{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T22:17:14Z","timestamp":1758406634420},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T00:00:00Z","timestamp":1367452800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0063437","type":"journal-article","created":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T06:23:15Z","timestamp":1367562195000},"page":"e63437","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mapping the Ligand-Binding Region of Borrelia hermsii Fibronectin-Binding Protein"],"prefix":"10.1371","volume":"8","author":[{"given":"Christiane","family":"Brenner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Bomans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcri","family":"Habicht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus M.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Wallich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,5,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1086\/516273","article-title":"Tick-borne relapsing fever in the northwestern United States and southwestern Canada","volume":"26","author":"MS Dworkin","year":"1998","journal-title":"Clinical Infectious Diseases"},{"key":"ref2","first-page":"56","article-title":"An overview of tick-borne relapsing fever with emphasis on outbreaks in Texas","volume":"91","author":"JA Rawlings","year":"1995","journal-title":"Tex Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1128\/JCM.40.4.1558-1562.2002","article-title":"Equine abortion associated with the Borrelia parkeri-B. turicatae tick-borne relapsing fever spirochete group","volume":"40","author":"RL Walker","year":"2002","journal-title":"J Clin Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1939-165X.2007.tb00213.x","article-title":"Spirochetemia caused by Borrelia turicatae infection in 3 dogs in Texas","volume":"36","author":"MS Whitney","year":"2007","journal-title":"Vet Clin Pathol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/00006454-200207000-00020","article-title":"Tick-borne relapsing fever caused by Borrelia turicatae","volume":"21","author":"H Davis","year":"2002","journal-title":"Pediatr Infect Dis J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"436","DOI":"10.3201\/eid1303.060958","article-title":"Diversity and distribution of Borrelia hermsii","volume":"13","author":"TG Schwan","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6647","DOI":"10.1128\/IAI.73.10.6647-6658.2005","article-title":"Variable tick protein in two genomic groups of the relapsing fever spirochete Borrelia hermsii in western North America","volume":"73","author":"SF Porcella","year":"2005","journal-title":"Infect Immun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1128\/JCM.43.8.3851-3859.2005","article-title":"Phylogenetic Analysis of the Spirochetes Borrelia parkeri and Borrelia turicatae and the Potential for Tick-Borne Relapsing Fever in Florida","volume":"43","author":"TG Schwan","year":"2005","journal-title":"J Clin Microbiol"},{"key":"ref9","first-page":"155","article-title":"Antigenic variation of a relapsing fever <italic>Borrelia<\/italic> species","volume":"44","author":"AG Barbour","year":"1990","journal-title":"AnnRevMicrobiol"},{"key":"ref10","first-page":"390","article-title":"Tandem insertion sequence-like elements define the expression site for variable antigen genes of <italic>Borrelia hermsii<\/italic>","volume":"59","author":"AG Barbour","year":"1991","journal-title":"InfectImmun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"18290","DOI":"10.1073\/pnas.0605302103","article-title":"Pathogen escape from host immunity by a genome program for antigenic variation","volume":"103","author":"AG Barbour","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"7292","DOI":"10.4049\/jimmunol.178.11.7292","article-title":"Dual binding specificity of a Borrelia hermsii-associated complement regulator-acquiring surface protein for factor H and plasminogen discloses a putative virulence factor of relapsing fever spirochetes","volume":"178","author":"E Rossmann","year":"2007","journal-title":"J Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1128\/IAI.00089-10","article-title":"Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators","volume":"78","author":"M Schott","year":"2010","journal-title":"Infect Immun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1128\/IAI.74.4.2007-2014.2006","article-title":"Molecular analyses of the interaction of Borrelia hermsii FhbA with the complement regulatory proteins factor H and factor H-like protein 1","volume":"74","author":"KM Hovis","year":"2006","journal-title":"Infect Immun"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1128\/JB.186.9.2612-2618.2004","article-title":"Identification and characterization of a linear-plasmid-encoded factor H-binding protein (FhbA) of the relapsing fever spirochete Borrelia hermsii","volume":"186","author":"KM Hovis","year":"2004","journal-title":"J Bacteriol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.4049\/jimmunol.155.12.5663","article-title":"Mapping of the complement