{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:46:18Z","timestamp":1767177978476,"version":"build-2238731810"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0063340","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T17:03:53Z","timestamp":1368551033000},"page":"e63340","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Perforin Is Detrimental to Controllin\u03b3 C. muridarum Replication In Vitro, but Not In Vivo"],"prefix":"10.1371","volume":"8","author":[{"given":"Raymond M.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micah S.","family":"Kerr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Slaven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,5,14]]},"reference":[{"key":"ref1","unstructured":"(2011) Sexually Transmitted Disease Surveillance 2010. In: Prevention CfDCa, editor. Atlanta, GA: U.S. Department of Health and Human Services."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1086\/497341","article-title":"The Unexpected Impact of a Chlamydia trachomatis Infection Control Program on Susceptibility to Reinfection","volume":"192","author":"RC Brunham","year":"2005","journal-title":"J Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/OLQ.0b013e31815e41a3","article-title":"The arrested immunity hypothesis and the epidemiology of chlamydia control","volume":"35","author":"RC Brunham","year":"2008","journal-title":"Sex Transm Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/sti.2007.027938","article-title":"Epidemiology of chlamydial infection: are we losing ground?","volume":"84","author":"ML Rekart","year":"2008","journal-title":"Sex Transm Infect"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/clinids\/7.6.713","article-title":"Overview of Chlamydia trachomatis infection and the requirements for a vaccine","volume":"7","author":"J Schachter","year":"1985","journal-title":"Rev Infect Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1128\/IAI.70.6.2741-2751.2002","article-title":"Immunity to murine chlamydial genital infection","volume":"70","author":"RP Morrison","year":"2002","journal-title":"Infect Immun"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1086\/605411","article-title":"Role of T lymphocytes in the pathogenesis of Chlamydia disease","volume":"200","author":"JU Igietseme","year":"2009","journal-title":"J Infect Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1128\/IAI.05022-11","article-title":"Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infection","volume":"79","author":"AK Murthy","year":"2011","journal-title":"Infect Immun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2567.1996.d01-655.x","article-title":"The molecular mechanism of T-cell control of Chlamydia in mice: role of nitric oxide","volume":"87","author":"JU Igietseme","year":"1996","journal-title":"Immunology"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/jlb.59.5.656","article-title":"Integrin-mediated epithelial-T cell interaction enhances nitric oxide production and increased intracellular inhibition of Chlamydia","volume":"59","author":"JU Igietseme","year":"1996","journal-title":"J Leukoc Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1128\/IAI.66.4.1282-1286.1998","article-title":"Chlamydial infection in inducible nitric oxide synthase knockout mice","volume":"66","author":"JU Igietseme","year":"1998","journal-title":"Infect Immun"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1128\/IAI.66.2.835-838.1998","article-title":"Inducible nitric oxide synthase does not affect resolution of murine chlamydial genital tract infections or eradication of chlamydiae in primary murine cell culture","volume":"66","author":"KH Ramsey","year":"1998","journal-title":"Infect Immun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.4049\/jimmunol.1102764","article-title":"Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract","volume":"188","author":"RM Johnson","year":"2012","journal-title":"J Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1128\/IAI.69.8.5131-5137.2001","article-title":"Chlamydia trachomatis persistence in the female mouse genital tract: inducible nitric oxide synthase and infection outcome","volume":"69","author":"KH Ramsey","year":"2001","journal-title":"Infect Immun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1128\/IAI.67.3.1379-1385.1999","article-title":"Clearance of Chlamydia trachomatis from the murine genital mucosa does not require perforin-mediated cytolysis or Fas-mediated apoptosis","volume":"67","author":"LL Perry","year":"1999","journal-title":"Infect Immun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.4049\/jimmunol.1002596","article-title":"Chlamydia-specific CD4 T cell clones control Chlamydia muridarum replication in epithelial cells by nitric oxide-dependent and -independent mechanisms","volume":"185","author":"K Jayarapu","year":"2010","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4469","DOI":"10.1128\/IAI.00491-09","article-title":"Chlamydia muridarum-specific CD4 T-cell clones recognize infected reproductive tract epithelial cells in an interferon-dependent fashion","volume":"77","author":"K Jayarapu","year":"2009","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1128\/IAI.72.7.3951-3960.2004","article-title":"Murine oviduct epithelial cell cytokine responses to Chlamydia muridarum infection include interleukin-12-p70 