{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:10:44Z","timestamp":1790745044167,"version":"4.1.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0061799","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T20:59:20Z","timestamp":1366145960000},"page":"e61799","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Macrophage Depletion Impairs Corneal Wound Healing after Autologous Transplantation in Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Suxia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingli","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyun","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1046\/j.1524-475X.1996.40404.x","article-title":"Interactions of cytokines, growth factors, and proteases in acute and chronic wounds","volume":"4","author":"BA Mast","year":"1996","journal-title":"Wound Repair Regen"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1468-3083.2011.04415.x","article-title":"Cytokines, chemokines and growth factors in wound healing","volume":"26","author":"B Behm","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"S Barrientos","year":"2008","journal-title":"Wound Repair Regen"},{"key":"ref4","unstructured":"KR FA (2005) Wound healing: Taylor & Francis Group."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1373\/49.1.32","article-title":"Angiogenesis assays: a critical overview","volume":"49","author":"R Auerbach","year":"2003","journal-title":"Clin Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.2353\/ajpath.2007.070172","article-title":"Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis","volume":"171","author":"S Nakao","year":"2007","journal-title":"Am J Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1167\/iovs.09-3860","article-title":"Human corneal fibrosis: an in vitro model","volume":"51","author":"D Karamichos","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/j.biocel.2006.03.010","article-title":"The keratocyte: corneal stromal cell with variable repair phenotypes","volume":"38","author":"JA West-Mays","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2174\/157339912800840479","article-title":"Corneal changes in diabetes mellitus","volume":"8","author":"G Bikbova","year":"2012","journal-title":"Curr Diabetes Rev"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1097\/ICO.0b013e3181930bcd","article-title":"Opposite roles of CCR2 and CX3CR1 macrophages in alkali-induced corneal neovascularization","volume":"28","author":"P Lu","year":"2009","journal-title":"Cornea"},{"key":"ref11","first-page":"2239","article-title":"Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in rats","volume":"41","author":"TP Slegers","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1076\/ceyr.26.2.73.14510","article-title":"Effect of local macrophage depletion on cellular immunity and tolerance evoked by corneal allografts","volume":"26","author":"TP Slegers","year":"2003","journal-title":"Curr Eye Res"},{"key":"ref13","first-page":"3505","article-title":"Prevention of corneal allograft rejection in rats treated with subconjunctival injections of liposomes containing dichloromethylene diphosphonate","volume":"35","author":"G Van der Veen","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1167\/iovs.07-1237","article-title":"Potential role of macrophages in experimental keratomycosis","volume":"50","author":"J Hu","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1053\/j.gastro.2009.12.041","article-title":"In vitro-derived alternatively activated macrophages reduce colonic inflammation in mice","volume":"138","author":"MM Hunter","year":"2010","journal-title":"Gastroenterology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/archopht.125.6.783","article-title":"Very late antigen 1 blockade markedly promotes survival of corneal allografts","volume":"125","author":"L Chen","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"6737","DOI":"10.4049\/jimmunol.1100101","article-title":"IL-17A-dependent CD4+CD25+ regulatory T cells promote immune privilege of corneal allografts","volume":"186","author":"K Cunnusamy","year":"2011","journal-title":"J Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1084\/jem.20010838","article-title":"Draining lymph nodes of corneal transplant hosts exhibit evidence for donor major histocompatibility complex (MHC) class II-positive dendritic cells derived from MHC class II-negative grafts","volume":"195","author":"Y Liu","year":"2002","journal-title":"J Exp Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1172\/JCI20465","article-title":"VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment","volume":"113","author":"C Cursiefen","year":"2004","journal-title":"J Clin Invest"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1172\/JCI42540","article-title":"Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4\/80+CD11b(high)Gr1(low) macrophages","volume":"121","author":"G Schiechl","year":"2011","journal-title":"J Clin Invest"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1189\/jlb.0711351","article-title":"Peritoneal macrophage from male and female SJL mice differ in IL-10 expression and macrophage maturation","volume":"91","author":"S Hussain","year":"2012","journal-title":"J Leukoc Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"G723","DOI":"10.1152\/ajpgi.00414.2010","article-title":"Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages","volume":"300","author":"L Barron","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.biocel.2010.10.013","article-title":"TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P","volume":"43","author":"LA Murray","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.imbio.2011.01.001","article-title":"Macrophages in skin injury and repair","volume":"216","author":"B Mahdavian Delavary","year":"2011","journal-title":"Immunobiology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.4049\/jimmunol.0903356","article-title":"Differential roles of macrophages in diverse phases of skin repair","volume":"184","author":"T Lucas","year":"2010","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/00042728-200506000-00011","article-title":"Normal cutaneous wound healing: clinical correlation with cellular and molecular events","volume":"31","author":"CL Baum","year":"2005","journal-title":"Dermatol Surg"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e8852","DOI":"10.1371\/journal.pone.0008852","article-title":"Macrophage