{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:58:09Z","timestamp":1787021889388,"version":"build-2736575974"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:00:00Z","timestamp":1366848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0062862","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T16:59:03Z","timestamp":1366909143000},"page":"e62862","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":52,"title":["A Central Role for C1q\/TNF-Related Protein 13 (CTRP13) in Modulating Food Intake and Body Weight"],"prefix":"10.1371","volume":"8","author":[{"given":"Mardi S.","family":"Byerly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Swanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus M.","family":"Seldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.","family":"McCulloh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. William","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,4,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/35007534","article-title":"Central nervous system control of food intake","volume":"404","author":"MW Schwartz","year":"2000","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Y Zhang","year":"1994","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.psyneuen.2006.06.006","article-title":"Plasma agouti-related protein levels in women with anorexia nervosa","volume":"31","author":"J Moriya","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1017\/S0033291711000365","article-title":"Agouti-related protein in patients with acute and weight-restored anorexia nervosa","volume":"41","author":"JV Merle","year":"2011","journal-title":"Psychol Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/sj.mp.4000854","article-title":"Association between an agouti-related protein gene polymorphism and anorexia nervosa","volume":"6","author":"T Vink","year":"2001","journal-title":"Mol Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/27376","article-title":"Leptin and the regulation of body weight in mammals","volume":"395","author":"JM Friedman","year":"1998","journal-title":"Nature"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nm1029","article-title":"Adiponectin acts in the brain to decrease body weight","volume":"10","author":"Y Qi","year":"2004","journal-title":"Nat Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cmet.2007.06.003","article-title":"Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake","volume":"6","author":"N Kubota","year":"2007","journal-title":"Cell Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/S0140-6736(95)91955-4","article-title":"Plasma concentrations of obese protein in anorexia nervosa","volume":"346","author":"J Hebebrand","year":"1995","journal-title":"Lancet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1210\/jc.2003-031260","article-title":"Adiponectin in anorexia nervosa and bulimia nervosa","volume":"89","author":"T Tagami","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1210\/jc.2004-1364","article-title":"Serum adiponectin and resistin concentrations in patients with restrictive and binge\/purge form of anorexia nervosa and bulimia nervosa","volume":"90","author":"J Housova","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1210\/jc.2006-2855","article-title":"Relationships between serum adipokines, insulin levels, and bone density in girls with anorexia nervosa","volume":"92","author":"M Misra","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/ejcn.2010.66","article-title":"Specific adipocytokines profiles in patients with hyperactive and\/or binge\/purge form of anorexia nervosa","volume":"64","author":"JP Nogueira","year":"2010","journal-title":"Eur J Clin Nutr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"10302","DOI":"10.1073\/pnas.0403760101","article-title":"A family of Acrp30\/adiponectin structural and functional paralogs","volume":"101","author":"GW Wong","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1096\/fj.08-114991","article-title":"Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin","volume":"23","author":"GW Wong","year":"2009","journal-title":"FASEB J"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1042\/BJ20081240","article-title":"Molecular, biochemical and functional characterizations of C1q\/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions","volume":"416","author":"GW Wong","year":"2008","journal-title":"Biochem J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"10301","DOI":"10.1074\/jbc.M111.303651","article-title":"C1q\/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes","volume":"287","author":"Z Wei","year":"2012","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15652","DOI":"10.1074\/jbc.M110.201087","article-title":"Metabolic regulation by C1q\/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling","volume":"286","author":"Z Wei","year":"2011","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"11968","DOI":"10.1074\/jbc.M111.336834","article-title":"Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis","volume":"287","author":"MM Seldin","year":"2012","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Wei Z, Seldin MM, Natarajan N, Djemal DC, Peterson JM, <etal>et al<\/etal>.. (2013) C1q\/TNF-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. J Biol Chem (<italic>in press<\/italic>).","DOI":"10.1074\/jbc.M113.458711"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"39691","DOI":"10.1074\/jbc.M110.180695","article-title":"C1q\/TNF-related