{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:43:03Z","timestamp":1792248183354,"version":"4.4.0"},"reference-count":80,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T00:00:00Z","timestamp":1366588800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0061516","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T03:06:50Z","timestamp":1366686410000},"page":"e61516","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":103,"title":["Investigation of the Effect of Type 2 Diabetes Mellitus on Subgingival Plaque Microbiota by High-Throughput 16S rDNA Pyrosequencing"],"prefix":"10.1371","volume":"8","author":[{"given":"Mi","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruichen","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Munro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunfeng","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/0022034510385236","article-title":"Inflammation and uncoupling as mechanisms of periodontal bone loss","volume":"90","author":"DT Graves","year":"2011","journal-title":"J Dent Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"BL Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1600-0757.2005.00107.x","article-title":"Periodontal microbial ecology","volume":"38","author":"SS Socransky","year":"2005","journal-title":"Periodontol 2000"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/ismej.2011.191","article-title":"Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing","volume":"6","author":"AL Griffen","year":"2012","journal-title":"ISME J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e37919","DOI":"10.1371\/journal.pone.0037919","article-title":"Deep sequencing of the oral microbiome reveals signatures of periodontal disease","volume":"7","author":"B Liu","year":"2012","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1902\/annals.2001.6.1.99","article-title":"Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective","volume":"6","author":"GW Taylor","year":"2001","journal-title":"Ann Periodontol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"836","DOI":"10.2337\/diacare.13.8.836","article-title":"Periodontal disease and NIDDM in Pima Indians","volume":"13","author":"RG Nelson","year":"1990","journal-title":"Diabetes Care"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"532","DOI":"10.14219\/jada.archive.1990.0211","article-title":"Type 2 diabetes mellitus and periodontal disease","volume":"121","author":"M Shlossman","year":"1990","journal-title":"J Am Dent Assoc"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2337\/diacare.16.1.329","article-title":"Periodontal disease. The sixth complication of diabetes mellitus","volume":"16","author":"H Loe","year":"1993","journal-title":"Diabetes Care"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2174\/157339911797579205","article-title":"Diabetes and periodontal diseases: interplay and links","volume":"7","author":"F Lakschevitz","year":"2011","journal-title":"Curr Diabetes Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1601-0825.2008.01442.x","article-title":"Periodontal disease: associations with diabetes, glycemic control and complications","volume":"14","author":"GW Taylor","year":"2008","journal-title":"Oral Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1902\/jop.2006.050459","article-title":"Diabetes mellitus and periodontal diseases","volume":"77","author":"BL Mealey","year":"2006","journal-title":"J Periodontol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1902\/jop.1996.67.10s.1085","article-title":"Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus","volume":"67","author":"GW Taylor","year":"1996","journal-title":"J Periodontol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nrendo.2011.106","article-title":"Diabetes mellitus and periodontitis: a tale of two common interrelated diseases","volume":"7","author":"E Lalla","year":"2011","journal-title":"Nat Rev Endocrinol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1600-051X.1997.tb01178.x","article-title":"Monocytic TNF alpha secretion patterns in IDDM patients with periodontal diseases","volume":"24","author":"GE Salvi","year":"1997","journal-title":"J Clin Periodontol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1902\/jop.1997.68.2.127","article-title":"Inflammatory mediator response as a potential risk marker for periodontal diseases in insulin-dependent diabetes mellitus patients","volume":"68","author":"GE Salvi","year":"1997","journal-title":"J Periodontol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1189\/jlb.1004583","article-title":"Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis","volume":"78","author":"M Karima","year":"2005","journal-title":"J Leukoc Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-0765.2007.01060.x","article-title":"Oxidative stress causes alveolar bone loss in metabolic syndrome model mice with type 2 diabetes","volume":"44","author":"T Ohnishi","year":"2009","journal-title":"J Periodontal Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1034\/j.1600-0757.2000.2230104.x","article-title":"Hyperglycemia, glycoxidation and receptor for advanced glycation endproducts: potential mechanisms