{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T12:44:57Z","timestamp":1781268297807,"version":"3.54.1"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:00:00Z","timestamp":1366934400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0061657","type":"journal-article","created":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T21:06:24Z","timestamp":1367010384000},"page":"e61657","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["On the Respiratory Mechanics Measured by Forced Oscillation Technique in Patients with Systemic Sclerosis"],"prefix":"10.1371","volume":"8","author":[{"given":"Ingrid Almeida","family":"Miranda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro Camilo","family":"Dias Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnaldo Jos\u00e9","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manoel","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Lopes de Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,4,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev-pathol-011110-130312","article-title":"The pathogenesis of systemic sclerosis","volume":"6","author":"TR Katsumoto","year":"2011","journal-title":"Annual Review of Pathology: Mechanisms of Disease"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00408-007-9012-3","article-title":"Interstitial lung disease in systemic sclerosis","volume":"185(4)","author":"P Ostojic","year":"2007","journal-title":"Lung"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1378\/chest.105.2.489","article-title":"Interrelations between pulmonary and extrapulmonary involvement in systemic sclerosis: A longitudinal analysis","volume":"105(2)","author":"DP Tashkin","year":"1994","journal-title":"Chest"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.jbspin.2008.07.003","article-title":"Systemic sclerosis: an update in 2008","volume":"75(6)","author":"Y Allanore","year":"2008","journal-title":"Joint Bone Spine"},{"key":"ref5","first-page":"81","article-title":"Relationship between cutaneous and pulmonary involvement in systemic sclerosis","volume":"24(1)","author":"S Morelli","year":"1997","journal-title":"J Rheumatol"},{"key":"ref6","first-page":"434","article-title":"Mechanisms of scleroderma-induced lung disease. Proc Am Thorac Soc","volume":"4(5)","author":"RM Du Bois","year":"2007"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1002\/art.22099","article-title":"Scleroderma lung: initial forced vital capacity as predictor of pulmonary function decline","volume":"55(4)","author":"SC Plastiras","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0272-5231(05)70112-X","article-title":"Manifestations of scleroderma pulmonary disease","volume":"19(4)","author":"OA Minai","year":"1998","journal-title":"Clin Chest Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1002\/art.1780370903","article-title":"Severe restrictive lung disease in systemic sclerosis","volume":"37(9)","author":"VD Steen","year":"1994","journal-title":"Arthritis Rheum"},{"key":"ref10","first-page":"2","article-title":"Mortality in systemic sclerosis: an international meta-analysis of individual patient data","volume":"Med118(1)","author":"JP Ioannidis","year":"2005","journal-title":"Am J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/art.1780280706","article-title":"Pulmonary involvement in systemic sclerosis (scleroderma)","volume":"28(7)","author":"VD Steen","year":"1985","journal-title":"Arthritis Rheum"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0002-9343(87)90501-8","article-title":"Longitudinal changes in lung function and respiratory symptoms in progressive systemic sclerosis: Prospective study","volume":"83(1)","author":"GI Greenwald","year":"1987","journal-title":"Am J Med"},{"key":"ref13","first-page":"1248","article-title":"Interstitial lung disease in systemic sclerosis: a simple staging system","volume":"Med177(11)","author":"NSL Goh","year":"2008","journal-title":"Am J Respir Crit Care"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1136\/ard.62.2.97","article-title":"Predictors of end stage lung disease in systemic sclerosis","volume":"62(2)","author":"V Steen","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1148\/radiology.188.2.8327704","article-title":"Pulmonary involvement in progressive systemic sclerosis: sequential evaluation with CT, pulmonary function tests and bronchoalveolar lavage","volume":"188(2)","author":"M Remy-Jardin","year":"1993","journal-title":"Radiology"},{"key":"ref16","first-page":"97","article-title":"Static lung mechanics in patients of progressive systemic sclerosis without obvious pulmonary involvement","volume":"43(2)","author":"D Gupta","year":"2001","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/art.22532","article-title":"Pulmonary involvement in systemic sclerosis: associations with genetic, serologic, sociodemographic and behavioral factors","volume":"57(2)","author":"TA McNearney","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1378\/chest.114.6.1623","article-title":"Relationship between abnormalities on high-resolution CT and pulmonary function in systemic