secretion","volume":"72","author":"RM Johnson","year":"2004","journal-title":"Infect Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5132","DOI":"10.1128\/IAI.70.9.5132-5139.2002","article-title":"A Chlamydia trachomatis-specific Th2 clone does not provide protection against a genital infection and displays reduced trafficking to the infected genital mucosa","volume":"70","author":"RA Hawkins","year":"2002","journal-title":"Infect Immun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.4049\/jimmunol.1002952","article-title":"Immunization with live and dead Chlamydia muridarum induces different levels of protective immunity in a murine genital tract model: correlation with MHC class II peptide presentation and multifunctional Th1 cells","volume":"186","author":"H Yu","year":"2011","journal-title":"J Immunol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1093\/humrep\/17.8.2073","article-title":"HLA DQ alleles and interleukin-10 polymorphism associated with Chlamydia trachomatis-related tubal factor infertility: a case-control study","volume":"17","author":"AH Kinnunen","year":"2002","journal-title":"Hum Reprod"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e1001339","DOI":"10.1371\/journal.ppat.1001339","article-title":"Interleukin-13 promotes susceptibility to chlamydial infection of the respiratory and genital tracts","volume":"7","author":"KL Asquith","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref23","unstructured":"Johnson RM (2012) Chlamydial Infections. In: Eugene Rosenberg EFD, Fabiano Thompson, Stephen Lory, Erko Stackebrandt editor. The Prokaryotes, 4th Edition. NY: Springer Publishing Co."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1128\/IAI.69.4.2643-2649.2001","article-title":"Resolution of secondary Chlamydia trachomatis genital tract infection in immune mice with depletion of both CD4+ and CD8+ T cells","volume":"69","author":"SG Morrison","year":"2001","journal-title":"Infect Immun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"7536","DOI":"10.4049\/jimmunol.175.11.7536","article-title":"A predominant role for antibody in acquired immunity to chlamydial genital tract reinfection","volume":"175","author":"SG Morrison","year":"2005","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.0019-2805.2001.01354.x","article-title":"Fc receptor regulation of protective immunity against Chlamydia trachomatis","volume":"105","author":"T Moore","year":"2002","journal-title":"Immunology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"10658","DOI":"10.1073\/pnas.0504198102","article-title":"Chlamydial IFN-{gamma} immune evasion is linked to host infection tropism","volume":"102","author":"DE Nelson","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1128\/IAI.06339-11","article-title":"PmpG303\u2013311, a protective vaccine epitope that elicits persistent cellular immune responses in Chlamydia muridarum-immune mice","volume":"80","author":"RM Johnson","year":"2012","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1365-2249.2004.02596.x","article-title":"Effects of Chlamydia trachomatis infection on the expression of natural killer (NK) cell ligands and susceptibility to NK cell lysis","volume":"138","author":"CE Hook","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1574-695X.2012.00930.x","article-title":"Modulation of MICA on the surface of Chlamydia trachomatis-infected endocervical epithelial cells promotes NK cell-mediated killing","volume":"65","author":"JA Ibana","year":"2012","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1128\/IAI.61.5.1829-1834.1993","article-title":"Characterization of kinetics and target proteins for binding of human complement component C3 to the surface-exposed outer membrane of Chlamydia trachomatis serovar L2","volume":"61","author":"RT Hall","year":"1993","journal-title":"Infect Immun"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1128\/IAI.60.6.2547-2550.1992","article-title":"Early complement components enhance neutralization of Chlamydia trachomatis infectivity by human sera","volume":"60","author":"JS Lin","year":"1992","journal-title":"Infect Immun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e50327","DOI":"10.1371\/journal.pone.0050327","article-title":"A New Role of the Complement System: C3 Provides Protection in a Mouse Model of Lung Infection with Intracellular Chlamydia psittaci","volume":"7","author":"J Bode","year":"2012","journal-title":"PLoS ONE"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1128\/IAI.45.3.674-678.1984","article-title":"Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis)","volume":"45","author":"DM Williams","year":"1984","journal-title":"Infect Immun"}],"updated-by":[{"DOI":"10.1371\/annotation\/b7213da3-498c-43bf-b42c-1f22934e17dd","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,7,2]],"date-time":"2013-07-02T00:00:00Z","timestamp":1372723200000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0063340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T15:12:44Z","timestamp":1595776364000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0063340"}},"subtitle":[],"editor":[{"given":"Kyle","family":"Ramsey","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,14]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0063340","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,14]]}}}