{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:50:58Z","timestamp":1790797858719,"version":"4.1.0"},"reference-count":76,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T00:00:00Z","timestamp":1378425600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0064547","type":"journal-article","created":{"date-parts":[[2013,9,6]],"date-time":"2013-09-06T21:02:22Z","timestamp":1378501342000},"page":"e64547","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":50,"title":["Promising Aedes aegypti Repellent Chemotypes Identified through Integrated QSAR, Virtual Screening, Synthesis, and Bioassay"],"prefix":"10.1371","volume":"8","author":[{"given":"Polina V.","family":"Oliferenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Oliferenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennadiy I.","family":"Poda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry I.","family":"Osolodkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girinath G.","family":"Pillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich R.","family":"Bernier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maia","family":"Tsikolia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha M.","family":"Agramonte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary G.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Linthicum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan R.","family":"Katritzky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2013,9,6]]},"reference":[{"key":"ref1","article-title":"Insect repellents. Principles, methods, and uses","author":"M Debboun","year":"2007"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature05403","article-title":"Insects as chemosensors of humans and crops","volume":"444","author":"van der Goes","year":"2006","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"8575","DOI":"10.1073\/pnas.1001313107","article-title":"Behavioral insensitivity to DEET in <italic>Aedes aegypti<\/italic> is a genetically determined trait residing in changes in sensillum function","volume":"107","author":"NM Stanczyk","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ttbdis.2012.05.005","article-title":"Different tick-borne encephalitis virus (TBEV) prevalences in unfed versus partially engorged ixodid ticks \u2013 Evidence of virus replication and changes in tick behavior","volume":"3","author":"OA Belova","year":"2012","journal-title":"Ticks and Tickborne Diseases"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1741-7007-7-47","article-title":"Evidence for inhibition of cholinesterases in insect and mammalian nervous systems by the insect repellent DEET","volume":"7","author":"V Corbel","year":"2009","journal-title":"BMC Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e12138","DOI":"10.1371\/journal.pone.0012138","article-title":"Insect repellents: Modulators of mosquito odorant receptor activity","volume":"5","author":"JD Bohbot","year":"2010","journal-title":"PLOS ONE"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/ps.1974","article-title":"Mosquito repellents: A review of chemical structure diversity and olfaction","volume":"66","author":"G Paluch","year":"2010","journal-title":"Pest Manag Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e17705","DOI":"10.1371\/journal.pone.0017705","article-title":"Generic insect repellent detector from the fruit fly <italic>Drosophila melanogaster<\/italic>","volume":"6","author":"Z Syed","year":"2011","journal-title":"PLOS ONE"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/qsar.200430914","article-title":"3D pharmacophore model for insect repellent activity and discovery of new repellent candidates","volume":"24","author":"AK Bhattacharjee","year":"2005","journal-title":"Qsar Comb Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/(SICI)1096-9063(199612)48:4<359::AID-PS490>3.0.CO;2-Z","article-title":"Acetylated 1,3-aminopropanols as repellents against bloodsucking arthropods","volume":"48","author":"J Boeckh","year":"1996","journal-title":"Pestic Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/jps.2600801111","article-title":"Structure-activity relationship studies with mosquito repellent amides","volume":"80","author":"MV Suryanarayana","year":"1991","journal-title":"J Pharn Sci"},{"key":"ref12","first-page":"333","article-title":"Quantitative structure-activity relationship modeling of mosquito repellents using calculated descriptors","volume":"81","author":"R Natarajan","year":"2008","journal-title":"Croat Chem Acta"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"7359","DOI":"10.1073\/pnas.0800571105","article-title":"Synthesis and bioassay of improved mosquito repellents predicted from chemical structure","volume":"105","author":"AR Katritzky","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1093\/jmedent\/47.5.924","article-title":"Novel carboxamides as potential mosquito repellents","volume":"47","author":"AR Katritzky","year":"2010","journal-title":"J Med Entomol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"7618","DOI":"10.1021\/jf900964e","article-title":"Quantitative