{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:16:14Z","timestamp":1790118974760,"version":"4.0.1"},"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T00:00:00Z","timestamp":1368403200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0062723","type":"journal-article","created":{"date-parts":[[2013,5,13]],"date-time":"2013-05-13T21:06:01Z","timestamp":1368479161000},"page":"e62723","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Color Doppler Imaging Analysis of Retrobulbar Blood Flow Velocities in Primary Open-Angle Glaucomatous Eyes: A Meta-Analysis"],"prefix":"10.1371","volume":"8","author":[{"given":"Nana","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huadong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0002-9394(14)76171-9","article-title":"Glaucomatous optic neuropathy","volume":"113","author":"EM Van Buskirk","year":"1992","journal-title":"Am J Ophthalmol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1136\/bjo.54.7.461","article-title":"Vasogenic origin of visual field defects and optic nerve changes in glaucoma","volume":"54","author":"SS Hayreh","year":"1970","journal-title":"Br J Ophthalmol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1755-3768.2007.01167.x","article-title":"Endothelial dysfunction in glaucoma","volume":"87","author":"H Resch","year":"2009","journal-title":"Acta Ophthalmol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1350-9462(02)00008-3","article-title":"The impact of ocular blood flow in glaucoma","volume":"21","author":"J Flammer","year":"2002","journal-title":"Prog Retin Eye Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1350-9462(03)00064-8","article-title":"The effects of antiglaucoma and systemic medications on ocular blood flow","volume":"22","author":"VP Costa","year":"2003","journal-title":"Prog Retin Eye Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.ophtha.2007.03.016","article-title":"Predictors of long-term progression in the early manifest glaucoma trial","volume":"114","author":"MC Leske","year":"2007","journal-title":"Ophthalmology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0161-6420(93)31444-2","article-title":"Retinal hemodynamics using scanning laser ophthalmoscopy and hemorheology in chronic open-angle glaucoma","volume":"100","author":"S Wolf","year":"1993","journal-title":"Ophthalmology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1136\/bjo.83.4.466","article-title":"Peripapillary retinal blood flow in normal tension glaucoma","volume":"83","author":"HS Chung","year":"1999","journal-title":"Br J Ophthalmol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00061198-199604000-00003","article-title":"Perfusion of the juxtapapillary retina and the neuroretinal rim area in primary open angle glaucoma","volume":"5","author":"G Michelson","year":"1996","journal-title":"J Glaucoma"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/bjo.75.2.71","article-title":"Postural studies in pulsatile ocular blood flow: II. Chronic open angle glaucoma","volume":"75","author":"DR Trew","year":"1991","journal-title":"Br J Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1016\/0039-6257(94)90061-2","article-title":"Ocular blood flow and vision in healthy and glaucomatous eyes","volume":"38","author":"ME Langham","year":"1994","journal-title":"Surv Ophthalmol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1001\/archopht.1991.01080040095036","article-title":"Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy","volume":"109","author":"WE Lieb","year":"1991","journal-title":"Arch Ophthalmol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0002-9394(14)72063-X","article-title":"Blood-flow velocities in the extraocular vessels in normal volunteers","volume":"122","author":"HJ Kaiser","year":"1996","journal-title":"Am J Ophthalmol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6652","DOI":"10.1167\/iovs.10-5490","article-title":"Retrobulbar blood flow velocities in open angle glaucoma and their association with mean arterial blood pressure","volume":"51","author":"G Garhofer","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000310708","article-title":"Colour Doppler analysis of the choroidal circulation in chronic open-angle glaucoma","volume":"210","author":"M Cellini","year":"1996","journal-title":"Ophthalmologica"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S0002-9394(14)76579-1","article-title":"Color Doppler analysis of ocular vessel blood velocity in normal-tension glaucoma","volume":"118","author":"A Harris","year":"1994","journal-title":"Am J Ophthalmol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1148\/radiology.173.2.2678264","article-title":"Color Doppler flow imaging of the normal and abnormal orbit","volume":"173","author":"SJ Erickson","year":"1989","journal-title":"Radiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1755-3768.2011.02335.x","article-title":"Disturbed correlation between arterial resistance and pulsatility in glaucoma patients","volume":"90","author":"L Abegao Pinto","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"ref19","first-page":"690","article-title":"Color Doppler imaging in untreated high- and normal-pressure open-angle glaucoma","volume":"38","author":"Z Butt","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/eye.1995.4","article-title":"Measurement of ocular blood flow velocity using colour Doppler imaging in low tension glaucoma","volume":"1)","author":"Z Butt","year":"1995","journal-title":"Eye (Lond) 9 (Pt"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0002-9394(14)72771-0","article-title":"Color Doppler imaging and spectral analysis of the optic nerve vasculature in glaucoma","volume":"119","author":"SJ Rankin","year":"1995","journal-title":"Am J Ophthalmol"},{"key":"ref22","first-page":"127","article-title":"[Study of carotid circulation by means of ultrasonic methods and thermography]","volume":"126","author":"T Planiol","year":"1972","journal-title":"Rev Neurol (Paris)"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"JP Higgins","year":"2003","journal-title":"Bmj"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"M Egger","year":"1997","journal-title":"Bmj"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"CB Begg","year":"1994","journal-title":"Biometrics"},{"key":"ref26","first-page":"604","article-title":"Color Doppler ultrasound of orbital and optic nerve blood flow: effects of posture and timolol 0.5%","volume":"33","author":"GM Baxter","year":"1992","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/eye.1993.79","article-title":"Doppler ultrasonography of the central retinal artery in normals treated with topical timolol","volume":"3)","author":"RD Steigerwalt Jr","year":"1993","journal-title":"Eye (Lond) 7 (Pt"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Abegao Pinto L, Vandewalle E, De Clerck E, Marques-Neves C, Stalmans I (2012) Lack of spontaneous venous pulsation: possible risk indicator in normal tension glaucoma? Acta Ophthalmol.","DOI":"10.1111\/j.1755-3768.2012.02472.x"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1159\/000067553","article-title":"Ocular blood flow in healthy and primary open-angle glaucomatous eyes","volume":"216","author":"H Birinci","year":"2002","journal-title":"Ophthalmologica"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s00417-006-0439-7","article-title":"Hemodynamic evaluation of the posterior ciliary circulation in exfoliation syndrome and exfoliation glaucoma","volume":"245","author":"ET Detorakis","year":"2007","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.ophtha.2006.05.030","article-title":"Compromised autoregulatory control of ocular hemodynamics in glaucoma patients after postural change","volume":"113","author":"P Galambos","year":"2006","journal-title":"Ophthalmology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0002-9394(00)00766-2","article-title":"Relationship between ocular perfusion pressure and retrobulbar blood flow in patients with glaucoma with progressive damage","volume":"130","author":"D Gherghel","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1076\/ceyr.19.6.496.5286","article-title":"Is corneal temperature correlated with blood-flow velocity in the ophthalmic artery?","volume":"19","author":"K Gugleta","year":"1999","journal-title":"Curr Eye Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0002-9394(14)70127-8","article-title":"Blood-flow velocities of the extraocular vessels in patients with high-tension and normal-tension primary open-angle glaucoma","volume":"123","author":"HJ Kaiser","year":"1997","journal-title":"Am J Ophthalmol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1034\/j.1600-0420.1999.770610.x","article-title":"Variations in ocular hemodynamics in patients with early and late glaucoma","volume":"77","author":"CJ Liu","year":"1999","journal-title":"Acta Ophthalmol Scand"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1755-3768.2010.01878.x","article-title":"The effects of moxaverine on ocular blood flow in patients with age-related macular degeneration or primary open angle glaucoma and in healthy control subjects","volume":"90","author":"B Pemp","year":"2012","journal-title":"Acta Ophthalmol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1755-3768.2009.01713.x","article-title":"The association of ocular blood flow with haemorheological parameters in primary open-angle and exfoliative glaucoma","volume":"89","author":"MA Sekeroglu","year":"2011","journal-title":"Acta Ophthalmol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1177\/112067210901900410","article-title":"Color