{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:32:10Z","timestamp":1787596330511,"version":"build-2736575974"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0063233","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T21:08:42Z","timestamp":1369084122000},"page":"e63233","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":56,"title":["Clinical Effectiveness of Hymenoptera Venom Immunotherapy: A Prospective Observational Multicenter Study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity"],"prefix":"10.1371","volume":"8","author":[{"given":"Franziska","family":"Ru\u00ebff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Przybilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Beatrice","family":"Bil\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Scheipl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Aberer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bodzenta-Lukaszyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriano","family":"Bonifazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Campi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Darsow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Haeberli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hawranek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"K\u00fcchenhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliviero","family":"Quercia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Reider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schmid-Grendelmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Severino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunter Johannes","family":"Sturm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Treudler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunello","family":"W\u00fcthrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,5,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jaci.2009.08.027","article-title":"Predictors of severe systemic anaphylactic reactions in Hymenoptera venom allergy: the importance of baseline serum tryptase","volume":"124","author":"F Ru\u00ebff","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000328760","article-title":"Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal","volume":"157","author":"P Valent","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000073719","article-title":"Correlation between T-cell and mast cell activity in patients with chronic urticaria","volume":"132","author":"B Hidv\u00e9gi","year":"2003","journal-title":"Int Arch Allergy Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1610-0387.2005.05706.x","article-title":"Baseline serum levels of mast cell tryptase are raised in hemodialysis patients and associated with severity of pruritus","volume":"3","author":"S Dugas-Breit","year":"2005","journal-title":"J Dtsch Dermatol Ges"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.4049\/jimmunol.175.7.4167","article-title":"Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance","volume":"175","author":"T Kawakami","year":"2005","journal-title":"J Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1398-9995.2010.02470.x","article-title":"Influence of total and specific IgE, serum tryptase, and age on severity of allergic reactions to Hymenoptera stings","volume":"66","author":"S Blum","year":"2011","journal-title":"Allergy"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jaci.2010.04.025","article-title":"European Academy of Allergy and Clinical Immunology Interest Group. Predictors of side effects during the buildup phase of venom immunotherapy for Hymenoptera venom allergy: the importance of baseline serum tryptase","volume":"126","author":"F Ru\u00ebff","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"ref8","first-page":"852","article-title":"Joint Task Force on Practice Parameters; American Academy of Allergy, Asthma & Immunology (AAAAI); American College of Allergy, Asthma & Immunology (ACAAI); Joint Council of Allergy, Asthma and Immunology. Stinging insect hypersensitivity: a practice parameter update 2011","volume":"127","author":"DB Golden","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1046\/j.1365-2222.2003.01755.x","article-title":"Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy","volume":"33","author":"G Haeberli","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1111\/j.1398-9995.2009.02118.x","article-title":"Mastocytosis and insect venom allergy: diagnosis, safety and efficacy of venom immunotherapy","volume":"64","author":"M Niedoszytko","year":"2009","journal-title":"Allergy"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1111\/j.1398-9995.2005.00960.x","article-title":"EAACI Interest Group on Insect Venom Hypersensitivity. Prevention and treatment of hymenoptera venom allergy: guidelines for clinical practice","volume":"60","author":"F Bonifazi","year":"2005","journal-title":"Allergy"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/ACI.0b013e32833b280c","article-title":"Mastocytosis and insect venom allergy","volume":"10","author":"P Bonadonna","year":"2010","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"ref13","first-page":"216","article-title":"The sting challenge test in Hymenoptera venom allergy. Position paper of the Subcommittee on Insect Venom Allergy of the European Academy of Allergology and Clinical Immunology","volume":"51","author":"F Ru\u00ebff","year":"1996","journal-title":"Allergy"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1610-0387.2009.07125.x","article-title":"Hymenoptera venom allergy","volume":"8","author":"B Przybilla","year":"2010","journal-title":"J Dtsch Dermatol