sclerosis","volume":"114(6)","author":"E Diot","year":"1998","journal-title":"Chest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1164\/ajrccm\/144.3_Pt_1.706","article-title":"Structural features of interstitial lung disease in systemic sclerosis","volume":"1)","author":"NK Harrison","year":"1991","journal-title":"Am Rev Respir Dis 144(3 Pt"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1183\/09031936.03.00089403","article-title":"The forced oscillation technique in clinical practice: methodology, recommendations and future developments","volume":"22","author":"E Oostveen","year":"2003","journal-title":"Eur Respir J"},{"key":"ref21","volume":"1","unstructured":"Bates JHT, Irvin CG, Farr\u00e9 R, Hantos Z (2011) Oscillation Mechanics of the Respiratory System. Compr Physiol, vol. <volume>1<\/volume> : pp. 1233-1272, ISSN: 9780470650714 0470650710."},{"key":"ref22","volume":"39","unstructured":"Kaczka DW, Dellac\u00e1 RL (2011). Oscillation Mechanics of the Respiratory System: Applications to Lung Disease. <italic>Critical Reviews<\/italic>\u2122 <italic>in Biomedical Engineering<\/italic>, Vol. <volume>39<\/volume> , No. 4, pp. 337\u2013359, ISSN: 0278\u2013940X."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.rmed.2005.07.005","article-title":"Changes in respiratory mechanics with increasing degree of airway obstruction in COPD: detection by forced oscillation technique","volume":"100(3)","author":"AMTG Di Mango","year":"2006","journal-title":"Resp Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/j.rmed.2006.03.009","article-title":"Detection of changes in respiratory mechanics due to increasing degrees of airway obstruction in asthma by forced oscillation technique","volume":"100(12)","author":"JV Cavalcanti","year":"2006","journal-title":"Resp Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000213756","article-title":"Assessment of respiratory mechanics in patients with sarcoidosis using forced oscillation: correlations with spirometric and volumetric measurements and diagnostic accuracy","volume":"78(1)","author":"AC Faria","year":"2009","journal-title":"Respiration"},{"key":"ref26","volume":"8","unstructured":"Faria ACD, Lopes AL, Jansen JM, Lopes PL (2009). Evaluating the Forced Oscillation Technique in the Detection of Early Smoking-induced Respiratory Changes. <italic>BioMed Eng Online<\/italic>, Vol. <volume>8<\/volume> , pp. 22."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1183\/09031936.04.00046804","article-title":"Detection of expiratory flow limitation in COPD using the forced oscillation technique","volume":"23","author":"RL Dellac\u00e0","year":"2004","journal-title":"Eur Respir J"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1183\/09031936.00038006","article-title":"Expiratory flow limitation detected by forced oscillation and negative expiratory pressure","volume":"29","author":"RL Dellac\u00e0","year":"2007","journal-title":"Eur Respir J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1183\/09031936.00139608","article-title":"Effect of bronchodilation on expiratory flow limitation and resting lung mechanics in COPD","volume":"33(6)","author":"RL Dellac\u00e0","year":"2009","journal-title":"Eur Respir J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1590\/S1807-59322009000700008","article-title":"Within-breath analysis of respiratory mechanics in asthmatic patients by forced oscillation","volume":"64(7)","author":"J Veiga","year":"2009","journal-title":"Clinics"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1590\/S1807-59322011001200014","article-title":"Total inspiratory and expiratory impedance in patients with severe chronic obstructive pulmonary disease","volume":"66(12)","author":"KK Silva","year":"2011","journal-title":"Clinics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1378\/chest.112.4.1017","article-title":"Expiratory flow limitation during spontaneous breathing: comparison of patients with restrictive and obstructive respiratory disorders","volume":"112(4)","author":"A Baydur","year":"1997","journal-title":"Chest"},{"key":"ref33","first-page":"80","article-title":"Respiratory mechanics in chest wall disease: implications for expiratory flow-limitation during resting breathing","volume":"48","author":"J Milic-Emili","year":"1993","journal-title":"Monaldi Arch Chest Dis"},{"key":"ref34","volume":"38","unstructured":"Sociedade Brasileira de Pneumologia e Tisiologia - SBPT (2009) Diretrizes para Testes de Fun\u00e7\u00e3o Pulmonar. J Pneumol <volume>38<\/volume> Suppl 3."},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","article-title":"Standardization of spirometry","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"ref36","unstructured":"Hyatt RE, Scandon PD, Nakamura M (1997) Interpretation of pulmonary function tests. Philadelphia, Lippincott Raven 76\u201378."