Doppler imaging and ocular pulse amplitude in glaucomatous and healthy eyes","volume":"19","author":"I Stalmans","year":"2009","journal-title":"Eur J Ophthalmol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1159\/000050902","article-title":"Comparison of blood flow velocities of the extraocular vessels in patients with pseudoexfoliation or primary open-angle glaucoma","volume":"215","author":"N Yuksel","year":"2001","journal-title":"Ophthalmologica"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00417-007-0709-z","article-title":"Ocular perfusion pressure and retrobulbar haemodynamics in pseudoexfoliative glaucoma","volume":"246","author":"F Galassi","year":"2008","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref41","first-page":"1270","article-title":"Dorzolamide effect on ocular blood flow","volume":"40","author":"GF Martinez A","year":"1999"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1136\/bjo.2002.008995","article-title":"Ocular haemodynamic responses to induced hypercapnia and hyperoxia in glaucoma","volume":"88","author":"SL Hosking","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"ref43","first-page":"138","article-title":"Hemodynamics of ophthalmic artery and central retinal artery and correlation with other factors in patients with primary open angle glaucoma","volume":"14","author":"X Liu","year":"1998","journal-title":"Yan Ke Xue Bao"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1600-0420.2007.01091.x","article-title":"Diagnostic compatibility of structural and haemodynamic parameters in open-angle glaucoma patients","volume":"86","author":"SI Januleviciene I","year":"2008","journal-title":"Acta Ophthalmol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00417-003-0809-3","article-title":"Color Doppler imaging in ocular hypertension and open-angle glaucoma","volume":"242","author":"C Akarsu","year":"2004","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10633-009-9192-7","article-title":"Color Doppler imaging and pattern visual evoked potential in normal tension glaucoma and hypertension glaucoma","volume":"119","author":"Y Zhong","year":"2009","journal-title":"Doc Ophthalmol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/jop.2006.22.79","article-title":"Comparative analysis of the effects of brimonidine and dorzolamide on ocular blood flow velocity in patients with newly diagnosed primary open-angle glaucoma","volume":"22","author":"T Simsek","year":"2006","journal-title":"J Ocul Pharmacol Ther"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"HA Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1542\/peds.72.4.526","article-title":"Validity of Doppler measurements of anterior cerebral artery blood flow velocity: correlation with brain blood flow in piglets","volume":"72","author":"NB Hansen","year":"1983","journal-title":"Pediatrics"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1148\/radiology.176.1.2112768","article-title":"Intracranial blood flow: quantification with duplex Doppler and color Doppler flow US","volume":"176","author":"GA Taylor","year":"1990","journal-title":"Radiology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2214\/ajr.154.6.2110732","article-title":"Intrarenal arterial Doppler sonography in patients with nonobstructive renal disease: correlation of resistive index with biopsy findings","volume":"154","author":"JF Platt","year":"1990","journal-title":"AJR Am J Roentgenol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"759","DOI":"10.2214\/ajr.148.4.759","article-title":"Evaluation of renal transplant rejection by duplex Doppler examination: value of the resistive index","volume":"148","author":"MD Rifkin","year":"1987","journal-title":"AJR Am J Roentgenol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.eye.6702654","article-title":"Stratus-OCT imaging in early glaucomatous and in ocular hypertensive patients with and without frequency-doubling technology abnormalities","volume":"22","author":"P Brusini","year":"2008","journal-title":"Eye (Lond)"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1167\/iovs.05-1102","article-title":"Diagnostic capability of optical coherence tomography in evaluating the degree of glaucomatous retinal nerve fiber damage","volume":"47","author":"R Sihota","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0062723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T23:03:38Z","timestamp":1645052618000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0062723"}},"subtitle":[],"editor":[{"given":"Keisuke","family":"Mori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,13]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0062723","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,13]]}}}