structure-activity relationship of botanical sesquiterpenes: Spatial and contact repellency to the yellow fever mosquito <italic>Aedes aegypti<\/italic>","volume":"57","author":"G Paluch","year":"2009","journal-title":"J Agric Food Chem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1126\/science.1153121","article-title":"Insect odorant receptors are molecular targets of the insect repellent DEET","volume":"319","author":"M Ditzen","year":"2008","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e6851","DOI":"10.1371\/journal.pone.0006851","article-title":"Selective and irreversible inhibitors of mosquito acetylcholinesterases for controlling malaria and other mosquito-borne diseases","volume":"4","author":"YP Pang","year":"2009","journal-title":"PLOS ONE"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neuron.2010.07.006","article-title":"Avoiding DEET through insect gustatory receptors","volume":"67","author":"Y Lee","year":"2010","journal-title":"Neuron"},{"key":"ref19","article-title":"Insect pheromone biochemistry and molecular biology. Chapter 14. Biochemical diversity of odor detection: OBPs, ODEs and SNMPs","author":"GJ Blomquist","year":"2003"},{"key":"ref20","first-page":"10","article-title":"Odorant and pheromone receptors in insects","volume":"3","author":"TS Ha","year":"2009","journal-title":"Front Cell Neurosci"},{"key":"ref21","article-title":"Insect olfaction: Receptors, signal transduction and behaviour. Res. Probl","volume":"47","author":"K Sato","year":"2009","journal-title":"Cell Differ"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1007\/s10886-004-7941-3","article-title":"Insect olfactory receptors: Contributions of molecular biology to chemical ecology","volume":"30","author":"E Jacquin-Joly","year":"2004","journal-title":"J Chem Ecol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.cell.2004.05.012","article-title":"The molecular basis of odor coding in the <italic>Drosophila<\/italic> antenna","volume":"117","author":"EA Hallem","year":"2004","journal-title":"Cell"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1073\/pnas.0913392107","article-title":"Molecular basis of odor coding in the malaria vector mosquito <italic>Anopheles gambiae<\/italic>","volume":"107","author":"G Wang","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cell.2006.01.050","article-title":"Coding of odors by a receptor repertoire","volume":"125","author":"EA Hallem","year":"2006","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0092-8674(00)80581-4","article-title":"Combinatorial receptor codes for odors","volume":"96","author":"B Malnic","year":"1999","journal-title":"Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.pneurobio.2011.09.007","article-title":"The neurobiology of insect olfaction: Sensory processing in a comparative context","volume":"95","author":"JP Martin","year":"2011","journal-title":"Prog Neurobiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1046\/j.1460-9568.2003.02766.x","article-title":"Relation between stimulus and response in frog olfactory receptor neurons <italic>in vivo<\/italic>","volume":"18","author":"JP Rospars","year":"2003","journal-title":"Eur J Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"10415","DOI":"10.1073\/pnas.0504099102","article-title":"Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons","volume":"102","author":"DP Dougherty","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e1000321","DOI":"10.1371\/journal.pcbi.1000321","article-title":"Computational model of the insect pheromone transduction cascade","volume":"5","author":"Y Gu","year":"2009","journal-title":"PLOS Comput Biol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.biosystems.2006.05.015","article-title":"Modelling the early steps of transduction in insect olfactory receptor neurons","volume":"89","author":"JP Rospars","year":"2007","journal-title":"Biosystems"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s00359-009-0461-4","article-title":"Olfactory perireceptor and receptor events in moths: A kinetic model revised","volume":"195","author":"KE Kaissling","year":"2009","journal-title":"J Comp Physiol A Neurothol Sens Neural Behav Physiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10827-009-0147-5","article-title":"Modeling the response of a population of olfactory receptor neurons to an odorant","volume":"27","author":"M Sandstr\u00f6m","year":"2009","journal-title":"J Comput Neurosci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1752-153X-1-11","article-title":"Predicting olfactory receptor neuron responses from odorant structure","volume":"1","author":"M Schmuker","year":"2007","journal-title":"Chem Cent J"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"20285","DOI":"10.1073\/pnas.0705683104","article-title":"Processing and classification of chemical data inspired by insect olfaction","volume":"104","author":"M Schmuker","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref36","first-page":"AaegOBP22","article-title":"Expression purification and functional analysis of an odorant binding protein","author":"G