underlying diabetic complications, including diabetes-associated periodontitis","volume":"23","author":"E Lalla","year":"2000","journal-title":"Periodontol 2000"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000080650","article-title":"Pathogenic role of inflammatory cytokines in obesity: from insulin resistance to diabetes mellitus","volume":"9","author":"A Marette","year":"2004","journal-title":"Nestle Nutr Workshop Ser Clin Perform Programme"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1196\/annals.1372.039","article-title":"Inflammatory process in type 2 diabetes: The role of cytokines","volume":"1084","author":"K Alexandraki","year":"2006","journal-title":"Ann N Y Acad Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00011-010-0248-7","article-title":"Gingival crevicular fluid IL-6, tPA, PAI-2, albumin levels following initial periodontal treatment in chronic periodontitis patients with or without type 2 diabetes","volume":"60","author":"L Kardesler","year":"2011","journal-title":"Inflamm Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1902\/jop.2008.080246","article-title":"The role of inflammatory cytokines in diabetes and its complications","volume":"79","author":"GL King","year":"2008","journal-title":"J Periodontol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00125-011-2342-y","article-title":"Periodontitis and diabetes: a two-way relationship","volume":"55","author":"PM Preshaw","year":"2012","journal-title":"Diabetologia"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1600-0765.1975.tb00022.x","article-title":"A comparison of the glucose and protein content of gingival fluid from diabetics and nondiabetics","volume":"10","author":"AJ Ficara","year":"1975","journal-title":"J Periodontal Res"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v2i0.5818","article-title":"Diabetes, periodontitis, and the subgingival microbiota","volume":"2","author":"EJ Ohlrich","year":"2010","journal-title":"J Oral Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1902\/jop.1983.54.7.420","article-title":"The periodontal microflora of juvenile diabetics. Culture, immunofluorescence, and serum antibody studies","volume":"54","author":"PA Mashimo","year":"1983","journal-title":"J Periodontol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1600-051X.1995.tb00176.x","article-title":"Some suspected periodontopathogens and serum antibody response in adult long-duration insulin-dependent diabetics","volume":"22","author":"H Thorstensson","year":"1995","journal-title":"J Clin Periodontol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1902\/jop.1998.69.2.120","article-title":"Periodontal status and subgingival microbiota of insulin-dependent juvenile diabetics: a 3-year longitudinal study","volume":"69","author":"L Sbordone","year":"1998","journal-title":"J Periodontol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1399-302X.2007.00341.x","article-title":"The microbiological profiles of saliva, supragingival and subgingival plaque and dental caries in adults with and without type 2 diabetes mellitus","volume":"22","author":"J Hintao","year":"2007","journal-title":"Oral Microbiol Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1111\/j.1600-051X.2006.00996.x","article-title":"Periodontal infection profiles in type 1 diabetes","volume":"33","author":"E Lalla","year":"2006","journal-title":"J Clin Periodontol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1902\/jop.2008.070455","article-title":"Microbiologic and immunologic characteristics of periodontal disease in Hispanic americans with type 2 diabetes","volume":"79","author":"JL Ebersole","year":"2008","journal-title":"J Periodontol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1034\/j.1600-0765.2001.90613.x","article-title":"Detection of putative periodontal pathogens in non-insulin-dependent diabetes mellitus and non-diabetes mellitus by polymerase chain reaction","volume":"36","author":"K Yuan","year":"2001","journal-title":"J Periodontal Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.archoralbio.2011.03.017","article-title":"Periodontal conditions and prevalence of putative periodontopathogens and Candida spp. in insulin-dependent type 2 diabetic and non-diabetic patients with chronic periodontitis\u2013a pilot study","volume":"56","author":"JC Sardi","year":"2011","journal-title":"Arch Oral Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1600-0765.2011.01455.x","article-title":"Investigation and quantification of key periodontal pathogens in patients with type 2 diabetes","volume":"47","author":"CA Field","year":"2012","journal-title":"J Periodontal Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature03959","article-title":"Genome sequencing in microfabricated high-density picolitre reactors","volume":"437","author":"M Margulies","year":"2005","journal-title":"Nature"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","year":"2012","journal-title":"Nature"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1186\/1471-2164-11-523","article-title":"Study of inter- and intra-individual variations in the salivary microbiota","volume":"11","author":"V