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Xiao","year":"2012","journal-title":"Neuroscience"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/00034983.1983.11811707","article-title":"The effect of congenital and adult-acquired <italic>Toxoplasma<\/italic> infections on the motor performance of mice","volume":"77","author":"J Hay","year":"1983","journal-title":"Ann Trop Med Parasitol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/BF00928348","article-title":"The influence of <italic>Toxoplasma<\/italic> infection on the spontaneous running activity of mice","volume":"71","author":"J Hay","year":"1985","journal-title":"Z Parasitenkd"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1017\/S0031182007002673","article-title":"Poorer results of mice with latent toxoplasmosis in learning tests: impaired learning processes or the novelty discrimination mechanism?","volume":"134","author":"H 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Hrd\u00e1","year":"2000","journal-title":"J Parasitol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.14411\/fp.2010.019","article-title":"<italic>Toxoplasma gondii<\/italic> strain-dependent effects on mouse behaviour","volume":"57","author":"G Kannan","year":"2010","journal-title":"Folia Parasitol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/BF00926588","article-title":"<italic>Toxoplasma<\/italic> infection and response to novelty in mice","volume":"70","author":"J Hay","year":"1984","journal-title":"Z Parasitenkd"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1098\/rspb.2000.1182","article-title":"Fatal attraction in rats infected with <italic>Toxoplasma gondii<\/italic>","volume":"267","author":"M Berdoy","year":"2000","journal-title":"Proc R Soc Biol Sci Ser B"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1073\/pnas.0608310104","article-title":"Behavioral changes induced by <italic>Toxoplasma<\/italic> infection of rodents are highly specific to aversion of cat odors","volume":"104","author":"A Vyas","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","article-title":"Predator cat odors activate sexual arousal pathways in brains of <italic>Toxoplasma gondii<\/italic> infected rats","author":"PK House","year":"2011","journal-title":"PLoS ONE 6"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.exppara.2011.03.014","article-title":"Direct evidence of <italic>Toxoplasma<\/italic>-induced changes in serum testosterone in mice","volume":"128","author":"\u0160 Ka\u0148kov\u00e1","year":"2011","journal-title":"Exp Parasitol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e4801","DOI":"10.1371\/journal.pone.0004801","article-title":"A unique dual activity amino acid hydroxylase in <italic>Toxoplasma gondii<\/italic>","volume":"4","author":"EA 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attractiveness increased for <italic>Toxoplasma<\/italic>-infected men while decreased for infected women","volume":"5","author":"J Flegr","year":"2011","journal-title":"PLoS Neglect Trop Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.14411\/fp.2010.010","article-title":"Influence of latent toxoplasmosis on the phenotype of intermediate hosts","volume":"57","author":"J Flegr","year":"2010","journal-title":"Folia Parasitol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1017\/S003118200800485X","article-title":"<italic>Toxoplasma<\/italic> and reaction time: Role of toxoplasmosis in the origin, preservation and geographical distribution of Rh blood group polymorphism","volume":"135","author":"M Novotn\u00e1","year":"2008","journal-title":"Parasitology"},{"key":"ref28","first-page":"475","article-title":"Neurophysiological effect of the Rh factor. 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Faculty of Philosophy: Charles University."},{"key":"ref34","first-page":"521","article-title":"Internal consistency of the Czech version of the NEO Personality Inventory (NEO-PI-R)","volume":"46","author":"M H\u0159eb\u00ed\u010dkov\u00e1","year":"2002","journal-title":"Cesk Psychol"},{"key":"ref35","unstructured":"Formann AK, Piswanger K (1979) Wiener Matrizen-Test. Weinheim: Beltz."},{"key":"ref36","unstructured":"Rasch G (1960) Probabilistic models for some intelligence and attainment tests. Chicago, IL: MESA Press."},{"key":"ref37","unstructured":"Raven JC (1947) Advanced progressive matrices. London: Lewis."},{"key":"ref38","unstructured":"Raven JC (1958) Advanced progressive matrices (2nd ed.). London: Lewis."},{"key":"ref39","unstructured":"Raven JC (1958) Standard progressive matrices. London: Lewis."},{"key":"ref40","unstructured":"Klose J, \u010cernochov\u00e1 D, Kr\u00e1l P (2002) Vienna Matrix Test (V\u00edde\u0148sk\u00fd maticov\u00fd test). Prague: Testcentrum."},{"key":"ref41","unstructured":"Otis AS (1954) Otis Quick-Scoring Mental Ability Test, New Edition. Tarrytown-on-Hudson, NY: Word Book Co."},{"key":"ref42","unstructured":"Siegel S, Castellan NJ (1988) Nonparametric statistics for the behavioral sciences. New York: McGraw-Hill. xxiii, 399 p."