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J Wildl Dis","volume":"28","author":"M Meagher","year":"1992"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.7589\/0090-3558-32.2.326","article-title":"Infectious keratoconjunctivitis in free-ranging mule deer (<italic>Odocoileus hemionus<\/italic>) from Zion National Park, Utah","volume":"32","author":"SK Taylor","year":"1996","journal-title":"J Wildl Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.7589\/0090-3558-36.2.241","article-title":"Association of <italic>Moraxella ovis<\/italic> with keratoconjunctivitis in mule deer and moose in Wyoming","volume":"36","author":"SA Dubay","year":"2000","journal-title":"J Wildl Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2307\/3802069","article-title":"Demographic patterns after an epizootic of keratoconjunctivitis in a chamois population","volume":"(3)","author":"A Loison","year":"1996","journal-title":"J Wildl Manage 60"},{"key":"ref14","unstructured":"S\u00e1nchez A, Mart\u00ednez J (1985) Contribution au diagnostique de la kerato-conjonctivite du chamois (<italic>Rupicapra rupicapra<\/italic>) en Espagne. In: Balbo T, Lanfranchi P, Rossi L, Stero P editors. Atti del Simposio internazionale sulla cheratocongiuntivite infettiva del camoscio. University of Torino, Torino, Italy, 73\u201377."},{"key":"ref15","first-page":"57","article-title":"Estudio de un brote de querato-conjuntivitis infecciosa en los rebecos (<italic>Rupicapra pyrenaica<\/italic>) del Pirineo leridano. Veterinaria en Praxis","volume":"6","author":"I Marco","year":"1992"},{"key":"ref16","first-page":"79","article-title":"Queratoconjuntivitis clamidial en el rebeco (<italic>Rupicapra rupicapra ssp. pyrenaica<\/italic>)","volume":"17","author":"A Blanco","year":"1982","journal-title":"INIA: Serie Ganadera"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1017\/S0030605310000761","article-title":"Inter-agency coordination fosters the recovery of the Pyrenean chamois <italic>Rupicapra pyrenaica pyrenaica<\/italic> at its western limit","volume":"44(4)","author":"J Herrero","year":"2010","journal-title":"Oryx"},{"key":"ref18","unstructured":"Herrero J, Escudero E, Garc\u00eda JM, Garc\u00eda-Serrano A, Prada C, et al.. (2004) Management and survey of the Pyrenean chamois in the Aragonian Pyrenees. In: Herrero J, Escudero E, Fern\u00e1ndez de Luco D, Garc\u00eda-Gonz\u00e1lez R editors. The Pyrenean Chamois <italic>Rupicapra p.<\/italic> <italic>pyrenaica<\/italic>: Biology, Pathology and Management. Publications of the Council for the Protection of Nature, Government of Aragon, Saragossa, Spain. 69\u201383."},{"key":"ref19","unstructured":"Arnal MC, Fern\u00e1ndez de Luco D (2004) Sanitary survey of Pyrenean chamois in the Aragonian Pyrenees (1997\u20132002). In: Herrero J, Escudero E, Fern\u00e1ndez de Luco D, Garc\u00eda-Gonz\u00e1lez R editors. The Pyrenean Chamois <italic>Rupicapra p.<\/italic> <italic>pyrenaica<\/italic>: Biology, Pathology and Management. Publications of the Council for the Protection of Nature, Government of Aragon, Saragossa, Spain. 125\u2013132."},{"key":"ref20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0378-1127(96)03806-6","article-title":"Habitat use in a forest <italic>Rupicapra pyrenaica pyrenaica<\/italic> population","volume":"88","author":"J Herrero","year":"1996","journal-title":"Forest Ecol Manag"},{"key":"ref21","unstructured":"Garc\u00eda-Gonz\u00e1lez R, Hidalgo R, Ameztoy JM, Herrero J (1992). Census, population structure and habitat use of chamois population in Ordesa N.P. living in sympatry with the Pyrenean wild goat. In: Spitz F, Janeau G, Gonzalez G, Aulagnier S editors, Ongul\u00e9s\/Ungulates 91. SFEPMIRGM, Toulouse, 321\u2013325."