{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:44:34Z","timestamp":1790037874749,"version":"4.0.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T00:00:00Z","timestamp":1368489600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0064239","type":"journal-article","created":{"date-parts":[[2013,5,14]],"date-time":"2013-05-14T21:00:21Z","timestamp":1368565221000},"page":"e64239","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Glucose Sensor-Like Protein Hxs1 Is a High-Affinity Glucose Transporter and Required for Virulence in Cryptococcus neoformans"],"prefix":"10.1371","volume":"8","author":[{"given":"Tong-Bao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yina","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany","family":"Fahmy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghuo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoyang","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Casadevall A, Perfect JR (1998) <italic>Cryptococcus neoformans<\/italic>. Washington, DC: ASM Press.","DOI":"10.1128\/9781555818241"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1101\/gad.11.23.3206","article-title":"<italic>Cryptococcus neoformans<\/italic> mating and virulence are regulated by the G-protein alpha subunit <italic>GPA1<\/italic> and cAMP","volume":"11","author":"JA Alspaugh","year":"1997","journal-title":"Genes Dev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S1369-5274(99)80063-0","article-title":"Signal transduction cascades regulating mating, filamentation, and virulence in <italic>Cryptococcus neoformans<\/italic>","volume":"2","author":"P Wang","year":"1999","journal-title":"Curr Opin Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nrmicro1245","article-title":"Deciphering the model pathogenic fungus <italic>Cryptococcus neoformans<\/italic>","volume":"3","author":"A Idnurm","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrmicro1578","article-title":"Sensing the environment: lessons from fungi","volume":"5","author":"YS Bahn","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1128\/MMBR.70.1.253-282.2006","article-title":"Glucose signaling in <italic>Saccharomyces cerevisiae<\/italic>","volume":"70","author":"GM Santangelo","year":"2006","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1172\/JCI18309","article-title":"Identification of App1 as a regulator of phagocytosis and virulence of <italic>Cryptococcus neoformans<\/italic>","volume":"112","author":"C Luberto","year":"2003","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1128\/EC.00252-10","article-title":"Role of glucose in the expression of <italic>Cryptococcus neoformans<\/italic> antiphagocytic protein 1, App1","volume":"10","author":"V Williams","year":"2011","journal-title":"Eukaryot Cell"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e00103","DOI":"10.1128\/mBio.00103-11","article-title":"<italic>Cryptococcus neoformans<\/italic> requires a functional glycolytic pathway for disease but not persistence in the host","volume":"2","author":"MS Price","year":"2011","journal-title":"mBio"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1128\/EC.05273-11","article-title":"Adaptation of <italic>Cryptococcus neoformans<\/italic> to mammalian hosts: integrated regulation of metabolism and virulence","volume":"11","author":"J Kronstad","year":"2012","journal-title":"Eukaryot Cell"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"51669","DOI":"10.1074\/jbc.M408889200","article-title":"UDP-glucose dehydrogenase plays multiple roles in the biology of the pathogenic fungus <italic>Cryptococcus neoformans<\/italic>","volume":"279","author":"CL Griffith","year":"2004","journal-title":"J Biol Chem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.micro.62.081307.162753","article-title":"How sweet it is! Cell wall biogenesis and polysaccharide capsule formation in <italic>Cryptococcus neoformans<\/italic>","volume":"63","author":"TL Doering","year":"2009","journal-title":"Annu Rev Microbiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1574-6976.2001.tb00582.x","article-title":"Conserved cAMP signaling cascades regulate fungal developement and virulence","volume":"25","author":"aHJ D'Souza CA","year":"2001","journal-title":"FEMS Microbiology Reviews"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1567-1356(03)00241-1","article-title":"Cyclic AMP signaling in <italic>Cryptococcus neoformans<\/italic>","volume":"4","author":"R Pukkila-Worley","year":"2004","journal-title":"FEMS Yeast Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1091\/mbc.E05-07-0699","article-title":"G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in <italic>Cryptococcus neoformans<\/italic>","volume":"17","author":"C Xue","year":"2006","journal-title":"Mol Biol Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1128\/EC.4.12.1971-1981.2005","article-title":"Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in <italic>Cryptococcus neoformans<\/italic>","volume":"4","author":"JK Hicks","year":"2005","journal-title":"Eukaryot Cell"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1128\/EC.05179-11","article-title":"Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli","volume":"10","author":"LH Okagaki","year":"2011","journal-title":"Eukaryot Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/BST0330247","article-title":"Glucose as a hormone: receptor-mediated glucose sensing in the yeast <italic>Saccharomyces cerevisiae<\/italic>","volume":"33","author":"M Johnston","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1128\/EC.3.1.221-231.2004","article-title":"Regulatory network connecting two glucose signal transduction pathways in <italic>Saccharomyces