{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:17:43Z","timestamp":1789507063817,"version":"build-2803163510"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0062653","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T07:04:28Z","timestamp":1367478268000},"page":"e62653","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["Mycobacterium tuberculosis Infection Is Associated with the Development of Erythema Nodosum and Nodular Vasculitis"],"prefix":"10.1371","volume":"8","author":[{"given":"Sheng\u2019an","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiazhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao\u2019an","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,5,1]]},"reference":[{"key":"ref1","first-page":"773","article-title":"Erythema nodosum: etiological factors and relapses in a retrospective cohort study","volume":"20","author":"A Papagrigoraki","year":"2010","journal-title":"Eur J Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.sder.2007.02.009","article-title":"Erythema nodosum","volume":"26","author":"L Requena","year":"2007","journal-title":"Semin Cutan Med Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.sder.2007.02.010","article-title":"Erythema nodosum leprosum: reactional leprosy","volume":"26","author":"J Cuevas","year":"2007","journal-title":"Semin Cutan Med Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/bmj.4.5625.223","article-title":"Acute necrotizing lepromatous lymphadenitis: an erythema-nodosum-leprosum-like reaction in lymph nodes","volume":"4","author":"AB Karat","year":"1968","journal-title":"Br Med J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/0019-5154.94278","article-title":"A retrospective analysis of histopathology of 64 cases of lepra reactions","volume":"57","author":"V Adhe","year":"2012","journal-title":"Indian J Dermatol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/1529-0131(200003)43:3<584::AID-ANR15>3.0.CO;2-6","article-title":"Erythema nodosum: etiologic and predictive factors in a defined population","volume":"43","author":"C Garcia-Porrua","year":"2000","journal-title":"Arthritis Rheum"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1529-8019.2010.01332.x","article-title":"Erythema nodosum and erythema induratum (nodular vasculitis): diagnosis and management","volume":"23","author":"H Gilchrist","year":"2010","journal-title":"Dermatol Ther"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1365-4362.1996.tb02979.x","article-title":"Erythema induratum of Bazin","volume":"35","author":"KH Cho","year":"1996","journal-title":"Int J Dermatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1001\/archderm.1997.03890400057008","article-title":"Detection of Mycobacterium tuberculosis DNA in lobular granulomatous panniculitis (erythema induratum-nodular vasculitis)","volume":"133","author":"E Baselga","year":"1997","journal-title":"Arch Dermatol"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Marker M, Ortiz-Urda S, Lilgenau N, Rappersberger K (2004) [Erythema induratum-nodular vasculitis]. J Dtsch Dermatol Ges 2: 206\u2013214; quiz 215.","DOI":"10.1046\/j.1439-0353.2004.03627.x"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1365-4362.2002.01390.x","article-title":"Erythema nodosum associated with reactivation tuberculous lymphadenitis (scrofula)","volume":"41","author":"SN Gupta","year":"2002","journal-title":"Int J Dermatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1346-8138.2004.tb00509.x","article-title":"Primary tuberculosis cases presenting with erythema nodosum","volume":"31","author":"A Mert","year":"2004","journal-title":"J Dermatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1080\/00365540410027184","article-title":"Erythema Nodosum: An Experience of 10 Years","volume":"36","author":"A Mert","year":"2004","journal-title":"Scandinavian Journal of Infectious Diseases"},{"key":"ref14","first-page":"287","article-title":"An aetiological analysis of erythema nodosum in a community hospital","volume":"67","author":"KN Sarveswari","year":"2001","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref15","first-page":"1095","article-title":"Long-term follow-up of erythema nodosum","volume":"86","author":"O Tantisirin","year":"2003","journal-title":"J Med Assoc Thai"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1186\/1471-2458-12-885","article-title":"The spatial epidemiology of tuberculosis in Linyi City, China, 2005\u20132010","volume":"12","author":"T Wang","year":"2012","journal-title":"BMC Public Health"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1186\/1471-2458-12-1110","article-title":"Evaluation of the tuberculosis programme in Ningxia Hui Autonomous region, the People\u2019s Republic of China: a retrospective case study","volume":"12","author":"YR Yang","year":"2012","journal-title":"BMC Public Health"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"949","DOI":"10.3892\/etm.2012.699","article-title":"Molecular typing of Mycobacterium tuberculosis isolates circulating in Henan, central China","volume":"4","author":"Y Zhao","year":"2012","journal-title":"Exp Ther Med"},{"key":"ref19","first-page":"353","article-title":"Clinical analysis on 81 cases of erythema nodosum","volume":"20","author":"DL Wan XF","year":"2006","journal-title":"Chin J Derm Venereol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e12287","DOI":"10.1371\/journal.pone.0012287","article-title":"The