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European Commission website. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/ec.europa.eu\/food\/food\/biosafety\/tse_bse\/docs\/annual_report_tse2010_en.pdf\" xlink:type=\"simple\">http:\/\/ec.europa.eu\/food\/food\/biosafety\/tse_bse\/docs\/annual_report_tse2010_en.pdf<\/ext-link>. Accessed 2013 Mar 11."},{"key":"ref5","unstructured":"Commission Regulation (EC) No 36\/2005 of 12 January 2005 amending Annexes III and X to Regulation (EC) No 999\/2001 of the European Parliament and of the Council as regards epidemio-surveillance for transmissible spongiform encephalopathies in bovine, ovine and caprine animals. Text with EEA relevance."},{"key":"ref6","unstructured":"Animal Health and Veterinary Laboratory Agency website. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.defra.gov.uk\/ahvla-en\/files\/pub-tse-oie-rl-handbook.pdf\" xlink:type=\"simple\">http:\/\/www.defra.gov.uk\/ahvla-en\/files\/pub-tse-oie-rl-handbook.pdf<\/ext-link>. Accessed 2013 Mar 11."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jcpa.2004.06.004","article-title":"Immunohistochemical distinction between preclinical bovine spongiform encephalopathy and scrapie infection in sheep","volume":"132","author":"CM Thuring","year":"2005","journal-title":"J Comp Pathol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jcpa.2009.12.003","article-title":"Characterization of strains of ovine transmissible spongiform encephalopathy with a short PrPd profiling method","volume":"142","author":"S Sis\u00f3","year":"2010","journal-title":"J Comp Pathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1051\/vetres:2007061","article-title":"TSE pathogenesis in cattle and sheep","volume":"39","author":"VK Lucien","year":"2008","journal-title":"Vet Res"},{"key":"ref10","unstructured":"Eurostat website. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/appsso.eurostat.ec.europa.eu\/nui\/show.do?dataset=ef_ls_gzgoat&lang=en#\" xlink:type=\"simple\">http:\/\/appsso.eurostat.ec.europa.eu\/nui\/show.do?dataset=ef_ls_gzgoat&amp;lang=en#<\/ext-link>. Accessed 2012 Mar 6."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1017\/S0950268804002110","article-title":"A scrapie epidemic in Cyprus","volume":"132","author":"MB Gravenor","year":"2004","journal-title":"Epidemiol Infect"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1099\/0022-1317-77-11-2885","article-title":"Novel polymorphisms in the caprine PrP gene: a codon 142 mutation associated with scrapie incubation period","volume":"77","author":"W Goldmann","year":"1996","journal-title":"J Gen Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tvjl.2009.10.015","article-title":"PrP gene polymorphisms in Cyprus goats and their association with resistance or susceptibility to natural scrapie","volume":"187","author":"P Papasavva-Stylianou","year":"2011","journal-title":"Vet 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Virol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1172\/JCI104619","article-title":"Humoral stimulation of adrenal cortical secretion","volume":"41","author":"JR Blair-West","year":"1962","journal-title":"J Clin Invest"},{"key":"ref41","article-title":"Neuroinvasion in prion diseases: the roles of ascending neural infection and blood dissemination","author":"S Siso","year":"2010","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.1106460","article-title":"Chronic lymphocytic inflammation specifies the organ tropism of prions","volume":"307","author":"M Heikenwalder","year":"2005","journal-title":"Science"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1439-0264.2011.01088.x","article-title":"Distribution of the lingual lymphoid tissue in domestic ruminants","volume":"40","author":"S Breugelmans","year":"2011","journal-title":"Anat Histol Embryol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1099\/vir.0.022574-0","article-title":"Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe","volume":"91","author":"L Gonz\u00e1lez","year":"2010","journal-title":"J Gen Virol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/104063870501700601","article-title":"Diagnosis of transmissible spongiform encephalopathies in animals: a review","volume":"17","author":"D Gavier-Widen","year":"2005","journal-title":"J Vet Diagn Invest"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1006\/jmbi.1999.2831","article-title":"Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein","volume":"289","author":"F Wopfner","year":"1999","journal-title":"J Mol Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/vr.155.6.177","article-title":"Genetic variability of the PrP gene in a goat herd in the UK","volume":"155","author":"W Goldmann","year":"2004","journal-title":"Vet Rec"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/01652176.1997.9694751","article-title":"Prion protein and scrapie susceptibility","volume":"19","author":"MA Smits","year":"1997","journal-title":"Vet Q"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1212\/WNL.47.5.1305","article-title":"Mutation of the prion protein gene at codon 208 in familial Creutzfeldt-Jakob disease","volume":"47","author":"JA Mastrianni","year":"1996","journal-title":"Neurology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0169-328X(95)00034-P","article-title":"New variant prion protein in a Japanese family with Gerstmann-Str\u00e4ussler 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