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Delta of Egypt","volume":"18","author":"A Settin","year":"2009","journal-title":"Acta Dermatovenerol Alp Panonica Adriat"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.3390\/ijms12085052","article-title":"A pilot study of the association of tumor necrosis factor alpha polymorphisms with psoriatic arthritis in the romanian population","volume":"12","author":"OM Popa","year":"2011","journal-title":"Int J Mol Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1002\/art.22590","article-title":"TNF polymorphisms in psoriasis: association of psoriatic arthritis with the promoter polymorphism TNF*-857 independent of the PSORS1 risk allele","volume":"56","author":"K Reich","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref22","unstructured":"Wells GA, Shea B, O&apos;Connell D, Peterson J, Welch V, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. ottawa hospital research institute website. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp\" xlink:type=\"simple\">http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp<\/ext-link>. Accessed 2013 Apr 22."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"JP Higgins","year":"2002","journal-title":"Stat Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1002\/sim.1187","article-title":"How should meta-regression analyses be undertaken and interpreted?","volume":"21","author":"SG Thompson","year":"2002","journal-title":"Stat Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"M Egger","year":"1997","journal-title":"BMJ"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/art.10935","article-title":"Cytokine gene polymorphisms: association with psoriatic arthritis susceptibility and severity","volume":"48","author":"J Balding","year":"2003","journal-title":"Arthritis Rheum"},{"key":"ref27","first-page":"973","article-title":"MICA rather than MICB, TNFA, or HLA-DRB1 is associated with susceptibility to psoriatic arthritis","volume":"29","author":"S Gonzalez","year":"2002","journal-title":"J Rheumatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/rheumatology\/41.5.525","article-title":"Tumour necrosis factor-alpha polymorphism and the HLA-Cw*0602 allele in psoriatic arthritis","volume":"41","author":"AM Al-Heresh","year":"2002","journal-title":"Rheumatology (Oxford)"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1136\/ard.61.3.213","article-title":"Differential association of polymorphisms in the TNFalpha region with psoriatic arthritis but not psoriasis","volume":"61","author":"T Hohler","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0198-8859(01)00242-7","article-title":"Polymorphism in MICA rather than HLA-B\/C genes is associated with psoriatic arthritis in the Jewish population","volume":"62","author":"S Gonzalez","year":"2001","journal-title":"Hum Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1046\/j.1523-1747.2000.0202a-5.x","article-title":"Lack of association between promoter polymorphism of the tumor necrosis factor-alpha gene and psoriatic arthritis in Japanese patients","volume":"115","author":"Y Hamamoto","year":"2000","journal-title":"J Invest Dermatol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/1523-1747.ep12337469","article-title":"A TNF-alpha promoter polymorphism is associated with juvenile onset psoriasis and psoriatic arthritis","volume":"109","author":"T Hohler","year":"1997","journal-title":"J Invest Dermatol"},{"key":"ref33","first-page":"113","article-title":"A - 308 promoter polymorphism of tumor necrosis factor alpha gene does not associate with the susceptibility to psoriasis vulgaris. 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