tuberculin skin test (TST) is affected by recent BCG vaccination but not by exposure to non-tuberculosis mycobacteria (NTM) during early life","volume":"5","author":"S Burl","year":"2010","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.7326\/0003-4819-149-3-200808050-00241","article-title":"Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update","volume":"149","author":"M Pai","year":"2008","journal-title":"Ann Intern Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e32652","DOI":"10.1371\/journal.pone.0032652","article-title":"Interferon-gamma release assay performance in pulmonary and extrapulmonary tuberculosis","volume":"7","author":"Y Feng","year":"2012","journal-title":"PLoS One"},{"key":"ref23","first-page":"2786","article-title":"IFN-gamma release assay: a diagnostic assistance tool of tuberculin skin test in pediatric tuberculosis in China","volume":"123","author":"L Sun","year":"2010","journal-title":"Chin Med J (Engl)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.1365-2133.2007.08227.x","article-title":"Usefulness of the QuantiFERON test in the confirmation of latent tuberculosis in association with erythema induratum","volume":"157","author":"J Angus","year":"2007","journal-title":"Br J Dermatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/jcp.49.4.290","article-title":"Single-tube nested PCR in the diagnosis of tuberculosis","volume":"49","author":"CM Chan","year":"1996","journal-title":"Journal of Clinical Pathology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1099\/mic.0.026484-0","article-title":"Detection of Mycobacterium tuberculosis complex organisms in the stools of patients with pulmonary tuberculosis","volume":"155","author":"A El Khechine","year":"2009","journal-title":"Microbiology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1128\/JCM.01200-07","article-title":"Novel wide-range quantitative nested real-time PCR assay for Mycobacterium tuberculosis DNA: development and methodology","volume":"46","author":"T Takahashi","year":"2008","journal-title":"J Clin Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1046\/j.1365-4362.1999.00576.x","article-title":"Detection of Mycobacterium tuberculosis DNA using polymerase chain reaction in cutaneous tuberculosis and tuberculids","volume":"38","author":"SH Tan","year":"1999","journal-title":"Int J Dermatol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1128\/JCM.41.10.4565-4572.2003","article-title":"Rapid diagnosis of mycobacterial infections and quantitation of Mycobacterium tuberculosis load by two real-time calibrated PCR assays","volume":"41","author":"F Broccolo","year":"2003","journal-title":"J Clin Microbiol"},{"key":"ref30","first-page":"463","article-title":"Evaluation of whole blood IFNgamma test using PPD and recombinant antigen challenge for diagnosis of pulmonary and extra-pulmonary tuberculosis","volume":"47","author":"Y Kalantri","year":"2009","journal-title":"Indian J Exp Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.eimc.2009.05.012","article-title":"Interferon gamma release assays: principles and practice","volume":"28","author":"A Lalvani","year":"2010","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"ref32","unstructured":"Mahan CS, Johnson DF, Curley C, van der Kuyp F (2011) Concordance of a positive tuberculin skin test and an interferon gamma release assay in bacille Calmette-Guerin vaccinated persons. Int J Tuberc Lung Dis 15: 174\u2013178, i."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1128\/CVI.00294-10","article-title":"Evaluation of gamma interferon release assays using Mycobacterium tuberculosis antigens for diagnosis of latent and active tuberculosis in Mycobacterium bovis BCG-vaccinated populations","volume":"17","author":"S Zhang","year":"2010","journal-title":"Clin Vaccine Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e1000199","DOI":"10.1371\/journal.pmed.1000199","article-title":"Sexual inequality in tuberculosis","volume":"6","author":"O Neyrolles","year":"2009","journal-title":"PLoS Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jaad.2008.07.030","article-title":"Vasculitis in erythema induratum of Bazin: a histopathologic study of 101 biopsy specimens from 86 patients","volume":"59","author":"S Segura","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1371\/journal.pone.0000043","article-title":"Is adipose tissue a place for Mycobacterium tuberculosis persistence?","volume":"1","author":"O Neyrolles","year":"2006","journal-title":"PLoS One"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e1000204","DOI":"10.1371\/journal.ppat.1000204","article-title":"Foamy macrophages from tuberculous patients\u2019 granulomas constitute a nutrient-rich reservoir for M. tuberculosis persistence","volume":"4","author":"P Peyron","year":"2008","journal-title":"PLoS Pathog"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0062653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T08:35:41Z","timestamp":1563006941000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0062653"}},"subtitle":[],"editor":[{"given":"Olivier","family":"Neyrolles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,1]]},"references-count":37,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0062653","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,1]]}}}