Yang","year":"2011"},{"key":"ref37","article-title":"Expression pattern of a &apos;Plus-C&apos; class odorant binding protein in the antenna of the malaria vector <italic>Anopheles gambiae<\/italic>","author":"A Schultze","year":"2011","journal-title":"Insect Mol Biol 21 (2)"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.bbrc.2008.05.064","article-title":"Multiple functions of an odorant-binding protein in the mosquito <italic>Aedes aegypti<\/italic>","volume":"372","author":"S Li","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jmb.2011.10.005","article-title":"The crystal structure of odorant binding protein 7 from <italic>Anopheles gambiae<\/italic> exhibits an outstanding adaptability of its binding site","volume":"414","author":"A Lagarde","year":"2011","journal-title":"J Mol Biol"},{"key":"ref40","article-title":"Protein data bank refcodes 3QME 3L4A 3L4L RCSB Protein Data Bank","author":"H Ren","year":"2011"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"34175","DOI":"10.1074\/jbc.M111.274712","article-title":"New insights into the mechanism of odorant detection by the malaria-transmitting mosquito <italic>Anopheles gambiae<\/italic>","volume":"286","author":"F Davrazou","year":"2011","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/BJ20110522","article-title":"Crystal structure of a novel type of odorant-binding protein from <italic>Anopheles gambiae<\/italic> belonging to the C-plus class","volume":"437","author":"A Lagarde","year":"2007","journal-title":"Biochem J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e9471","DOI":"10.1371\/journal.pone.0009471","article-title":"The <italic>Anopheles gambiae<\/italic> odorant binding protein 1 (AgamOBP1) mediates indole recognition in the antennae of female mosquitoes","volume":"5","author":"H Biessmann","year":"2010","journal-title":"PLOS ONE"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e15403","DOI":"10.1371\/journal.pone.0015403","article-title":"Odorant-binding proteins of the malaria mosquito <italic>Anopheles funestus sensu stricto<\/italic>","volume":"5","author":"W Xu","year":"2010","journal-title":"PLOS ONE"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbrc.2005.10.191","article-title":"The crystal structure of an odorant binding protein from <italic>Anopheles gambiae<\/italic>: Evidence for a common ligand release mechanism","volume":"339","author":"M Wogulis","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref46","article-title":"<italic>Anopheles gambiae<\/italic> odorant binding protein crystal complex with the synthetic repellent DEET: Implication for structure-based design of novel mosquito repellents","author":"KE Tsitsanou","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"19102","DOI":"10.1073\/pnas.1012274107","article-title":"Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone","volume":"107","author":"Y Mao","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e8006","DOI":"10.1371\/journal.pone.0008006","article-title":"Structure of an odorant-binding protein from the mosquito <italic>Aedes aegypti<\/italic> suggests a binding pocket covered by a pH-sensitive \u2018lid\u2019","volume":"4","author":"NR Leite","year":"2009","journal-title":"PLOS ONE"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"11925","DOI":"10.1073\/pnas.0811089106","article-title":"Large-scale production and study of a synthetic G protein-coupled receptor: Human olfactory receptor 17-4","volume":"106","author":"BL Cook","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e15428","DOI":"10.1371\/journal.pone.0015428","article-title":"Expression and membrane topology of <italic>Anopheles gambiae<\/italic> odorant receptors in lepidopteran insect cells","volume":"5","author":"P Tsitoura","year":"2010","journal-title":"PLOS ONE"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/157489309787158143","article-title":"Computational biology of olfactory receptors. Curr","volume":"4","author":"CJ Crasto","year":"2009","journal-title":"Bioinf"},{"key":"ref52","first-page":"1","article-title":"A high-throughput behavioural paradigm for <italic>Drosophila<\/italic> olfaction","volume":"361","author":"K Steck","year":"2012","journal-title":"Sci. Rep"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1365-2915.2011.00949.x","article-title":"Multiple activities of insect repellents on odorant receptors in mosquitoes","volume":"25","author":"JD Bohbot","year":"2011","journal-title":"Med Vet Entomol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/nature08834","article-title":"Odorant reception in the malaria mosquito <italic>Anopheles gambiae<\/italic>","volume":"464","author":"AF Carey","year":"2010","journal-title":"Nature"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1021\/ja00226a005","article-title":"Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins","volume":"110","author":"RD Cramer","year":"1988","journal-title":"J Am Chem Soc"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10631-005-0039-9","article-title":"Generation of molecular graphs for QSAR studies","volume":"402","author":"AA