{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:44:39Z","timestamp":1781732679633,"version":"3.54.5"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0063473","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T21:08:20Z","timestamp":1368565700000},"page":"e63473","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Galanin Protects against Nerve Injury after Shear Stress in Primary Cultured Rat Cortical Neurons"],"prefix":"10.1371","volume":"8","author":[{"given":"Meili","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1124\/mi.3.3.137","article-title":"Galanin in Alzheimer disease","volume":"3","author":"SE Counts","year":"2003","journal-title":"Mol Interv"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1159\/000090906","article-title":"Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer\u2019s disease","volume":"21","author":"SE Counts","year":"2006","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/MCC.0b013e3280895d5c","article-title":"Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature","volume":"13","author":"JW Schouten","year":"2007","journal-title":"Curr Opin Crit Care"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"11569","DOI":"10.1073\/pnas.210254597","article-title":"Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons","volume":"97","author":"G O\u2019Meara","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1046\/j.1471-4159.2002.01208.x","article-title":"Gene expression analysis of spontaneously hypertensive rat cerebral cortex following transient focal cerebral ischemia","volume":"83","author":"VL Raghavendra Rao","year":"2002","journal-title":"J Neurochem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"9960","DOI":"10.1073\/pnas.161293598","article-title":"Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: selective actions via GalR1 and GalR2 receptors","volume":"98","author":"HX Liu","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.nbd.2005.08.016","article-title":"Galanin attenuates beta-amyloid (Abeta) toxicity in rat cholinergic basal forebrain neurons","volume":"21","author":"X Ding","year":"2006","journal-title":"Neurobiol Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jbiomech.2009.09.011","article-title":"Neural mechanobiology and neuronal vulnerability to traumatic loading","volume":"43","author":"MC Laplaca","year":"2010","journal-title":"J Biomech"},{"key":"ref9","first-page":"5395","article-title":"Poloxamer 188 reduces axonal beading following mechanical trauma to cultured neurons","volume":"2007","author":"D Kilinc","year":"2007","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.expneurol.2008.04.025","article-title":"Mechanically-induced membrane poration causes axonal beading and localized cytoskeletal damage","volume":"212","author":"D Kilinc","year":"2008","journal-title":"Exp Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0021-9290(99)00177-3","article-title":"Techniques for mechanical stimulation of cells in vitro: a review","volume":"33","author":"TD Brown","year":"2000","journal-title":"J Biomech"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1263\/jbb.101.120","article-title":"Effects of mechanical stimuli and microfiber-based substrate on neurite outgrowth and guidance","volume":"101","author":"IA Kim","year":"2006","journal-title":"J Biosci Bioeng"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/107632703764664701","article-title":"Optimization of Schwann cell adhesion in response to shear stress in an in vitro model for peripheral nerve tissue engineering","volume":"9","author":"D Chafik","year":"2003","journal-title":"Tissue Eng"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0165-6147(00)01446-2","article-title":"Galanin receptor subtypes","volume":"21","author":"TA Branchek","year":"2000","journal-title":"Trends Pharmacol Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.neuroscience.2005.02.042","article-title":"Role of galanin receptor 1 and galanin receptor 2 activation in synaptic plasticity associated with 3\u2032,5\u2032-cyclic AMP response element-binding protein phosphorylation in the dentate gyrus: studies with a galanin receptor 2 agonist and galanin receptor 1 knockout mice","volume":"133","author":"H Badie-Mahdavi","year":"2005","journal-title":"Neuroscience"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.3233\/JAD-2010-091234","article-title":"Galanin protects amyloid-beta-induced neurotoxicity on primary cultured hippocampal neurons of rats","volume":"20","author":"Y Cheng","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"7178","DOI":"10.1128\/JVI.00404-07","article-title":"A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus","volume":"81","author":"D Westphal","year":"2007","journal-title":"J Virol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1093\/jnci\/djj395","article-title":"Critical role for mitochondrial oxidative phosphorylation in the activation of tumor suppressors Bax and Bak","volume":"98","author":"A Tomiyama","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s12640-011-9240-4","article-title":"Potential protection of green tea polyphenols against 1800 MHz electromagnetic radiation-induced injury on rat cortical