},{"key":"ref37","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/art.1780230510","article-title":"Preliminary criteria for the classification of systemic sclerosis (scleroderma)","volume":"23","author":"AT Masi","year":"1980","journal-title":"Arthritis Rheum"},{"key":"ref38","first-page":"725","article-title":"Changes in the normal maximal expiratory flow-volume curve with growth and aging","volume":"127(6)","author":"RJ Knudson","year":"1983","journal-title":"Am Rev Respir Dis"},{"key":"ref39","unstructured":"Sociedade Brasileira de Pneumologia e Tisiologia \u2013 SBPT (1996) I Consenso Brasileiro sobre Espirometria. J Pneumol 22(3)."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/BF02345140","article-title":"Respiratory input impedance measurement: forced oscillation methods","volume":"39","author":"D MacLeod","year":"2001","journal-title":"Med Biol Eng Comput"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Lorino AM, Zerah F, Marinette A, Harf A, Lorino H (1997). Respiratory resistive impedance in obstructive patients: linear regression analysis vs viscoelastic modeling. Eur Respir J10, 150\u2013155.","DOI":"10.1183\/09031936.97.10010150"},{"key":"ref42","first-page":"140","article-title":"Evaluation of a modified head generator for respiratory impedance measurements","volume":"1(3)","author":"R Peslin","year":"1991","journal-title":"Eur Respir Rev"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/thx.47.4.317","article-title":"Forced oscillation technique for measuring mechanical properties of the respiratory system","volume":"47","author":"NB Pride","year":"1992","journal-title":"Thorax"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1183\/09031936.93.03101186","article-title":"Respiratory input and transfer mechanical impedances in patients with chronic obstructive pulmonary disease","volume":"3","author":"Y Ying","year":"1990","journal-title":"Eur Respir J"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1152\/jappl.1980.49.3.408","article-title":"Mechanical properties of lungs and chest wall during spontaneous breathing","volume":"49(3)","author":"J Nagels","year":"1980","journal-title":"J Appl Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1053\/rmed.2001.1062","article-title":"Diagostic value of respiratory impedance measurements in elderly subjects","volume":"95(5)","author":"JP Janssens","year":"2001","journal-title":"Respir Med"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1378\/chest.108.1.41","article-title":"Forced oscillation technique vs spirometry to assess bronchodilatation in patients with asthma and COPD","volume":"108(1)","author":"F Zerah","year":"1995","journal-title":"Chest"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1183\/09031936.96.09010132","article-title":"Total respiratory impedance measured by means of the forced oscillation technique in subjects with and without respiratory complaints","volume":"9","author":"HG Pasker","year":"1996","journal-title":"Eur Respir J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0034-5687(00)00171-7","article-title":"Diurnal variations of respiratory system resistance and compliance derived from input impedance in asthmatic children","volume":"23(1)","author":"W Tomalak","year":"2000","journal-title":"Respir Physiol"},{"key":"ref50","first-page":"178","article-title":"Infuence of amplitude, phase and frequency content of pseudorandom pressure input on impedance data and their variability","volume":"1","author":"M Rotger","year":"1991","journal-title":"Eur Respir Rev"},{"key":"ref51","volume":"3","unstructured":"Peslin R, Fredberg JJ (1986) Oscillation mechanics of the respiratory system. In: Fishman PA, Macklem PT, Mead J. eds. Handbook of Physiology. The Respiratory System, Vol. <volume>3<\/volume> . Mechanics of Breathing. Part 1, 145\u2013177. Baltimore, William &amp; Wilkins."},{"key":"ref52","first-page":"10","article-title":"Valores de refer\u00eancia para espirometria em uma amostra da popula\u00e7\u00e3o brasileira adulta","volume":"18(1)","author":"CAC Pereira","year":"1992","journal-title":"J Pneumol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1164\/ajrccm\/144.5.1202","article-title":"Lung function testing: selection of reference values and interpretative strategies","volume":"144","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1109\/MEMB.2007.289121","article-title":"Modeling human respiratory impedance: comparing the best method with the least estimation errors","volume":"26(1)","author":"B Diong","year":"2007","journal-title":"IEEE Eng Med Biol Mag"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1088\/0967-3334\/34\/1\/67","article-title":"The feasibility of home monitoring of impedance with the forced oscillation technique in chronic obstructive pulmonary disease subjects","volume":"34","author":"SC Timmins","year":"2013","journal-title":"Physiol Meas"},{"key":"ref56","unstructured":"Dawson B, Trapp RG (2001) Basic &amp; Clinical Biostatistics. Collumbus, The Mcgraw-Hill Companies, 3<sup>rd<\/sup> ed. ISBN:0-8385-0510-4. Philadelphia, Lippincott Raven."