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with AIDS","volume":"158","author":"M Narita","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0140-6736(84)90478-1","article-title":"Paradoxical expansion of intracranial tuberculomas during chemotherapy","volume":"2","author":"ST Chambers","year":"1984","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/clinids\/19.6.1092","article-title":"Paradoxical enlargement or development of intracranial tuberculomas during therapy: case report and review","volume":"19","author":"B Afghani","year":"1994","journal-title":"Clin Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/thx.2003.019224","article-title":"Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection","volume":"59","author":"RA 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Microbiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/QAD.0b013e328011efac","article-title":"Tuberculosis-associated immune reconstitution disease: incidence, risk factors and impact in an antiretroviral treatment service in South Africa","volume":"21","author":"SD Lawn","year":"2007","journal-title":"AIDS"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1056\/NEJMoa0905848","article-title":"Timing of initiation of antiretroviral drugs during tuberculosis therapy","volume":"362","author":"SS Abdool Karim","year":"2010","journal-title":"N Engl J Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1056\/NEJMoa1014181","article-title":"Integration of antiretroviral therapy with tuberculosis treatment","volume":"365","author":"SS Abdool Karim","year":"2011","journal-title":"N Engl J Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1056\/NEJMoa1013911","article-title":"Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis","volume":"365","author":"FX Blanc","year":"2011","journal-title":"N Engl J Med"},{"key":"ref15","unstructured":"Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines forthe use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. Available at http:\/\/aidsinfo.nih.gov\/ContentFiles\/AdultandAdolescentGL.pdf<\/ext-link>. Accessed on 2013 Mar 25."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1097\/QAD.0b013e32833dfc68","article-title":"Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome","volume":"24","author":"G Meintjes","year":"2010","journal-title":"AIDS"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.clim.2010.02.010","article-title":"d-Dimer and CRP levels are elevated prior to antiretroviral treatment in patients who develop IRIS","volume":"136","author":"BO Porter","year":"2010","journal-title":"Clin Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1093\/infdis\/jir134","article-title":"Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death","volume":"203","author":"DR Boulware","year":"2011","journal-title":"J Infect Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/infdis\/jit037","article-title":"Role of Interleukin 6 in Innate Immunity to Mycobacterium tuberculosis Infection","volume":"207","author":"AN Martinez","year":"2013","journal-title":"J Infect Dis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1183\/09031936.00091010","article-title":"Hypercytokinaemia accompanies HIV-tuberculosis immune reconstitution inflammatory syndrome","volume":"37","author":"R Tadokera","year":"2011","journal-title":"Eur Respir J"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1164\/rccm.201201-0094OC","article-title":"Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome","volume":"186","author":"G Meintjes","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1097\/QAD.0b013e32832d72c6","article-title":"Interleukin-2 cycling causes transient increases in high-sensitivity C-reactive protein and D-dimer that are not associated with plasma HIV-RNA levels","volume":"23","author":"BO Porter","year":"2009","journal-title":"AIDS"},{"key":"ref23","unstructured":"Narendran G (2009) Comparing Daily vs Intermittent Regimen of ATT in HIV With Pulmonary Tuberculosis. Available at http:\/\/clinicaltrials.gov\/ct2\/show\/NCT00933790?term=DailyVsintermittentATTinHIV&rank=1<\/ext-link>. Accessed on 2013 Mar 25."},{"key":"ref24","unstructured":"Allen B, Baker FJ (1968) Mycobacteria: Isolation, identification and sensitivity testing. London: Butterworth."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1164\/rccm.200903-0439OC","article-title":"Efficacy of a 6-month versus 9-month intermittent treatment regimen in HIV-infected patients with tuberculosis: a randomized clinical trial","volume":"181","author":"S Swaminathan","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/cid\/cir447","article-title":"Efficacy and safety of once-daily nevirapine- or efavirenz-based antiretroviral therapy in HIV-associated tuberculosis: a randomized clinical trial","volume":"53","author":"S Swaminathan","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1258\/ijsa.2009.009439","article-title":"Immune reconstitution inflammatory syndrome in HIV-infected patients with and without prior tuberculosis","volume":"23","author":"SR Kumar","year":"2012","journal-title":"Int J STD AIDS"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1056\/NEJMoa1013607","article-title":"Timing of antiretroviral therapy for HIV-1 infection and tuberculosis","volume":"365","author":"DV Havlir","year":"2011","journal-title":"N Engl J Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1093\/cid\/cir230","article-title":"Timing of initiation of antiretroviral therapy in human immunodeficiency virus (HIV)\u2013associated tuberculous meningitis","volume":"52","author":"ME Torok","year":"2011","journal-title":"Clin Infect Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1097\/01.aids.0000131375.21070.06","article-title":"Immune restoration disease after antiretroviral therapy","volume":"18","author":"MA French","year":"2004","journal-title":"AIDS"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"841","DOI":"10.3851\/IMP2108","article-title":"Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis-HIV coinfection","volume":"17","author":"W Worodria","year":"2012","journal-title":"Antivir Ther"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1086\/323898","article-title":"Clinical indicators of immune restoration following highly active antiretroviral therapy","volume":"34","author":"EL Cooney","year":"2002","journal-title":"Clin Infect Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jinf.2006.01.002","article-title":"Immune reconstitution inflammatory syndrome of tuberculosis among HIV-infected patients receiving antituberculous and antiretroviral therapy","volume":"53","author":"W Manosuthi","year":"2006","journal-title":"J Infect"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1086\/596764","article-title":"Novel relationship between tuberculosis immune reconstitution inflammatory syndrome and antitubercular drug resistance","volume":"48","author":"G Meintjes","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref35","unstructured":"Toman K (1979) What is the \u201cfall and rise phenomenon\u201d. Tuberculosis case finding and chemotherapy, questions and answers. Geneva: WHO."},{"key":"ref36","unstructured":"WHO (2011) Guidelines for the programmatic management of drug-resistant tuberculosis WHO. Available at http:\/\/whqlibdoc.who.int\/publications\/2011\/9789241501583_eng.pdf<\/ext-link>. 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