{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:08:09Z","timestamp":1788433689935,"version":"build-2803163510"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T00:00:00Z","timestamp":1366588800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0062702","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T03:06:04Z","timestamp":1366686364000},"page":"e62702","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Diaphragm Atrophy and Contractile Dysfunction in a Murine Model of Pulmonary Hypertension"],"prefix":"10.1371","volume":"8","author":[{"given":"Bumsoo","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyacinth M.","family":"Empinado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monsour","family":"Al-Rajhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Judge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo F.","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1378\/chest.07-0903","article-title":"Pulmonary hypertension: from an orphan disease to a public health problem","volume":"132","author":"M Humbert","year":"2007","journal-title":"Chest"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/S0735-1097(02)02964-9","article-title":"Pulmonary function in primary pulmonary hypertension","volume":"41","author":"XG Sun","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1164\/rccm.201003-0354OC","article-title":"Diaphragm muscle fiber weakness in pulmonary hypertension","volume":"183","author":"FS de Man","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1136\/hrt.2003.026880","article-title":"The putative satiety hormone PYY is raised in cardiac cachexia associated with primary pulmonary hypertension","volume":"91","author":"CW le Roux","year":"2005","journal-title":"Heart"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/S0140-6736(96)07015-8","article-title":"Wasting as independent risk factor for mortality in chronic heart failure","volume":"349","author":"SD Anker","year":"1997","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1042\/CS20070238","article-title":"Impairment of respiratory muscle function in pulmonary hypertension","volume":"114","author":"HJ Kabitz","year":"2008","journal-title":"Clin Sci (Lond)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"L1070","DOI":"10.1152\/ajplung.00135.2012","article-title":"Diaphragm weakness in pulmonary arterial hypertension: role of sarcomeric dysfunction","volume":"303","author":"E Manders","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0378-4274(98)00398-1","article-title":"Reversal of impaired calcium homeostasis in the rat diaphragm subjected to Monocrotaline-induced pulmonary hypertension","volume":"105","author":"NA Kanj","year":"1999","journal-title":"Toxicol Lett"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00424-010-0866-5","article-title":"Changes in contractile properties of skinned single rat soleus and diaphragm fibres after chronic hypoxia","volume":"460","author":"H Degens","year":"2010","journal-title":"Pflugers Arch"},{"key":"ref10","first-page":"350","article-title":"Temporal changes of angiopoietins and Tie2 expression in rat lungs after monocrotaline-induced pulmonary hypertension","volume":"59","author":"YJ Cho","year":"2009","journal-title":"Comp Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1471-2466-8-25","article-title":"Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury","volume":"8","author":"R Dumitrascu","year":"2008","journal-title":"BMC Pulm Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF02899076","article-title":"Monocrotaline pneumotoxicity in mice","volume":"57","author":"A Molteni","year":"1989","journal-title":"Virchows Arch B Cell Pathol Incl Mol Pathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1111\/j.1538-7836.2006.02174.x","article-title":"Protective role of protein C inhibitor in monocrotaline-induced pulmonary hypertension","volume":"4","author":"Y Nishii","year":"2006","journal-title":"J Thromb Haemost"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1152\/japplphysiol.90884.2008","article-title":"Anti-TNF treatment reduces rat skeletal muscle wasting in monocrotaline-induced cardiac cachexia","volume":"105","author":"BT Steffen","year":"2008","journal-title":"J Appl Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1161\/HYPERTENSIONAHA.108.125468","article-title":"Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer","volume":"54","author":"Y Yamazato","year":"2009","journal-title":"Hypertension"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.yjmcc.2005.02.023","article-title":"Skeletal muscle myofibrillar protein oxidation in heart failure and the protective effect of Carvedilol","volume":"38","author":"L Dalla Libera","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1006\/jmcc.1998.0807","article-title":"Apoptosis of skeletal muscle myofibers and interstitial cells in experimental heart failure","volume":"30","author":"G Vescovo","year":"1998","journal-title":"J Mol Cell Cardiol"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Rubenfire M, Bayram M, Hector-Word Z (2007) Pulmonary hypertension in the critical care setting: classification, pathophysiology, diagnosis, and management. Crit Care Clin 23: 801\u2013834, vi\u2013vii.","DOI":"10.1016\/j.ccc.2007.07.006"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s11606-006-0032-0","article-title":"Reversible pulmonary hypertension and isolated right-sided heart failure associated with hyperthyroidism","volume":"22","author":"HM Ismail","year":"2007","journal-title":"J Gen Intern Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1538-7836.2010.03751.x","article-title":"Pulmonary hypertension is ameliorated in mice deficient in thrombin-activatable fibrinolysis inhibitor","volume":"8","author":"L Qin","year":"2010","journal-title":"J Thromb Haemost"},{"key":"ref21","unstructured":"Nih\/Od\/Oer\/Olaw (2010) Guide for the Care and Use of Laboratory Animals: Eighth Edition: National Academies Press. 246 p."