{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T20:40:28Z","timestamp":1781124028616,"version":"3.54.1"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T00:00:00Z","timestamp":1366070400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0061962","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T21:00:19Z","timestamp":1366146019000},"page":"e61962","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Immunization with a MOMP-Based Vaccine Protects Mice against a Pulmonary Chlamydia Challenge and Identifies a Disconnection between Infection and Pathology"],"prefix":"10.1371","volume":"8","author":[{"given":"Connor P.","family":"O\u2019Meara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles W.","family":"Armitage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina C. G.","family":"Harvie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Timms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils Y.","family":"Lycke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Beagley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,4,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S402","DOI":"10.1086\/315596","article-title":"Background and current knowledge of Chlamydia pneumoniae and atherosclerosis","volume":"181","author":"JT Grayston","year":"2000","journal-title":"J Infect Dis"},{"key":"ref2","first-page":"73","article-title":"Chlamydia pneumoniae infection and its role in asthma and chronic obstructive pulmonary disease","volume":"12","author":"P Clementsen","year":"2002","journal-title":"J Investig Allergol Clin Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/infdis\/167.4.841","article-title":"Demonstration of Chlamydia pneumoniae in atherosclerotic lesions of coronary arteries","volume":"167","author":"CC Kuo","year":"1993","journal-title":"J Infect Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1099\/jmm.0.020362-0","article-title":"Serological diagnosis of Chlamydia pneumoniae infection: limitations and perspectives","volume":"59","author":"E Villegas","year":"2010","journal-title":"J Med Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/clinids\/14.1.178","article-title":"Persistent infection with Chlamydia pneumoniae following acute respiratory illness","volume":"14","author":"MR Hammerschlag","year":"1992","journal-title":"Clin Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/infdis\/166.3.646","article-title":"Seroepidemiology of Chlamydia pneumoniae TWAR infection in Seattle families, 1966\u20131979","volume":"166","author":"MB Aldous","year":"1992","journal-title":"J Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1128\/IAI.66.11.5113-5118.1998","article-title":"Local immune responses to Chlamydia pneumoniae in the lungs of BALB\/c mice during primary infection and reinfection","volume":"66","author":"JM Penttila","year":"1998","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1056\/NEJMoa030595","article-title":"Use of the inactivated intranasal influenza vaccine and the risk of Bell&apos;s palsy in Switzerland","volume":"350","author":"M Mutsch","year":"2004","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(08)60839-9","article-title":"Use of a patch containing heat-labile toxin from Escherichia coli against travellers&apos; diarrhoea: a phase II, randomised, double-blind, placebo-controlled field trial","volume":"371","author":"SA Frech","year":"2008","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3936","DOI":"10.4049\/jimmunol.158.8.3936","article-title":"Genetically engineered nontoxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit","volume":"158","author":"LC Agren","year":"1997","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.4049\/jimmunol.173.5.3310","article-title":"The cholera toxin-derived CTA1-DD vaccine adjuvant administered intranasally does not cause inflammation or accumulate in the nervous tissues","volume":"173","author":"AM Eriksson","year":"2004","journal-title":"J Immunol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2954","DOI":"10.1099\/vir.0.2008\/005470-0","article-title":"CTA1-DD adjuvant promotes strong immunity against human immunodeficiency virus type 1 envelope glycoproteins following mucosal immunization","volume":"89","author":"C Sundling","year":"2008","journal-title":"J Gen Virol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.vaccine.2005.08.061","article-title":"The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection","volume":"24","author":"M De Filette","year":"2006","journal-title":"Vaccine"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-3083.2005.01713.x","article-title":"The nontoxic CTA1-DD adjuvant enhances protective immunity against Helicobacter pylori infection following mucosal immunization","volume":"63","author":"AA Akhiani","year":"2006","journal-title":"Scand J Immunol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1128\/IAI.01290-06","article-title":"The combined CTA1-DD\/ISCOMs vector is an effective intranasal adjuvant for boosting prior Mycobacterium bovis BCG immunity to Mycobacterium tuberculosis","volume":"75","author":"CS Andersen","year":"2007","journal-title":"Infect Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6224","DOI":"10.1016\/j.vaccine.2007.05.065","article-title":"Intrarectal immunization of mice with VP6 and either LT(R192G) or CTA1-DD as adjuvant protects against fecal rotavirus shedding after EDIM challenge","volume":"25","author":"MM