neurons","volume":"20","author":"ML Liu","year":"2011","journal-title":"Neurotox Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.arcmed.2010.10.002","article-title":"Effect of fluid shear stress on cardiomyogenic differentiation of rat bone marrow mesenchymal stem cells","volume":"41","author":"Y Huang","year":"2010","journal-title":"Arch Med Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuroscience.2006.08.083","article-title":"L-carnitine protects neurons from 1-methyl-4-phenylpyridinium-induced neuronal apoptosis in rat forebrain culture","volume":"144","author":"C Wang","year":"2007","journal-title":"Neuroscience"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3233\/JAD-2010-1246","article-title":"Galanin protects against intracellular amyloid toxicity in human primary neurons","volume":"19","author":"J Cui","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/cne.10692","article-title":"Chronic nerve compression induces concurrent apoptosis and proliferation of Schwann cells","volume":"461","author":"R Gupta","year":"2003","journal-title":"J Comp Neurol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/S0014-4886(03)00288-7","article-title":"Apoptosis of auditory neurons following central process injury","volume":"184","author":"T Sekiya","year":"2003","journal-title":"Exp Neurol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1007\/s11064-011-0506-2","article-title":"Neurotoxic effect of the complex of the ovine prion protein (OvPrP(C)) and RNA on the cultured rat cortical neurons","volume":"36","author":"ML Liu","year":"2011","journal-title":"Neurochem Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"MW Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0169-328X(97)00070-3","article-title":"Persisting expression of galanin in axotomized mamillary and septal neurons of adult rats labeled for c-Jun and NADPH-diaphorase","volume":"48","author":"S Brecht","year":"1997","journal-title":"Brain Res Mol Brain Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.neuroscience.2010.07.009","article-title":"The effect of mechanical strain or hypoxia on cell death in subpopulations of rat dorsal root ganglion neurons in vitro","volume":"171","author":"SJ Gladman","year":"2010","journal-title":"Neuroscience"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1471-4159.2009.06531.x","article-title":"Initial calcium release from intracellular stores followed by calcium dysregulation is linked to secondary axotomy following transient axonal stretch injury","volume":"112","author":"JA Staal","year":"2010","journal-title":"J Neurochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.pharmthera.2007.05.009","article-title":"The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease","volume":"115","author":"R Lang","year":"2007","journal-title":"Pharmacol Ther"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1471-4159.2006.04239.x","article-title":"Activation of the galanin receptor 2 (GalR2) protects the hippocampus from neuronal damage","volume":"100","author":"CR Elliott-Hunt","year":"2007","journal-title":"J Neurochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1006\/bbrc.1997.6301","article-title":"Changes of p53 in the brains of patients with Alzheimer\u2019s disease","volume":"232","author":"Y Kitamura","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s007020050001","article-title":"Cell death mechanisms in Parkinson\u2019s disease","volume":"107","author":"KA Jellinger","year":"2000","journal-title":"J Neural Transm"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s004010050817","article-title":"Bcl-2 and Bax protein expression in Alzheimer\u2019s disease","volume":"95","author":"A Tortosa","year":"1998","journal-title":"Acta Neuropathol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1002\/eji.200324817","article-title":"Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome C release, and caspase-9 activation","volume":"34","author":"E Eldering","year":"2004","journal-title":"Eur J Immunol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/mc.20559","article-title":"Activation of p53\/p21\/PUMA alliance and disruption of PI-3\/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata","volume":"48","author":"S Bhushan","year":"2009","journal-title":"Mol Carcinog"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1092734","article-title":"Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis","volume":"303","author":"JE Chipuk","year":"2004","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1471-4159.2004.02517.x","article-title":"Inhibition of the E2F-1\/p53\/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells","volume":"90","author":"RM Ramalho","year":"2004","journal-title":"J Neurochem"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0063473","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T20:35:12Z","timestamp":1563050112000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0063473"}},"subtitle":[],"editor":[{"given":"Stefan","family":"Strack","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,14]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0063473","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,14]]}}}