},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1126\/science.3287615","article-title":"Measuring the accuracy of diagnostic systems","volume":"240","author":"JA Swets","year":"1988","journal-title":"Science"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1378\/chest.81.5.586","article-title":"Normal values of total respiratory resistance and reactance determined by forced oscillations","volume":"81","author":"FJ L\u00e0nds\u00e9r","year":"1982","journal-title":"Chest"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0007-0971(70)80003-1","article-title":"Lungs in progressive systemic sclerosis","volume":"64","author":"JS Guleria","year":"1970","journal-title":"Br J Dis Chest"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1378\/chest.84.5.546","article-title":"Pulmonary function in progressive systemic sclerosis \u2013 comparison of crest syndrome variant with diffuse scleroderma","volume":"84(5)","author":"GR Owens","year":"1983","journal-title":"Chest"},{"key":"ref61","first-page":"1","article-title":"Lung function in progressive systemic sclerosis is dominated by poorly compliant lungs and stiff airways","volume":"66(1)","author":"B Blom-B\u00fclow","year":"1985","journal-title":"Eur J Respir Dis"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Lamblin C, Bergoin C, Saelens T, Wallaert B (2001) Interstitial lung diseases in collagen vascular diseases. Eur Respir J 18: Suppl 32: S 69\u201380.","DOI":"10.1183\/09031936.01.18s320069"},{"key":"ref63","first-page":"875","article-title":"Small airways dysfunction in systemic sclerosis - a controlled study","author":"C Kostopoulos","year":"1992","journal-title":"Chest102(3)"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/art.1780200506","article-title":"Pulmonary function in scleroderma","volume":"20(5)","author":"M Guttadauria","year":"1977","journal-title":"Arthritis Rheum"},{"key":"ref65","first-page":"258","article-title":"Interstitial lung disease in systemic sclerosis: an HRCT-clinical correlative study","volume":"44(3)","author":"GC Oor","year":"2003","journal-title":"Acta radiol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1164\/rccm.2106012","article-title":"Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome","volume":"Med165","author":"D Bouros","year":"2002","journal-title":"Am J Respir Crit Care"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1183\/09031936.93.02090846","article-title":"Total respiratory resistance and reactance in patients with diffuse interstitial lung disease","volume":"2(9)","author":"JA Van Noord","year":"1989","journal-title":"Eur Respir J"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1183\/09031936.93.04080945","article-title":"Total respiratory resistance and reactance in ankylosing spondylitis and kyphoscoliosis","volume":"4(8)","author":"JA Van Noord","year":"1991","journal-title":"Eur Respir J"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1159\/000079642","article-title":"Value of spirometry in detecting volume restriction in interstitial lung disease patients","volume":"71(4)","author":"PW Boros","year":"2004","journal-title":"Respiration"},{"key":"ref70","unstructured":"Levitzky MG (2003) Pulmonary Physiology. Columbus, The Mcgraw-Hill Companies, 6<sup>th<\/sup> ed. ISBN: 0-07-138765-X."},{"key":"ref71","volume":"22 (7)","unstructured":"Golpe R, Jimen\u00e9z A, Carpizo R, Cifrian JM (1999) Utility of home oximetry as a screening test for patients with moderate and severe symptoms of obstructive sleep apnea. Sleep <volume>22 (7)<\/volume> : 932\u2013937, ISSN: 1550\u20139109."},{"key":"ref72","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1109\/TBME.1986.325866","article-title":"Statistical measures of parameter estimates from models fi t to respiratory impedance data: Emphasis on joint variabilities","volume":"33","author":"KR Lutchen","year":"1986","journal-title":"IEEE Trans Biomed Eng"},{"key":"ref73","first-page":"403","article-title":"Reliability of parameter estimates from models applied to respiratory impedance data","volume":"62","author":"KR Lutchen","year":"1987","journal-title":"J Appl Phys"},{"key":"ref74","unstructured":"Faria ACD, Silva KKD, Costa GM, Lopes AJ, Melo PL (2012) Forced oscillation technique in the detection of smoking-induced respiratory changes. Biomedical engineering: technical applications in medicine 291\u2013322. InTech Europe, ISBN 978-953-51-0733-0."},{"key":"ref75","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1152\/jappl.1956.8.6.587","article-title":"Oscillation mechanics of lungs and chest in man","volume":"8","author":"AB Dubois","year":"1956","journal-title":"J Appl Physiol"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1440-1843.2011.02013.x","article-title":"Cutting edge technologies in respiratory research: lung function testing","volume":"16(6)","author":"GG King","year":"2011","journal-title":"Respirology"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0061657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T06:43:50Z","timestamp":1745995430000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0061657"}},"subtitle":[],"editor":[{"given":"Daniel J.","family":"Tschumperlin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,26]]},"references-count":76,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0061657","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,26]]}}}