},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S1286-4579(01)01459-9","article-title":"Rats, cats, people and parasites: the impact of latent toxoplasmosis on behaviour","volume":"3","author":"JP Webster","year":"2001","journal-title":"Microb Infect"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/schbul\/sbl074","article-title":"Effects of <italic>Toxoplasma<\/italic> on human behavior","volume":"33","author":"J Flegr","year":"2007","journal-title":"Schizophr Bull"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/per.838","article-title":"Higher extraversion and lower conscientiousness in humans infected with <italic>Toxoplasma<\/italic>","volume":"26","author":"J Lindov\u00e1","year":"2012","journal-title":"Eur J Person"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1098\/rspb.2006.3641","article-title":"Can the common brain parasite, <italic>Toxoplasma gondii<\/italic>, influence human culture?","volume":"273","author":"KD Lafferty","year":"2006","journal-title":"Proc R Soc Biol Sci Ser B"},{"key":"ref47","article-title":"Rhesus factor modulation of effects of smoking and age on psychomotor performance, intelligence, personality profile, and health in Czech soldiers","author":"J Flegr","year":"2012","journal-title":"PLoS ONE 7"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1017\/S0031182000066269","article-title":"Induction of changes in human behaviour by the parasitic protozoan <italic>Toxoplasma gondii<\/italic>","volume":"113","author":"J Flegr","year":"1996","journal-title":"Parasitology"},{"key":"ref49","first-page":"22","article-title":"Changes in the personality profile of young women with latent toxoplasmosis","volume":"46","author":"J Flegr","year":"1999","journal-title":"Folia Parasitol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/hmg\/6.6.843","article-title":"Evolution of the human RH (rhesus) blood group genes: A 50 year old prediction (partially) fulfilled","volume":"6","author":"B Carritt","year":"1997","journal-title":"Hum Mol Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.tracli.2006.02.011","article-title":"Molecular genetics of RH and its clinical application","volume":"13","author":"WA Flegel","year":"2006","journal-title":"Transfus Clin Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.tracli.2006.03.003","article-title":"Physiological role of the putative ammonium transporter RhCG in the mouse","volume":"13","author":"S Biver","year":"2006","journal-title":"Transfus Clin Biol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.tracli.2006.03.001","article-title":"Biological gas channels for NH<sub>3<\/sub> and CO<sub>2<\/sub>: evidence that Rh (rhesus) proteins are CO<sub>2<\/sub> channels","volume":"13","author":"S Kustu","year":"2006","journal-title":"Transfus Clin Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"9638","DOI":"10.1073\/pnas.1003587107","article-title":"Function of human Rh based on structure of RhCG at 2.1 A","volume":"107","author":"F Gruswitz","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.1182\/blood.V95.12.3662","article-title":"RHD gene deletion occurred in the Rhesus box","volume":"95","author":"FF Wagner","year":"2000","journal-title":"Blood"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/01.mjt.0000140648.30948.bd","article-title":"Possible pathomechanisms of sudden infant death syndrome: key role of chronic hypoxia, infection\/inflammation states, cytokine irregularities, and metabolic trauma in genetically predisposed infants","volume":"11","author":"J Prandota","year":"2004","journal-title":"Am J Ther"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/00207450903458647","article-title":"Migraine associated with patent foramen ovale may be caused by reactivation of cerebral toxoplasmosis triggered by arterial blood oxygen desaturation","volume":"120","author":"J Prandota","year":"2010","journal-title":"Int J Neurosci"},{"key":"ref58","unstructured":"Prandota J (2012) Rhesus-associated glycoprotein (RhAG) phenotype of the red blood cells modulates <italic>T. gondii<\/italic> infection-associated psychomotor performance reaction times and changes in the human personality profile. Impaired function of the CO<sub>2<\/sub>, AQP1, and AQP4 gas channels may cause hypoxia and thus enhance neuroinflammation in autistic individuals. In: Gemma C, editor. Neuroinflammation: Pathogenesis, Mechanisms and Management. New York: Nova Publishers."},{"key":"ref59","doi-asserted-by":"crossref","first-page":"136","DOI":"10.14411\/fp.2010.017","article-title":"Pattern of money allocation in experimental games supports the stress hypothesis of gender differences in <italic>Toxoplasma gondii<\/italic>-induced behavioural changes","volume":"57","author":"J Lindov\u00e1","year":"2010","journal-title":"Folia Parasitol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1471-2334-5-54","article-title":"Probable neuroimmunological link between <italic>Toxoplasma<\/italic> and cytomegalovirus infections and personality changes in the human host","volume":"5","author":"M Novotn\u00e1","year":"2005","journal-title":"BMC Infect Dis"},{"key":"ref61","first-page":"369","article-title":"Blood groups and personality traits","volume":"17","author":"AS Wiener","year":"1965","journal-title":"Am J Hum Genet"},{"key":"ref62","first-page":"485","article-title":"Blood-groups and personality traits","volume":"24","author":"RB Cattell","year":"1972","journal-title":"Am J Hum Genet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/S0191-8869(02)00101-0","article-title":"Blood type and personality","volume":"34","author":"M Rogers","year":"2003","journal-title":"Pers Individ Diff"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.paid.2004.06.004","article-title":"Blood type and the five factors of personality in Asia","volume":"38","author":"KH Wu","year":"2005","journal-title":"Pers Individ Diff"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0061272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T06:33:21Z","timestamp":1595658801000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0061272"}},"subtitle":[],"editor":[{"given":"Martin E.","family":"Rottenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,10]]},"references-count":64,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0061272","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,10]]}}}