{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:47:22Z","timestamp":1778834842232,"version":"3.51.4"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0063321","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T03:08:23Z","timestamp":1367464103000},"page":"e63321","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Overexpression of Retinal Degeneration Slow (RDS) Protein Adversely Affects Rods in the rd7 Model of Enhanced S-Cone Syndrome"],"prefix":"10.1371","volume":"8","author":[{"given":"Dibyendu","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon M.","family":"Conley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muna I.","family":"Naash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,5,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1073\/pnas.96.9.4814","article-title":"Identification of a photoreceptor cell-specific nuclear receptor","volume":"96","author":"M Kobayashi","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/ng774","article-title":"Nrl is required for rod photoreceptor development","volume":"29","author":"AJ Mears","year":"2001","journal-title":"Nature Genetics"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainres.2008.01.028","article-title":"Rod differentiation factor NRL activates the expression of nuclear receptor NR2E3 to suppress the development of cone photoreceptors","volume":"1236","author":"EC Oh","year":"2008","journal-title":"Brain Research"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/hmg\/ddi070","article-title":"The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes","volume":"14","author":"GH Peng","year":"2005","journal-title":"Hum Mol Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1523\/JNEUROSCI.3571-04.2005","article-title":"The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes","volume":"25","author":"J Chen","year":"2005","journal-title":"J Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1073\/pnas.0508214103","article-title":"Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors","volume":"103","author":"M Akimoto","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/72777","article-title":"Mutation of a nuclear receptor gene, NR2E3, causes enhanced S cone syndrome, a disorder of retinal cell fate","volume":"24","author":"NB Haider","year":"2000","journal-title":"Nat Genet"},{"key":"ref8","first-page":"827","article-title":"SWS (blue) cone hypersensitivity in a newly identified retinal degeneration","volume":"31","author":"SG Jacobson","year":"1990","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/S0002-9394(14)72379-7","article-title":"Relatively enhanced S cone function in the Goldmann-Favre syndrome","volume":"111","author":"SG Jacobson","year":"1991","journal-title":"American Journal of Ophthalmology"},{"key":"ref10","first-page":"1970","article-title":"The Gly56Arg mutation in NR2E3 accounts for 1\u20132% of autosomal dominant retinitis pigmentosa","volume":"13","author":"AI Gire","year":"2007","journal-title":"Molecular Vision"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ajo.2007.03.012","article-title":"Atypical mild enhanced S-cone syndrome with novel compound heterozygosity of the NR2E3 gene","volume":"144","author":"BL Lam","year":"2007","journal-title":"American Journal of Ophthalmology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.ophtha.2005.07.002","article-title":"Novel NR2E3 mutations (R104Q, R334G) associated with a mild form of enhanced S-cone syndrome demonstrate compound heterozygosity","volume":"112","author":"T Hayashi","year":"2005","journal-title":"Ophthalmology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1136\/bjo.2005.068130","article-title":"An Arg311Gln NR2E3 mutation in a family with classic Goldmann-Favre syndrome","volume":"89","author":"SH Chavala","year":"2005","journal-title":"British Journal of Ophthalmology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1136\/bjo.60.5.345","article-title":"Diagnostic features of the Favre-Goldmann syndrome","volume":"60","author":"GA Fishman","year":"1976","journal-title":"British Journal of Ophthalmology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1073\/pnas.97.10.5551","article-title":"A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse","volume":"97","author":"NB Akhmedov","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1093\/hmg\/10.16.1619","article-title":"Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7\/rd7 mice","volume":"10","author":"NB Haider","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1371\/journal.pgen.0010011","article-title":"A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome","volume":"1","author":"JC Corbo","year":"2005","journal-title":"PLoS Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1093\/hmg\/ddr334","article-title":"Excess cones in the retinal degeneration rd7 mouse, caused by the loss of function of orphan nuclear receptor Nr2e3, originate from early-born photoreceptor precursors","volume":"20","author":"H Cheng","year":"2011","journal-title":"Human Molecular Genetics"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00335-008-9138-5","article-title":"A novel mutation in Prph2, a gene regulated by Nr2e3, causes retinal degeneration and outer-segment defects similar to Nr2e3 ( rd7\/rd7 ) retinas","volume":"19","author":"AM Nystuen","year":"2008","journal-title":"Mamm Genome"},{"key":"ref20","first-page":"50","article-title":"Peripherin. A rim-specific membrane protein of rod outer segment discs","volume":"28","author":"RS Molday","year":"1987","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1083\/jcb.116.3.659","article-title":"Localization of peripherin\/rds in the disk membranes of cone and rod photoreceptors: relationship to disk membrane morphogenesis and retinal degeneration","volume":"116","author":"K Arikawa","year":"1992","journal-title":"J Cell Biol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/354480a0","article-title":"Mutations in the human retinal degeneration slow gene in autosomal dominant retinitis pigmentosa","volume":"354","author":"K