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A marker with high specificity for cardiac injury","volume":"88","year":"1993","journal-title":"Circulation"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1503\/cmaj\/051291","article-title":"Troponin: the biomarker of choice for the detection of cardiac injury","volume":"173","author":"L Babuin","year":"2005","journal-title":"Cmaj"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1161\/01.CIR.87.5.1715","article-title":"Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes","volume":"87","author":"H Ito","year":"1993","journal-title":"Circulation"},{"key":"ref85","first-page":"1020","article-title":"Melanocortin receptor type 2 (MC2R, ACTH receptor) expression in patients with alopecia areata","volume":"19","author":"HW Guo","year":"2011","journal-title":"Exp Dermatol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1677\/JOE-07-0055","article-title":"Expression of extracellular matrix proteins and integrins in rat adrenal gland: importance for ACTH-associated functions","volume":"193","author":"M Otis","year":"2007","journal-title":"J Endocrinol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.matbio.2004.09.004","article-title":"Collagen, type V, alpha1 (COL5A1) is regulated by TGF-beta in osteoblasts","volume":"23","author":"S Kahai","year":"2004","journal-title":"Matrix Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mce.2012.01.019","article-title":"Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells","volume":"355","author":"JF Evans","year":"2012","journal-title":"Mol Cell Endocrinol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1749-6632.2009.05231.x","article-title":"ACTH is a novel regulator of bone mass","volume":"1192","author":"CM Isales","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"53331","DOI":"10.1074\/jbc.M409622200","article-title":"Type V collagen controls the initiation of collagen fibril assembly","volume":"279","author":"RJ Wenstrup","year":"2004","journal-title":"J Biol Chem"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3233\/THC-1997-51-209","article-title":"Structure and function of myocardial fibrillar collagen","volume":"5","author":"JB Caulfield","year":"1997","journal-title":"Technol Health Care"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1210\/jc.2010-0192","article-title":"Urinary cortisol and six-year risk of all-cause and cardiovascular mortality","volume":"95","author":"N Vogelzangs","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jad.2008.10.025","article-title":"HPA axis hyperactivity and cardiovascular mortality in mood disorder inpatients","volume":"116","author":"J Jokinen","year":"2009","journal-title":"J Affect Disord"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00004872-200502000-00024","article-title":"Adrenocorticotropic hormone is produced in the ventricle of patients with essential hypertension","volume":"23","author":"Y Mizuno","year":"2005","journal-title":"J Hypertens"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0062935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T08:29:01Z","timestamp":1688200141000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0062935"}},"subtitle":[],"editor":[{"given":"Christine","family":"Beeton","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,4,26]]},"references-count":94,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,4,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0062935","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,26]]}}}