Protein-3 (CTRP3), a Novel Adipokine That Regulates Hepatic Glucose Output","volume":"285","author":"JM Peterson","year":"2010","journal-title":"J Biol Chem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1074\/jbc.M111.278333","article-title":"C1q\/TNF-related protein-1 (CTRP1) enhances fatty acid oxidation via AMPK activation and ACC inhibition","volume":"287","author":"JM Peterson","year":"2012","journal-title":"J Biol Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1677\/jme.1.01808","article-title":"Hypothalamic neuropeptide expression following chronic food restriction in sedentary and wheel-running rats","volume":"35","author":"CE de Rijke","year":"2005","journal-title":"J Mol Endocrinol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.peptides.2004.11.027","article-title":"alpha-MSH enhances activity-based anorexia","volume":"26","author":"JJ Hillebrand","year":"2005","journal-title":"Peptides"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.biopsych.2005.03.011","article-title":"Leptin treatment in activity-based anorexia","volume":"58","author":"JJ Hillebrand","year":"2005","journal-title":"Biol Psychiatry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"R148","DOI":"10.1152\/ajpregu.00041.2006","article-title":"Intracerebroventricular C75 decreases meal frequency and reduces AgRP gene expression in rats","volume":"291","author":"S Aja","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref27","unstructured":"Lusk G (1928) The elements of the science of nutrition. Philadelphia London: W. B. Saunders company."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0031-9384(03)00102-1","article-title":"Hyperactivity in patients with anorexia nervosa and in semistarved rats: evidence for a pivotal role of hypoleptinemia","volume":"79","author":"J Hebebrand","year":"2003","journal-title":"Physiol Behav"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0010-440X(97)90927-5","article-title":"The prevalence of high-level exercise in the eating disorders: etiological implications","volume":"38","author":"C Davis","year":"1997","journal-title":"Compr Psychiatry"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.neuroscience.2012.03.024","article-title":"Animal models of eating disorders","volume":"211","author":"SF Kim","year":"2012","journal-title":"Neuroscience"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/978-1-61779-458-2_25","article-title":"The activity-based anorexia mouse model","volume":"829","author":"SJ Klenotich","year":"2012","journal-title":"Methods Mol Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"e50453","DOI":"10.1371\/journal.pone.0050453","article-title":"Identifying predictors of activity based anorexia susceptibility in diverse genetic rodent populations","volume":"7","author":"E Pjetri","year":"2012","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.euroneuro.2006.04.007","article-title":"Difference in susceptibility to activity-based anorexia in two inbred strains of mice","volume":"17","author":"C Gelegen","year":"2007","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1601-183X.2008.00394.x","article-title":"Dopaminergic and brain-derived neurotrophic factor signalling in inbred mice exposed to a restricted feeding schedule","volume":"7","author":"C Gelegen","year":"2008","journal-title":"Genes Brain Behav"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1038\/npp.2012.7","article-title":"Olanzapine, but not fluoxetine, treatment increases survival in activity-based anorexia in mice","volume":"37","author":"SJ Klenotich","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.euroneuro.2010.04.002","article-title":"Activity-based anorexia in C57\/BL6 mice: effects of the phytocannabinoid, Delta9-tetrahydrocannabinol (THC) and the anandamide analogue, OMDM-2","volume":"20","author":"DY Lewis","year":"2010","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.med.050208.200745","article-title":"Anorexia nervosa: current status and future directions","volume":"61","author":"E Attia","year":"2010","journal-title":"Annu Rev Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0140-6736(09)61748-7","article-title":"Eating disorders","volume":"375","author":"J Treasure","year":"2010","journal-title":"Lancet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev.nutr.27.061406.093713","article-title":"The genetics of anorexia nervosa","volume":"27","author":"CM Bulik","year":"2007","journal-title":"Annu Rev Nutr"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/eat.20484","article-title":"Familiality and heritability of binge eating disorder: results of a case-control family study and a twin study","volume":"41","author":"KN Javaras","year":"2008","journal-title":"Int J Eat Disord"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/PSY.0b013e31815c40f1","article-title":"Shared temperament risk factors for anorexia nervosa: a twin study","volume":"70","author":"TD Wade","year":"2008","journal-title":"Psychosom Med"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0062862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T21:03:41Z","timestamp":1562965421000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0062862"}},"subtitle":[],"editor":[{"given":"Wanli","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,25]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0062862","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,25]]}}}