{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T03:20:59Z","timestamp":1770780059253,"version":"3.50.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T00:00:00Z","timestamp":1366761600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0061961","type":"journal-article","created":{"date-parts":[[2013,4,24]],"date-time":"2013-04-24T21:23:43Z","timestamp":1366838623000},"page":"e61961","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":75,"title":["Role of Arginase 1 from Myeloid Cells in Th2-Dominated Lung Inflammation"],"prefix":"10.1371","volume":"8","author":[{"given":"Luke","family":"Barron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim C.","family":"El Kasmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph E.","family":"Qualls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allen","family":"Cheever","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee A.","family":"Borthwick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A.","family":"Wynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,4,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/01.all.0000182542.30100.6f","article-title":"Exploiting worm and allergy models to understand Th2 cytokine biology","volume":"5","author":"TR Ramalingam","year":"2005","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/mi.2008.85","article-title":"Pulmonary fibrosis: pathogenesis, etiology and regulation","volume":"2","author":"MS Wilson","year":"2009","journal-title":"Mucosal Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"S Gordon","year":"2010","journal-title":"Immunity"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0030-1255354","article-title":"Macrophages: master regulators of inflammation and fibrosis","volume":"30","author":"TA Wynn","year":"2010","journal-title":"Semin Liver Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"PJ Murray","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1089\/jir.2011.0027","article-title":"Macrophages in allergic asthma: fine-tuning their pro- and anti-inflammatory actions for disease resolution","volume":"31","author":"AP Moreira","year":"2011","journal-title":"J Interferon Cytokine Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1600-065X.2011.01034.x","article-title":"Immune modulation for treatment of allergic disease","volume":"242","author":"TH Nguyen","year":"2011","journal-title":"Immunol Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"13058","DOI":"10.1073\/pnas.0504027102","article-title":"Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response","volume":"102","author":"L Di Costanzo","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1476-5381.2009.00278.x","article-title":"Recent advances in arginine metabolism: roles and regulation of the arginases","volume":"157","author":"SM Morris Jr","year":"2009","journal-title":"Br J Pharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1602S","DOI":"10.1093\/jn\/137.6.1602S","article-title":"Arginine metabolism: boundaries of our knowledge","volume":"137","author":"SM Morris Jr","year":"2007","journal-title":"J Nutr"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1189\/jlb.0710409","article-title":"Obstacles and opportunities for understanding macrophage polarization","volume":"89","author":"PJ Murray","year":"2011","journal-title":"J Leukoc Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1172\/JCI200317912","article-title":"Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis","volume":"111","author":"N Zimmermann","year":"2003","journal-title":"J Clin Invest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2172-10-33","article-title":"Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice","volume":"10","author":"KA Niese","year":"2009","journal-title":"BMC Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"L911","DOI":"10.1152\/ajplung.00025.2009","article-title":"Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma","volume":"296","author":"ML North","year":"2009","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1182\/blood-2006-06-032599","article-title":"Arginase 1 is expressed in myelocytes\/metamyelocytes and localized in gelatinase granules of human neutrophils","volume":"109","author":"LC Jacobsen","year":"2007","journal-title":"Blood"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1182\/blood-2004-07-2521","article-title":"Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity","volume":"105","author":"M Munder","year":"2005","journal-title":"Blood"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ni.1671","article-title":"Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens","volume":"9","author":"KC El Kasmi","year":"2008","journal-title":"Nat Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"ra62","DOI":"10.1126\/scisignal.2000955","article-title":"Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling","volume":"3","author":"JE Qualls","year":"2010","journal-title":"Sci Signal"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.4049\/jimmunol.171.7.3655","article-title":"Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair","volume":"171","author":"NG Sandler","year":"2003","journal-title":"J Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/j.1476-5381.2009.00374.x","article-title":"Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel therapeutic perspectives","volume":"158","author":"H Maarsingh","year":"2009","journal-title":"Br J Pharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"5432","DOI":"10.1021\/jm200443b","article-title":"Binding of alpha,alpha-disubstituted amino acids to arginase suggests new avenues for inhibitor design","volume":"54","author":"M Ilies","year":"2011","journal-title":"J Med Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ejphar.2008.02.096","article-title":"Arginine homeostasis in allergic asthma","volume":"585","author":"H Maarsingh","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1164\/rccm.200710-1588OC","article-title":"Arginase inhibition protects against allergen-induced airway obstruction, hyperresponsiveness, and inflammation","volume":"178","author":"H Maarsingh","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"5595","DOI":"10.4049\/jimmunol.177.8.5595","article-title":"Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness","volume":"177","author":"M Yang","year":"2006","journal-title":"J Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1183\/09031936.00057710","article-title":"Increased arginase activity contributes to airway remodelling in chronic allergic asthma","volume":"38","author":"H Maarsingh","year":"2011","journal-title":"Eur Respir J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"L17","DOI":"10.1152\/ajplung.00216.2009","article-title":"Direct inhibition of arginase attenuated airway allergic reactions and inflammation in a Dermatophagoides farinae-induced NC\/Nga mouse model","volume":"299","author":"N Takahashi","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref27","unstructured":"Nieuwenhuizen NE, Kirstein F, Jayakumar J, Emedi B, Hurdayal R, <etal>et al<\/etal>.. (2012) Allergic airway disease is unaffected by the absence of IL-4Ralpha-dependent alternatively activated macrophages. J Allergy Clin Immunol 130: 743\u2013750 e748."