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In: Paintal AS, Gill-Kumar P, editors. Krogh Centennary Symposium on Respiratory Adaptation. Delhi: Vallabhbhai Patel Chest Inst. pp. 393\u2013406."},{"key":"ref40","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1113\/jphysiol.1969.sp008877","article-title":"Mechanism of stimulation of type J pulmonary receptors","volume":"203","author":"AS Paintal","year":"1969","journal-title":"J Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BFb0027715","article-title":"Afferent vagal C fibre innervation of the lungs and airways and its functional significance","volume":"99","author":"JC Coleridge","year":"1984","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/CIRCULATIONAHA.105.605980","article-title":"Reduced peripheral skeletal muscle mass and abnormal reflex physiology in chronic heart failure","volume":"114","author":"MF Piepoli","year":"2006","journal-title":"Circulation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1161\/01.CIR.96.7.2221","article-title":"Lung function and exercise gas exchange in chronic heart failure","volume":"96","author":"K Wasserman","year":"1997","journal-title":"Circulation"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1164\/rccm.201006-0965CI","article-title":"Excess ventilation during exercise and prognosis in chronic heart failure","volume":"183","author":"DY Sue","year":"2011","journal-title":"Am J Respir Crit Care Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0061877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T17:03:25Z","timestamp":1562951005000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0061877"}},"subtitle":[],"editor":[{"given":"Marco","family":"Idzko","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,16]]},"references-count":44,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0061877","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,16]]}}}