plasticity in experimental atherosclerosis","volume":"5","author":"J Khallou-Laschet","year":"2010","journal-title":"PLoS One"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2249.2005.02934.x","article-title":"Macrophage activation switching: an asset for the resolution of inflammation","volume":"142","author":"F Porcheray","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1017\/S1462399411001943","article-title":"Inflammation and wound healing: the role of the macrophage","volume":"13","author":"TJ Koh","year":"2011","journal-title":"Expert Rev Mol Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"L198","DOI":"10.1152\/ajplung.90472.2008","article-title":"Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits with Pseudomonas aeruginosa pneumonia","volume":"296","author":"K Kurahashi","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/TP.0b013e318160f0d1","article-title":"Infiltrated macrophages contribute to recovery after ischemic injury but not to ischemic preconditioning in kidneys","volume":"85","author":"HS Jang","year":"2008","journal-title":"Transplantation"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1152\/japplphysiol.00995.2006","article-title":"Alveolar macrophage depletion is associated with increased surfactant pool sizes in adult rats","volume":"103","author":"A Forbes","year":"2007","journal-title":"J Appl Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1097\/01.TP.0000129410.89410.F2","article-title":"Macrophages play a role in the early phase of corneal allograft rejection in rats","volume":"77","author":"TP Slegers","year":"2004","journal-title":"Transplantation"},{"key":"ref34","first-page":"1271","article-title":"The role of macrophages in Acanthamoeba keratitis","volume":"37","author":"F van Klink","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0022-1759(94)90012-4","article-title":"Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications","volume":"174","author":"N Van Rooijen","year":"1994","journal-title":"J Immunol Methods"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2567.2008.02868.x","article-title":"Turnover of bone marrow-derived cells in the irradiated mouse cornea","volume":"125","author":"HR Chinnery","year":"2008","journal-title":"Immunology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1167\/iovs.06-0783","article-title":"LYVE-1-positive macrophages are present in normal murine eyes","volume":"48","author":"H Xu","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1189\/jlb.0806502","article-title":"CXCL1\/KC and CXCL5\/LIX are selectively produced by corneal fibroblasts and mediate neutrophil infiltration to the corneal stroma in LPS keratitis","volume":"81","author":"M Lin","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"35502","DOI":"10.1074\/jbc.M705823200","article-title":"Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1","volume":"282","author":"EC Carlson","year":"2007","journal-title":"J Biol Chem"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1167\/iovs.04-0741","article-title":"Visualization and characterization of inflammatory cell recruitment and migration through the corneal stroma in endotoxin-induced keratitis","volume":"47","author":"EC Carlson","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000335582","article-title":"Depletion of macrophages and dendritic cells in ischemic acute kidney injury","volume":"35","author":"L Lu","year":"2012","journal-title":"Am J Nephrol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1365-2249.2005.02868.x","article-title":"Histological analysis of CD11c-DTR\/GFP mice after in vivo depletion of dendritic cells","volume":"141","author":"HC Probst","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1097\/TP.0b013e318188d433","article-title":"Depletion of cells of monocyte lineage prevents loss of renal microvasculature in murine kidney transplantation","volume":"86","author":"F Qi","year":"2008","journal-title":"Transplantation"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1126\/science.173.3996.548","article-title":"Contraction of granulation tissue in vitro: similarity to smooth muscle","volume":"173","author":"G Majno","year":"1971","journal-title":"Science"},{"key":"ref45","first-page":"809","article-title":"Expression of alpha-smooth muscle (alpha-SM) actin during corneal stromal wound healing","volume":"36","author":"JV Jester","year":"1995","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref46","first-page":"3754","article-title":"Temporal stimulation of corneal fibroblast wound healing activity by differentiating epithelium in vitro","volume":"41","author":"JT Daniels","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref47","first-page":"699","article-title":"Transforming growth factor-beta 1 promotes contraction of collagen gel by bovine corneal fibroblasts through differentiation of myofibroblasts","volume":"39","author":"H Kurosaka","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","article-title":"Regulation of wound healing by growth factors and cytokines","volume":"83","author":"S Werner","year":"2003","journal-title":"Physiol Rev"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"569","DOI":"10.4049\/jimmunol.180.1.569","article-title":"Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function","volume":"180","author":"Y Ishida","year":"2008","journal-title":"J Immunol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"4743","DOI":"10.1167\/iovs.08-2462","article-title":"Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators","volume":"50","author":"Y Jin","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.2353\/ajpath.2009.080515","article-title":"Contribution of macrophages to angiogenesis induced by vascular endothelial growth factor receptor-3-specific ligands","volume":"175","author":"ES Chung","year":"2009","journal-title":"Am J Pathol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0061799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T23:45:02Z","timestamp":1644795902000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0061799"}},"subtitle":[],"editor":[{"given":"Fu-Shin","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,16]]},"references-count":51,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0061799","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,16]]}}}