},{"key":"ref22","first-page":"135","article-title":"Veinte a\u00f1os de seguimiento poblacional de ungulados silvestres de Arag\u00f3n. Pirineos","volume":"166","author":"J Marco","year":"2011","journal-title":"Revista de Ecolog\u00eda de Monta\u00f1a"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1515\/mamm.2000.64.4.411","article-title":"Historical examination of the status of large mammals in Aragon, Spain","volume":"(4)","author":"C Gort\u00e1zar","year":"2000","journal-title":"Mammalia 64"},{"key":"ref24","first-page":"153","article-title":"Dynamique des populations d\u2019isards du Parc National des Pyr\u00e9n\u00e9es Occidentales de 1968\u20131981","volume":"1","author":"C Berducou","year":"1982","journal-title":"Acta Biol Montana"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.mimet.2007.05.007","article-title":"Validation and diagnostic efficacy of a TaqMan real-time PCR for the detection of <italic>Mycoplasma conjunctivae<\/italic> in eyes of infected Caprinae","volume":"70","author":"EM Vilei","year":"2007","journal-title":"J Microbiol Methods"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1128\/AEM.60.1.149-152.1994","article-title":"Detection of mycoplasma contamination in cell cultures by a mycoplasma group-specific PCR","volume":"60","author":"FJ Van Kuppeveld","year":"1994","journal-title":"Appl Environ Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1099\/mic.0.27590-0","article-title":"Suppression subtractive hybridization as a basis to assess <italic>Mycoplasma agalactiae<\/italic> and <italic>Mycoplasma bovis<\/italic> genomic diversity and species-specific sequences","volume":"151","author":"MS Marenda","year":"2005","journal-title":"Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-1135(95)00176-X","article-title":"A PCR scheme for differentiation of organisms belonging to the <italic>Mycoplasma mycoides<\/italic> cluster","volume":"49","author":"H Hotzel","year":"1996","journal-title":"Vet Microbiol"},{"key":"ref29","unstructured":"Kleinbaum DG, Lawrence KL, Keith ME (1988) Applied regression analysis and other multivariable methods. 2nd edition. The Duxbury Series in Statistics and Decision Sciences. PWS-KENT Publishing Co., Boston, Mssachusettes, USA."},{"key":"ref30","unstructured":"Domenech JM, Navarro JB (2005) Regresi\u00f3n log\u00edstica binaria, multinomial y de Poisson. Signo, Barcelona, Spain."},{"key":"ref31","unstructured":"R Development Core Team (2012) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3\u2013900051\u201307\u20130. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.R-project.org\" xlink:type=\"simple\">http:\/\/www.R-project.org<\/ext-link>. Accessed 2013 Feb 28."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"413","DOI":"10.7589\/0090-3558-33.3.413","article-title":"Lesions associated with infectious keratoconjunctivitis in alpine ibex","volume":"33","author":"D Mayer","year":"1997","journal-title":"J Wildl Dis"},{"key":"ref33","first-page":"520","article-title":"An outbreak of infectious keratoconjunctivitis in Apine chamois, (<italic>Rupicapra r.rupicapra<\/italic>) in Simmental-Gruy\u00e8res, Switzerland","volume":"(9)","author":"MP Degiorgis","year":"2000","journal-title":"Schweiz Arch Thierheilk 142"},{"key":"ref34","unstructured":"Balbo T, Lanfranchi P, Rossi L (1985) Parasitological and Pathological Observations on the Chamois in the Western Alps. In: Lovari S editor. The Biology and Management of Mountain Ungulates. Proceedings of the Fourth International Conference on Chamois and other Mountain Ungulates, held in Pescasseroli, Abruzzo National Park, Italy, June 17\u201319 1983. Editorial Croom Helm, London, UK."},{"key":"ref35","unstructured":"Gauthier D (1991) La k\u00e9rato-conjunctivitie infectieuse du chamois. Etude \u00e9pid\u00e9miologique dans le d\u00e9partemente de la Savoie, 1983\u20131990. PhD Thesis. Universit\u00e9 de Lyon, Lyon, France."