Ges"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2222.1991.tb01659.x","article-title":"Emergency treatment of allergic reactions to Hymenoptera stings","volume":"21","author":"U M\u00fcller","year":"1991","journal-title":"Clin Exp Allergy"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0140-6736(77)91953-5","article-title":"Incidence and severity of anaphylactoid reactions to colloid volume substitutes","volume":"1","author":"J Ring","year":"1977","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1111\/j.1398-9995.2012.02795.x","article-title":"Symptom profile and risk factors of anaphylaxis in Central Europe","volume":"67","author":"M Worm","year":"2012","journal-title":"Allergy"},{"key":"ref18","unstructured":"Wood SN. mgcv: GAMs with GCV\/AIC\/REML Smoothness Estimation and GAMMs by PQL. Available: http:\/\/stat.ethz.ch\/R-manual\/R-devel\/library\/mgcv\/html\/mgcv-package.html<\/ext-link>. Accessed 2013 Apr 24."},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Wood SN (2006) Generalized Additive Models: An Introduction with R. Chapman & Hall\/CRC.","DOI":"10.1201\/9781420010404"},{"key":"ref20","unstructured":"R Development Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. Version 2.14.2; Available: http:\/\/www.r-project.org<\/ext-link>. Accessed 2013 Apr 24."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/sim.3472","article-title":"Selecting variables in non-parametric regression models for binary response. An application to the computerized detection of breast cancer","volume":"28","author":"J Roca-Pardinas","year":"2008","journal-title":"Statistics in Medicine"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Elremeli M, Bulsara Max K, Daniels M, Boyle RJ (2010) Venom immunotherapy for preventing allergic reactions to insect stings. Cochrane Database Syst Rev; DOI: 10.1002\/14651858.CD008838.","DOI":"10.1002\/14651858.CD008838"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1590\/S1516-31802010000100007","article-title":"Specific immunotherapy using Hymenoptera venom: systematic review","volume":"128","author":"AS Watanabe","year":"2010","journal-title":"Sao Paulo Med J"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0149-2918(00)80039-9","article-title":"Effectiveness of specific immunotherapy in the treatment of hymenoptera venom hypersensitivity: a meta-analysis","volume":"22","author":"RN Ross","year":"2000","journal-title":"Clin Ther"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Hockenhull J, Elremeli M, Cherry MG, Mahon J, Lai M, et al<\/etal>.. (2012) A systematic review of the clinical effectiveness and cost-effectiveness of Pharmalgen\u00ae for the treatment of bee and wasp venom allergy. Health Technol Assess; 16: III\u2013IV, 1\u2013110.","DOI":"10.3310\/hta16120"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0091-6749(88)90008-5","article-title":"The Hymenoptera venom study I, 1979\u20131982: demographics and history-sting data","volume":"82","author":"RF Lockey","year":"1988","journal-title":"J Allergy Clin Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S1081-1206(10)61259-8","article-title":"Stinging and biting insect allergy: an Australian experience","volume":"93","author":"GO Solley","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref28","first-page":"900","article-title":"Determining whether a patient is feeling better: pitfalls from the science of human perception. J Gen Intern Med","volume":"26","author":"DA Redelmeier","year":"2011"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Hassan E (2006) Recall Bias can be a threat to retrospective and prospective research designs. Internet J Epidemiol. The Internet Journal of Epidemiology 3. DOI: 10.5580\/2732.","DOI":"10.5580\/2732"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.jaci.2005.12.1313","article-title":"Clinical and entomological factors influence the outcome of sting challenge studies","volume":"117","author":"DB Golden","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1111\/j.1365-2222.2011.03788.x","article-title":"British Society for Allergy and Clinical Immunology. Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines","volume":"41","author":"MT Krishna","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"ref32","first-page":"380","article-title":"[The registry for severe allergic reactions in German-speaking countries. Recent data and perspectives]","volume":"55","author":"M Worm","year":"2012","journal-title":"Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1398-9995.2009.02198.x","article-title":"Bee venom immunotherapy - how early is it effective?","volume":"65","author":"A Goldberg","year":"2010","journal-title":"Allergy"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2249.2010.04287.x","article-title":"Raised tryptase without anaphylaxis or mastocytosis: heterophilic antibody interference in the serum tryptase assay","volume":"163","author":"R Sargur","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.jaci.2005.07.023","article-title":"False-elevated serum tryptase assay result caused by heterophilic antibodies","volume":"116","author":"AW Van Toorenenbergen","year":"2005","journal-title":"J Allergy Clin Immunol"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0063233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T22:31:04Z","timestamp":1715380264000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0063233"}},"subtitle":[],"editor":[{"given":"Edward Gautier","family":"Brooks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,20]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0063233","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,20]]}}}