McNeal","year":"2007","journal-title":"Vaccine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/S0264-410X(02)00043-9","article-title":"The level of protection against rotavirus shedding in mice following immunization with a chimeric VP6 protein is dependent on the route and the coadministered adjuvant","volume":"20","author":"AH Choi","year":"2002","journal-title":"Vaccine"},{"key":"ref18","article-title":"CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa","author":"KA Cunningham","year":"2009","journal-title":"J Reprod Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.vaccine.2005.07.104","article-title":"Comparison of intranasal and transcutaneous immunization for induction of protective immunity against Chlamydia muridarum respiratory tract infection","volume":"24","author":"KA Skelding","year":"2006","journal-title":"Vaccine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"8598","DOI":"10.1016\/j.vaccine.2007.09.073","article-title":"Sublingual immunization induces broad-based systemic and mucosal immune responses in mice","volume":"25","author":"N Cuburu","year":"2007","journal-title":"Vaccine"},{"key":"ref21","article-title":"Mucosal Delivery Routes for Optimal Immunization: Targeting Immunity to the Right Tissues","author":"C Czerkinsky","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1128\/IAI.31.3.1161-1176.1981","article-title":"Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis","volume":"31","author":"HD Caldwell","year":"1981","journal-title":"Infect Immun"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1128\/IAI.72.2.1019-1028.2004","article-title":"Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection","volume":"72","author":"LJ Berry","year":"2004","journal-title":"Infect Immun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"6217","DOI":"10.1016\/j.vaccine.2009.08.001","article-title":"Transcutaneous immunization with a novel lipid-based adjuvant protects against Chlamydia genital and respiratory infections","volume":"27","author":"DK Hickey","year":"2009","journal-title":"Vaccine"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/1566524054863906","article-title":"Induction of anti-chlamydial mucosal immunity by transcutaneous immunization is enhanced by topical application of GM-CSF","volume":"5","author":"DK Hickey","year":"2005","journal-title":"Curr Mol Med"},{"key":"ref26","article-title":"Transcutaneous immunization using common chemicals","author":"P Karande","year":"2009","journal-title":"J Control Release"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.4049\/jimmunol.156.11.4338","article-title":"Genetically determined differences in IL-10 and IFN-gamma responses correlate with clearance of Chlamydia trachomatis mouse pneumonitis infection","volume":"156","author":"X Yang","year":"1996","journal-title":"J Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1128\/IAI.65.7.2876-2882.1997","article-title":"Humoral and cellular immunity in secondary infection due to murine Chlamydia trachomatis","volume":"65","author":"DM Williams","year":"1997","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.4049\/jimmunol.161.3.1439","article-title":"Gene knockout B cell-deficient mice demonstrate that B cells play an important role in the initiation of T cell responses to Chlamydia trachomatis (mouse pneumonitis) lung infection","volume":"161","author":"X Yang","year":"1998","journal-title":"J Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.it.2004.04.011","article-title":"The immunobiology of the TLR9 subfamily","volume":"25","author":"H Wagner","year":"2004","journal-title":"Trends Immunol"},{"key":"ref31","first-page":"153","article-title":"Cholera toxin - a foe &amp; a friend","volume":"133","author":"J Sanchez","year":"2010","journal-title":"Indian J Med Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.4049\/jimmunol.1101107","article-title":"Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant","volume":"187","author":"J Mattsson","year":"2011","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.4049\/jimmunol.162.4.2432","article-title":"Adjuvanticity of the cholera toxin A1-based gene fusion protein, CTA1-DD, is critically dependent on the ADP-ribosyltransferase and Ig-binding activity","volume":"162","author":"LC Agren","year":"1999","journal-title":"J Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1111\/j.1365-2222.2009.03337.x","article-title":"Mapping of the lingual immune system reveals the presence of both regulatory and effector CD4+ T cells","volume":"39","author":"L Mascarell","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"ref35","unstructured":"Bos JD (2005) Skin Immune System (SIS). Skin Immune System: Cutaneous Immunology and Clinical Immunodermatology 3\u201313."