Lazarevic","year":"2010","journal-title":"BMC Genomics"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e19709","DOI":"10.1371\/journal.pone.0019709","article-title":"The microbial communities in male first catch urine are highly similar to those in paired urethral swab specimens","volume":"6","author":"Q Dong","year":"2011","journal-title":"PLoS One"},{"key":"ref40","article-title":"Diversity of bacteria at healthy human conjunctiva","author":"Q Dong","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1128\/JCM.05852-11","article-title":"Evidence of uncultivated bacteria in the adult female bladder","volume":"50","author":"AJ Wolfe","year":"2012","journal-title":"J Clin Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"e22788","DOI":"10.1371\/journal.pone.0022788","article-title":"Oral microbiome profiles: 16S rRNA pyrosequencing and microarray assay comparison","volume":"6","author":"J Ahn","year":"2011","journal-title":"PLoS One"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3945\/jn.112.158766","article-title":"454 pyrosequencing reveals a shift in fecal microbiota of healthy adult men consuming polydextrose or soluble corn fiber","volume":"142","author":"S Hooda","year":"2012","journal-title":"J Nutr"},{"key":"ref44","article-title":"Subgingival biodiversity in subjects with uncontrolled type-2 diabetes and chronic periodontitis","author":"RC Casarin","year":"2012","journal-title":"J Periodontal Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1034\/j.1399-302X.1999.140510.x","article-title":"Sampling of periodontal pathogens by paper points: evaluation of basic parameters","volume":"14","author":"B Hartroth","year":"1999","journal-title":"Oral Microbiol Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1399-302X.1986.tb00310.x","article-title":"Sampling of microorganisms associated with periodontal disease","volume":"1","author":"AC Tanner","year":"1986","journal-title":"Oral Microbiol Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/JB.183.12.3770-3783.2001","article-title":"Bacterial diversity in human subgingival plaque","volume":"183","author":"BJ Paster","year":"2001","journal-title":"J Bacteriol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e20956","DOI":"10.1371\/journal.pone.0020956","article-title":"Target region selection is a critical determinant of community fingerprints generated by 16S pyrosequencing","volume":"6","author":"PS Kumar","year":"2011","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"D870","DOI":"10.1093\/nar\/gkp1078","article-title":"Archiving next generation sequencing data","volume":"38","author":"M Shumway","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1128\/AEM.01541-09","article-title":"Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities","volume":"75","author":"PD Schloss","year":"2009","journal-title":"Appl Environ Microbiol"},{"key":"ref51","article-title":"The arthropod, but not the vertebrate host or its environment, dictates bacterial community composition of fleas and ticks","author":"H Hawlena","year":"2012","journal-title":"ISME J"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1099\/00207713-44-4-846","article-title":"A place for DNA-DNA reassociation and 16S rRNA sequence analysis in the present species definition in bacteriology","volume":"44","author":"E Stackebrandt","year":"1994","journal-title":"Int J Syst Bacteriol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nmeth.1361","article-title":"Accurate determination of microbial diversity from 454 pyrosequencing data","volume":"6","author":"C Quince","year":"2009","journal-title":"Nat Methods"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1462-2920.2009.02051.x","article-title":"Wrinkles in the rare biosphere: pyrosequencing errors can lead to artificial inflation of diversity estimates","volume":"12","author":"V Kunin","year":"2010","journal-title":"Environ Microbiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1186\/1471-2164-13-S8-S17","article-title":"Species-level classification of the vaginal microbiome","volume":"13 Suppl 8","author":"JM Fettweis","year":"2012","journal-title":"BMC Genomics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Q Wang","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"W5","DOI":"10.1093\/nar\/gkn201","article-title":"NCBI BLAST: a better web interface","volume":"36","author":"M Johnson","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"C Quast","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"baq013","DOI":"10.1093\/database\/baq013","article-title":"The Human Oral Microbiome Database: a web accessible resource for investigating oral microbe taxonomic and genomic information","volume":"2010","author":"T Chen","year":"2010","journal-title":"Database (Oxford)"},{"key":"ref60","first-page":"235","article-title":"Phyloseq: a bioconductor package for handling and analysis of high-throughput phylogenetic sequence data","author":"PJ McMurdie","year":"2012","journal-title":"Pac Symp Biocomput"},{"key":"ref61","unstructured":"Oksanen J, Kindt R, Legendre P, O&apos;Hara RB, Simpson GL, <etal>et al<\/etal>.. (2012) vegan: Community Ecology Package. R package version 20-5."