position statement on adrenal incidentaloma","volume":"164","author":"M Terzolo","year":"2011","journal-title":"Eur J Endocrinol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0140-6736(06)68699-6","article-title":"Cushing's syndrome","volume":"367","author":"J Newell-Price","year":"2006","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"12952","DOI":"10.1016\/S0021-9258(18)31478-9","article-title":"Glucocorticoids regulate the induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes","volume":"268","author":"JE Friedman","year":"1993","journal-title":"J Biol Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1210\/me.2004-0497","article-title":"The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements","volume":"19","author":"BT Vander Kooi","year":"2005","journal-title":"Mol Endocrinol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"34841","DOI":"10.1074\/jbc.C000600200","article-title":"Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets","volume":"275","author":"B Davani","year":"2000","journal-title":"J Biol Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"E654","DOI":"10.1152\/ajpendo.00453.2006","article-title":"Glucocorticoids produce whole body insulin resistance with changes in cardiac metabolism","volume":"292","author":"D Qi","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1210\/jcem-57-3-529","article-title":"Insulin resistance in Cushing's syndrome","volume":"57","author":"R Nosadini","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1161\/01.ATV.20.2.538","article-title":"Insulin resistance syndrome predicts the risk of coronary heart disease and stroke in healthy middle-aged men: the 22-year follow-up results of the Helsinki Policemen Study","volume":"20","author":"M Pyorala","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1210\/jc.2001-011766","article-title":"Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk","volume":"87","author":"L Tauchmanova","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","article-title":"Mifepristone, a Glucocorticoid Receptor Antagonist, Produces Clinical and Metabolic Benefits in Patients with Cushing's Syndrome","author":"M Fleseriu","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1210\/jc.2010-2722","article-title":"Clinical review: Diagnosis and treatment of subclinical hypercortisolism","volume":"96","author":"I Chiodini","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2105\/AJPH.94.3.361","article-title":"Improving the reporting quality of nonrandomized evaluations of behavioral and public health interventions: the TREND statement","volume":"94","author":"DC Des Jarlais","year":"2004","journal-title":"Am J Public Health"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0022-5347(25)00290-3","article-title":"Pharmacokinetic properties of the antiglucocorticoid and antiprogesterone steroid RU 486 in man","volume":"241","author":"S Kawai","year":"1987","journal-title":"J Pharmacol Exp Ther"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2165\/00003088-199733010-00002","article-title":"Clinical pharmacokinetics of mifepristone","volume":"33","author":"O Heikinheimo","year":"1997","journal-title":"Clin Pharmacokinet"},{"key":"ref17","first-page":"647","article-title":"The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states","volume":"19","author":"J Newell-Price","year":"1998","journal-title":"Endocr Rev"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1210\/jc.2008-0125","article-title":"The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline","volume":"93","author":"LK Nieman","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1016\/j.diabres.2011.08.025","article-title":"Reproducibility of multiple repeated oral glucose tolerance tests","volume":"94","author":"BA Gordon","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"DR Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"M Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1016\/j.jchromb.2009.09.014","article-title":"Simultaneous measurement of cortisol and cortisone in human saliva using liquid chromatography-tandem mass spectrometry: application in basal and stimulated conditions","volume":"877","author":"I Perogamvros","year":"2009","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.1152\/ajpendo.00645.2007","article-title":"Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage","volume":"294","author":"R Muniyappa","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1046\/j.1365-2265.1998.00509.x","article-title":"Elevated post-dexamethasone suppression cortisol concentrations correlate with hormonal alterations of the hypothalamo-pituitary adrenal axis in patients with adrenal incidentalomas","volume":"49","author":"S Tsagarakis","year":"1998","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/EJE-11-1039","article-title":"Progressively increased patterns of subclinical cortisol hypersecretion in adrenal incidentalomas differently predict major metabolic and cardiovascular outcomes: a large cross-sectional study","volume":"166","author":"G Di Dalmazi","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1210\/jc.2009-2387","article-title":"Beneficial metabolic effects of prompt surgical treatment in patients with an adrenal incidentaloma causing biochemical hypercortisolism","volume":"95","author":"I Chiodini","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1210\/jc.2010-0633","article-title":"Is subclinical Cushing's syndrome an entity or a statistical fallout from diagnostic testing? Consensus surrounding the diagnosis is required before optimal treatment can be defined","volume":"95","author":"PM Stewart","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1046\/j.1365-2265.2001.01274.x","article-title":"The improvement of insulin resistance in patients with adrenal incidentaloma by surgical resection","volume":"54","author":"S Midorikawa","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref29","first-page":"1440","article-title":"Subclinical Cushing's syndrome in patients with adrenal incidentaloma: clinical and biochemical features","volume":"85","author":"R Rossi","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1210\/jcem.87.3.8277","article-title":"Adrenal incidentaloma: a new cause of the metabolic syndrome?","volume":"87","author":"M Terzolo","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/SLA.0b013e31819a47d2","article-title":"Surgical versus conservative management for subclinical Cushing syndrome in adrenal incidentalomas: a prospective randomized study","volume":"249","author":"A Toniato","year":"2009","journal-title":"Ann Surg"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2265.2010.03794.x","article-title":"Subclinical hypercortisolism: correlation between biochemical diagnostic criteria and clinical aspects","volume":"73","author":"V Morelli","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1210\/jc.2008-0139","article-title":"Accuracy of diagnostic tests for Cushing's syndrome: a systematic review and metaanalyses","volume":"93","author":"MB Elamin","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1007\/BF03346701","article-title":"Pros and cons of dexamethasone suppression test for screening of subclinical Cushing's syndrome in patients with adrenal incidentalomas","volume":"34","author":"G Reimondo","year":"2011","journal-title":"J Endocrinol Invest"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1001\/archinte.1993.00410050018004","article-title":"Recent evidence on drug therapy of mild to moderate hypertension and decreased risk of coronary heart disease","volume":"153","author":"PR Hebert","year":"1993","journal-title":"Arch Intern Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1161\/01.STR.0000116869.64771.5A","article-title":"Blood pressure and stroke: an overview of published reviews","volume":"35","author":"CM Lawes","year":"2004","journal-title":"Stroke"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0039-128X(94)00033-9","article-title":"Mechanisms of cortisol-induced hypertension in humans","volume":"60","author":"JA Whitworth","year":"1995","journal-title":"Steroids"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0024-3205(00)00787-6","article-title":"Involvement of tyrosine hydroxylase up regulation in dexamethasone-induced hypertension of rats","volume":"67","author":"T Kumai","year":"2000","journal-title":"Life Sci"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1210\/jc.2011-2813","article-title":"Impact of mifepristone, a glucocorticoid\/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function","volume":"97","author":"ST Page","year":"2012","journal-title":"J Clin Endocrinol Metab"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0060984","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T23:23:57Z","timestamp":1745969037000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0060984"}},"subtitle":[],"editor":[{"given":"Harpal Singh","family":"Randeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,5]]},"references-count":39,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0060984","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718006705.793477118","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,5]]}}}