},{"key":"ref36","doi-asserted-by":"crossref","first-page":"5581","DOI":"10.1128\/IAI.00574-08","article-title":"Protection of wild-type and severe combined immunodeficiency mice against an intranasal challenge by passive immunization with monoclonal antibodies to the Chlamydia trachomatis mouse pneumonitis major outer membrane protein","volume":"76","author":"S Pal","year":"2008","journal-title":"Infect Immun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.cellimm.2004.09.002","article-title":"Chlamydia trachomatis pulmonary infection induces greater inflammatory pathology in immunoglobulin A deficient mice","volume":"230","author":"AK Murthy","year":"2004","journal-title":"Cell Immunol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"18406","DOI":"10.1073\/pnas.1115348108","article-title":"Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport","volume":"108","author":"Y Bai","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.0019-2805.2001.01354.x","article-title":"Fc receptor regulation of protective immunity against Chlamydia trachomatis","volume":"105","author":"T Moore","year":"2002","journal-title":"Immunology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1600-0897.2010.00894.x","article-title":"Chlamydia muridarum major outer membrane protein-specific antibodies inhibit in vitro infection but enhance pathology in vivo","volume":"65","author":"KA Cunningham","year":"2011","journal-title":"Am J Reprod Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1110\/ps.45201","article-title":"Single amino acid substitutions on the surface of Escherichia coli maltose-binding protein can have a profound impact on the solubility of fusion proteins","volume":"10","author":"JD Fox","year":"2001","journal-title":"Protein Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"11143","DOI":"10.1073\/pnas.93.20.11143","article-title":"A recombinant Chlamydia trachomatis major outer membrane protein binds to heparan sulfate receptors on epithelial cells","volume":"93","author":"H Su","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"5020","DOI":"10.1016\/j.vaccine.2009.05.008","article-title":"Protection against an intranasal challenge by vaccines formulated with native and recombinant preparations of the Chlamydia trachomatis major outer membrane protein","volume":"27","author":"G Sun","year":"2009","journal-title":"Vaccine"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1128\/IAI.00486-06","article-title":"Potential role for Toll-like receptor 4 in mediating Escherichia coli maltose-binding protein activation of dendritic cells","volume":"75","author":"S Fernandez","year":"2007","journal-title":"Infect Immun"},{"key":"ref45","article-title":"Sublingual vaccination with fusion protein consisting of the functional domain of hemagglutinin A of Porphyromonas gingivalis and Escherichia coli maltose-binding protein elicits protective immunity in the oral cavity","author":"S Yuzawa","year":"2012","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4269\/ajtmh.2001.65.159","article-title":"Short report: Antibody responses of mice immunized with a tetravalent dengue recombinant protein subunit vaccine","volume":"65","author":"M Simmons","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"420","DOI":"10.4269\/ajtmh.2001.65.420","article-title":"Characterization of antibody responses to combinations of a dengue-2 DNA and dengue-2 recombinant subunit vaccine","volume":"65","author":"M Simmons","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1365-3024.2001.00390.x","article-title":"Immunogenicity of recombinant fragments of Plasmodium falciparum acidic basic repeat antigen produced in Escherichia coli","volume":"23","author":"A Kushwaha","year":"2001","journal-title":"Parasite Immunol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1600-065X.1999.tb01339.x","article-title":"Mucosal immunity and tolerance: relevance to vaccine development","volume":"170","author":"C Czerkinsky","year":"1999","journal-title":"Immunol Rev"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.mad.2004.05.009","article-title":"Mucosal immunity and tolerance in the elderly","volume":"125","author":"K Fujihashi","year":"2004","journal-title":"Mech Ageing Dev"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"6933","DOI":"10.4049\/jimmunol.0901144","article-title":"Intranasal immunization promotes th17 immune responses","volume":"183","author":"BM Zygmunt","year":"2009","journal-title":"J Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.4049\/jimmunol.162.2.1010","article-title":"IL-10 gene knockout mice show enhanced Th1-like protective immunity and absent granuloma formation following Chlamydia trachomatis lung infection","volume":"162","author":"X Yang","year":"1999","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1128\/IAI.67.4.1763-1769.1999","article-title":"Interleukin-12 production is required for chlamydial antigen-pulsed dendritic cells to induce protection against live Chlamydia trachomatis infection","volume":"67","author":"H Lu","year":"1999","journal-title":"Infect Immun"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"4148","DOI":"10.4049\/jimmunol.180.6.4148","article-title":"Endogenous IFN-gamma production is induced and required for protective immunity against pulmonary chlamydial infection in neonatal mice","volume":"180","author":"M Jupelli","year":"2008","journal-title":"J Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.4049\/jimmunol.0901584","article-title":"IL-17\/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function","volume":"183","author":"H Bai","year":"2009","journal-title":"J Immunol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1128\/IAI.63.7.2801-2803.1995","article-title":"Inhibition of Chlamydia pneumoniae growth in HEp-2 cells pretreated with gamma interferon and tumor necrosis factor alpha","volume":"63","author":"JT Summersgill","year":"1995","journal-title":"Infect Immun"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1089\/107999003322277829","article-title":"Synergistic transcriptional activation of indoleamine dioxygenase by IFN-gamma and tumor necrosis factor-alpha","volume":"23","author":"CM