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Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/emedicine.medscape.com\/article\/820298-differential\" xlink:type=\"simple\">http:\/\/emedicine.medscape.com\/article\/820298-differential<\/ext-link>. Accessed 3 January 2013."},{"key":"ref49","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/(SICI)1097-0274(199602)29:2<209::AID-AJIM12>3.0.CO;2-7","article-title":"Chronic lung disease secondary to ammonia inhalation injury: a report on three cases","volume":"29","author":"RE de la Hoz","year":"1996","journal-title":"American Journal of Industrial Medicine"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0062746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T16:56:38Z","timestamp":1644857798000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0062746"}},"subtitle":[],"editor":[{"given":"Martin Gerbert","family":"Frasch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,26]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0062746","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,26]]}}}