{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:51:53Z","timestamp":1792479113319,"version":"4.5.0"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T00:00:00Z","timestamp":1366156800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    The effects of pyrroloquinoline quinine (PQQ) on RANKL-induced osteoclast differentiation and on wear particle-induced osteolysis were examined in this study. PQQ inhibited RANKL-mediated osteoclast differentiation in bone marrow macrophages (BMMs) in a dose-dependent manner without any evidence of cytotoxicity. The mRNA expression of c-Fos, NFATc1, and TRAP in RANKL-treated BMMs was inhibited by PQQ treatment. Moreover, RANKL-induced c-Fos and NFATc1 protein expression was suppressed by PQQ. PQQ additionally inhibited the bone resorptive activity of differentiated osteoclasts. Further a UHMWPE-induced murine calvaria erosion model study was performed to assess the effects of PQQ on wear particle-induced osteolysis\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Mice treated with PQQ demonstrated marked attenuation of bone erosion based on Micro-CT and histologic analysis of calvaria. These results collectively suggested that PQQ demonstrated inhibitory effects on osteoclast differentiation\n                    <jats:italic>in vitro<\/jats:italic>\n                    and may suppress wear particle-induced osteolysis\n                    <jats:italic>in vivo<\/jats:italic>\n                    , indicating that PQQ may therefore serve as a useful drug in the prevention of bone loss.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0061013","type":"journal-article","created":{"date-parts":[[2013,4,17]],"date-time":"2013-04-17T16:47:53Z","timestamp":1366217273000},"page":"e61013","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["RETRACTED: Pyrroloquinoline Quinine Inhibits RANKL-Mediated Expression of NFATc1 in Part via Suppression of c-Fos in Mouse Bone Marrow Cells and Inhibits Wear Particle-Induced Osteolysis in Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Lingbo","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongfei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanli","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,4,17]]},"reference":[{"key":"pone.0061013-Wei1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.prp.2008.07.002","article-title":"Mechanisms modulating inflammatory osteolysis: A review with insights into therapeutic targets","volume":"10","author":"S Wei","year":"2008","journal-title":"Pathology Research and Practice"},{"key":"pone.0061013-Harris1","first-page":"46","article-title":"The problem is osteolysis.Clin Orthop Relat Res","volume":"311","author":"WH Harris","year":"1995"},{"key":"pone.0061013-Goldring1","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/art.1780290704","article-title":"Formation of a synovial-like membrane at the bone\u2013cement interface. 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