Kajiwara","year":"1991","journal-title":"Nature"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ng0393-213","article-title":"Mutations in the human retinal degeneration slow (RDS) gene can cause either retinitis pigmentosa or macular dystrophy","volume":"3","author":"J Wells","year":"1993","journal-title":"Nature Genetics"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1167\/iovs.04-0065","article-title":"Modulating expression of peripherin\/rds in transgenic mice: critical levels and the effect of overexpression","volume":"45","author":"M Nour","year":"2004","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/978-0-387-74904-4_14","article-title":"Genetic supplementation of RDS alleviates a loss-of-function phenotype in C214S model of retinitis pigmentosa","volume":"613","author":"M Nour","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1093\/hmg\/ddh211","article-title":"The R172W mutation in peripherin\/rds causes a cone-rod dystrophy in transgenic mice","volume":"13","author":"XQ Ding","year":"2004","journal-title":"Human Molecular Genetics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"8118","DOI":"10.1523\/JNEUROSCI.17-21-08118.1997","article-title":"The effect of peripherin\/rds haploinsufficiency on rod and cone photoreceptors","volume":"17","author":"T Cheng","year":"1997","journal-title":"J Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/0014-4835(85)90179-4","article-title":"Development and degeneration of retina in rds mutant mice: photoreceptor abnormalities in the heterozygotes","volume":"41","author":"RK Hawkins","year":"1985","journal-title":"Exp Eye Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1093\/hmg\/ddq410","article-title":"Differences in RDS trafficking, assembly and function in cones versus rods: insights from studies of C150S-RDS","volume":"19","author":"D Chakraborty","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1083\/jcb.200509036","article-title":"Retention of function without normal disc morphogenesis occurs in cone but not rod photoreceptors","volume":"173","author":"R Farjo","year":"2006","journal-title":"Journal of Cell Biology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/hmg\/ddn406","article-title":"Differential requirements for retinal degeneration slow intermolecular disulfide-linked oligomerization in rods versus cones","volume":"18","author":"D Chakraborty","year":"2009","journal-title":"Hum Mol Genet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/978-1-4614-0631-0_83","article-title":"Mislocalization of Oligomerization-Incompetent RDS is Associated with Mislocalization of Cone Opsins and Cone Transducin","volume":"723","author":"SM Conley","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.exer.2009.04.006","article-title":"Nr2e3-directed transcriptional regulation of genes involved in photoreceptor development and cell-type specific phototransduction","volume":"89","author":"NB Haider","year":"2009","journal-title":"Experimental Eye Research"},{"key":"ref34","first-page":"589","article-title":"The relationship between opsin overexpression and photoreceptor degeneration","volume":"42","author":"E Tan","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.bpj.2008.10.016","article-title":"Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors","volume":"96","author":"XH Wen","year":"2009","journal-title":"Biophys J"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1021\/bi701807c","article-title":"Outer segment oligomerization of rds: evidence from mouse models and subcellular fractionation","volume":"47","author":"D Chakraborty","year":"2008","journal-title":"Biochemistry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/cne.21476","article-title":"Effect of Rds abundance on cone outer segment morphogenesis, photoreceptor gene expression, and outer limiting membrane integrity","volume":"504","author":"R Farjo","year":"2007","journal-title":"Journal of Comparative Neurology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.preteyeres.2008.01.002","article-title":"The spectrum of retinal dystrophies caused by mutations in the peripherin\/RDS gene","volume":"27","author":"CJ Boon","year":"2008","journal-title":"Prog Retin Eye Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00335-008-9138-5","article-title":"A novel mutation in Prph2, a gene regulated by Nr2e3, causes retinal degeneration and outer-segment defects similar to Nr2e3 ( rd7\/rd7 ) retinas","volume":"19","author":"AM Nystuen","year":"2008","journal-title":"Mammalian Genome"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.1021\/bi048414i","article-title":"Role of the second intradiscal loop of peripherin\/rds in homo and hetero associations","volume":"44","author":"XQ Ding","year":"2005","journal-title":"Biochemistry"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1042\/BJ20041960","article-title":"The Cys214\u2192Ser mutation in peripherin\/rds causes a loss-of-function phenotype in transgenic mice","volume":"388","author":"HM Stricker","year":"2005","journal-title":"Biochemical Journal"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1172\/JCI64833","article-title":"DNA nanoparticle-mediated ABCA4 delivery rescues Stargardt dystrophy in mice","volume":"122","author":"Z Han","year":"2012","journal-title":"Journal of Clinical Investigation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1021\/bi901622w","article-title":"Biochemical analysis of phenotypic diversity associated with mutations in codon 244 of the retinal degeneration slow gene","volume":"49","author":"SM Conley","year":"2010","journal-title":"Biochemistry"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0063321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T04:36:01Z","timestamp":1562992561000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0063321"}},"subtitle":[],"editor":[{"given":"Alexander V.","family":"Ljubimov","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,1]]},"references-count":43,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0063321","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,1]]}}}