Mel\u2019nikov","year":"2005","journal-title":"Dokl Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1021\/cr0780006","article-title":"Some new trends in chemical graph theory","volume":"108","author":"R Garc\u00eda-Domenech","year":"2008","journal-title":"Chem Rev"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"5655","DOI":"10.1021\/jm070679i","article-title":"Discovery of small molecule CXCR4 antagonists","volume":"50","author":"W Zhan","year":"2007","journal-title":"J Med Chem"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1134\/S1607672908010122","article-title":"Modeling of the relationships between the structure of o-phosphorylated oximes and their anticholinesterase activity and selectivity using Molecular Field Topology Analysis (MFTA)","volume":"418","author":"EV Radchenko","year":"2008","journal-title":"Dokl Biochem Biophys"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1134\/S0012500808090073","article-title":"Computer-aided design of selective ligands of the benzodiazepine-binding site of the GABA-A receptor","volume":"422","author":"VI Chupakhin","year":"2008","journal-title":"Dokl Chem"},{"key":"ref61"},{"key":"ref62","first-page":"566","article-title":"An air-flow apparatus for selecting female mosquitos for use in repellent and attraction studies","volume":"41","author":"KH Posey","year":"1981","journal-title":"Mosq News"},{"key":"ref63","year":"2009"},{"key":"ref64","first-page":"810","article-title":"EPA Product Performance Test Guidelines OPPTS","year":"1999"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1007\/BF01013489","article-title":"Plant\u2013insect coevolution and inhibition of acetylcholinesterase","volume":"14","author":"MF Ryan","year":"1988","journal-title":"J Chem Ecol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ps.1899","article-title":"Evaluation of semiochemical toxicity to <italic>Aedes aegypti<\/italic>, <italic>Ae. albopictus<\/italic>, and <italic>Anopheles quadrimaculatus<\/italic> (Diptera: Culicidae)","volume":"66","author":"PE Kaufman","year":"2010","journal-title":"Pest Manag Sci"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1532-0456(01)00255-1","article-title":"Insecticidal activity of essential oils: Octopaminergic sites of action","volume":"130","author":"E Enan","year":"2001","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol."},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/ps.548","article-title":"Activation of octopaminergic receptors by essential oil constituents isolated from aromatic plants: Possible mode of action against insect pests","volume":"58","author":"M Kostyukovsky","year":"2002","journal-title":"Pest Manag Sci"},{"key":"ref69","first-page":"403","article-title":"Cinnamic acid derivatives: A new chapter of various pharmacological activities","volume":"3","author":"P Sharma","year":"2011","journal-title":"J Chem Pharm Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1021\/jf0497152","article-title":"Chemical composition and mosquito larvicidal activity of essential oils from leaves of different <italic>Cinnamomum osmophloeum<\/italic> provenances","volume":"52","author":"SS Cheng","year":"2004","journal-title":"J Agric Food Chem"},{"key":"ref71","article-title":"Plant secondary compounds \u2013 A basis for new avian repellents","author":"DR Crocker","year":"1990"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.ibmb.2005.03.010","article-title":"Antennal expressed genes of the yellow fever mosquito (<italic>Aedes aegypti<\/italic> L.); Characterisation of odorant-binding protein 10 and takeout","volume":"35","author":"J Bohbot","year":"2005","journal-title":"Insect Biochem Mol Biol"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1126\/science.104.2699.266","article-title":"Two new effective insect repellents NMRI-201 and NMRI-448","volume":"104","author":"LA Jachowski","year":"1946","journal-title":"Science"},{"key":"ref74"},{"key":"ref75","article-title":"Insect repellent compositions","author":"HA Jones","year":"1946"},{"key":"ref76","first-page":"204","article-title":"N-acylamides and N-alkylsulfonamides from heterocyclic amines as repellents or yellow fever mosquitoes","volume":"35","author":"TP McGovern","year":"1975","journal-title":"Mosq News"}],"updated-by":[{"DOI":"10.1371\/annotation\/1dc83f26-8045-4b63-8a86-24c7b71a7f79","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T00:00:00Z","timestamp":1388966400000}}],"container-title":["PLoS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0064547","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T14:58:54Z","timestamp":1563893934000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0064547"}},"subtitle":[],"editor":[{"given":"Pedro\u00a0Lagerblad","family":"Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2013,9,6]]},"references-count":76,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2013,9,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0064547","relation":{"correction":[{"id-type":"doi","id":"10.1371\/annotation\/1dc83f26-8045-4b63-8a86-24c7b71a7f79","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,6]]}}}