Robinson","year":"2003","journal-title":"J Interferon Cytokine Res"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.4049\/jimmunol.162.6.3541","article-title":"Differential sensitivity of distinct Chlamydia trachomatis isolates to IFN-gamma-mediated inhibition","volume":"162","author":"LL Perry","year":"1999","journal-title":"J Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jor.21206","article-title":"Interleukin-17 synergizes with IFNgamma or TNFalpha to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells","volume":"29","author":"MA Gabr","year":"2011","journal-title":"J Orthop Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1095\/biolreprod60.2.508","article-title":"Differential expression of immunobiological mediators by immortalized human cervical and vaginal epithelial cells","volume":"60","author":"RN Fichorova","year":"1999","journal-title":"Biol Reprod"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1046\/j.1365-2567.1999.00926.x","article-title":"The intercellular adhesion molecule type-1 is required for rapid activation of T helper type 1 lymphocytes that control early acute phase of genital chlamydial infection in mice","volume":"98","author":"JU Igietseme","year":"1999","journal-title":"Immunology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/jlb.59.5.656","article-title":"Integrin-mediated epithelial-T cell interaction enhances nitric oxide production and increased intracellular inhibition of Chlamydia","volume":"59","author":"JU Igietseme","year":"1996","journal-title":"J Leukoc Biol"},{"key":"ref63","first-page":"317","article-title":"Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone","volume":"5","author":"JU Igietseme","year":"1993","journal-title":"Reg Immunol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1128\/IAI.01374-09","article-title":"Chlamydia muridarum T-cell antigens formulated with the adjuvant DDA\/TDB induce immunity against infection that correlates with a high frequency of gamma interferon (IFN-gamma)\/tumor necrosis factor alpha and IFN-gamma\/interleukin-17 double-positive CD4+ T cells","volume":"78","author":"H Yu","year":"2010","journal-title":"Infect Immun"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S1074-7613(00)80461-6","article-title":"The duration of antigenic stimulation determines the fate of naive and effector T cells","volume":"8","author":"G Iezzi","year":"1998","journal-title":"Immunity"},{"key":"ref66","first-page":"17","article-title":"Dendritic cells: translating innate to adaptive immunity","volume":"311","author":"RM Steinman","year":"2006","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1074-7613(00)80533-6","article-title":"Cytokines induce the development of functionally heterogeneous T helper cell subsets","volume":"8","author":"A O'Garra","year":"1998","journal-title":"Immunity"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1084\/jem.20021109","article-title":"Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2","volume":"197","author":"X Zhao","year":"2003","journal-title":"J Exp Med"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, <etal>et al<\/etal>.. (2011) Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad Sci U S A.","DOI":"10.1073\/pnas.1117194109"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S1359-6101(03)00060-1","article-title":"Cytokine regulation of pulmonary fibrosis in scleroderma","volume":"14","author":"SP Atamas","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.4049\/jimmunol.173.2.1209","article-title":"Activation, differentiation, and migration of naive virus-specific CD8+ T cells during pulmonary influenza virus infection","volume":"173","author":"CW Lawrence","year":"2004","journal-title":"J Immunol"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"5236","DOI":"10.4049\/jimmunol.169.9.5236","article-title":"Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza","volume":"169","author":"FE Lund","year":"2002","journal-title":"J Immunol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.vaccine.2011.10.059","article-title":"Protective immunity against mouse upper genital tract pathology correlates with high IFNgamma but low IL-17 T cell and anti-secretion protein antibody responses induced by replicating chlamydial organisms in the airway","volume":"30","author":"C Lu","year":"2011","journal-title":"Vaccine"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1016\/S0264-410X(02)00247-5","article-title":"Tracking the tissue distribution of marker dye following intranasal delivery in mice and chinchillas: a multifactorial analysis of parameters affecting nasal retention","volume":"20","author":"A Visweswaraiah","year":"2002","journal-title":"Vaccine"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"e33781","DOI":"10.1371\/journal.pone.0033781","article-title":"Host genetics and Chlamydia disease: prediction and validation of disease severity mechanisms","volume":"7","author":"I Miyairi","year":"2012","journal-title":"PLoS One"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0061962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T02:12:53Z","timestamp":1688177573000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0061962"}},"subtitle":[],"editor":[{"given":"Paulo Lee","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,16]]},"references-count":75,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0061962","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,16]]}}}