},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Lewis F (2001) Schistosomiasis. Curr Protoc Immunol Chapter 19: Unit 19 11.","DOI":"10.1002\/0471142735.im1901s28"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Wynn TA, Barron L, Thompson RW, Madala SK, Wilson MS, <etal>et al<\/etal>.. (2011) Quantitative assessment of macrophage functions in repair and fibrosis. Curr Protoc Immunol Chapter 14: Unit14 22.","DOI":"10.1002\/0471142735.im1422s93"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"9099","DOI":"10.1073\/pnas.0900591106","article-title":"A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma","volume":"106","author":"AI Caceres","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1365-2222.2011.03840.x","article-title":"A protective role for periostin and TGF-beta in IgE-mediated allergy and airway hyperresponsiveness","volume":"42","author":"ED Gordon","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e1000371","DOI":"10.1371\/journal.ppat.1000371","article-title":"Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis","volume":"5","author":"JT Pesce","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"6438","DOI":"10.4049\/jimmunol.0902009","article-title":"Arginase I suppresses IL-12\/IL-23p40-driven intestinal inflammation during acute schistosomiasis","volume":"184","author":"DR Herbert","year":"2010","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e1000023","DOI":"10.1371\/journal.ppat.1000023","article-title":"Cationic amino acid transporter-2 regulates immunity by modulating arginase activity","volume":"4","author":"RW Thompson","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1084\/jem.179.5.1551","article-title":"Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology","volume":"179","author":"TA Wynn","year":"1994","journal-title":"J Exp Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.4049\/jimmunol.172.5.3157","article-title":"The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells","volume":"172","author":"M Hesse","year":"2004","journal-title":"J Immunol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.4049\/jimmunol.176.10.5839","article-title":"Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector population","volume":"176","author":"JJ Taylor","year":"2006","journal-title":"J Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1128\/IAI.00783-07","article-title":"Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10","volume":"77","author":"LG Pacifico","year":"2009","journal-title":"Infect Immun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1365-2249.2009.04084.x","article-title":"Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumin-induced airway inflammation","volume":"160","author":"LS Cardoso","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.jaci.2004.09.004","article-title":"Asthma is induced by intranasal coadministration of allergen and natural killer T-cell ligand in a mouse model","volume":"114","author":"JO Kim","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.abb.2010.02.004","article-title":"Inhibition of human arginase I by substrate and product analogues","volume":"496","author":"L Di Costanzo","year":"2010","journal-title":"Arch Biochem Biophys"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1007\/s00018-008-7554-z","article-title":"Evolution of the arginase fold and functional diversity","volume":"65","author":"DP Dowling","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/eji.1830250436","article-title":"Reciprocal regulation of the nitric oxide synthase\/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines","volume":"25","author":"M Modolell","year":"1995","journal-title":"Eur J Immunol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.4049\/jimmunol.166.4.2173","article-title":"Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production","volume":"166","author":"R Rutschman","year":"2001","journal-title":"J Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.4049\/jimmunol.171.9.4561","article-title":"Translational control of inducible nitric oxide synthase by IL-13 and arginine availability in inflammatory macrophages","volume":"171","author":"S El-Gayar","year":"2003","journal-title":"J Immunol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni1001-907","article-title":"Nitric oxide and the immune response","volume":"2","author":"C Bogdan","year":"2001","journal-title":"Nat Immunol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"6533","DOI":"10.4049\/jimmunol.167.11.6533","article-title":"Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1\/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolism","volume":"167","author":"M Hesse","year":"2001","journal-title":"J Immunol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"14895","DOI":"10.1073\/pnas.0605478103","article-title":"Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung","volume":"103","author":"ME Rothenberg","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s12026-010-8200-z","article-title":"Impaired pulmonary immunity post-bone marrow transplant","volume":"50","author":"SM Coomes","year":"2011","journal-title":"Immunol Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nri1668","article-title":"Regulation of immune responses by L-arginine metabolism","volume":"5","author":"V Bronte","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1074-7613(04)00107-4","article-title":"Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology","volume":"20","author":"DR Herbert","year":"2004","journal-title":"Immunity"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0061961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T20:46:34Z","timestamp":1595709994000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0061961"}},"subtitle":[],"editor":[{"given":"Stephania Ann","family":"Cormier","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,24]]},"references-count":51,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0061961","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,24]]}}}