regulatory domains in the human factor H-like protein 1 and in factor H1","volume":"155","author":"S Kuhn","year":"1995","journal-title":"J Immunol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"12594","DOI":"10.1073\/pnas.91.26.12594","article-title":"The outer surface protein A of the spirochete Borrelia burgdorferi is a plasmin(ogen) receptor","volume":"91","author":"H Fuchs","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Brissette CA, Haupt K, Barthel D, Cooley AE, Bowman A, <etal>et al<\/etal>.. (2008) The Borrelia burgdorferi infection-associated surface proteins ErpP, ErpA, and ErpC bind human plasminogen. Infect Immun.","DOI":"10.1128\/IAI.01133-08"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e4858","DOI":"10.1371\/journal.pone.0004858","article-title":"Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity","volume":"4","author":"S Grosskinsky","year":"2009","journal-title":"PLoS ONE"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e698","DOI":"10.1371\/journal.pntd.0000698","article-title":"Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of Borrelia recurrentis","volume":"4","author":"S Grosskinsky","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref21","first-page":"4157","article-title":"Relapsing Fever Spirochetes Borrelia recurrentis and B. duttonii Acquire Complement Regulators C4b-Binding Protein and Factor H. Infect Immun","volume":"74","author":"T Meri","year":"2006"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1111\/j.1365-2958.2004.04027.x","article-title":"The molecular basis of fibronectin-mediated bacterial adherence to host cells","volume":"52","author":"U Schwarz-Linek","year":"2004","journal-title":"Mol Microbiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e1000169","DOI":"10.1371\/journal.ppat.1000169","article-title":"Molecular mechanisms involved in vascular interactions of the Lyme disease pathogen in a living host","volume":"4","author":"MU Norman","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1128\/IAI.73.4.2351-2359.2005","article-title":"Identification and functional characterization of complement regulator-acquiring surface protein 1 of the Lyme disease spirochetes Borrelia afzelii and Borrelia garinii","volume":"73","author":"R Wallich","year":"2005","journal-title":"Infect Immun"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1099\/00207713-47-4-958","article-title":"Borrelia recurrentis characterization and comparison with relapsing-fever, Lyme-associated, and other Borrelia spp","volume":"47","author":"SJ Cutler","year":"1997","journal-title":"Int J Syst Bacteriol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/j.1365-2958.2006.05318.x","article-title":"Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1","volume":"61","author":"K Hartmann","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1128\/IAI.67.7.3257-3266.1999","article-title":"Comparative analysis and immunological characterization of the Borrelia Bdr protein family","volume":"67","author":"WR Zuckert","year":"1999","journal-title":"Infect Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1128\/IAI.72.3.1463-1469.2004","article-title":"Cross-species surface display of functional spirochetal lipoproteins by recombinant Borrelia burgdorferi","volume":"72","author":"WR Zuckert","year":"2004","journal-title":"Infect Immun"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature03959","article-title":"Genome sequencing in microfabricated high-density picolitre reactors","volume":"437","author":"M Margulies","year":"2005","journal-title":"Nature"},{"key":"ref30","first-page":"1674","article-title":"Immune evasion of Borrelia burgdorferi by acquisition of human complement regulators FHL-1\/reconectin and Factor H. Eur J Immunol","volume":"31","author":"P Kraiczy","year":"2001"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0022-1759(95)00121-P","article-title":"A modified ROC analysis for the selection of cut-off values and the definition of intermediate results of serodiagnostic tests","volume":"185","author":"M Greiner","year":"1995","journal-title":"Journal of Immunological Methods"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1074\/jbc.M308343200","article-title":"Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins","volume":"279","author":"P Kraiczy","year":"2004","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1099\/00221287-146-7-1491","article-title":"Spirochaetal lipoproteins and pathogenesis","volume":"7)","author":"DA Haake","year":"2000","journal-title":"Microbiology 146 (Pt"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1110\/ps.0303703","article-title":"Prediction of lipoprotein signal peptides in Gram-negative bacteria","volume":"12","author":"AS Juncker","year":"2003","journal-title":"Protein Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1021\/bi00186a007","article-title":"Fibronectin receptors from gram-positive bacteria: comparison of active sites","volume":"33","author":"HJ Joh","year":"1994","journal-title":"Biochemistry"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1128\/IAI.69.6.4129-4133.2001","article-title":"Mapping