{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:18:06Z","timestamp":1768436286617,"version":"3.49.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T00:00:00Z","timestamp":1370390400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0064392","type":"journal-article","created":{"date-parts":[[2013,6,5]],"date-time":"2013-06-05T19:26:50Z","timestamp":1370460410000},"page":"e64392","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Treatment Response and Mortality among Patients Starting Antiretroviral Therapy with and without Kaposi Sarcoma: A Cohort Study"],"prefix":"10.1371","volume":"8","author":[{"given":"Mhairi","family":"Maskew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"van Cutsem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"MacPhail","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Boulle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Egger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"for IeDEA Southern","family":"Africa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2013,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0140-6736(07)61050-2","article-title":"Incidence of cancers in people with HIV\/AIDS compared with immunosuppressed transplant recipients: a meta-analysis","volume":"370","author":"AE Grulich","year":"2007","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1038\/sj.bjc.6690782","article-title":"Seroprevalence of human herpesvirus-8 (HHV-8) in countries of Southeast Asia compared to the USA, the Caribbean and Africa","volume":"81","author":"D Ablashi","year":"1999","journal-title":"Br J Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/(SICI)1097-0215(20000101)85:1<54::AID-IJC10>3.0.CO;2-D","article-title":"Cancer incidence in the African population of Harare, Zimbabwe: second results from the cancer registry 1993\u20131995","volume":"85","author":"E Chokunonga","year":"2000","journal-title":"Int J Cancer"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1470-2045(08)70175-X","article-title":"Part I: Cancer in Indigenous Africans\u2013burden, distribution, and trends","volume":"Oncol9","author":"DM Parkin","year":"2008","journal-title":"Lancet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1002\/ijc.23391","article-title":"The spectrum of human immunodeficiency virus-associated cancers in a South African black population: results from a case-control study, 1995\u20132004","volume":"122","author":"L Stein","year":"2008","journal-title":"Int J Cancer"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-med-050409-103711","article-title":"The increasing burden of HIV-associated malignancies in resource-limited regions","volume":"62","author":"C Casper","year":"2011","journal-title":"Annu Rev Med"},{"key":"ref7","first-page":"1","article-title":"Kaposi&apos;s sarcoma in South Africa","volume":"28","author":"F Sitas","year":"2001","journal-title":"J Natl Cancer Inst Monogr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1758-2652-13-23","article-title":"AIDS-associated Kaposi&apos;s sarcoma is linked to advanced disease and high mortality in a primary care HIV programme in South Africa","volume":"13","author":"KM Chu","year":"2010","journal-title":"J Int AIDS Soc"},{"key":"ref9","unstructured":"WHO U, UNAIDS (2011) Progress report 2011: Global HIV\/AIDS response. In. Geneva: World Health Organization."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1097\/00002030-199910220-00014","article-title":"Highly active anti-retroviral therapy (HAART) prolongs time to treatment failure in Kaposi&apos;s sarcoma","volume":"13","author":"M Bower","year":"1999","journal-title":"AIDS"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1200\/JCO.2004.08.064","article-title":"Highly active antiretroviral therapy in AIDS-associated Kaposi&apos;s sarcoma: implications for the design of therapeutic trials in patients with advanced, symptomatic Kaposi&apos;s sarcoma","volume":"22","author":"SE Krown","year":"2004","journal-title":"J Clin Oncol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/S0959-8049(01)00106-X","article-title":"Impact of HAART on the clinical management of AIDS-related cancers","volume":"37","author":"U Tirelli","year":"2001","journal-title":"Eur J Cancer"},{"key":"ref13","first-page":"13","article-title":"Management of Kaposi&apos;s sarcoma in resource-limited settings in the era of HAART","volume":"7","author":"L Lynen","year":"2005","journal-title":"AIDS Rev"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1097\/QAD.0b013e32832d080d","article-title":"The effect of HAART in 254 consecutive patients with AIDS-related Kaposi&apos;s sarcoma","volume":"23","author":"M Bower","year":"2009","journal-title":"AIDS"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199803263381301","article-title":"Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators","volume":"338","author":"FJ Palella Jr","year":"1998","journal-title":"N Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/sj.bjc.6603056","article-title":"Remission from Kaposi&apos;s sarcoma on HAART is associated with suppression of HIV replication and is independent of protease inhibitor therapy","volume":"94","author":"V Martinez","year":"2006","journal-title":"Br J Cancer"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0140-6736(06)68649-2","article-title":"A prognostic index for AIDS-associated Kaposi&apos;s sarcoma in the era of highly active antiretroviral therapy","volume":"367","author":"J Stebbing","year":"2006","journal-title":"Lancet"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Fox MP, Maskew M, MacPhail AP, Long L, Brennan AT, <etal>et al<\/etal>.. (2012) Cohort Profile: The Themba Lethu Clinical Cohort, Johannesburg, South Africa. International Journal of Epidemiology 1\u201310 