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An alternative for the treatment of American cutaneous leishmaniasis","volume":"13","author":"L Lopez","year":"2012","journal-title":"Trials"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"551","DOI":"10.4269\/ajtmh.2011.10-0423","article-title":"Antihelminthic therapy and antimony in cutaneous leishmaniasis: a randomized, double-blind, placebo-controlled trial in patients co-infected with helminths and Leishmania braziliensis","volume":"84","author":"T Newlove","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"255","DOI":"10.4269\/ajtmh.2011.10-0155","article-title":"Randomized controlled clinical trial to access efficacy and safety of miltefosine in the treatment of cutaneous leishmaniasis Caused by Leishmania (Viannia) guyanensis in Manaus, Brazil","volume":"84","author":"A Chrusciak-Talhari","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"e912","DOI":"10.1371\/journal.pntd.0000912","article-title":"Miltefosine in the treatment of cutaneous leishmaniasis caused by Leishmania braziliensis in Brazil: a randomized and controlled trial","volume":"4","author":"PR Machado","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4269\/ajtmh.2010.10-0060","article-title":"Efficacy of miltefosine for the treatment of American cutaneous leishmaniasis","volume":"83","author":"I Velez","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"e491","DOI":"10.1371\/journal.pntd.0000491","article-title":"First-line therapy for human cutaneous leishmaniasis in Peru using the TLR7 agonist imiquimod in combination with pentavalent antimony","volume":"3","author":"C Miranda-Verastegui","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4269\/ajtmh.2008.78.210","article-title":"Efficacy of miltefosine for Bolivian cutaneous leishmaniasis","volume":"78","author":"J Soto","year":"2008","journal-title":"Am J Trop Med Hyg"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"387","DOI":"10.4269\/ajtmh.2009.81.387","article-title":"Efficacy of extended (six weeks) treatment with miltefosine for mucosal leishmaniasis in Bolivia","volume":"81","author":"J Soto","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1093\/cid\/cir496","article-title":"High-dose oral fluconazole therapy effective for cutaneous leishmaniasis due to Leishmania (Vianna) braziliensis","volume":"53","author":"AQ Sousa","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1468-3083.2011.04070.x","article-title":"A pilot study comparing low-dose liposomal amphotericin B with N-methyl glucamine for the treatment of American cutaneous leishmaniasis","volume":"26","author":"JO Motta","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4269\/ajtmh.2010.09-0287","article-title":"A controlled, randomized-blinded clinical trial to assess the efficacy of a nitric oxide releasing patch in the treatment of cutaneous leishmaniasis by Leishmania (V.) panamensis","volume":"83","author":"P Lopez-Jaramillo","year":"2010","journal-title":"Am J Trop Med Hyg"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"7427","DOI":"10.1016\/j.vaccine.2010.08.092","article-title":"A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with sodium stibogluconate for the treatment of mucosal leishmaniasis","volume":"28","author":"A Llanos-Cuentas","year":"2010","journal-title":"Vaccine"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1016\/j.vaccine.2010.07.063","article-title":"A clinical trial to evaluate the safety and immunogenicity of the LEISH-F1+MPL-SE vaccine when used in combination with meglumine antimoniate for the treatment of cutaneous leishmaniasis","volume":"28","author":"E Nascimento","year":"2010","journal-title":"Vaccine"},{"key":"ref84","unstructured":"Garcia RG, Rincon Acelas M, Silva SY, Lopez M, Velez ID, et al. Double-blind, randomised controlled trial, to evaluate the effectiveness of a controlled nitric oxide releasing patch versus meglumine antimoniate in the treatment of cutaneous leishmaniasis; 2009; Helsinki Finland."},{"key":"ref85","first-page":"497","article-title":"Advances in the treatment of cutaneous leishmaniasis in the New World in the last ten years: a systematic review","volume":"86","author":"OLS Almeida","year":"2011","journal-title":"An Bras Dermatol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.actatropica.2011.02.007","article-title":"Systematic review of the adverse effects of cutaneous leishmaniasis treatment in the New World","volume":"118","author":"LF Oliveira","year":"2011","journal-title":"Acta Trop"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.bbi.2010.12.009","article-title":"Hormone levels are associated with clinical markers and cytokine levels in human localized cutaneous leishmaniasis","volume":"25","author":"GC Baccan","year":"2011","journal-title":"Brain Behav Immun"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4269\/ajtmh.2001.65.456","article-title":"Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: therapeutic response to meglumine antimoniate","volume":"65","author":"GA Romero","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1086\/524042","article-title":"Clinical and parasite species risk factors for pentavalent antimonial treatment failure in cutaneous leishmaniasis in Peru","volume":"46","author":"A Llanos-Cuentas","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/1874104501105010031","article-title":"Structures, targets and recent approaches in antileishmanial drug discovery and development","volume":"5","author":"K Seiffert","year":"2011","journal-title":"The open medicinal chemistry journal"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.inhe.2012.06.004","article-title":"Local or systemic treatment for New World Cutaneous Leishmaniasis? Re-evaluating the evidence for the risk of mucosal leishmaniasis","volume":"4","author":"J Blum","year":"2012","journal-title":"International Health"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1086\/655134","article-title":"Designing and reporting clinical trials on treatments for cutaneous leishmaniasis","volume":"51","author":"U Gonz\u00e1lez","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1590\/S0074-02762012000500014","article-title":"Development and validation of PCR-based assays for diagnosis of American cutaneous leishmaniasis and identification of the parasite species","volume":"107","author":"GC da Graca","year":"2012","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.meegid.2011.08.008","article-title":"Multilocus genotyping reveals a polyphyletic pattern among naturally antimony-resistant Leishmania braziliensis isolates from Peru","volume":"11","author":"V Adaui","year":"2011","journal-title":"Infect Genet Evol"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.meegid.2010.05.006","article-title":"Targeted gene expression profiling in Leishmania braziliensis and Leishmania guyanensis parasites isolated from Brazilian patients with different antimonial treatment outcomes","volume":"10","author":"DC Torres","year":"2010","journal-title":"Infect Genet Evol"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-3024.2009.01125.x","article-title":"Recruitment of CD8(+) T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis","volume":"31","author":"DR Faria","year":"2009","journal-title":"Parasite Immunol"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1086\/510860","article-title":"Pharmacokinetics of antimony in children treated for leishmaniasis with meglumine antimoniate","volume":"195","author":"A Cruz","year":"2007","journal-title":"J Infect Dis"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0061843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:56:58Z","timestamp":1588967818000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0061843"}},"subtitle":[],"editor":[{"given":"Henk D. 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