the ligand-binding region of Borrelia burgdorferi fibronectin- binding protein BBK32","volume":"69","author":"WS Probert","year":"2001","journal-title":"Infect Immun"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0925-4439(98)00038-6","article-title":"Fibronectin-binding activity in Borrelia burgdorferi","volume":"1407","author":"DJ Grab","year":"1998","journal-title":"Biochimica et Biophysica Acta"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1365-2958.1998.01127.x","article-title":"Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31","volume":"30","author":"WS Probert","year":"1998","journal-title":"Mol Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1128\/IAI.01424-07","article-title":"A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin","volume":"76","author":"MB Brinkman","year":"2008","journal-title":"Infect Immun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1073\/pnas.86.2.699","article-title":"Nucleotide sequence of the gene for a fibronectin-binding protein from Staphylococcus aureus: use of this peptide sequence in the synthesis of biologically active peptides","volume":"86","author":"C Signas","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1365-2958.1996.6381353.x","article-title":"Characterization of the fibronectin-attachment protein of Mycobacterium avium reveals a fibronectin-binding motif conserved among mycobacteria","volume":"21","author":"JS Schorey","year":"1996","journal-title":"Mol Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/j.1460-2075.1996.tb00435.x","article-title":"A two-domain mechanism for group A streptococcal adherence through protein F to the extracellular matrix","volume":"15","author":"V Ozeri","year":"1996","journal-title":"Embo J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1074\/jbc.273.5.2905","article-title":"The novel fibronectin-binding motif and key residues of mycobacteria","volume":"273","author":"M Naito","year":"1998","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e1000185","DOI":"10.1371\/journal.pgen.1000185","article-title":"The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii","volume":"4","author":"M Lescot","year":"2008","journal-title":"PLoS Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1365-2958.1993.tb01729.x","article-title":"Bacterial proteins binding to the mammalian extracellular matrix","volume":"9","author":"B Westerlund","year":"1993","journal-title":"Mol Microbiol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0955-0674(03)00099-1","article-title":"Bacterial pathogenesis: exploiting cellular adherence","volume":"15","author":"EC Boyle","year":"2003","journal-title":"Curr Opin Cell Biol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1128\/.61.2.136-169.1997","article-title":"Common themes in microbial pathogenicity revisited","volume":"61","author":"BB Finlay","year":"1997","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"18803","DOI":"10.1074\/jbc.M501731200","article-title":"Borrelia burgdorferi binds fibronectin through a tandem beta-zipper, a common mechanism of fibronectin binding in staphylococci, streptococci, and spirochetes","volume":"280","author":"S Raibaud","year":"2005","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"41706","DOI":"10.1074\/jbc.M401691200","article-title":"BBK32, a fibronectin binding MSCRAMM from Borrelia burgdorferi, contains a disordered region that undergoes a conformational change on ligand binding","volume":"279","author":"JH Kim","year":"2004","journal-title":"J Biol Chem"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/j.1365-2958.2005.05042.x","article-title":"Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi","volume":"59","author":"J Seshu","year":"2006","journal-title":"Mol Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.4049\/jimmunol.164.10.5344","article-title":"Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission","volume":"164","year":"2000","journal-title":"J Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"e1000090","DOI":"10.1371\/journal.ppat.1000090","article-title":"Real-time high resolution 3D imaging of the lyme disease spirochete adhering to and escaping from the vasculature of a living host","volume":"4","author":"TJ Moriarty","year":"2008","journal-title":"PLoS Pathog"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Hyde JA, Weening EH, Chang M, Trzeciakowski JP, Hook M, <etal>et al<\/etal>.. (2011) Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity. Molecular microbiology.","DOI":"10.1111\/j.1365-2958.2011.07801.x"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0063437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T13:01:45Z","timestamp":1688216505000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0063437"}},"subtitle":[],"editor":[{"given":"Brian","family":"Stevenson","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,2]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0063437","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,2]]}}}