{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:24:18Z","timestamp":1758709458973},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T00:00:00Z","timestamp":1369094400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0063861","type":"journal-article","created":{"date-parts":[[2013,5,21]],"date-time":"2013-05-21T21:22:27Z","timestamp":1369171347000},"page":"e63861","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["High-Throughput Screening for GPR119 Modulators Identifies a Novel Compound with Anti-Diabetic Efficacy in db\/db Mice"],"prefix":"10.1371","volume":"8","author":[{"given":"Meng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Nosjean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Boutin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Renard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.2337\/diacare.15.3.318","article-title":"Pathogenesis of NIDDM. A balanced overview","volume":"15","author":"RA DeFronzo","year":"1992","journal-title":"Diabetes Care"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2337\/diab.43.6.735","article-title":"Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM","volume":"43","author":"SI Taylor","year":"1994","journal-title":"Diabetes"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0140-6736(05)61032-X","article-title":"Type 2 diabetes: principles of pathogenesis and therapy","volume":"365","author":"M Stumvoll","year":"2005","journal-title":"Lancet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/S0140-6736(06)69705-5","article-title":"The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes","volume":"368","author":"DJ Drucker","year":"2006","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0140-6736(98)07037-8","article-title":"Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group","volume":"352","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1210\/en.2008-0182","article-title":"GPR119: \u201cdouble-dipping\u201d for better glycemic control","volume":"149","author":"L Lauffer","year":"2008","journal-title":"Endocrinology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1210\/en.2007-0966","article-title":"A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release","volume":"149","author":"ZL Chu","year":"2008","journal-title":"Endocrinology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.bbrc.2006.10.076","article-title":"Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: predominant localization in pancreatic polypeptide-secreting PP-cells","volume":"351","author":"Y Sakamoto","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cmet.2006.02.004","article-title":"Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents","volume":"3","author":"HA Overton","year":"2006","journal-title":"Cell Metab"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1210\/en.2006-1608","article-title":"A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release","volume":"148","author":"ZL Chu","year":"2007","journal-title":"Endocrinology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1517\/13543770903153878","article-title":"GPR119 agonists for the treatment of type 2 diabetes","volume":"19","author":"RM Jones","year":"2009","journal-title":"Expert Opin Ther Pat"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.2174\/1381612043384303","article-title":"Allosteric modulation of G protein-coupled receptors","volume":"10","author":"LT May","year":"2004","journal-title":"Curr Pharm Des"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"5172","DOI":"10.1021\/jm8006867","article-title":"Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119","volume":"51","author":"G Semple","year":"2008","journal-title":"J Med Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1210\/me.2009-0239","article-title":"N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119","volume":"24","author":"ZL Chu","year":"2010","journal-title":"Mol Endocrinol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays","volume":"4","author":"JH Zhang","year":"1999","journal-title":"J Biomol Screen"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1111\/j.1476-5381.2011.01754.x","article-title":"Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways","volume":"165","author":"H Lan","year":"2012","journal-title":"Br J Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1210\/endo.139.10.6228","article-title":"Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line","volume":"139","author":"PL Brubaker","year":"1998","journal-title":"Endocrinology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrd1306","article-title":"cAMP detection methods in HTS: selecting the best from the rest","volume":"3","author":"C Williams","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.bbrc.2010.08.141","article-title":"AS1907417, a novel GPR119 agonist, as an insulinotropic and beta-cell preservative agent for the treatment of type 2 diabetes","volume":"400","author":"S Yoshida","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/379069a0","article-title":"A role for glucagon-like peptide-1 in the central regulation of feeding","volume":"379","author":"MD Turton","year":"1996","journal-title":"nature"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0026-0495(96)90192-4","article-title":"Dose-responses for the slowing of gastric emptying in a rodent model by glucagon-like peptide (7\u201336) NH2, amylin, cholecystokinin, and other possible regulators of nutrient uptake","volume":"45","author":"AA Young","year":"1996","journal-title":"Metabolism"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature01921","article-title":"Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha","volume":"425","author":"J Fu","year":"2003","journal-title":"nature"},{"key":"ref23","first-page":"402","article-title":"The potential role of glucagon-like peptide 1 in diabetes","volume":"5","author":"JJ Meier","year":"2004","journal-title":"Curr Opin Investig Drugs"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0063861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:59:25Z","timestamp":1588971565000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0063861"}},"subtitle":[],"editor":[{"given":"Aimin","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,21]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0063861","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,21]]}}}