{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:41:12Z","timestamp":1777426872329,"version":"3.51.4"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T00:00:00Z","timestamp":1369699200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0063410","type":"journal-article","created":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T04:01:04Z","timestamp":1369800064000},"page":"e63410","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":68,"title":["Thrombocytopenia in Plasmodium vivax Malaria Is Related to Platelets Phagocytosis"],"prefix":"10.1371","volume":"8","author":[{"given":"Helena Cristina C.","family":"Coelho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie C. P.","family":"Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo D.","family":"Pimentel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo A.","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio T. M.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 M.","family":"Siqueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisely C.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuelton M.","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Malheiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus V. G.","family":"Lacerda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,5,28]]},"reference":[{"key":"ref1","unstructured":"World Health Organization. (2011) World malaria report 2011. Geneva: World Health Organization. xii, 246 p. p."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1371\/journal.pmed.0050038","article-title":"The limits and intensity of Plasmodium falciparum transmission: implications for malaria control and elimination worldwide","volume":"5","author":"CA Guerra","year":"2008","journal-title":"PLoS Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.pt.2009.02.003","article-title":"The pathophysiology of vivax malaria","volume":"25","author":"NM Anstey","year":"2009","journal-title":"Trends Parasitol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1475-2875-11-12","article-title":"Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature","volume":"11","author":"MV Lacerda","year":"2012","journal-title":"Malar J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e774","DOI":"10.1371\/journal.pntd.0000774","article-title":"The international limits and population at risk of Plasmodium vivax transmission in 2009","volume":"4","author":"CA Guerra","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1475-2875-9-115","article-title":"Malaria in Brazil: an overview","volume":"9","author":"J Oliveira-Ferreira","year":"2010","journal-title":"Malar J"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1053\/beha.1999.0072","article-title":"Blood and bone marrow changes in malaria","volume":"13","author":"SN Wickramasinghe","year":"2000","journal-title":"Baillieres Best Pract Res Clin Haematol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1590\/S0074-02762011000900007","article-title":"Thrombocytopenia in malaria: who cares?","volume":"106","author":"MV Lacerda","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref9","unstructured":"Alecrim MGC (2000) Clinical aspects, resistance and parasitary polymorphism of Plasmodium vivax malaria in Manaus. Bras\u00edlia: Universidade de Bras\u00edlia. 176 p."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3109\/09537104.2010.505308","article-title":"Thrombocytopenia in Plasmodium falciparum, Plasmodium vivax and mixed infection malaria: a study from Bikaner (Northwestern India)","volume":"21","author":"DK Kochar","year":"2010","journal-title":"Platelets"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3109\/09537104.2011.607520","article-title":"Thrombocytopenia in childhood malaria with special reference to P. vivax monoinfection: A study from Bikaner (Northwestern India)","volume":"23","author":"GS Tanwar","year":"2012","journal-title":"Platelets"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00018-009-0211-3","article-title":"The role of platelets in the pathogenesis of cerebral malaria","volume":"67","author":"D Cox","year":"2010","journal-title":"Cell Mol Life Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S0036-46652003000100006","article-title":"Clinical and laboratory findings of Plasmodium vivax malaria in Colombia, 2001","volume":"45","author":"M Echeverri","year":"2003","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1023\/A:1014341611412","article-title":"Thrombocytopenia in an animal model of malaria is associated with an increased caspase-mediated death of thrombocytes","volume":"7","author":"PF Piguet","year":"2002","journal-title":"Apoptosis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4269\/ajtmh.2004.70.8","article-title":"Hematologic and clinical indices of malaria in a semi-immune population of western Thailand","volume":"70","author":"LM Erhart","year":"2004","journal-title":"Am J Trop Med Hyg"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1136\/bmj.2.5865.515","article-title":"Mechanisms of thrombocytopenia in malignant tertian malaria","volume":"2","author":"RB Skudowitz","year":"1973","journal-title":"Br Med J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1172\/JCI110836","article-title":"Immune-mediated thrombocytopenia of malaria","volume":"71","author":"JG Kelton","year":"1983","journal-title":"J Clin Invest"},{"key":"ref18","first-page":"44","article-title":"Thrombocytopenia in malaria","volume":"23","author":"S Looareesuwan","year":"1992","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/(SICI)1096-8652(199711)56:3<183::AID-AJH9>3.0.CO;2-U","article-title":"Severe thrombocytopenia suggesting immunological mechanisms in two cases of vivax malaria","volume":"56","author":"S Yamaguchi","year":"1997","journal-title":"Am J Hematol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-0038-1655955","article-title":"Plasma macrophage colony-stimulating factor and P-selectin levels in malaria-associated thrombocytopenia","volume":"77","author":"SH Lee","year":"1997","journal-title":"Thromb Haemost"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1182\/blood-2011-02-336420","article-title":"Peripheral hemophagocytosis in malaria infection","volume":"119","author":"E