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Chichester, UK: John Wiley and Sons. 285\u2013301."},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1210\/jc.2010-2877","article-title":"Effects of physiological variations in circulating insulin levels on bone turnover in humans","volume":"96","author":"R Basu","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1210\/jcem.87.7.8660","article-title":"Acute changes of bone turnover and PTH induced by insulin and glucose: euglycemic and hypoglycemic hyperinsulinemic clamp studies","volume":"87","author":"JA Clowes","year":"2002","journal-title":"J Clin Endocrinol Metab"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0063036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T09:00:09Z","timestamp":1595754009000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0063036"}},"subtitle":[],"editor":[{"given":"Bridget","family":"Wagner","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,3]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0063036","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,3]]}}}