doi:10.1093\/ije\/dys029.","DOI":"10.1093\/ije\/dys029"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1097\/QAD.0b013e328333bfb7","article-title":"Seven-year experience of a primary care antiretroviral treatment programme in Khayelitsha, South Africa","volume":"24","author":"A Boulle","year":"2010","journal-title":"AIDS"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"A11","DOI":"10.1111\/j.1365-3156.2004.01259.x","article-title":"Integrating tuberculosis and HIV care in the primary care setting in South Africa","volume":"9","author":"D Coetzee","year":"2004","journal-title":"Trop.Med Int Health"},{"key":"ref21","first-page":"1256","article-title":"Cohort Profile: The international epidemiological databases to evaluate AIDS (IeDEA) in sub-Saharan Africa. International Journal of Epidemiology","volume":"41","author":"M Egger","year":"2011"},{"key":"ref22","unstructured":"South African National Ministry of Health (2004) South African National Antiretroviral Treatment Guidelines. First Edition. In: National Department of Health Republic of South Africa, editor. Pretoria."},{"key":"ref23","first-page":"405","article-title":"Using vital registration data to update mortality among patients lost to follow-up from ART programmes: evidence from the Themba Lethu Clinic, South Africa","volume":"15","author":"MP Fox","year":"2010","journal-title":"Trop Med Int Health"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/S0959-8049(01)00104-6","article-title":"AIDS and cancer in the era of highly active antiretroviral therapy (HAART)","volume":"37","author":"CS Rabkin","year":"2001","journal-title":"Eur J Cancer"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1258\/ijsa.2008.008353","article-title":"Presentation and survival of patients with AIDS-related Kaposi&apos;s sarcoma in Jos, Nigeria","volume":"20","author":"PA Agaba","year":"2009","journal-title":"Int J STD AIDS"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/QAD.0b013e3282fc9c03","article-title":"Predicting the evolution of Kaposi sarcoma, in the highly active antiretroviral therapy era","volume":"22","author":"EB El Amari","year":"2008","journal-title":"AIDS"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0959-8049(01)00120-4","article-title":"Epidemiology of AIDS-related tumours in developed and developing countries","volume":"37","author":"L Dal Maso","year":"2001","journal-title":"Eur J Cancer"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1002\/cncr.20309","article-title":"The changing pattern of Kaposi sarcoma in patients with HIV, 1994\u20132003: the EuroSIDA Study","volume":"100","author":"A Mocroft","year":"2004","journal-title":"Cancer"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Khammissa RAG, Pantanowitz L, Feller L (2012) Oral HIV-Associated Kaposi Sarcoma: A Clinical Study from the Ga-Rankuwa Area, South Africa. AIDS Res Treat doi: 10.1155\/2012\/873171.","DOI":"10.1155\/2012\/873171"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1097\/QAD.0b013e3283121ca9","article-title":"Long-term immunologic response to antiretroviral therapy in low-income countries: Collaborative analysis of prospective studies","volume":"22","author":"D Nash","year":"2008","journal-title":"AIDS"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/00002030-200203080-00003","article-title":"Effects of combination chemotherapy and highly active antiretroviral therapy on immune parameters in HIV-1 associated lymphoma","volume":"16","author":"T Powles","year":"2002","journal-title":"AIDS"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Brinkhof MWG, Pujades-Rodriguez M, Egger M (2009) Mortality of patients lost to follow-up in antiretroviral treatment programmes in resource-limited settings: systematic review and meta-analysis. PloS one 4(6), e5790. doi:10.1371\/journal.pone.0005790.","DOI":"10.1371\/journal.pone.0005790"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1001\/jama.300.5.506","article-title":"Sampling-Based Approach to Determining Outcomes of Patients Lost to Follow-Up in Antiretroviral Therapy Scale-Up Programs in Africa","volume":"300","author":"EH Geng","year":"2008","journal-title":"JAMA"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-3156.2010.02512.x","article-title":"Cost of using a patient tracer to reduce loss to follow-up and ascertain patient status in a large antiretroviral therapy program in Johannesburg, South Africa","volume":"15","author":"S Rosen","year":"2010","journal-title":"Tropical Medicine and International Health"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/ijc.20606","article-title":"Treatment of AIDS-associated Kaposi\u2019s sarcoma in Zimbabwe: Results of a randomized quality of life focused clinical trial","volume":"113","author":"CLM Olweny","year":"2005","journal-title":"Int J Cancer"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1200\/JCO.2002.12.038","article-title":"A phase II evaluation of low-dose oral etoposide for the treatment of relapsed or progressive AIDS-related Kaposi&apos;s sarcoma: An ACTG clinical study","volume":"20","author":"SR Evans","year":"2002","journal-title":"J Clin Oncol"},{"key":"ref37","first-page":"138","article-title":"Weekly oral etoposide in Kaposi&apos;s sarcoma: A phase I multicenter trial of the AIDS Clinical Trials Group","volume":"9","author":"J Paredes","year":"1995","journal-title":"J. Acquired Immune Defic Syndr"}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0064392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T07:17:20Z","timestamp":1540279040000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0064392"}},"subtitle":[],"editor":[{"given":"Thomas F.","family":"Schulz","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2013,6,5]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,6,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0064392","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,5]]}}}