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-1135(98)00186-2","article-title":"Susceptibility of alpine ibex to conjunctivitis caused by instillation of a sheep-strain of <italic>Mycoplasma conjunctivae<\/italic>","volume":"61","author":"M Giacometti","year":"1998","journal-title":"Vet Microbiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/104063871102300223","article-title":"Occurrence of <italic>Chlamydiaceae<\/italic>, <italic>Mycoplasma conjunctivae<\/italic>, and pestiviruses in Alpine chamois (<italic>Rupicapra r. rupicapra<\/italic>) of Grisons, Switzerland","volume":"23(2)","author":"N Holzwarth","year":"2011","journal-title":"J Vet Diagn Invest"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.vetmic.2008.09.034","article-title":"Molecular evidence for chlamydial infections in the eyes of sheep","volume":"135","author":"A Polkinghorne","year":"2009","journal-title":"Vet Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/vr.161.5.167","article-title":"Mycoplasmas isolated from Spanish ibex (<italic>Capra pyrenaica hispanica<\/italic>): frequency and risk factors","volume":"161","author":"M Gonz\u00e1lez-Candela","year":"2007","journal-title":"Vet Rec"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/vr.147.3.72","article-title":"Epidemiological and microbiological study of an outbreak of infectious keratoconjunctivitis in sheep","volume":"147","author":"T Nagli\u0107","year":"2000","journal-title":"Vet Rec"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"369","DOI":"10.7589\/0090-3558-44.2.369","article-title":"Epidemiology of <italic>Mycoplasma agalactiae<\/italic> infection in free-ranging Spanish ibex (<italic>Capra pyrenaica<\/italic>) in Andalusia, southern Spain","volume":"44","author":"G Verbisck-Bucker","year":"2008","journal-title":"J Wildl Dis"},{"key":"ref42","unstructured":"Berducou C, Bousses P (1985) Social grouping patterns of a dense population of chamois in the western Pyrenees national Park, France. In: Lovari S editor. The biology and management of mountain ungulates. Editorial Croom Helm, London, UK, 166\u2013175."},{"key":"ref43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3989\/pirineos.2002.v157.64","article-title":"Grouping patterns in a forest dwelling population of Pyrenean chamois","volume":"157","author":"J Herrero","year":"2002","journal-title":"Pirineos"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-1135(01)00407-2","article-title":"<italic>Mycoplasma conjunctivae<\/italic> infection is self-maintained in the Swiss domestic sheep population","volume":"83","author":"M Janovsky","year":"2001","journal-title":"Vet Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"619","DOI":"10.7589\/0090-3558-48.3.619","article-title":"Occurrence, quantification, and genotyping of Mycoplasma conjunctivae in wild Caprinae with and without infectious keratoconjunctivitis","volume":"48(3)","author":"F Mavrot","year":"2012","journal-title":"J Wildl Dis"},{"key":"ref46","first-page":"17","article-title":"Brain lesions associated with infectious keratoconjunctivitis in chamois and Alpine ibex","volume":"2","author":"B Bassano","year":"1994","journal-title":"Ibex J Mount Ecol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"407","DOI":"10.7589\/0090-3558-42.2.407","article-title":"Infectious keratoconjunctivitis in Bighorn Sheep, Silver Bell Mountains, Arizona, USA","volume":"42","author":"BD Jansen","year":"1996","journal-title":"J Wildl Dis"},{"key":"ref48","first-page":"547","article-title":"Ovine infectious keratoconjunctivitis: an update","volume":"61","author":"GO Egwu","year":"1991","journal-title":"Vet Bull"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2981\/0909-6396(2008)14[118:SOMCSF]2.0.CO;2","article-title":"Specificity of <italic>Mycoplasma conjunctivae<\/italic> strains for alpine <italic>Rupicapra r.rupicapra<\/italic>","volume":"14","author":"L Zimmermann","year":"2008","journal-title":"Wildlife Biol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0061887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T07:52:10Z","timestamp":1688197930000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0061887"}},"subtitle":[],"editor":[{"given":"Marco","family":"Festa-Bianchet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,24]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0061887","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,24]]}}}