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1096\/fj.08-110163","article-title":"Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy","volume":"22","author":"SM Senf","year":"2008","journal-title":"FASEB J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1096\/fj.11-189977","article-title":"Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy","volume":"26","author":"SA Reed","year":"2012","journal-title":"FASEB J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1139\/Y10-068","article-title":"Calculation of muscle maximal shortening velocity by extrapolation of the force-velocity relationship: afterloaded versus isotonic release contractions","volume":"88","author":"SR Bullimore","year":"2010","journal-title":"Can J Physiol Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ijcard.2007.06.080","article-title":"Impaired isotonic contractility and structural abnormalities in the diaphragm of congestive heart failure rats","volume":"128","author":"HW van Hees","year":"2008","journal-title":"Int J Cardiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1046\/j.1365-201X.2001.00895.x","article-title":"The effect of hypoxia on shortening contractions in rat diaphragm muscle","volume":"173","author":"HA Machiels","year":"2001","journal-title":"Acta Physiol Scand"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1152\/physrev.1972.52.1.129","article-title":"Dynamic properties of mammalian skeletal muscles","volume":"52","author":"RI Close","year":"1972","journal-title":"Physiol Rev"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1098\/rspb.1938.0050","article-title":"The Heat of Shortening and the Dynamic Constants of Muscle","volume":"126","author":"AV Hill","year":"1938","journal-title":"Proceedings of the Royal Society of London Series B \u2013 Biological Sciences"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"11910","DOI":"10.1074\/jbc.M112410200","article-title":"Contraction regulation of Akt in rat skeletal muscle","volume":"277","author":"K Sakamoto","year":"2002","journal-title":"J Biol Chem"},{"key":"ref30","first-page":"1137","article-title":"Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. FASEB J","volume":"19","author":"J Layland","year":"2005"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijcard.2007.11.077","article-title":"Reversibility of cachexia after bilateral lung transplantation","volume":"133","author":"D Habedank","year":"2009","journal-title":"Int J Cardiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00000658-200101000-00003","article-title":"Muscle cachexia: current concepts of intracellular mechanisms and molecular regulation","volume":"233","author":"PO Hasselgren","year":"2001","journal-title":"Ann Surg"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nrc927","article-title":"Cachexia in cancer patients","volume":"2","author":"MJ Tisdale","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2012.06.011","article-title":"Cancer cachexia: mediators, signaling, and metabolic pathways","volume":"16","author":"KC Fearon","year":"2012","journal-title":"Cell Metab"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1183\/09031936.04.00095804","article-title":"Respiratory muscle dysfunction in idiopathic pulmonary arterial hypertension","volume":"25","author":"FJ Meyer","year":"2005","journal-title":"Eur Respir J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1469-7793.1998.565bn.x","article-title":"Effect of hydrogen peroxide and dithiothreitol on contractile function of single skeletal muscle fibres from the mouse","volume":"2)","author":"FH Andrade","year":"1998","journal-title":"J Physiol 509 (Pt"},{"key":"ref37","first-page":"189","article-title":"Reactive oxygen species reduce myofibrillar Ca2+ sensitivity in fatiguing mouse skeletal muscle at 37 degrees C. J Physiol","volume":"564","author":"TR Moopanar","year":"2005"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1152\/jappl.2001.90.1.45","article-title":"Superoxide, hydroxyl radical, and hydrogen peroxide effects on single-diaphragm fiber contractile apparatus","volume":"90","author":"LA Callahan","year":"2001","journal-title":"J Appl Physiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1152\/japplphysiol.91247.2008","article-title":"The effect of denervation on protein synthesis and degradation in adult rat diaphragm muscle","volume":"107","author":"HM Argadine","year":"2009","journal-title":"J Appl Physiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"L1260","DOI":"10.1152\/ajplung.00035.2008","article-title":"Proteasome inhibition improves diaphragm function in congestive heart failure rats","volume":"294","author":"HW van Hees","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1465-9921-9-12","article-title":"Diaphragm adaptations in patients with COPD","volume":"9","author":"CA Ottenheijm","year":"2008","journal-title":"Respir Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"C706","DOI":"10.1152\/ajpcell.00626.2008","article-title":"Interleukin-1 stimulates catabolism in C2C12 myotubes","volume":"297","author":"W Li","year":"2009","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jmb.2008.08.087","article-title":"Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice","volume":"384","author":"V Adams","year":"2008","journal-title":"J Mol Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"9935","DOI":"10.1074\/jbc.R110.197731","article-title":"Protein phosphorylation and signal transduction in cardiac thin filaments","volume":"286","author":"RJ Solaro","year":"2011","journal-title":"J Biol Chem"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"H870","DOI":"10.1152\/ajpheart.00714.2003","article-title":"Evidence of myofibrillar protein oxidation induced by postischemic reperfusion in isolated rat hearts","volume":"286","author":"M Canton","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/eurheartj\/ehi751","article-title":"Oxidative modification of tropomyosin and myocardial dysfunction following coronary microembolization","volume":"27","author":"M Canton","year":"2006","journal-title":"Eur Heart J"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2466-12-23","article-title":"Ventilatory efficiency testing as prognostic value in patients with pulmonary hypertension","volume":"12","author":"M Schwaiblmair","year":"2012","journal-title":"BMC Pulm Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0062702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T23:12:59Z","timestamp":1562973179000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0062702"}},"subtitle":[],"editor":[{"given":"Rebecca","family":"Berdeaux","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,22]]},"references-count":47,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0062702","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,22]]}}}