Klein","year":"2012","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1136\/jcp.38.11.1318","article-title":"Platelet phagocytosis: a probable mechanism of thrombocytopenia in Plasmodium falciparum infection","volume":"38","author":"MS Jaff","year":"1985","journal-title":"J Clin Pathol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0035-9203(03)90065-4","article-title":"Simultaneous identification of the four human Plasmodium species and quantification of Plasmodium DNA load in human blood by real-time polymerase chain reaction","volume":"97","author":"F Monbrison","year":"2003","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"841","DOI":"10.4269\/ajtmh.2009.80.841","article-title":"Increased phagocytosis of platelets from patients with secondary dengue virus infection by human macrophages","volume":"80","author":"S Honda","year":"2009","journal-title":"Am J Trop Med Hyg"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"686","DOI":"10.4269\/ajtmh.2002.66.686","article-title":"Prognostic value of thrombocytopenia in African children with falciparum malaria","volume":"66","author":"P Gerardin","year":"2002","journal-title":"Am J Trop Med Hyg"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/adc.2003.045179","article-title":"Thrombocytopenia is predictive of lethality in severe childhood falciparum malaria","volume":"89","author":"C Rogier","year":"2004","journal-title":"Arch Dis Child"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3201\/eid1101.040519","article-title":"Plasmodium vivax malaria","volume":"11","author":"DK Kochar","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1475-2875-9-13","article-title":"Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance","volume":"9","author":"BB Andrade","year":"2010","journal-title":"Malar J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1475-2875-9-S3-S4","article-title":"Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya","volume":"9","author":"RN Maina","year":"2010","journal-title":"Malar J"},{"key":"ref30","first-page":"187","article-title":"[Hematologic variations in patient with malaria caused by Plasmodium vivax before, during and after treatment]","volume":"50","author":"B Gonzalez","year":"2009","journal-title":"Invest Clin"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1179\/2047773211Y.0000000013","article-title":"Thrombocytopenia in vivax and falciparum malaria: an observational study of 131 patients in Karnataka, India","volume":"105","author":"K Saravu","year":"2011","journal-title":"Ann Trop Med Parasitol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/0972-9062.213462","article-title":"Platelet count and parasite density: independent variable in Plasmodium vivax malaria","volume":"49","author":"DK Kochar","year":"2012","journal-title":"J Vector Borne Dis"},{"key":"ref33","first-page":"678","article-title":"[Platelet antibody activity in malaria thrombocytopenia]","volume":"38","author":"JE Touze","year":"1990","journal-title":"Pathol Biol (Paris)"},{"key":"ref34","first-page":"12","article-title":"Naturally occurring plasmodia-specific circulating immune complexes in individuals of malaria endemic areas in India","volume":"36","author":"P Tyagi","year":"1999","journal-title":"Indian J Malariol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/j.1537-2995.2006.00913.x","article-title":"Platelet binding and phagocytosis by macrophages","volume":"46","author":"BA Badlou","year":"2006","journal-title":"Transfusion"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/j.1365-2141.2010.08399.x","article-title":"Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy","volume":"151","author":"Q Mast","year":"2010","journal-title":"Br J Haematol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1365-2141.2000.02314.x","article-title":"Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: evidence for decreased platelet production","volume":"111","author":"JA Sosman","year":"2000","journal-title":"Br J Haematol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4269\/ajtmh.2006.75.434","article-title":"Thrombocytopenia in falciparum malaria is associated with high concentrations of IL-10","volume":"75","author":"C Casals-Pascual","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1179\/000349803235002416","article-title":"Serum cytokine profiles in patients with Plasmodium vivax malaria: a comparison between those who presented with and without thrombocytopenia","volume":"97","author":"JW Park","year":"2003","journal-title":"Ann Trop Med Parasitol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"6182","DOI":"10.4049\/jimmunol.160.12.6182","article-title":"Role of TNFR1 and TNFR2 in TNF-induced platelet consumption in mice","volume":"160","author":"F Tacchini-Cottier","year":"1998","journal-title":"J Immunol"},{"key":"ref41","first-page":"103","article-title":"Cytokines and clinical manifestations of malaria in adults with severe and uncomplicated disease","volume":"56","author":"A Wroczynska","year":"2005","journal-title":"Int Marit Health"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1590\/S0074-02762011000900009","article-title":"Biomarkers for susceptibility to infection and disease severity in human malaria","volume":"106","author":"BB Andrade","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"17097","DOI":"10.1073\/pnas.0805782105","article-title":"Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria","volume":"105","author":"TW Yeo","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/ijerph2005010123","article-title":"Cytokines and adhesion molecules expression in the brain in human cerebral malaria","volume":"2","author":"H Armah","year":"2005","journal-title":"Int J Environ Res Public Health"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0063410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T11:36:04Z","timestamp":1746012964000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0063410"}},"subtitle":[],"editor":[{"given":"Luzia Helena","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,28]]},"references-count":44,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0063410","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,28]]}}}