cerevisiae<\/italic>","volume":"3","author":"A Kaniak","year":"2004","journal-title":"Eukaryot Cell"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1567-1364.2002.tb00084.x","article-title":"Glucose-sensing and -signalling mechanisms in yeast","volume":"2","author":"F Rolland","year":"2002","journal-title":"FEMS Yeast Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1093\/emboj\/17.7.1996","article-title":"<italic>GPR1<\/italic> encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathway","volume":"17","author":"Y Xue","year":"1998","journal-title":"Embo J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.molcel.2004.10.004","article-title":"Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast <italic>Saccharomyces cerevisiae<\/italic>","volume":"16","author":"K Lemaire","year":"2004","journal-title":"Mol Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1128\/MMBR.63.3.554-569.1999","article-title":"Function and regulation of yeast hexose transporters","volume":"63","author":"S Ozcan","year":"1999","journal-title":"Microbiol Mol Biol Rev"},{"key":"ref24","first-page":"1572","article-title":"Glucose sensing and signaling in <italic>Saccharomyces cerevisiae<\/italic> through the Rgt2 glucose sensor and casein kinase I. Proc Natl Acad Sci U S A","volume":"101","author":"H Moriya","year":"2004"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"26144","DOI":"10.1074\/jbc.M603636200","article-title":"Two glucose-sensing pathways converge on Rgt1 to regulate expression of glucose transporter genes in <italic>Saccharomyces cerevisiae<\/italic>","volume":"281","author":"JH Kim","year":"2006","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1128\/EC.00186-06","article-title":"A glucose sensor in <italic>Candida albicans<\/italic>","volume":"5","author":"V Brown","year":"2006","journal-title":"Eukaryot Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1128\/EC.00028-08","article-title":"Identification of hexose transporter-like sensor <italic>HXS1<\/italic> and functional hexose transporter <italic>HXT1<\/italic> in the methylotrophic yeast <italic>Hansenula polymorpha<\/italic>","volume":"7","author":"OG Stasyk","year":"2008","journal-title":"Eukaryot Cell"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1128\/EC.00004-11","article-title":"The F-Box protein Fbp1 regulates sexual reproduction and virulence in <italic>Cryptococcus neoformans<\/italic>","volume":"10","author":"TB Liu","year":"2011","journal-title":"Eukaryot Cell"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/(SICI)1097-0061(199702)13:2<127::AID-YEA68>3.0.CO;2-#","article-title":"Expression of the <italic>SUC2<\/italic> gene of <italic>Saccharomyces cerevisiae<\/italic> is induced by low levels of glucose","volume":"13","author":"S Ozcan","year":"1997","journal-title":"Yeast"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0014-5793(99)01698-1","article-title":"Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in <italic>Saccharomyces cerevisiae<\/italic>","volume":"464","author":"R Wieczorke","year":"1999","journal-title":"FEBS Lett"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1093\/emboj\/17.9.2566","article-title":"Glucose sensing and signaling by two glucose receptors in the yeast <italic>Saccharomyces cerevisiae<\/italic>","volume":"17","author":"S Ozcan","year":"1998","journal-title":"EMBO J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.fgb.2005.04.004","article-title":"A new hexose transporter from <italic>Cryptococcus neoformans<\/italic>: molecular cloning and structural and functional characterization","volume":"42","author":"M Chikamori","year":"2005","journal-title":"Fungal Genet Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0959-437X(98)80146-9","article-title":"Mechanisms of silencing in <italic>Saccharomyces cerevisiae<\/italic>","volume":"8","author":"AJ Lustig","year":"1998","journal-title":"Curr Opin Genet Dev"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/sj.onc.1205078","article-title":"Transcriptional silencing at <italic>Saccharomyces<\/italic> telomeres: implications for other organisms","volume":"21","author":"WH Tham","year":"2002","journal-title":"Oncogene"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"513","DOI":"10.4161\/nucl.2.6.17710","article-title":"Dare to challenge the silence? Telomeric gene silencing revisited","volume":"2","author":"K Yankulov","year":"2011","journal-title":"Nucleus"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s002940100244","article-title":"Sensors of extracellular nutrients in <italic>Saccharomyces cerevisiae<\/italic>","volume":"40","author":"H Forsberg","year":"2001","journal-title":"Curr Genet"},{"key":"ref37","first-page":"e00084","article-title":"Role of an expanded inositol transporter repertoire in <italic>Cryptococcus neoformans<\/italic> sexual reproduction and virulence","volume":"1","author":"C Xue","year":"2010","journal-title":"mBio"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1128\/EC.00327-10","article-title":"Two major inositol transporters and their role in cryptococcal virulence","volume":"10","author":"Y Wang","year":"2011","journal-title":"Eukaryot Cell"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0064239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T19:12:12Z","timestamp":1595790732000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0064239"}},"subtitle":[],"editor":[{"given":"Yong-Sun","family":"Bahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,5,14]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,5,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0064239","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,14]]}}}