},{"key":"ref62","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/ismej.2010.133","article-title":"UniFrac: an effective distance metric for microbial community comparison","volume":"5","author":"C Lozupone","year":"2011","journal-title":"ISME J"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1177\/154405910308200503","article-title":"New bacterial species associated with chronic periodontitis","volume":"82","author":"PS Kumar","year":"2003","journal-title":"J Dent Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1128\/JCM.43.8.3944-3955.2005","article-title":"Identification of candidate periodontal pathogens and beneficial species by quantitative 16S clonal analysis","volume":"43","author":"PS Kumar","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1399-302X.1996.tb00180.x","article-title":"Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions","volume":"11","author":"A Ashimoto","year":"1996","journal-title":"Oral Microbiol Immunol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"SS Socransky","year":"1998","journal-title":"J Clin Periodontol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-0757.2005.00113.x","article-title":"Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia: the \u201cred complex\u201d, a prototype polybacterial pathogenic consortium in periodontitis","volume":"38","author":"SC Holt","year":"2005","journal-title":"Periodontol 2000"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1128\/JCM.36.5.1399-1403.1998","article-title":"Molecular epidemiology of oral treponemes associated with periodontal disease","volume":"36","author":"A Moter","year":"1998","journal-title":"J Clin Microbiol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1902\/jop.2009.090185","article-title":"Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray","volume":"80","author":"AP Colombo","year":"2009","journal-title":"J Periodontol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1902\/jop.2012.110566","article-title":"Impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray","volume":"83","author":"AP Colombo","year":"2012","journal-title":"J Periodontol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1177\/0022034512456039","article-title":"Microbiological characterization in children with aggressive periodontitis","volume":"91","author":"LM Shaddox","year":"2012","journal-title":"J Dent Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2989","DOI":"10.1007\/s10096-012-1651-5","article-title":"Pattern of distribution of Prevotella species\/phylotypes associated with healthy gingiva and periodontal disease","volume":"31","author":"MA Nadkarni","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1600-0765.1985.tb00830.x","article-title":"Distribution of capnocytophaga in periodontal microfloras","volume":"20","author":"LV Holdeman","year":"1985","journal-title":"J Periodontal Res"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF00408042","article-title":"Capnocytophaga: new genus of gram-negative gliding bacteria. III. Physiological characterization","volume":"122","author":"SS Socransky","year":"1979","journal-title":"Arch Microbiol"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1902\/jop.2005.76.3.418","article-title":"Diabetes and periodontal disease: a case-control study","volume":"76","author":"G Campus","year":"2005","journal-title":"J Periodontol"},{"key":"ref76","article-title":"The Sociodemographic Characteristics, Periodontal Health Status, and Subgingival Microbiota of Chronic Periodontitis Patients With Type 2 Diabetes Mellitus: A Case Control Study in a Chinese Population","author":"C Li","year":"2012","journal-title":"J Periodontol"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/j.1600-051X.2004.00597.x","article-title":"Subgingival microbiota of chronic periodontitis subjects from different geographic locations","volume":"31","author":"AD Haffajee","year":"2004","journal-title":"J Clin Periodontol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.archoralbio.2008.10.005","article-title":"Differences in subgingival microflora of Korean and German periodontal patients","volume":"54","author":"TS Kim","year":"2009","journal-title":"Arch Oral Biol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/10454411960070020601","article-title":"Human oral microbial ecology and dental caries and periodontal diseases","volume":"7","author":"WF Liljemark","year":"1996","journal-title":"Crit Rev Oral Biol Med"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1600-0757.2006.00174.x","article-title":"The breadth of bacterial diversity in the human periodontal pocket and other oral sites","volume":"42","author":"BJ Paster","year":"2006","journal-title":"Periodontol 2000"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0061516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T19:17:57Z","timestamp":1595704677000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0061516"}},"subtitle":[],"editor":[{"given":"Michael","family":"Tunney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,22]]},"references-count":80,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0061516","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,22]]}}}