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Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.thomsonhc.com\/hcs\/librarian\/PFDefaultActionId\/pf\" xlink:type=\"simple\">http:\/\/www.thomsonhc.com\/hcs\/librarian\/PFDefaultActionId\/pf<\/ext-link>. Accessed 10 August 2012."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1535-7511.2007.00186.x","article-title":"Epilepsy surgery in the frontal lobe: terra incognita or new frontier?","volume":"7","author":"JW Miller","year":"2007","journal-title":"Epilepsy Curr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.2217\/14622416.7.4.551","article-title":"ABCB1 polymorphisms influence the response to antiepileptic drugs in Japanese epilepsy patients","volume":"7","author":"T Seo","year":"2006","journal-title":"Pharmacogenomics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.seizure.2011.01.008","article-title":"Lack of association of ABCB1 and PXR polymorphisms with response to treatment in epilepsy","volume":"20","author":"BS Haerian","year":"2011","journal-title":"Seizure"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000109264","article-title":"Association of MDR1 (C3435T) polymorphism and resistance to carbamazepine in epileptic patients from Turkey","volume":"59","author":"GO Ozgon","year":"2008","journal-title":"Eur Neurol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1111\/j.1528-1167.2008.01661.x","article-title":"Association of ABCB1 genetic variants 3435C&gt;T and 2677G&gt;T to ABCB1 mRNA and protein expression in brain tissue from refractory epilepsy patients","volume":"49","author":"I Mosyagin","year":"2008","journal-title":"Epilepsia"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.biochi.2010.04.008","article-title":"Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients","volume":"92","author":"S Grover","year":"2010","journal-title":"Biochimie"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2133\/dmpk.24.255","article-title":"Analysis of genotype and haplotype effects of ABCB1 (MDR1) polymorphisms in the risk of medically refractory epilepsy in an Indian population","volume":"24","author":"SA Vahab","year":"2009","journal-title":"Drug Metab Pharmacokinet"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/FPC.0b013e328338073a","article-title":"A nonsynonymous variation on MRP2\/ABCC2 is associated with neurological adverse drug reactions of Carbamazapine in patients with epilepsy","volume":"20","author":"WJ Kim","year":"2010","journal-title":"Pharmacogenet Genomics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1756-9966-28-153","article-title":"ERCC2, ERCC1 polymorphisms and haplotypes, cooking oil fume and adenocarcinoma risk in Chinese non-smoking females","volume":"28","author":"Z Yin","year":"2009","journal-title":"J Exp Clin Cancer Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/sj.cr.7290272","article-title":"SHEsis, a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci","volume":"15","author":"YY Shi","year":"2005","journal-title":"Cell Res"},{"key":"ref17","volume":"19","unstructured":"Li Z, Zhang Z, He Z, Tang W, Li T, <etal>et al<\/etal>.. (2009) A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis (<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/analysis.bio-x.cn\" xlink:type=\"simple\">http:\/\/analysis.bio-x.cn<\/ext-link>). Cell Res <volume>19<\/volume>: : 519\u2013523. doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dx.doi.org\/10.1038\/cr.2009.33\" xlink:type=\"simple\">10.1038\/cr.2009.33<\/ext-link>."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1182\/blood.V80.11.2735.bloodjournal80112735","article-title":"Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes","volume":"80","author":"PM Chaudhary","year":"1992","journal-title":"Blood"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/00007691-200404000-00017","article-title":"Clinical aspects of the MDR1 (ABCB1) gene polymorphism","volume":"26","author":"M Eichelbaum","year":"2004","journal-title":"Ther Drug Monit"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.tips.2004.06.002","article-title":"Importance of P-glycoprotein at blood-tissue 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